Perforomist Flashcards
49 Questions
100 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the dosing of Perforomist?

  • 20mcg/2mL, twice daily (correct)
  • 30mcg/3mL, once daily
  • 5mcg/1mL, three times daily
  • 10mcg/1mL, twice daily

    • What is the active ingredient in Spiriva?

    Tiotropium

    What is formoterol fumarate used for?

    Bronchodilator

    Which medications are administered via nebulizer?

    <p>Brovana and DuoNeb</p> Signup and view all the answers

    What is the indication for Symbicort, Budesonide-formoterol?

    <p>Asthma and maintenance treatment of airflow obstruction in patients with COPD</p> Signup and view all the answers

    What are the components of DuoNeb?

    <p>Albuterol sulfate and Ipratropium Bromide</p> Signup and view all the answers

    What is a combination product indicated for treatment of COPD?

    <p>Breo Ellipta</p> Signup and view all the answers

    What is a nebulizer?

    <p>Device that creates a mist used to deliver medication for giving respiratory treatment</p> Signup and view all the answers

    What should be considered when prescribing inhaled therapy according to GOLD?

    <p>Patients' ability to use, cost and reimbursement, convenience and patient preference</p> Signup and view all the answers

    What is the delivery mechanism of dry powder inhalers like Spiriva and Advair?

    <p>Breath actuation</p> Signup and view all the answers

    Spacers are devices fitted to which delivery device?

    <p>MDI meter dose inhaler</p> Signup and view all the answers

    Which medications are indicated for treatment of COPD via nebulizer?

    <p>Perforomist, Brovana, DuoNeb</p> Signup and view all the answers

    What are the three main classes of bronchodilators?

    <p>Beta2 adrenergic agonists or LABA, methylxanthines, muscarinic receptors or anticholinergics</p> Signup and view all the answers

    What is a bronchodilator?

    <p>A medication that expands the opening of the passages into the lungs</p> Signup and view all the answers

    What does SABA stand for?

    <p>Short-acting beta agonists</p> Signup and view all the answers

    What do LABAs provide?

    <p>Bronchodilation for up to 12 hours and used as maintenance medication</p> Signup and view all the answers

    Why have methylxanthines reduced in usage to treat COPD?

    <p>Due to frequency of side effects and relatively low efficacy</p> Signup and view all the answers

    What is the role of corticosteroids in treating severe COPD?

    <p>Risk of exacerbations is reduced when used</p> Signup and view all the answers

    What are PDE-4 inhibitors like Daliresp indicated for?

    <p>Severe COPD &amp; exacerbations</p> Signup and view all the answers

    Under which parts of Medicare is Perforomist billed?

    <p>Part A, B, C and D</p> Signup and view all the answers

    What are the effects of systemic corticosteroids?

    <p>Reduces treatment failure, length of hospital stay, improves lung function, but associated with increased side effects</p> Signup and view all the answers

    What FEV1/FVC ratio confirms persistent airflow limitation in COPD?

    <p>70%</p> Signup and view all the answers

    What percentage of patients achieved a 15% increase from baseline in FEV1 in a 12-week pivotal trial?

    <p>78%</p> Signup and view all the answers

    What are common comorbidities of COPD?

    <p>Cardiovascular disease, skeletal muscle dysfunction, metabolic syndrome, depression, osteoporosis and lung cancer</p> Signup and view all the answers

    What is central to symptom management in COPD?

    <p>Bronchodilators</p> Signup and view all the answers

    What is the most important thing a patient can do to slow the progression of COPD?

    <p>Smoking cessation</p> Signup and view all the answers

    What are the components of COPD?

    <p>Chronic bronchitis and emphysema</p> Signup and view all the answers

    What are characteristic symptoms of COPD?

    <p>Dyspnea, chronic cough and sputum production</p> Signup and view all the answers

    How many mL are in each vial of Perforomist?

    <p>2mL</p> Signup and view all the answers

    What percent of albuterol use was reduced in a 12-week clinical trial?

    <p>42%</p> Signup and view all the answers

    Nelson's 12-week trial showed no significant increases in all cardiac markers.

    <p>True</p> Signup and view all the answers

    What is the most common risk factor for COPD?

    <p>Smoking</p> Signup and view all the answers

    What is the most common cause of COPD exacerbation?

    <p>Bacterial infections</p> Signup and view all the answers

    How many breaths does an average adult take in one minute?

    <p>12</p> Signup and view all the answers

    What marks the start of the lower respiratory system?

    <p>Larynx</p> Signup and view all the answers

    All LABAs are contraindicated for use in patients with asthma without which medication?

    <p>Controller medication/ICS</p> Signup and view all the answers

    What does spirometry measure?

    <p>A measurement of breathing to diagnose COPD</p> Signup and view all the answers

    How many hours of long-term O2 therapy per day can reverse hypoxemia in COPD patients?

    <p>15 hours</p> Signup and view all the answers

    What is the unrefrigerated shelf life of Perforomist?

    <p>12 weeks</p> Signup and view all the answers

    What is pulmonary rehabilitation?

    <p>COPD treatment that produces significant improvement in respiratory symptoms, exercise capacity, and quality of life</p> Signup and view all the answers

    What might explain the disparity between FEV1 and exercise tolerance in patients?

    <p>Hyperinflation</p> Signup and view all the answers

    What does FEV1 stand for?

    <p>Forced expiratory volume in 1 second</p> Signup and view all the answers

    What is dyspnea?

    <p>Hallmark symptom of COPD</p> Signup and view all the answers

    What is the half-life of Perforomist?

    <p>7 hours</p> Signup and view all the answers

    What causes increased airway resistance in COPD and asthma?

    <p>Obstruction or collapse of airways</p> Signup and view all the answers

    What are beta2 adrenergic receptors involved in?

    <p>Bronchodilation</p> Signup and view all the answers

    Perforomist should only be administered via which device?

    <p>Standard jet nebulizer</p> Signup and view all the answers

    What is the purpose of lung volume reduction surgery?

    <p>Rejection of severely emphysematous area of the lung</p> Signup and view all the answers

    Some patients with chronic asthma can be distinguished from COPD with current testing.

    <p>False</p> Signup and view all the answers

    Study Notes

    Dosing and Administration

    • Perforomist dosing is 20 mcg in 2 mL, administered twice daily.
    • Nebulizer treatments include Brovana and DuoNeb, which are effective for respiratory conditions.
    • Perforomist and DuoNeb are nebulizer medications indicated for COPD treatment.

    Key Medications and Ingredients

    • Spiriva contains Tiotropium as its active ingredient.
    • Formoterol fumarate is a bronchodilator used in managing respiratory conditions.
    • DuoNeb combines Albuterol sulfate and Ipratropium Bromide for treatment.
    • Breo Ellipta is a combination product specifically indicated for COPD management.
    • Symbicort is used for asthma and as a maintenance treatment for COPD airflow obstruction.

    Mechanisms and Effects

    • Bronchodilators, including SABA and LABA, help expand lung air passages; SABA serves as a rescue medication, while LABAs provide up to 12 hours of bronchodilation for maintenance.
    • Methylxanthines have fallen out of favor due to side effects and low efficacy for COPD treatment.
    • Corticosteroids effectively reduce exacerbations in severe COPD.
    • PDE-4 inhibitors like Daliresp are used to manage severe COPD and its exacerbations.

    Patient Considerations

    • Prescribing inhaled therapy should consider patient ability, cost, convenience, and preferences according to GOLD guidelines.
    • Spacers can enhance delivery with Meter Dose Inhalers (MDIs).
    • Smoking cessation remains the most crucial action to slow COPD progression and alleviate symptoms.

    Diagnostic and Treatment Guidelines

    • Spirometry is a key diagnostic tool for COPD, measuring FEV1/FVC ratio, with a ratio of 70% indicating persistent airflow limitation.
    • A pivotal trial showed that 78% of patients achieved a 15% increase in FEV1 after the first dose throughout a 12-week study.

    COPD Characteristics and Comorbidities

    • Characteristic symptoms include dyspnea, chronic cough, and sputum production; hyperinflation may explain discrepancies between FEV1 results and exercise tolerance.
    • Common comorbidities include cardiovascular disease, muscle dysfunction, metabolic syndrome, depression, osteoporosis, and lung cancer.

    Important Metrics and Data

    • An average adult takes about 12 breaths per minute; long-term oxygen therapy for at least 15 hours can improve life expectancy in COPD patients.
    • Unrefrigerated shelf life for Perforomist is 12 weeks, and its half-life spans 7 hours.

    Additional Considerations

    • Increased airway resistance in COPD and asthma results from airway obstruction or collapse.
    • Beta2 adrenergic receptors play a crucial role in bronchodilation.
    • Some patients with chronic asthma may present similar symptoms to COPD, complicating accurate distinction with current testing.
    • Patients reduced albuterol use by 1.25 puffs or 42% during a 12-week clinical trial.

    Therapeutic Techniques and Education

    • Pulmonary rehabilitation significantly improves respiratory symptoms, exercise capacity, and overall quality of life in COPD patients.
    • Perforomist must be delivered via a standard jet nebulizer for effective treatment.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Test your knowledge on the dosing and active ingredients related to Perforomist and other bronchodilators. This quiz includes key definitions and relevant medications used in respiratory treatment. Perfect for healthcare professionals or students studying respiratory pharmacology.

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser