35 Questions
Which of the following statements about the use of uricosuric agents like probenecid and sulfinpyrazone is correct?
They should not be used during an acute gout attack as they may precipitate an attack.
What is the primary side effect associated with the use of uricosuric agents like probenecid and sulfinpyrazone?
Urolithiasis (formation of urate stones)
How do probenecid and allopurinol interact?
Probenecid decreases the clearance of allopurinol, thereby increasing dose requirements of allopurinol.
Which of the following drugs should not be used concomitantly with uricosuric agents like probenecid and sulfinpyrazone?
Aspirin and other salicylates
What is the potential role of interleukin-1 (IL-1) inhibitors in the treatment of gout?
They may provide a promising treatment option for acute gout in patients with contraindications to or who are refractory to traditional therapies like NSAIDs and/or colchicine.
What is the typical presentation of acute gout?
Inflammation in the large toe at night
Which of the following drugs is not recommended for acute gout treatment?
Allopurinol
What is the action of Colchicine when used for gout prophylaxis?
Inhibits microtubule assembly and prevents leucocyte migration
Which of the following is an unlabeled use of Colchicine?
Treating multiple sclerosis
In what form should Colchicine be taken for gout prophylaxis?
Intravenous (IV)
Which of the following drugs is contraindicated in patients with glucose-6-phosphate dehydrogenase deficiency?
Pegloticase
Which of the following is a potential side effect of pegloticase?
All of the above
What is the mechanism of action of probenecid and sulfinpyrazone?
Inhibit renal tubular reabsorption of uric acid
Which of the following is a concern associated with the development of antibodies against pegloticase?
All of the above
Which of the following statements is true regarding the monitoring of pegloticase therapy?
Rising plasma uric acid level indicates antibody production
What is the main risk associated with co-administration of NSAIDs with anticoagulants like warfarin?
Elevated risk of gastrointestinal bleeding
What effect does the co-administration of NSAIDs have on the nephrotoxicity of cyclosporine and tacrolimus?
Increased nephrotoxic effect
Why were most coxibs either severely restricted in use or withdrawn from the market?
Following reports of cardiovascular events
How do quinolone antimicrobials interact with NSAIDs when co-administered?
Risk of convulsions
What is the primary reason for the lower rate of ulceration associated with COX-2 inhibitors compared to older NSAIDs?
Selective inhibition of COX-2
Which NSAID is most likely to be recommended for a patient with a history of gastrointestinal bleeding?
Sulindac
Which NSAID has the least potential for inhibiting COX-1, and therefore causing gastrointestinal side effects?
Aspirin at low doses
Which NSAID is most likely to undergo enterohepatic circulation, leading to side effects in the lower intestine?
Sulindac
Which NSAID is a ketone prodrug that is metabolized to the active acidic form?
Nabumetone
Which NSAID is most likely to have less gastric irritation compared to other NSAIDs?
Sulindac
Which class of drugs includes Aspirin, Na-salicylate, and diflunisal?
Salicylates
Which of the following NSAIDs belongs to the Oxicams class?
Piroxicam (Feldene)
Which drug is a Pyrrolo-pyrrole NSAID?
Ketorolac (Ketrodol)
Which NSAID has both peripheral and central antipyretic effects?
Diclofenac (Voltaren)
Which class of NSAIDs includes Ibuprofen, Naproxen, and fenoprofen?
Phenylpropionic acid (profens)
How does aspirin achieve its anti-inflammatory effect?
By inhibiting prostaglandin biosynthesis
What is the primary mechanism through which aspirin prevents myocardial infarction?
Inhibiting platelet aggregation
Why is the inhibition of COX enzymes by aspirin significant in its mechanism of action?
It prevents the production of new platelets
Which effect of aspirin occurs at high doses?
Anti-inflammatory effect
How does aspirin differ from other NSAIDs in terms of COX enzyme inhibition?
Aspirin irreversibly inhibits COX enzymes, while other NSAIDs do not
Test your knowledge on the side effects and immunogenicity of pegloticase, a medication used in the treatment of gout. Learn about potential adverse effects including nephrolithiasis, arthralgia, and immune responses.
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