Periodontics: Locally Delivered Antimicrobials in Chronic Periodontitis
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Questions and Answers

What is the indication for PerioCol-TC in periodontal treatment?

  • For treatment of periodontal gingivitis
  • For treatment of acute periodontitis
  • For treatment of chronic adult periodontitis
  • As an adjunct to SRP for pockets more than 5 mm deep (correct)
  • How long does PerioCol-TC release tetracycline in vitro?

  • 15-20 days
  • 12-15 days
  • 8-10 days (correct)
  • 5-7 days
  • What is the composition of Syringe A in Doxycycline Gel?

  • 450 mg of doxycycline hyclate
  • 450 mg of a bioabsorbable polymeric formulation of poly (D,L,-lactide) (correct)
  • 50 mg of poly (D,L,-lactide)
  • 450 mg of N-methyl-2-pyrrolidone
  • What is the percentage of doxycycline hyclate in Doxycycline Gel?

    <p>10%</p> Signup and view all the answers

    What is the mechanism of action of doxycycline?

    <p>It inhibits bacterial protein biosynthesis by interfering with transfer RNA (tRNA) and messenger RNA (mRNA) at the ribosome</p> Signup and view all the answers

    What is the purpose of a periodontal dressing in PerioCol-TC treatment?

    <p>To avoid dislodging the fibers</p> Signup and view all the answers

    How often can PerioCol-TC be administered?

    <p>Every 3 months</p> Signup and view all the answers

    What is the composition of PerioCol-TC?

    <p>Fish type I collagen with tetracycline hydrochloride</p> Signup and view all the answers

    What is the indication for Doxycycline Gel?

    <p>For treatment of chronic adult periodontitis</p> Signup and view all the answers

    How is PerioCol-TC fiber packaged?

    <p>As a strip containing four individually packed and separable sterile product packs</p> Signup and view all the answers

    Study Notes

    Locally Delivered, Controlled-Release Antimicrobials

    • Chronic periodontitis is a bacterial infection, and the focus of nonsurgical periodontal therapy is to combat infection.
    • Controlled-release delivery systems have been developed to deposit antimicrobials directly into the periodontal pocket and maintain effective concentrations of the drug for an extended period.

    Chlorhexidine-Based Products

    • The chlorhexidine chip is a small chip that contains 2.5 mg of chlorhexidine gluconate in a resorbable, biodegradable matrix of hydrolyzed gelatin.
    • The chip is stored at 20° to 25° C (68° to 77°F).

    Surgical Therapy

    • Pocket sites that do not respond adequately to nonsurgical therapy and evidence residual probing depth with inflammation are often treated with follow-up surgical therapy.
    • The adjunctive use of locally delivered, controlled-release antimicrobials can improve clinical outcomes after periodontal surgery in regenerative and non-regenerative settings.

    Peri-Implantitis

    • Peri-implantitis is an inflammatory disease process that is initiated by local microorganisms and affects the tissues surrounding an implant.
    • There is a potential rationale for the use of locally delivered, controlled-release antimicrobials for the treatment of peri-implantitis.

    Tobacco Smoking

    • Smoking is a risk factor for the development or progression of periodontitis and can limit the effectiveness of periodontal therapy.
    • The adjunctive use of locally delivered, controlled-release antimicrobials can enhance the efficacy of SRP in smokers.

    Doxycycline-Based Products

    • Doxycycline gel is a subgingival, controlled-release delivery product composed of a two-syringe mixing system.
    • Doxycycline gel is indicated for the treatment of chronic adult periodontitis for a gain in clinical attachment, reduction in probing depth, and reduction of bleeding on probing.

    PerioCol-TC

    • PerioCol-TC is a product that contains fish type I collagen impregnated with tetracycline hydrochloride.
    • PerioCol-TC releases tetracycline in vitro for 8 to 10 days and is indicated for the treatment of adult periodontitis as an adjunct to SRP for pockets more than 5 mm deep.

    Adverse Effects and Cautions

    • There is a potential for hypersensitivity reactions.
    • The fibers are packaged as a strip containing four individually packed and separable sterile product packs.
    • The fiber biodegrades in the periodontal pocket within 7 days and should be retained with a periodontal dressing or covered with a dental adhesive for 10 days.

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    Description

    This quiz focuses on the use of locally delivered, controlled-release antimicrobials in the treatment of chronic periodontitis, a bacterial infection. It covers the role of mechanical therapy, such as scaling and root planing, in combating infection.

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