Podcast
Questions and Answers
Most drugs are classified as ______ or bases
Most drugs are classified as ______ or bases
acids
Partitioning characteristics describe the ability of a drug to transfer between different biological environments and predict the molecule's hydrophilicity and ______
Partitioning characteristics describe the ability of a drug to transfer between different biological environments and predict the molecule's hydrophilicity and ______
hydrophobicity
Weak organic acids and weak organic ______ are common acidic functional groups
Weak organic acids and weak organic ______ are common acidic functional groups
bases
The Arrhenius theory defines an acid as a substance that produces ______ ions in solution
The Arrhenius theory defines an acid as a substance that produces ______ ions in solution
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Bronsted-Lowry theory states that an acid must lose a ______ to become a base
Bronsted-Lowry theory states that an acid must lose a ______ to become a base
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The ______ barked
The ______ barked
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Relative Acid Strength (pKa) pH pKa and pH Henderson–Hasselbalch equation Measures basicity or acidity of a substance or solutions ______ How tightly a proton is held by a compound Shows how weak or strong an acid is HA – conjugate acid A - conjugate base Quantifies the extent to which a compound will lose or donate a proton in a solution
Relative Acid Strength (pKa) pH pKa and pH Henderson–Hasselbalch equation Measures basicity or acidity of a substance or solutions ______ How tightly a proton is held by a compound Shows how weak or strong an acid is HA – conjugate acid A - conjugate base Quantifies the extent to which a compound will lose or donate a proton in a solution
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True or False pH = ______ if the concentration of the conjugate base equals the concentration of the acid.
True or False pH = ______ if the concentration of the conjugate base equals the concentration of the acid.
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PKa of drugs and absorption Weak acid drugs are absorbed in ______ environment Ka – acid dissociation constant pKa – negative logarithmic value of acid True or False dissociation Weak acid drugs are usually absorbed in the stomach.
PKa of drugs and absorption Weak acid drugs are absorbed in ______ environment Ka – acid dissociation constant pKa – negative logarithmic value of acid True or False dissociation Weak acid drugs are usually absorbed in the stomach.
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The higher the pKa the ______ the acid The smaller the pKa the ______ the acid Weak acid they strongly hold their protons Strong acid they easily give up their protons 2|P ageC5.1 Felicitas, T.A.Pharma 2-A
The higher the pKa the ______ the acid The smaller the pKa the ______ the acid Weak acid they strongly hold their protons Strong acid they easily give up their protons 2|P ageC5.1 Felicitas, T.A.Pharma 2-A
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