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Pax5 and B-Cell Development
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Pax5 and B-Cell Development

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Questions and Answers

Which cells of the lymphoid lineage are derived from common lymphoid progenitor cells?

  • B cells
  • T cells
  • ILCs (innate lymphoid cells)
  • All of the above (correct)

    • Where do B cells and T cells develop from?

  • Stromal cells
  • Multipotent progenitor cells
  • Hematopoietic stem cells (correct)
  • Mature lymphocytes

    • What is the role of stromal cells in lymphocyte development?

  • They regulate hematopoietic stem cell differentiation
  • They differentiate into B cells and T cells
  • They produce cytokines and chemokines
  • They form adhesive contacts with developing lymphocytes (correct)

    • Which receptor tyrosine kinase is expressed by multipotent progenitor cells?

    <p>FLT3</p> Signup and view all the answers

    Where does the production of new lymphocytes take place?

    <p>In the bone marrow</p> Signup and view all the answers

    Where do B cells complete most of their development?

    <p>In the bone marrow</p> Signup and view all the answers

    Where do the precursors of most T cells migrate to?

    <p>Thymus</p> Signup and view all the answers

    Which lymphoid tissues are considered secondary lymphoid tissues?

    <p>Lymph nodes</p> Signup and view all the answers

    Which cells undergo positive selection during development?

    <p>T cells</p> Signup and view all the answers

    What is the default fate of developing lymphocytes in the absence of any signal from the receptor?

    <p>Death by apoptosis</p> Signup and view all the answers

    Where do B cells develop?

    <p>Bone marrow</p> Signup and view all the answers

    Which cells develop from bone marrow stem cells and comprise the cells of the adaptive immune response?

    <p>B and T cells</p> Signup and view all the answers

    Which cytokine is essential for the growth and survival of developing B cells in mice?

    <p>IL-7</p> Signup and view all the answers

    Which receptor is composed of the IL-7 receptor α chain and the common cytokine receptor γ chain?

    <p>IL-7 receptor</p> Signup and view all the answers

    Which cytokine receptor shares the tyrosine kinase Jak3?

    <p>IL-7 receptor</p> Signup and view all the answers

    Which membrane-bound cytokine stimulates the growth of hematopoietic stem cells and the earliest B-lineage progenitors?

    <p>IL-7</p> Signup and view all the answers

    Which receptor is expressed on multipotent progenitor cells and is required for differentiation into common lymphoid progenitors?

    <p>FLT3</p> Signup and view all the answers

    Which subset of common lymphoid progenitor cells is able to generate B cells, T cells, and NK cells?

    <p>Subset with broadest potential</p> Signup and view all the answers

    Which progenitor cell produces the ILC subsets ILC1, ILC2, and ILC3 cells?

    <p>Unnamed progenitor cell</p> Signup and view all the answers

    Which adhesion molecule on stromal cells is bound by progenitor cells through the integrin VLA-4?

    <p>VCAM-1</p> Signup and view all the answers

    Which protein is required for commitment of the pro-B cell to the B-cell lineage?

    <p>BLNK</p> Signup and view all the answers

    What is the function of the pre-B-cell receptor?

    <p>Signals via Igα, Igβ, and Btk</p> Signup and view all the answers

    Which cell surface markers are expressed throughout B-cell development?

    <p>CD19 and CD45R</p> Signup and view all the answers

    Where does the final maturation to IgM+IgD+ mature B cells occur?

    <p>Spleen</p> Signup and view all the answers

    Which reading frame(s) can most human D gene segments be translated in without encountering a stop codon?

    <p>Three reading frames</p> Signup and view all the answers

    At what stage is there no need to ensure that only one allele undergoes rearrangement?

    <p>Early pro-B cell stage</p> Signup and view all the answers

    What is the advantage of starting off with two successfully rearranged D–JH sequences?

    <p>Decreases the rate of failure at later stages</p> Signup and view all the answers

    In which type of B cell do VH to DJH rearrangements occur?

    <p>Late pro-B cell</p> Signup and view all the answers

    At which stage does the progression to light-chain gene rearrangement occur in small pre-B cells?

    <p>Immature B cell stage</p> Signup and view all the answers

    In which type of B cell is IgM expressed?

    <p>Mature B cell</p> Signup and view all the answers

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