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Questions and Answers
What is the purpose of using excipients in powder formulation?
Why is it important for powders to be non-adhesive?
What is the role of disintegrants in tablet formulation?
Why is uniform power mix needed in tablet formulation?
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What happens to gelatin shell in a higher pH environment?
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What is the function of a self-emulsifying system for drug delivery?
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What is the purpose of using a suspension for drug delivery?
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How does a higher pH environment affect gelatin hydrolysis?
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What are the key quality control tests for softgel capsules?
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What does the dissolution test measure?
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What is the purpose of opacifiers in softgel capsules?
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What is a disadvantage of softgel capsules?
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What is the composition of softgel capsules?
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What does the disintegration test for softgel capsules involve?
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What is the role of flavors in softgel capsules?
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What is the purpose of the polymer shell in softgel capsules?
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What is the significance of the ratio of dry plasticizer to dry gelatin in softgel capsules?
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What type of drug delivery are softgel capsules suitable for?
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What are the advantages of softgel capsules?
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What is the role of enteric coating in softgel capsules?
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What excipients can enhance the solubility of poorly soluble drugs?
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What is the purpose of disintegrants in capsules?
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What method can be used to reduce powder sticking to machine surfaces?
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What affects the release of the drug after swallowing?
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Which type of polymers can be used in the capsule material to create enteric capsules?
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What is the purpose of surfactants like sodium lauryl sulfate in capsule formulation?
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What is the purpose of using a tamping system in industrial scale capsule filling?
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What can be used to create a tamper-proof seal for capsules?
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What can be used to enhance the solubility of poorly soluble drugs?
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What can reduce the dissolution rate of powders?
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What is the purpose of using magnesium stearate in capsule formulation?
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What affects the dissolution rate of powders?
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Study Notes
Capsule Filling and Sealing Process Overview
- Capsules may need to break easily, especially for powders, and may require microcrystalline cellulose, sodium starch glycolate, and crospovidone for disintegration.
- Disintegrants work by swelling when wet, pushing particles apart, and the need for disintegrants depends on the powder's compression and space between particles.
- Starch is suitable for tablets but not for capsules due to its strength, and surfactants like sodium lauryl sulfate are used for hydrophobic drugs to aid in wetting.
- The release of the drug after swallowing depends on the shell disintegration, polymer dissolution at body temperature, and the powder's loose or plug form affecting the speed of drug release.
- Particle size affects dissolution rate, and powders that aggregate reduce the dissolution rate, necessitating a formulation where powders disperse effectively in the gastrointestinal tract.
- Excipients like wetting agents and sugars can enhance the solubility of poorly soluble drugs and draw water into the powder mass.
- Magnesium stearate can reduce powder sticking to machine surfaces, but excessive use can decrease drug release, and lubricants impact the cohesion and adhesion of powders.
- Bench scale filling involves manually filling empty caps with a powder blend, pushing the powder into the cap, and industrial scale filling can handle 5000-150,000 capsules per hour using various systems like the auger, dosing tube, and dising disc with a tamping system.
- Capsule sealing methods include creating a band using a polymer for extra security, tamper-proof seals, and using heat, color, or solvent to seal the capsule.
- Cleaning and coating processes involve dedusting and polishing the capsules, spraying coating solutions, and applying film or functional coatings based on the purpose.
- Enteric capsules can be made through enteric coating or by using pH-sensitive polymers in the capsule material.
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Description
Test your knowledge of the capsule filling and sealing process with this quiz. Explore topics such as disintegrants, excipients, filling methods, sealing techniques, and coating processes involved in the pharmaceutical industry.
