PEPCK Production

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Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

In the cytosol only
Both in the mitochondria and the cytosol (correct)
In the mitochondria only
In the nucleus

What is the function of PEPCK in gluconeogenesis?

Exporting PEP from the cytosol to the mitochondria
Converting malate to OAA in the mitochondria
Converting OAA to malate in the cytosol
Exporting PEP from the mitochondria to the cytosol (correct)

What is required for the production of PEP in the cytosol?

Transport of malate across the inner mitochondrial membrane
Transport of OAA across the outer mitochondrial membrane
Transport of malate across the outer mitochondrial membrane
Transport of OAA across the inner mitochondrial membrane (correct)

What is the fate of OAA that is transported from the mitochondria to the cytosol?

It is converted to malate by cytosolic malate dehydrogenase (A) Signup and view all the answers

What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?

Reducing OAA to malate in the mitochondria (B) Signup and view all the answers

What is the fate of malate that is transported from the mitochondria to the cytosol?

It is converted to OAA by mitochondrial malate dehydrogenase (D) Signup and view all the answers

What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?

In the mitochondria (C) Signup and view all the answers

What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?

In the cytosol (B) Signup and view all the answers

What is the role of oxaloacetate (OAA) in gluconeogenesis?

It is converted to glucose by gluconeogenesis (B) Signup and view all the answers

What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?

It is converted to glucose by gluconeogenesis (A) Signup and view all the answers

Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

Both in the mitochondria and the cytosol (B) Signup and view all the answers

What is the function of PEPCK in gluconeogenesis?

Exporting PEP from the mitochondria to the cytosol (D) Signup and view all the answers

What is required for the production of PEP in the cytosol?

Transport of OAA across the inner mitochondrial membrane (D) Signup and view all the answers

What is the fate of OAA that is transported from the mitochondria to the cytosol?

It is converted to malate by cytosolic malate dehydrogenase (C) Signup and view all the answers

What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?

Reducing OAA to malate in the mitochondria (D) Signup and view all the answers

What is the fate of malate that is transported from the mitochondria to the cytosol?

It is converted to OAA by mitochondrial malate dehydrogenase (B) Signup and view all the answers

What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?

In the mitochondria (B) Signup and view all the answers

What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?

In the cytosol (C) Signup and view all the answers

What is the role of oxaloacetate (OAA) in gluconeogenesis?

It is converted to glucose by gluconeogenesis (D) Signup and view all the answers

What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?

It is converted to glucose by gluconeogenesis (D) Signup and view all the answers

Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

In the mitochondria and the cytosol (D) Signup and view all the answers

What is the role of PEPCK in gluconeogenesis?

Exporting PEP from the mitochondria to the cytosol (B) Signup and view all the answers

Why is transport of oxaloacetate (OAA) across the inner mitochondrial membrane necessary for gluconeogenesis?

The inner mitochondrial membrane is impermeable to OAA (C) Signup and view all the answers

What is the first step in the production of PEP in the cytosol?

Transport of malate from the mitochondria to the cytosol (C) Signup and view all the answers

What is the role of cytosolic malate dehydrogenase in gluconeogenesis?

Oxidizing malate to OAA in the cytosol (B) Signup and view all the answers

What happens to malate after it is transported from the mitochondria to the cytosol?

It is reoxidized to OAA by cytosolic malate dehydrogenase (C) Signup and view all the answers

What is the function of mitochondrial malate dehydrogenase in gluconeogenesis?

Reducing OAA to malate in the mitochondria (A) Signup and view all the answers

What is the fate of PEP generated in the mitochondria?

It is transported to the cytosol for gluconeogenesis (C) Signup and view all the answers

What is the significance of the impermeability of the inner mitochondrial membrane to OAA?

It necessitates the reduction of OAA to malate in the mitochondria (B) Signup and view all the answers

What is the role of malate in gluconeogenesis?

To transport OAA from the mitochondria to the cytosol (C) Signup and view all the answers

PEPCK Production

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Questions and Answers

Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

What is the function of PEPCK in gluconeogenesis?

What is required for the production of PEP in the cytosol?

What is the fate of OAA that is transported from the mitochondria to the cytosol?

What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?

What is the fate of malate that is transported from the mitochondria to the cytosol?

What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?

What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?

What is the role of oxaloacetate (OAA) in gluconeogenesis?

What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?

Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

What is the function of PEPCK in gluconeogenesis?

What is required for the production of PEP in the cytosol?

What is the fate of OAA that is transported from the mitochondria to the cytosol?

What is the role of mitochondrial malate dehydrogenase in gluconeogenesis?

What is the fate of malate that is transported from the mitochondria to the cytosol?

What is the location of malate dehydrogenase that reduces OAA to malate in gluconeogenesis?

What is the location of malate dehydrogenase that reoxidizes malate to OAA in gluconeogenesis?

What is the role of oxaloacetate (OAA) in gluconeogenesis?

What is the fate of malate that is reoxidized to OAA in the cytosol during gluconeogenesis?

Where is phosphoenolpyruvate carboxykinase (PEPCK) located?

What is the role of PEPCK in gluconeogenesis?

Why is transport of oxaloacetate (OAA) across the inner mitochondrial membrane necessary for gluconeogenesis?

What is the first step in the production of PEP in the cytosol?

What is the role of cytosolic malate dehydrogenase in gluconeogenesis?

What happens to malate after it is transported from the mitochondria to the cytosol?

What is the function of mitochondrial malate dehydrogenase in gluconeogenesis?

What is the fate of PEP generated in the mitochondria?

What is the significance of the impermeability of the inner mitochondrial membrane to OAA?

What is the role of malate in gluconeogenesis?

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