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Questions and Answers
What is the indication for PerioCol-TC in periodontal treatment?
How long does PerioCol-TC release tetracycline in vitro?
What is the composition of Syringe A in Doxycycline Gel?
What is the percentage of doxycycline hyclate in Doxycycline Gel?
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What is the mechanism of action of doxycycline?
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What is the purpose of a periodontal dressing in PerioCol-TC treatment?
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How often can PerioCol-TC be administered?
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What is the composition of PerioCol-TC?
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What is the indication for Doxycycline Gel?
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How is PerioCol-TC fiber packaged?
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Study Notes
Locally Delivered, Controlled-Release Antimicrobials
- Chronic periodontitis is a bacterial infection, and the focus of nonsurgical periodontal therapy is to combat infection.
- Controlled-release delivery systems have been developed to deposit antimicrobials directly into the periodontal pocket and maintain effective concentrations of the drug for an extended period.
Chlorhexidine-Based Products
- The chlorhexidine chip is a small chip that contains 2.5 mg of chlorhexidine gluconate in a resorbable, biodegradable matrix of hydrolyzed gelatin.
- The chip is stored at 20° to 25° C (68° to 77°F).
Surgical Therapy
- Pocket sites that do not respond adequately to nonsurgical therapy and evidence residual probing depth with inflammation are often treated with follow-up surgical therapy.
- The adjunctive use of locally delivered, controlled-release antimicrobials can improve clinical outcomes after periodontal surgery in regenerative and non-regenerative settings.
Peri-Implantitis
- Peri-implantitis is an inflammatory disease process that is initiated by local microorganisms and affects the tissues surrounding an implant.
- There is a potential rationale for the use of locally delivered, controlled-release antimicrobials for the treatment of peri-implantitis.
Tobacco Smoking
- Smoking is a risk factor for the development or progression of periodontitis and can limit the effectiveness of periodontal therapy.
- The adjunctive use of locally delivered, controlled-release antimicrobials can enhance the efficacy of SRP in smokers.
Doxycycline-Based Products
- Doxycycline gel is a subgingival, controlled-release delivery product composed of a two-syringe mixing system.
- Doxycycline gel is indicated for the treatment of chronic adult periodontitis for a gain in clinical attachment, reduction in probing depth, and reduction of bleeding on probing.
PerioCol-TC
- PerioCol-TC is a product that contains fish type I collagen impregnated with tetracycline hydrochloride.
- PerioCol-TC releases tetracycline in vitro for 8 to 10 days and is indicated for the treatment of adult periodontitis as an adjunct to SRP for pockets more than 5 mm deep.
Adverse Effects and Cautions
- There is a potential for hypersensitivity reactions.
- The fibers are packaged as a strip containing four individually packed and separable sterile product packs.
- The fiber biodegrades in the periodontal pocket within 7 days and should be retained with a periodontal dressing or covered with a dental adhesive for 10 days.
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Description
This quiz focuses on the use of locally delivered, controlled-release antimicrobials in the treatment of chronic periodontitis, a bacterial infection. It covers the role of mechanical therapy, such as scaling and root planing, in combating infection.