PEPCK Production
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Questions and Answers

Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

  • In the cytosol only
  • Both in the mitochondria and the cytosol (correct)
  • In the mitochondria only
  • In the nucleus

    • What is the function of PEPCK in gluconeogenesis?

  • Exporting PEP from the cytosol to the mitochondria
  • Converting malate to OAA in the mitochondria
  • Converting OAA to malate in the cytosol
  • Exporting PEP from the mitochondria to the cytosol (correct)

    • What is required for the production of PEP in the cytosol?

  • Transport of malate across the inner mitochondrial membrane
  • Transport of OAA across the outer mitochondrial membrane
  • Transport of malate across the outer mitochondrial membrane
  • Transport of OAA across the inner mitochondrial membrane (correct)

    • What is the fate of OAA that is transported from the mitochondria to the cytosol?

    <p>It is converted to malate by cytosolic malate dehydrogenase</p> Signup and view all the answers

    What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?

    <p>Reducing OAA to malate in the mitochondria</p> Signup and view all the answers

    What is the fate of malate that is transported from the mitochondria to the cytosol?

    <p>It is converted to OAA by mitochondrial malate dehydrogenase</p> Signup and view all the answers

    What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?

    <p>In the mitochondria</p> Signup and view all the answers

    What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?

    <p>In the cytosol</p> Signup and view all the answers

    What is the role of oxaloacetate (OAA) in gluconeogenesis?

    <p>It is converted to glucose by gluconeogenesis</p> Signup and view all the answers

    What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?

    <p>It is converted to glucose by gluconeogenesis</p> Signup and view all the answers

    Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

    <p>Both in the mitochondria and the cytosol</p> Signup and view all the answers

    What is the function of PEPCK in gluconeogenesis?

    <p>Exporting PEP from the mitochondria to the cytosol</p> Signup and view all the answers

    What is required for the production of PEP in the cytosol?

    <p>Transport of OAA across the inner mitochondrial membrane</p> Signup and view all the answers

    What is the fate of OAA that is transported from the mitochondria to the cytosol?

    <p>It is converted to malate by cytosolic malate dehydrogenase</p> Signup and view all the answers

    What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?

    <p>Reducing OAA to malate in the mitochondria</p> Signup and view all the answers

    What is the fate of malate that is transported from the mitochondria to the cytosol?

    <p>It is converted to OAA by mitochondrial malate dehydrogenase</p> Signup and view all the answers

    What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?

    <p>In the mitochondria</p> Signup and view all the answers

    What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?

    <p>In the cytosol</p> Signup and view all the answers

    What is the role of oxaloacetate (OAA) in gluconeogenesis?

    <p>It is converted to glucose by gluconeogenesis</p> Signup and view all the answers

    What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?

    <p>It is converted to glucose by gluconeogenesis</p> Signup and view all the answers

    Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

    <p>In the mitochondria and the cytosol</p> Signup and view all the answers

    What is the role of PEPCK in gluconeogenesis?

    <p>Exporting PEP from the mitochondria to the cytosol</p> Signup and view all the answers

    Why is transport of oxaloacetate (OAA) across the inner mitochondrial membrane necessary for gluconeogenesis?

    <p>The inner mitochondrial membrane is impermeable to OAA</p> Signup and view all the answers

    What is the first step in the production of PEP in the cytosol?

    <p>Transport of malate from the mitochondria to the cytosol</p> Signup and view all the answers

    What is the role of cytosolic malate dehydrogenase in gluconeogenesis?

    <p>Oxidizing malate to OAA in the cytosol</p> Signup and view all the answers

    What happens to malate after it is transported from the mitochondria to the cytosol?

    <p>It is reoxidized to OAA by cytosolic malate dehydrogenase</p> Signup and view all the answers

    What is the function of mitochondrial malate dehydrogenase in gluconeogenesis?

    <p>Reducing OAA to malate in the mitochondria</p> Signup and view all the answers

    What is the fate of PEP generated in the mitochondria?

    <p>It is transported to the cytosol for gluconeogenesis</p> Signup and view all the answers

    What is the significance of the impermeability of the inner mitochondrial membrane to OAA?

    <p>It necessitates the reduction of OAA to malate in the mitochondria</p> Signup and view all the answers

    What is the role of malate in gluconeogenesis?

    <p>To transport OAA from the mitochondria to the cytosol</p> Signup and view all the answers

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