Peripheral Tolerance
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Questions and Answers

Which of the following is NOT a major factor determining whether T cells are activated or tolerized?

  • Regulatory T cells
  • Cell-intrinsic anergy (correct)
  • Antigen recognition
  • Costimulation

    • What are the three major mechanisms of peripheral T cell tolerance?

  • Antigen recognition, costimulation, and cell-intrinsic anergy
  • Anergy, apoptosis, and costimulation (correct)
  • Regulatory T cells, costimulation, and apoptosis
  • Apoptosis, antigen recognition, and regulatory T cells

    • What is required for normal T cell responses?

  • Antigen recognition and apoptosis
  • Antigen recognition and cell-intrinsic anergy
  • Antigen recognition and costimulation (correct)
  • Antigen recognition and regulatory T cells

    • Which of the following is a mechanism of peripheral tolerance for T cells?

    <p>Recognition of self antigens in peripheral tissues</p> Signup and view all the answers

    What is the role of costimulators in inducing T cell proliferation and differentiation?

    <p>To provide the second signal for T cell activation</p> Signup and view all the answers

    Why do dendritic cells in normal uninfected tissues and peripheral lymphoid organs express little or no costimulators?

    <p>They are in a resting state</p> Signup and view all the answers

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