Pharmaceutical Capsule Filling and Sealing Quiz
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Questions and Answers

What is the purpose of using excipients in powder formulation?

  • To improve powder stability
  • To bulk up the powder and form a plug (correct)
  • To enhance powder bioavailability
  • To reduce powder cohesion

    • Why is it important for powders to be non-adhesive?

  • To increase powder bioavailability
  • To improve powder appearance
  • To reduce powder cohesion
  • To prevent clumping and facilitate production (correct)

    • What is the role of disintegrants in tablet formulation?

  • To aid in tablet disintegration under high pressure (correct)
  • To reduce powder cohesion
  • To enhance powder bioavailability
  • To improve powder stability

    • Why is uniform power mix needed in tablet formulation?

    <p>To ensure accurate dosing</p> Signup and view all the answers

    What happens to gelatin shell in a higher pH environment?

    <p>It can cause cross-linking of gelatin molecules, making the shell harder to dissolve</p> Signup and view all the answers

    What is the function of a self-emulsifying system for drug delivery?

    <p>To ensure the oil containing drug and surfactant mixes in GI fluid</p> Signup and view all the answers

    What is the purpose of using a suspension for drug delivery?

    <p>For drugs not soluble in solvents</p> Signup and view all the answers

    How does a higher pH environment affect gelatin hydrolysis?

    <p>It inhibits gelatin hydrolysis</p> Signup and view all the answers

    What are the key quality control tests for softgel capsules?

    <p>Uniformity of weight, uniformity of content, disintegration, and dissolution tests</p> Signup and view all the answers

    What does the dissolution test measure?

    <p>How much drug dissolves from the capsule at specific time points</p> Signup and view all the answers

    What is the purpose of opacifiers in softgel capsules?

    <p>To block out light and protect the drug from photodegradation</p> Signup and view all the answers

    What is a disadvantage of softgel capsules?

    <p>Higher cost and slower production</p> Signup and view all the answers

    What is the composition of softgel capsules?

    <p>Gelatin, plasticizer, filling (liquid), colorants, opacifiers, flavors, and enteric coating</p> Signup and view all the answers

    What does the disintegration test for softgel capsules involve?

    <p>Placing capsules in a disintegration well, moving them in specified liquid, and checking the time for disintegration</p> Signup and view all the answers

    What is the role of flavors in softgel capsules?

    <p>To provide taste to the capsule shell</p> Signup and view all the answers

    What is the purpose of the polymer shell in softgel capsules?

    <p>It is pH-sensitive and does not require an enteric coating</p> Signup and view all the answers

    What is the significance of the ratio of dry plasticizer to dry gelatin in softgel capsules?

    <p>It is crucial for the flexibility and pliability of the shell</p> Signup and view all the answers

    What type of drug delivery are softgel capsules suitable for?

    <p>Liquids or suspensions as a single solid dose</p> Signup and view all the answers

    What are the advantages of softgel capsules?

    <p>High bioavailability, consumer preference, good appearance, and protection of the drug from oxidation and moisture</p> Signup and view all the answers

    What is the role of enteric coating in softgel capsules?

    <p>It protects the drug from gastric acid and facilitates release in the intestines</p> Signup and view all the answers

    What excipients can enhance the solubility of poorly soluble drugs?

    <p>Wetting agents and sugars</p> Signup and view all the answers

    What is the purpose of disintegrants in capsules?

    <p>To push particles apart by swelling when wet</p> Signup and view all the answers

    What method can be used to reduce powder sticking to machine surfaces?

    <p>Magnesium stearate</p> Signup and view all the answers

    What affects the release of the drug after swallowing?

    <p>Shell disintegration, polymer dissolution, and powder form</p> Signup and view all the answers

    Which type of polymers can be used in the capsule material to create enteric capsules?

    <p>pH-sensitive polymers</p> Signup and view all the answers

    What is the purpose of surfactants like sodium lauryl sulfate in capsule formulation?

    <p>To aid in wetting for hydrophobic drugs</p> Signup and view all the answers

    What is the purpose of using a tamping system in industrial scale capsule filling?

    <p>To ensure proper compaction of the powder blend</p> Signup and view all the answers

    What can be used to create a tamper-proof seal for capsules?

    <p>Creating a band using a polymer</p> Signup and view all the answers

    What can be used to enhance the solubility of poorly soluble drugs?

    <p>Wetting agents and sugars</p> Signup and view all the answers

    What can reduce the dissolution rate of powders?

    <p>Powders that aggregate</p> Signup and view all the answers

    What is the purpose of using magnesium stearate in capsule formulation?

    <p>To reduce powder sticking to machine surfaces</p> Signup and view all the answers

    What affects the dissolution rate of powders?

    <p>Particle size and aggregation</p> Signup and view all the answers

    Study Notes

    Capsule Filling and Sealing Process Overview

    • Capsules may need to break easily, especially for powders, and may require microcrystalline cellulose, sodium starch glycolate, and crospovidone for disintegration.
    • Disintegrants work by swelling when wet, pushing particles apart, and the need for disintegrants depends on the powder's compression and space between particles.
    • Starch is suitable for tablets but not for capsules due to its strength, and surfactants like sodium lauryl sulfate are used for hydrophobic drugs to aid in wetting.
    • The release of the drug after swallowing depends on the shell disintegration, polymer dissolution at body temperature, and the powder's loose or plug form affecting the speed of drug release.
    • Particle size affects dissolution rate, and powders that aggregate reduce the dissolution rate, necessitating a formulation where powders disperse effectively in the gastrointestinal tract.
    • Excipients like wetting agents and sugars can enhance the solubility of poorly soluble drugs and draw water into the powder mass.
    • Magnesium stearate can reduce powder sticking to machine surfaces, but excessive use can decrease drug release, and lubricants impact the cohesion and adhesion of powders.
    • Bench scale filling involves manually filling empty caps with a powder blend, pushing the powder into the cap, and industrial scale filling can handle 5000-150,000 capsules per hour using various systems like the auger, dosing tube, and dising disc with a tamping system.
    • Capsule sealing methods include creating a band using a polymer for extra security, tamper-proof seals, and using heat, color, or solvent to seal the capsule.
    • Cleaning and coating processes involve dedusting and polishing the capsules, spraying coating solutions, and applying film or functional coatings based on the purpose.
    • Enteric capsules can be made through enteric coating or by using pH-sensitive polymers in the capsule material.

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    Description

    Test your knowledge of the capsule filling and sealing process with this quiz. Explore topics such as disintegrants, excipients, filling methods, sealing techniques, and coating processes involved in the pharmaceutical industry.

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