Podcast
Questions and Answers
Penfluridol has a plasma half-life of less than 60 hours.
Penfluridol has a plasma half-life of less than 60 hours.
False
The typical dose of penfluridol is between 30mg to 50mg per week.
The typical dose of penfluridol is between 30mg to 50mg per week.
False
Penfluridol can lead to increased levels of prolactin and may cause tardive dyskinesia.
Penfluridol can lead to increased levels of prolactin and may cause tardive dyskinesia.
True
Penfluridol requires oral administration every day due to its short duration of action.
Penfluridol requires oral administration every day due to its short duration of action.
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Monitoring for penfluridol therapy may involve assessing parameters such as blood glucose and echocardiogram.
Monitoring for penfluridol therapy may involve assessing parameters such as blood glucose and echocardiogram.
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Study Notes
Penfluridol
- Diphenylbutylpiperidine FGA (first-generation antipsychotic)
- Available in some countries, importable to others
- Efficacy and tolerability similar to other FGAs
- Unique very long plasma half-life (at least 60 hours)
- Peak levels within 12 hours of oral administration
- Detectable for up to 168 hours
- Extended duration due to rapid distribution into fat tissue
- Allows for once-weekly oral administration
- Alternative to injectable antipsychotics
- Several trials tested once-weekly oral penfluridol (5mg to 160mg per week)
- At least as effective as depot FGAs and generally better tolerated
Dosage
- Dosing varies based on individual response
- Typical dose: 30mg per week
- Higher doses have been used (up to 120mg/day)
- Dose-response relationships are unclear
Adverse Effects
- Similar to other FGAs
- Acute extrapyramidal symptoms (EPS)
- Increased prolactin levels
- Tardive dyskinesia potential
- Minimal sedation
- QT interval prolongation (similar to pimozide)
- Cytotoxic agent with potential anticancer properties
Practical Use
- Typical starting dose: 20mg per week
- Maximum dose: 40mg per week
- Steady-state levels achieved within 2-3 weeks
- Monitoring includes renal and hepatic function, cardiometabolic parameters (lipids, blood glucose, echocardiogram), and general adverse events
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Description
This quiz explores the characteristics and clinical applications of Penfluridol, a first-generation antipsychotic. The focus is on its efficacy, unique pharmacokinetics, dosing, and potential side effects. Test your knowledge on how Penfluridol compares to traditional FGAs and its advantages in treatment.
