18 Questions
What is the recommended treatment duration for aminoglycoside therapy in penicillin-resistant cases of infective endocarditis?
More than 2 weeks
What is recommended when a patient with infective endocarditis caused by resistant isolates is clinically stable after 10-14 days of therapy?
Consider OPAT or outpatient oral antibiotic therapy
What percentage of patients in the retrospective series were treated with penicillin or ceftriaxone for infective endocarditis caused by penicillin-resistant streptococci?
78%
What is indicated if a patient has infective endocarditis caused by resistant isolates and is not clinically stable after 10-14 days of therapy?
Consider IV antibiotic treatment in the hospital
What is the incidence of resistant S.mitis and Streptococcus oralis reported in large strain collections?
>30%
Which antibiotic therapy is not recommended for short-term regimens in penicillin-resistant cases?
Aminoglycosides alone
What is the recommended treatment for penicillin-susceptible strains without meningitis?
Short-term 2-week therapy
In cases of meningitis, why should penicillin be avoided?
Poor penetration into cerebrospinal fluid
For infective endocarditis caused by group A streptococci, what is their susceptibility to beta-lactams?
Susceptible to beta-lactams
What is recommended when treating infective endocarditis due to the Streptococcus anginosus group?
Beta-lactam antibiotics alone
After 10-14 days of therapy for meningitis cases, what treatment option should be considered if the patient is clinically stable?
Outpatient oral antibiotic therapy
What is the recommended treatment when encountering penicillin-resistant strains without meningitis?
Cefotaxime or ceftriaxone alone or in combination with vancomycin
What is the mortality rate associated with group B infective endocarditis?
Exceeding 50%
Which streptococci induce infective endocarditis with large vegetations and high rates of complications?
Groups B, C, and G streptococci
What antibiotic is no longer recommended for staphylococcal native valve endocarditis due to increased renal toxicity?
Aminoglycoside
In penicillin-allergic patients with MSSA endocarditis, what antibiotic can be used if beta-lactams are contraindicated?
Cefazolin
In infective endocarditis caused by Staphylococcus aureus, what is the preferred treatment if vancomycin is deemed inferior to beta-lactams?
Daptomycin
What is the rationale behind adding rifampin after 3–5 days of effective antibiotic therapy once the bacteraemia has been cleared in Staphylococcus aureus endocarditis?
To enhance antibiotic activity and prevent resistance development
Explore recommendations for the antibiotic treatment of Infective Endocarditis caused by penicillin-resistant oral streptococci and Streptococcus gallolyticus. Learn about the incidence and resistance of these bacteria strains.
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