Podcast
Questions and Answers
What term did Shirkey use to refer to pediatric patients in 1968?
What term did Shirkey use to refer to pediatric patients in 1968?
- Treatment exiles
- Pharmacological outcasts
- Medical misfits
- Therapeutic orphans (correct)
Why were pediatric patients referred to as 'therapeutic orphans'?
Why were pediatric patients referred to as 'therapeutic orphans'?
- Because they were abandoned by the medical community
- As they were resistant to drug treatments
- For being hard to diagnose correctly
- Due to differences in drug metabolism in children compared to adults (correct)
At what age do some drugs show a decreased clearance in neonates and infants?
At what age do some drugs show a decreased clearance in neonates and infants?
- 1-3 years of age
- Up to 2 months of age (correct)
- 6-12 months of age
- 2-6 months of age
Which phase of hepatic drug metabolism at birth is 30% that of adults?
Which phase of hepatic drug metabolism at birth is 30% that of adults?
When does phase I metabolic capacity in children trend toward adult levels?
When does phase I metabolic capacity in children trend toward adult levels?
How does children having less acidic stomach contents impact drug absorption?
How does children having less acidic stomach contents impact drug absorption?
What factor contributes to infants experiencing increased levels of active drug in the circulation?
What factor contributes to infants experiencing increased levels of active drug in the circulation?
Why is there a lack of research in pediatric pharmacology according to the text?
Why is there a lack of research in pediatric pharmacology according to the text?
What are the main limitations to undertaking pharmacokinetic studies in newborns and infants as mentioned in the text?
What are the main limitations to undertaking pharmacokinetic studies in newborns and infants as mentioned in the text?
How do current guidelines suggest using data obtained from adults in pediatric clinical trials?
How do current guidelines suggest using data obtained from adults in pediatric clinical trials?
