Podcast
Questions and Answers
What term did Shirkey use to refer to pediatric patients in 1968?
What term did Shirkey use to refer to pediatric patients in 1968?
Why were pediatric patients referred to as 'therapeutic orphans'?
Why were pediatric patients referred to as 'therapeutic orphans'?
At what age do some drugs show a decreased clearance in neonates and infants?
At what age do some drugs show a decreased clearance in neonates and infants?
Which phase of hepatic drug metabolism at birth is 30% that of adults?
Which phase of hepatic drug metabolism at birth is 30% that of adults?
Signup and view all the answers
When does phase I metabolic capacity in children trend toward adult levels?
When does phase I metabolic capacity in children trend toward adult levels?
Signup and view all the answers
How does children having less acidic stomach contents impact drug absorption?
How does children having less acidic stomach contents impact drug absorption?
Signup and view all the answers
What factor contributes to infants experiencing increased levels of active drug in the circulation?
What factor contributes to infants experiencing increased levels of active drug in the circulation?
Signup and view all the answers
Why is there a lack of research in pediatric pharmacology according to the text?
Why is there a lack of research in pediatric pharmacology according to the text?
Signup and view all the answers
What are the main limitations to undertaking pharmacokinetic studies in newborns and infants as mentioned in the text?
What are the main limitations to undertaking pharmacokinetic studies in newborns and infants as mentioned in the text?
Signup and view all the answers
How do current guidelines suggest using data obtained from adults in pediatric clinical trials?
How do current guidelines suggest using data obtained from adults in pediatric clinical trials?
Signup and view all the answers
