PCOS Overview and Diagnosis Criteria
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Questions and Answers

What is the primary recommendation for treating infertility in women with PCOS aged under 35 years and a BMI over 25 kg/m2?

  • Gonadotropins
  • Laparoscopic ovarian drilling
  • Immediate referral to a fertility specialist
  • Intensive lifestyle program for 6 months (correct)
  • In women with PCOS, when should referral to a fertility specialist be initiated early?

  • If the woman has a BMI over 25 kg/m2
  • When there are other factors contributing to infertility (correct)
  • When the woman is aged 35 years or older (correct)
  • When lifestyle modifications fail after 6 months
  • What is the first-line treatment for ovulation induction in PCOS?

  • Gonadotropins
  • Letrozole (correct)
  • Laparoscopic ovarian drilling
  • Clomiphene citrate
  • What is the recommended treatment for PCOS when the first-line ovulation induction therapies fail or there are other contributing factors to infertility?

    <p>In vitro fertilization or intra-cytoplasmic sperm injection (D)</p> Signup and view all the answers

    What is the recommendation for lipid profile monitoring in women with PCOS?

    <p>Every two years if initially normal, annually if abnormal or overweight/obese (A)</p> Signup and view all the answers

    Which of the following metabolic assessments is recommended for women with PCOS?

    <p>Oral glucose tolerance test (oGTT) (D)</p> Signup and view all the answers

    In addition to lifestyle modification, what medication can be considered for women with PCOS to address weight, hormonal, and metabolic outcomes?

    <p>Metformin (C)</p> Signup and view all the answers

    What is the primary aim of laparoscopic ovarian drilling in women with PCOS?

    <p>To stimulate ovulation (D)</p> Signup and view all the answers

    What are the features associated with polycystic ovary syndrome (PCOS)?

    <p>Reproductive, metabolic, and psychological features (C)</p> Signup and view all the answers

    Which of the following best describes PCOS?

    <p>A common public health issue with various health implications (B)</p> Signup and view all the answers

    Which of these statements about PCOS is incorrect?

    <p>PCOS is only related to reproductive health. (A)</p> Signup and view all the answers

    What aspect is NOT typically considered in the assessment of PCOS?

    <p>Cardiovascular anomalies (C)</p> Signup and view all the answers

    Why is PCOS regarded as a public health issue?

    <p>Because it is a common condition that affects multiple health dimensions. (B)</p> Signup and view all the answers

    What percentage of women with PCOS are estimated to be undiagnosed?

    <p>70% (A)</p> Signup and view all the answers

    Which two of the following criteria are required for a PCOS diagnosis?

    <p>Oligo/anovulation and hyperandrogenism (D)</p> Signup and view all the answers

    Which of the following is NOT a common presentation associated with PCOS?

    <p>Regular menstrual cycles (D)</p> Signup and view all the answers

    What is considered an irregular menstrual cycle for a woman more than 3 years post menarche?

    <p>&lt;21 days or &gt;35 days (C)</p> Signup and view all the answers

    What is the primary characteristic of Phenotype A of PCOS?

    <p>Androgen excess, ovulatory dysfunction, and polycystic ovarian morphology (B)</p> Signup and view all the answers

    Which of the following is a potential differential diagnosis to be excluded in cases of suspected PCOS?

    <p>Cushing syndrome (B)</p> Signup and view all the answers

    Which hormonal test can help confirm anovulation in the context of PCOS?

    <p>Serum progesterone levels (A)</p> Signup and view all the answers

    Which symptom is commonly associated with hyperandrogenism in women with PCOS?

    <p>Male pattern balding (D)</p> Signup and view all the answers

    Obesity, dyslipidaemia, and diabetes are examples of which features related to PCOS?

    <p>Metabolic features (A)</p> Signup and view all the answers

    What is the maximum age for primary amenorrhea to be considered abnormal?

    <p>15 years old (C)</p> Signup and view all the answers

    What percentage of weight loss may help restore menstrual cycle regularity and ovulation?

    <p>5% (C)</p> Signup and view all the answers

    Which treatment option is not considered first line for managing PCOS due to its adverse effects?

    <p>Combined oral contraceptive pill (D)</p> Signup and view all the answers

    What is the best treatment for localized hirsutism?

    <p>Laser therapy (D)</p> Signup and view all the answers

    Which of the following should be used to induce a withdrawal bleed in women with oligo/amenorrhoea?

    <p>Intermittent progestin (B)</p> Signup and view all the answers

    What may benefit generalized hirsutism alongside cosmetic approaches?

    <p>Metformin (C)</p> Signup and view all the answers

    What is a potential barrier to accessing cosmetic therapy for hirsutism?

    <p>Cost and access (D)</p> Signup and view all the answers

    Which combination is commonly used in the treatment of hirsutism but lacks clear evidence for its specific benefits?

    <p>Ethinylestradiol and cyproterone acetate (B)</p> Signup and view all the answers

    Which of the following is NOT a benefit of lifestyle modification in managing conditions like PCOS?

    <p>Increasing risk of diabetes (A)</p> Signup and view all the answers

    What defines the presence of polycystic ovaries on ultrasound?

    <p>Presence of 12 small antral follicles per ovary measuring 2 to 9 mm (D)</p> Signup and view all the answers

    Which condition requires further investigations if free testosterone is significantly raised?

    <p>Late onset congenital adrenal hyperplasia (C)</p> Signup and view all the answers

    What is one of the major management strategies for PCOS?

    <p>Focus on emotional concerns and preventive activities (B)</p> Signup and view all the answers

    What percentage of young women may exhibit polycystic ovaries on ultrasound, according to the information provided?

    <p>70% (C)</p> Signup and view all the answers

    What is a common consequence for women with PCOS regarding weight gain?

    <p>They experience weight gain averaging 1-2 kg per year (D)</p> Signup and view all the answers

    Why is ultrasound considered unreliable for diagnosing polycystic ovaries in certain age groups?

    <p>Up to 70% of young women may exhibit polycystic features on ultrasound (D)</p> Signup and view all the answers

    Which of the following is true regarding the prevalence of PCOS in relation to weight?

    <p>The prevalence of PCOS is higher in overweight and obese women (D)</p> Signup and view all the answers

    Which option does NOT contribute to the management of PCOS?

    <p>Complete avoidance of medical interventions (A)</p> Signup and view all the answers

    Flashcards

    PCOS

    Polycystic ovary syndrome, a health issue affecting women.

    Reproductive features of PCOS

    Symptoms related to the female reproductive system, such as irregular periods.

    Metabolic features of PCOS

    Health aspects related to metabolism, such as insulin resistance.

    Psychological features of PCOS

    Emotional and mental health issues including anxiety or depression.

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    Public health issue

    A condition that affects a large group of people and requires attention.

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    Undiagnosed Rate

    Up to 70% of women with PCOS are undiagnosed.

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    Rotterdam Criteria

    Two of the three criteria required: Oligo/anovulation, Hyperandrogenism, and Polycystic ovaries.

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    Oligo/anovulation

    Irregular or absent ovulation, key symptom of PCOS.

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    Hyperandrogenism

    Excess androgens in women leading to symptoms like hirsutism.

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    Hirsutism

    Excess body hair in women due to elevated androgens.

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    PCOS Phenotypes

    Four classifications: A, B, C, D based on symptoms and findings.

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    Psychological Symptoms

    Anxiety, depression, and eating disorders often associated with PCOS.

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    Metabolic Features

    Associated conditions such as obesity, dyslipidemia, and diabetes in women with PCOS.

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    Ovulatory Dysfunction

    Irregular ovulation which can occur even in regular menstrual cycles.

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    Polycystic Ovaries Diagnosis

    Diagnosed via ultrasound showing 12+ small antral follicles or ovary volume >10 mL.

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    Management of PCOS

    Involves lifestyle modification, medical, and surgical treatments, focusing on symptoms, fertility, and health risks.

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    Risk Factors for PCOS

    Higher prevalence in women who are overweight or obese; weight gain is about 1-2 kg/year for those with PCOS.

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    Biochemical Hyperandrogenaemia

    Elevated levels of free testosterone in the blood, signaling a potential hormonal imbalance.

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    Ultrasound Limitations for PCOS

    Ultrasound is unreliable for diagnosing PCOS in adolescents within 8 years of menarche.

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    Ovarian Morphology

    One polycystic ovary is rare but significant in diagnosis; can indicate PCOS even if unilateral.

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    Laparoscopic ovarian drilling

    A minimally invasive surgical procedure to treat PCOS without damaging ovarian tissue.

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    Anovulatory infertility

    Infertility caused by the absence of ovulation, often seen in PCOS.

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    First-line treatment for PCOS

    Letrozole is more effective than clomiphene citrate for inducing ovulation.

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    Lifestyle modification for fertility

    Weight loss and lifestyle changes recommended for women under 35 with obesity before medication.

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    Referral to fertility specialist

    An early referral is advised for women over 35 or those with additional infertility factors.

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    Second-line treatment for infertility

    Gonadotrophins provided if first-line treatments fail or other issues are present.

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    Monitoring cardiovascular risk

    Regular checks on blood pressure and lipid profiles for PCOS patients, especially if overweight.

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    Metformin in PCOS

    Medication that helps manage weight, hormonal, and metabolic issues in women with PCOS.

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    Weight Loss Benefits

    A 5% weight loss can restore menstrual regularity, assist mental wellbeing, reduce diabetes risk, and prevent cardiometabolic issues.

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    Lifestyle Modification

    Involves healthy diet, caloric restriction, behavior change support, and exercise to aid weight loss and prevent future weight gain.

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    COCP

    Combined Oral Contraceptive Pill helps regulate menstrual cycles and provides contraception, but has risks such as venous thromboembolism.

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    Menstrual Cycle Induction

    In women with oligo/amenorrhoea, intermittent progestin every 3 months can induce a withdrawal bleed.

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    Hirsutism Treatment Options

    Treatment for hirsutism depends on patient preference, access, and affordability, including cosmetic therapies and medications.

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    Cosmetic Therapy for Hirsutism

    Best for localized hirsutism; laser and electrolysis are effective but can be costly and may have access barriers.

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    Eflornithine Use

    Topical eflornithine can aid in treating localized facial hirsutism but is costly.

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    Metformin for Hirsutism

    Metformin might be beneficial for generalized hirsutism when combined with cosmetic approaches.

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    Study Notes

    PCOS Overview

    • Polycystic ovary syndrome (PCOS) is a significant public health concern affecting reproductive, metabolic, and psychological health.
    • PCOS is one of the most prevalent conditions in women of reproductive age, impacting 8-13% of this demographic. Prevalence is higher in certain ethnic groups.
    • Up to 70% of women with PCOS remain undiagnosed.

    PCOS Background

    • PCOS is characterized by a range of reproductive, metabolic, and psychological features.

    Rotterdam Criteria

    • Two of the following three criteria are necessary for diagnosis:
      • Oligo/anovulation (irregular or absent menstruation)
      • Hyperandrogenism (increased male hormones; clinical features like hirsutism, acne, or male pattern baldness; or biochemical abnormalities in hormone levels)
      • Polycystic ovaries (12 or more small antral follicles visible on ultrasound; or increased ovarian volume)
    • Other potential causes of the above symptoms (e.g., congenital adrenal hyperplasia, androgen-secreting tumors, or thyroid dysfunction) must be ruled out.

    Presentation of PCOS

    • Possible signs and symptoms include:
      • Hirsutism (excessive hair growth) and male pattern baldness
      • Irregular or absent menstrual cycles
      • Subfertility or infertility
      • Psychological symptoms (anxiety, depression, psychosexual dysfunction, eating disorders)
      • Metabolic features (obesity, dyslipidemia, diabetes)

    PCOS Phenotypes

    • The NIH 2012 workshop categorized PCOS into four phenotypes:
      • Phenotype A: Androgen excess, ovulatory dysfunction, and polycystic ovarian morphology.
      • Phenotype B: Androgen excess and ovulatory dysfunction.
      • Phenotype C: Androgen excess and polycystic ovarian morphology.
      • Phenotype D: Ovulatory dysfunction and polycystic ovarian morphology.

    Oligo/anovulation

    • Irregular menstrual cycles are defined in various ways based on time since menarche and the timing of cycles.
      • Examples: Fewer than 21 days or more than 45 days between cycles
      • Examples: Less than 8 cycles per year
      • Examples: More than 90 days between cycles.
    • Primary amenorrhea (absence of menstruation by age 15) or no menstruation for 3 years after breast development (thelarche) can indicate a possible problem.
    • Ovulatory dysfunction can still occur with regular cycles.

    Hyperandrogenism

    • Hirsutism (excessive hair growth), acne, and male pattern baldness are all clinical signs of high male hormones
    • Male pattern alopecia is a frequent symptom
    • Biochemical testing (looking for high levels of free testosterone) may be helpful but is not always sufficient evidence on its own
    • If free testosterone is high or there is sudden hormonal change, further testing may be necessary to exclude other potential underlying factors.

    Ovarian Morphology

    • Ultrasound is used to assess ovaries for PCOS. Key details include:
      • The presence of 12 or more small antral follicles (2–9 mm in diameter) in one or both ovaries
      • An ovarian volume exceeding 10 mL for one or both ovaries
    • Ultrasound is not a reliable method for diagnosis during adolescence and the first 8 years after menarche.
    • A single ovary meeting the above criteria suffices for diagnosis.

    PCOS Management

    • PCOS management considers current symptoms, fertility, and emotional well-being, as well as the prevention of future issues.
    • Lifestyle modification (healthy diet and exercise).
    • Medical treatment (e.g., birth control pills, medication for ovulation induction, Metformin)
    • Surgical treatment (e.g., ovarian drilling).

    Lifestyle Modification

    • Weight loss (even a small amount) can significantly improve menstrual cycles, mental well-being, and diabetes risk.
    • Weight gain in PCOS patients occurs at a rate of 1–2 kg per year.
    • Healthy diet and exercise programs with behavior change support can effectively help achieve weight loss and improve health.

    Medical Treatment

    • Combined oral contraceptives (COCs) are effective for regulating menstrual cycles.
    • 35 mcg ethinyl estradiol and cyproterone acetate are not recommended for treating PCOS due to potential adverse side effects.
    • Other medications like progestins may be used intermittently to prevent endometrial hyperplasia.
    • Cosmetic treatments (laser hair removal, electrolysis) are useful for localized hirsutism.
    • Topical eflornithine can offer temporary relief from hirsutism.
    • Medical therapies like the COCP and Metformin are first-line options. Metformin is effective in improving insulin resistance and metabolic parameters.

    Surgical Treatment

    • Laparoscopic ovarian drilling (LOD) is a possible surgical intervention.
    • LOD involves creating controlled injuries on the ovarian surface.

    Subfertility

    • PCOS is a significant cause of anovulatory infertility.
    • Lifestyle modifications are initial interventions for women of childbearing age. For women under age 35 with a BMI greater than or equal to 25, initial treatment may not require medication.
    • Referral to infertility specialists is recommended in cases where lifestyle changes are ineffective or for women over 35.

    Ovulation Induction in PCOS

    • First-line ovulation induction includes Letrozole, followed by clomiphene citrate.
    • Gonadotropins are second-line.
    • In vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) can be considered for couples with other infertility factors.

    Cardiovascular Risk Modification

    • It's important to regularly monitor factors like weight, blood pressure, and lipid profiles to manage the risk of cardiovascular conditions often associated with PCOS.
    • Smoking cessation should be encouraged.

    Metformin

    • Metformin is a medication that is helpful for women with PCOS-related insulin resistance.
    • Metformin can improve hormonal profiles, metabolic function, and weight in women with PCOS.
    • Metformin can be used as an adjunct (additional) therapy to other standard medications that regulate cycle regularity.

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    PCOS PDF

    Description

    This quiz explores Polycystic Ovary Syndrome (PCOS), a common health issue affecting women of reproductive age. It covers the key features, prevalence, and the Rotterdam criteria necessary for diagnosis. Test your knowledge on the implications and understanding of PCOS.

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