30 Questions
Where is phosphoenolpyruvate carboxykinase (PEPCK) located?
Both in the mitochondria and the cytosol
What is the function of PEPCK in gluconeogenesis?
Exporting PEP from the mitochondria to the cytosol
What is required for the production of PEP in the cytosol?
Transport of OAA across the inner mitochondrial membrane
What is the fate of OAA that is transported from the mitochondria to the cytosol?
It is converted to malate by cytosolic malate dehydrogenase
What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?
Reducing OAA to malate in the mitochondria
What is the fate of malate that is transported from the mitochondria to the cytosol?
It is converted to OAA by mitochondrial malate dehydrogenase
What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?
In the mitochondria
What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?
In the cytosol
What is the role of oxaloacetate (OAA) in gluconeogenesis?
It is converted to glucose by gluconeogenesis
What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?
It is converted to glucose by gluconeogenesis
Where is phosphoenolpyruvate carboxykinase (PEPCK) located?
Both in the mitochondria and the cytosol
What is the function of PEPCK in gluconeogenesis?
Exporting PEP from the mitochondria to the cytosol
What is required for the production of PEP in the cytosol?
Transport of OAA across the inner mitochondrial membrane
What is the fate of OAA that is transported from the mitochondria to the cytosol?
It is converted to malate by cytosolic malate dehydrogenase
What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?
Reducing OAA to malate in the mitochondria
What is the fate of malate that is transported from the mitochondria to the cytosol?
It is converted to OAA by mitochondrial malate dehydrogenase
What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?
In the mitochondria
What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?
In the cytosol
What is the role of oxaloacetate (OAA) in gluconeogenesis?
It is converted to glucose by gluconeogenesis
What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?
It is converted to glucose by gluconeogenesis
Where is phosphoenolpyruvate carboxykinase (PEPCK) located?
In the mitochondria and the cytosol
What is the role of PEPCK in gluconeogenesis?
Exporting PEP from the mitochondria to the cytosol
Why is transport of oxaloacetate (OAA) across the inner mitochondrial membrane necessary for gluconeogenesis?
The inner mitochondrial membrane is impermeable to OAA
What is the first step in the production of PEP in the cytosol?
Transport of malate from the mitochondria to the cytosol
What is the role of cytosolic malate dehydrogenase in gluconeogenesis?
Oxidizing malate to OAA in the cytosol
What happens to malate after it is transported from the mitochondria to the cytosol?
It is reoxidized to OAA by cytosolic malate dehydrogenase
What is the function of mitochondrial malate dehydrogenase in gluconeogenesis?
Reducing OAA to malate in the mitochondria
What is the fate of PEP generated in the mitochondria?
It is transported to the cytosol for gluconeogenesis
What is the significance of the impermeability of the inner mitochondrial membrane to OAA?
It necessitates the reduction of OAA to malate in the mitochondria
What is the role of malate in gluconeogenesis?
To transport OAA from the mitochondria to the cytosol
Test your knowledge on the key steps involved in the production of phosphoenolpyruvate carboxykinase (PEPCK) for gluconeogenesis. Learn about the transportation of oxaloacetate (OAA) across the inner mitochondrial membrane, the role of mitochondrial malate dehydrogenase, and the conversion of malate to PEP in the cytosol. Take the quiz now and challenge yourself!
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