Environmental Health and Toxicology

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Questions and Answers

What are the common uses of PFAS substances in everyday products?

  • Non-stick cookware and stain-resistant fabrics (correct)
  • Cosmetics and cleaning agents
  • Construction materials and pesticides
  • Fuel additives and antifreeze

What does the abbreviation PFOA stand for?

  • Perfluoroacetic acid
  • Perfluorooctanoic acid (correct)
  • Perfluorohexanoic acid
  • Perfluorodecanoic acid

What health issues have been associated with PFOA exposure based on studies?

  • Heart disease and hypertension
  • Asthma and allergies
  • Birth defects and cancer (correct)
  • Obesity and diabetes

Why are PFAS substances considered durable?

<p>They resist breaking down over time (C)</p> Signup and view all the answers

What is a common misconception regarding dangerous chemicals?

<p>They are always regulated for public health. (C)</p> Signup and view all the answers

What is a challenge mentioned in finding alternatives for PFOA?

<p>Substitutes are just as toxic despite being less long-lasting. (D)</p> Signup and view all the answers

What was a suspected driving factor behind the 1918-1919 global influenza pandemic?

<p>Higher access to hospitals (A)</p> Signup and view all the answers

What percentage of children in the poorest countries die before the age of five?

<p>1 in 5 (D)</p> Signup and view all the answers

What is a common fate of children in the richest countries compared to those in the poorest?

<p>Lower chance of dying before age 5 (C)</p> Signup and view all the answers

What type of diseases were previously high on the list of illness burden?

<p>Communicable diseases (C)</p> Signup and view all the answers

What is becoming more common in the ranking of disease burden today?

<p>Chronic disorders related to age and diet (D)</p> Signup and view all the answers

Where is much of the change in disease burden occurring?

<p>Low-income regions (D)</p> Signup and view all the answers

What factor has contributed to changes in disease burden rankings?

<p>Adopting habits and diets of richer countries (C)</p> Signup and view all the answers

What was the primary measure used to rank the major causes of disease burden?

<p>Disability-adjusted life years (DALYs) (C)</p> Signup and view all the answers

Which population is most affected by emerging chronic disorders?

<p>Senior citizens (C)</p> Signup and view all the answers

What was a significant factor in the health transition observed in recent decades?

<p>An increase in sedentary lifestyles (B)</p> Signup and view all the answers

Which of the following was NOT a focus of health concerns decades ago?

<p>Chronic diseases (A)</p> Signup and view all the answers

What demographic shift is impacting health trends in low-income regions?

<p>Aging population (B)</p> Signup and view all the answers

Which of the following is an example of a chronic disorder?

<p>Heart disease (B)</p> Signup and view all the answers

How are health agencies adjusting for the costs of chronic illness?

<p>Calculating disease burden (A)</p> Signup and view all the answers

What is a consequence of the decrease in infectious diseases combined with an aging population?

<p>Shift in global disease burden (A)</p> Signup and view all the answers

What is the disease that is notably affected due to malnutrition?

<p>Tuberculosis (C)</p> Signup and view all the answers

What chronic condition is associated with increased disability-adjusted life years?

<p>COPD (D)</p> Signup and view all the answers

Which of the following problems is often seen in aging populations, contributing to the global health burden?

<p>Chronic conditions (D)</p> Signup and view all the answers

What role does substance abuse play in the overall disease burden?

<p>It contributes to chronic disease prevalence (A)</p> Signup and view all the answers

What does the acronym PFAS stand for?

<p>Perfluoroalkyl Substances (B)</p> Signup and view all the answers

Flashcards

PFAS (Per- and Polyfluoroalkyl Substances)

A group of manufactured chemicals used in non-stick coatings, stain-resistant fabrics, and other products known for their slipperiness and durability.

PFOA (Perfluoroactoic Acid)

One of the most widely used PFAS, often found in non-stick cookware.

PFOS (Perfluorooctane Sulfonate)

Another popular member of the PFAS family, known for its use in stain-resistant fabrics and furniture.

Toxicity

The ability of a chemical to cause harm to living organisms.

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Toxicology

The study of the adverse effects of chemical, physical, and biological agents on living organisms and the ecosystems.

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Risk Assessment

A process involving assessing the potential risks associated with exposure to a chemical substance, considering its toxicity and the likelihood of exposure.

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Health Policy

The process of developing policies and regulations to protect public health from environmental hazards, including chemicals.

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Concentration

The amount of a substance present in a given volume or weight. Often expressed as parts per billion (ppb).

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Proving Harm

The process of proving that a chemical is harmful to human health or the environment.

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Toxic Substances Control Act (TSCA)

A law that gives the EPA authority to regulate chemicals that pose a risk to human health or the environment.

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Long-term Exposure

The exposure of a living organism to a substance over a long period of time.

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Environmental Health

A range of interconnected issues related to human health and the environment.

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Finding Alternatives

Finding new ways to create a product or process that has lower toxicity or environmental impact.

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Persistence

The potential for a substance to persist in the environment for long periods.

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Pandemic

A worldwide outbreak of a disease, often caused by a virus or bacteria. Pandemics can spread quickly and have devastating consequences for human populations.

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Pathogens

Disease-causing organisms, including bacteria, viruses, parasites, and fungi. These pathogens can infect humans and spread through various means, causing illness.

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Endemic

A specific type of pathogen that only affects one person and doesn't spread to others. It's an individual infection and doesn't cause an epidemic.

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Communicable Diseases

Communicable diseases are illnesses that can be spread from person to person or through contact with contaminated objects or environments.

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Regional Diseases

This refers to diseases that tend to exist in a particular region or population more commonly than others, often due to environmental factors or lack of healthcare access.

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Disability Adjusted Life Years (DALYs)

A measure of the burden of disease, combining years of life lost due to premature death and years lived with disability.

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Disease Burden Ranking

The relative ranking of diseases based on their impact on populations, measured by DALYs.

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Epidemiological Transition

A shift in the main causes of disease in a population, where formerly prevalent diseases like infectious illnesses decrease, while chronic health issues become more common.

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Chronic Disorders

Illnesses that develop over a long period and are often associated with aging and lifestyle factors.

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Lifestyle Convergence

A significant change in lifestyle choices, often influenced by Western culture, leading to the adoption of habits and diets from wealthier regions.

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Improved Mortality Rates

A decline in mortality rates due to advances in healthcare, sanitation, and living conditions.

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Factors Contributing to Chronic Disorders

The conditions leading to an increase in chronic disorders, including aging, unhealthy diets, and sedentary lifestyles.

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Shift in Disease Burden

A significant change in the disease burden ranking where chronic disorders associated with aging and lifestyle choices become more prominent.

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Westernization of Lifestyle

The adoption of lifestyle choices common in wealthier nations, leading to changes in health outcomes in lower-income regions.

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Disease Burden Shift

The shift in global disease burden from primarily infectious diseases to chronic conditions, like cardiovascular disease, cancer, and diabetes.

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Chronic Diseases

Conditions that persist for a long duration and often require ongoing management, such as diabetes, heart disease, and arthritis.

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Disease Burden

A measure of the impact of a disease or health condition on a population, taking into account both mortality and disability.

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Malnutrition

The state of lacking sufficient nutrients for optimal health, impacting growth, development, and overall well-being.

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Health Revolution

The process of reducing the prevalence and impact of infectious diseases through various interventions like vaccinations, sanitation, and treatments.

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Immune System Dysfunction

Disruptions in the normal functioning of the body's immune system, making a person more susceptible to infections.

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COPD (Chronic Obstructive Pulmonary Disease)

A type of chronic respiratory disease characterized by inflammation and narrowing of the airways, leading to shortness of breath and wheezing.

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Intestinal Infections

Infections caused by microorganisms that are easily spread from person to person, often due to inadequate hygiene, sanitation, or access to clean water.

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Cardiovascular Diseases

Conditions related to the heart and blood vessels, comprising cardiovascular disease, stroke, and other circulatory issues.

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Chronic Kidney Disease (CKD)

A chronic condition affecting the kidneys' ability to filter waste products from the blood, leading to fluid buildup and complications.

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Study Notes

Learning Outcomes

  • Students should be able to describe health and disease, and how the global disease burden is changing.
  • Students should understand the principles of toxicology.
  • Students should be able to discuss the movement, distribution, and fate of toxic substances in the environment.
  • Students should be able to explain methods for evaluating toxicity and risk.
  • Students should be able to relate health policies.

Case Study: PFAS

  • PFAS (per- and polyfluoroalkyl substances) are used in many products (e.g., non-stick cookware, stain-resistant fabrics).
  • PFOA (perfluorooctanoic acid) and PFOS (perfluorooctane sulfonate) are two common types of PFAS.
  • PFAS are persistent and widespread in the environment.
  • Some PFAS have been linked to health problems in animals and humans.
  • Waste disposal was a key contributing factor to environmental contamination with PFOA and related chemicals.
  • Major manufacturers had documented associations of PFOA exposure with birth defects and cancer in laboratory animals.
  • Proving harm is challenging as long-term exposure to numerous compounds is common.

Environmental Health

  • The global disease burden is changing, with infectious diseases decreasing and chronic conditions (heart disease, stroke, diabetes) increasing.
  • Health concerns can be evaluated using DALYs (Disability-Adjusted Life Years) as well as death rates.
  • New diseases emerge as a result of travel, spread of pathogens, and environmental contact.
  • Environmental factors (food, clean water, sanitation, health care) play a significant role in health outcomes compared to the past.
  • Contaminants like PFAS are a growing concern.
  • Air and water pollution pose health risks, impacting millions annually.
  • Climate change acts as an environmental health concern, exacerbating air and water quality issues and increasing heat stress.

Infectious Diseases

  • Infectious diseases (e.g., COVID-19) remain a concern.
  • Viruses spread rapidly in a pandemic.
  • Global disease burden is influenced by environmental factors that trigger acute or chronic disease.

Chronic Diseases

  • Increasingly, chronic conditions are surpassing infectious diseases as leading causes of death, especially in low- and middle-income countries, a consequence of diet.
  • Diet (especially the reliance on foods from developed countries), high blood pressure, and tobacco use are major risks.

Infectious Diseases and Wild Species

  • Communicable diseases affect wildlife as well as humans.
  • Ecological diseases, such as Ebola and white-nose syndrome (WNS) are spreading rapidly, and are devastating wildlife populations.
  • The wildlife trade, where animals are often handled or sold close together, is a main contributor to the emergence of new diseases.

Persistence of Toxic Materials

  • Many toxic substances are hazardous in low concentrations, particularly persistent substances.
  • Substances in high concentrations, such as lead or mercury, accumulate in the environment.
  • Exposure routes (air, water, food) determine how substances affect humans, animals, and the environment.
  • Bioaccumulation and biomagnification are processes whereby chemicals build up in tissue and concentrate higher up in the food chain.

Assessing Toxicity and Risk

  • The dose makes the poison (even essential elements like sodium chloride, can be toxic in high amounts).
  • LD50 (lethal dose for 50% of the population) is used to measure toxicity
  • Dose response curves show how many individuals react to increasing dosages, with different substances impacting different individuals in different ways.

Critical Thinking Questions

  • Various questions are posed in this section, asking students to explore the consequences, the impact on global health, and how to mitigate these risks.

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