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Peptide Presentation by Class II MHC Molecules

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Peptide Presentation by Class II MHC Molecules

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Questions and Answers

Which type of cells are responsible for internalizing antigens in the class II MHC pathway?

B lymphocytes

Dendritic cells (correct)

T lymphocytes

Macrophages

What happens to the antigens after internalization into APCs?

They bind to class II MHC molecules

They are broken down by proteolytic enzymes (correct)

They are transported to the cell surface

They enter acidic intracellular vesicles

Where do peptides bind to newly synthesized class II MHC molecules?

In the endosomes or phagosomes

In the ER (correct)

In the extracellular environment

In the lysosomes

Which protein is attached to the newly synthesized class II molecule?

Invariant chain (Ii) Signup and view all the answers

Where does the newly synthesized class II molecule with its associated Ii migrate to?

Endosomes and lysosomes Signup and view all the answers

What is the function of the class II MHC–like protein called DM?

To exchange CLIP in the class II MHC molecule with other peptides Signup and view all the answers

What happens to class II molecules that do not find peptides they can bind?

They are degraded by lysosomal proteases Signup and view all the answers

Peptide Presentation by Class II MHC Molecules

Choose a study mode

Podcast

Questions and Answers

Which type of cells are responsible for internalizing antigens in the class II MHC pathway?

What happens to the antigens after internalization into APCs?

Where do peptides bind to newly synthesized class II MHC molecules?

Which protein is attached to the newly synthesized class II molecule?

Where does the newly synthesized class II molecule with its associated Ii migrate to?

What is the function of the class II MHC–like protein called DM?

What happens to class II molecules that do not find peptides they can bind?

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