Pegloticase Side Effects and Immunogenicity Quiz
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Questions and Answers

Which of the following statements about the use of uricosuric agents like probenecid and sulfinpyrazone is correct?

  • They should not be used during an acute gout attack as they may precipitate an attack. (correct)
  • They do not interact with other drugs that are actively secreted by the renal tubules.
  • Aspirin and other salicylates can be used concomitantly to enhance the uricosuric effect.
  • They can be used alone for the treatment of chronic gout without the need for colchicine.

    • What is the primary side effect associated with the use of uricosuric agents like probenecid and sulfinpyrazone?

  • Urolithiasis (formation of urate stones) (correct)
  • Hepatotoxicity
  • Nephrotoxicity
  • Cardiovascular events

    • How do probenecid and allopurinol interact?

  • Probenecid and allopurinol have no clinically significant interactions.
  • Probenecid increases the half-life of allopurinol and enhances its uricosuric effect.
  • Allopurinol increases the clearance of probenecid, thereby reducing its uricosuric effect.
  • Probenecid decreases the clearance of allopurinol, thereby increasing dose requirements of allopurinol. (correct)

    • Which of the following drugs should not be used concomitantly with uricosuric agents like probenecid and sulfinpyrazone?

    <p>Aspirin and other salicylates</p> Signup and view all the answers

    What is the potential role of interleukin-1 (IL-1) inhibitors in the treatment of gout?

    <p>They may provide a promising treatment option for acute gout in patients with contraindications to or who are refractory to traditional therapies like NSAIDs and/or colchicine.</p> Signup and view all the answers

    What is the typical presentation of acute gout?

    <p>Inflammation in the large toe at night</p> Signup and view all the answers

    Which of the following drugs is not recommended for acute gout treatment?

    <p>Allopurinol</p> Signup and view all the answers

    What is the action of Colchicine when used for gout prophylaxis?

    <p>Inhibits microtubule assembly and prevents leucocyte migration</p> Signup and view all the answers

    Which of the following is an unlabeled use of Colchicine?

    <p>Treating multiple sclerosis</p> Signup and view all the answers

    In what form should Colchicine be taken for gout prophylaxis?

    <p>Intravenous (IV)</p> Signup and view all the answers

    Which of the following drugs is contraindicated in patients with glucose-6-phosphate dehydrogenase deficiency?

    <p>Pegloticase</p> Signup and view all the answers

    Which of the following is a potential side effect of pegloticase?

    <p>All of the above</p> Signup and view all the answers

    What is the mechanism of action of probenecid and sulfinpyrazone?

    <p>Inhibit renal tubular reabsorption of uric acid</p> Signup and view all the answers

    Which of the following is a concern associated with the development of antibodies against pegloticase?

    <p>All of the above</p> Signup and view all the answers

    Which of the following statements is true regarding the monitoring of pegloticase therapy?

    <p>Rising plasma uric acid level indicates antibody production</p> Signup and view all the answers

    What is the main risk associated with co-administration of NSAIDs with anticoagulants like warfarin?

    <p>Elevated risk of gastrointestinal bleeding</p> Signup and view all the answers

    What effect does the co-administration of NSAIDs have on the nephrotoxicity of cyclosporine and tacrolimus?

    <p>Increased nephrotoxic effect</p> Signup and view all the answers

    Why were most coxibs either severely restricted in use or withdrawn from the market?

    <p>Following reports of cardiovascular events</p> Signup and view all the answers

    How do quinolone antimicrobials interact with NSAIDs when co-administered?

    <p>Risk of convulsions</p> Signup and view all the answers

    What is the primary reason for the lower rate of ulceration associated with COX-2 inhibitors compared to older NSAIDs?

    <p>Selective inhibition of COX-2</p> Signup and view all the answers

    Which NSAID is most likely to be recommended for a patient with a history of gastrointestinal bleeding?

    <p>Sulindac</p> Signup and view all the answers

    Which NSAID has the least potential for inhibiting COX-1, and therefore causing gastrointestinal side effects?

    <p>Aspirin at low doses</p> Signup and view all the answers

    Which NSAID is most likely to undergo enterohepatic circulation, leading to side effects in the lower intestine?

    <p>Sulindac</p> Signup and view all the answers

    Which NSAID is a ketone prodrug that is metabolized to the active acidic form?

    <p>Nabumetone</p> Signup and view all the answers

    Which NSAID is most likely to have less gastric irritation compared to other NSAIDs?

    <p>Sulindac</p> Signup and view all the answers

    Which class of drugs includes Aspirin, Na-salicylate, and diflunisal?

    <p>Salicylates</p> Signup and view all the answers

    Which of the following NSAIDs belongs to the Oxicams class?

    <p>Piroxicam (Feldene)</p> Signup and view all the answers

    Which drug is a Pyrrolo-pyrrole NSAID?

    <p>Ketorolac (Ketrodol)</p> Signup and view all the answers

    Which NSAID has both peripheral and central antipyretic effects?

    <p>Diclofenac (Voltaren)</p> Signup and view all the answers

    Which class of NSAIDs includes Ibuprofen, Naproxen, and fenoprofen?

    <p>Phenylpropionic acid (profens)</p> Signup and view all the answers

    How does aspirin achieve its anti-inflammatory effect?

    <p>By inhibiting prostaglandin biosynthesis</p> Signup and view all the answers

    What is the primary mechanism through which aspirin prevents myocardial infarction?

    <p>Inhibiting platelet aggregation</p> Signup and view all the answers

    Why is the inhibition of COX enzymes by aspirin significant in its mechanism of action?

    <p>It prevents the production of new platelets</p> Signup and view all the answers

    Which effect of aspirin occurs at high doses?

    <p>Anti-inflammatory effect</p> Signup and view all the answers

    How does aspirin differ from other NSAIDs in terms of COX enzyme inhibition?

    <p>Aspirin irreversibly inhibits COX enzymes, while other NSAIDs do not</p> Signup and view all the answers

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