Pharmaceutical and Medicinal Chemistry Lecture 1 Quiz
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Questions and Answers

What is the definition of drugs?

  • Chemical substances used to prevent or cure diseases in humans, animals, and plants (correct)
  • Chemical substances with no potential side effects
  • Chemical substances used to cure diseases in humans only
  • Chemical substances that are completely safe for humans
  • What is the activity of a drug?

  • Its physical form
  • Its color and taste
  • Its price in the market
  • Its pharmacological effect on the subject (correct)
  • What are analgesics?

  • Medications that induce sleep
  • Medications that relieve pain (correct)
  • Medications that prevent diseases in plants
  • Medications that cause pain
  • What happens if drugs are taken in excess?

    <p>They act as poisons</p> Signup and view all the answers

    What are the unwanted effects of drugs commonly referred to as?

    <p>Side effects</p> Signup and view all the answers

    What can over-usage of antibiotics lead to?

    <p>Development of resistance to that drug by both the patients, microorganisms, and virus the drug is intended to control</p> Signup and view all the answers

    What effect does repeated dosing of barbiturates have on the body's production of mixed function oxidases?

    <p>Increases the production of mixed function oxidases</p> Signup and view all the answers

    Who carried out the first rational development of synthetic drugs in 1910?

    <p>Paul Ehrlich and Sacachiro Hata</p> Signup and view all the answers

    What did Paul Ehrlich and Sacachiro Hata produce in 1910?

    <p>Arsphemamine</p> Signup and view all the answers

    What is the updated version of Ehrlich's chemotherapeutic index that takes into account individual variability?

    <p>Therapeutic index</p> Signup and view all the answers

    Who proposed the idea that chemical agents bind to receptors to cause biological or pharmacological effects?

    <p>John Langley</p> Signup and view all the answers

    What is the section of a ligand that binds to a receptor known as?

    <p>Pharmacophore</p> Signup and view all the answers

    What did Hansch and Fujita successfully incorporate into SAR determinations in the 1960s?

    <p>Quantitative measurements</p> Signup and view all the answers

    What are the products obtained from animal, vegetable, and mineral sources sometimes very effective but often very toxic?

    <p>$Atoxyl$</p> Signup and view all the answers

    What drug was used up to the mid-1940s, when it was replaced by penicillin?

    <p>$Arsphemamine$</p> Signup and view all the answers

    What effect does the binding of a chemical agent to a receptor set in motion?

    <p>$Biochemical events resulting in a biological or pharmacological effect$</p> Signup and view all the answers

    What is the aim of the experiment in Exp. 1?

    <p>The aim is to determine the vitamin C concentration in tablets by a redox titration using iodine.</p> Signup and view all the answers

    What is the chemical formula of Vitamin C?

    <p>The chemical formula is $C_6H_8O_6$.</p> Signup and view all the answers

    In which type of solvents is Vitamin C soluble?

    <p>Vitamin C is soluble in water, glycerol, ethanol, and propylene glycol.</p> Signup and view all the answers

    What role does Vitamin C play in the body?

    <p>Vitamin C plays a vital role in protecting the body from infection and disease, and is involved in tissue repair and enzymatic production of neurotransmitters.</p> Signup and view all the answers

    How is the concentration of vitamin C determined in a solution?

    <p>The concentration of vitamin C is determined by a redox titration using iodine.</p> Signup and view all the answers

    What is the classification of Vitamin C?

    <p>Vitamin C is classified as an organic compound.</p> Signup and view all the answers

    What is the function of vitamin C?

    <p>The function of vitamin C includes growth and repair of tissue, formation of collagen, prevention of scurvy, acting as an antioxidant, assisting in the synthesis of DNA, enhancing the absorption of iron, and reducing the risk of cancer and cardiovascular disease.</p> Signup and view all the answers

    Why is acid-base titration not suitable for measuring vitamin C concentration?

    <p>Acid-base titration is not suitable for measuring vitamin C concentration because there are many acids and bases in foodstuffs, as well as other products that interfere with acid-base titration.</p> Signup and view all the answers

    What are the potential symptoms of not consuming enough vitamin C?

    <p>The potential symptoms of not consuming enough vitamin C include hemorrhage, scurvy disease, bleeding gums and joints, loose teeth, weakness, swollen ankles and wrists, bone pain and fractures, depression, and anemia.</p> Signup and view all the answers

    What are the potential harmful effects of mega doses (more than 2000 mg) of vitamin C supplements?

    <p>The potential harmful effects of mega doses of vitamin C supplements include diarrhea, nausea, vomiting, heartburn, and abdominal cramps.</p> Signup and view all the answers

    What is the endpoint of the titration method used for vitamin C measurement?

    <p>The endpoint of the titration method used for vitamin C measurement is the formation of the blue-black starch-iodine complex.</p> Signup and view all the answers

    What equipment is needed for the experimental part of the titration method?

    <p>The equipment needed for the experimental part of the titration method includes burette, stand, measuring cylinders, volumetric flask, conical flasks, pipette, and wash bottle.</p> Signup and view all the answers

    What solutions are needed for the titration method?

    <p>The solutions needed for the titration method include iodine solution (0.005 mole/L) and starch indicator solution (0.5%).</p> Signup and view all the answers

    What is the recommended amount of vitamin C for adults?

    <p>The recommended amount of vitamin C for adults is 75 mg/day for women aged 19 years and older, and 90 mg/day for men aged 19 and older.</p> Signup and view all the answers

    What are the good sources of vitamin C?

    <p>The good sources of vitamin C include vitamin C tablets, fresh or packaged fruit juices, solid fruits, and vegetables.</p> Signup and view all the answers

    What is the role of iodine in the titration method for measuring vitamin C?

    <p>The role of iodine is to oxidize ascorbic acid to dehydroascorbic acid during the titration process.</p> Signup and view all the answers

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