Podcast
Questions and Answers
Which cells of the lymphoid lineage are derived from common lymphoid progenitor cells?
Which cells of the lymphoid lineage are derived from common lymphoid progenitor cells?
- B cells
- T cells
- ILCs (innate lymphoid cells)
- All of the above (correct)
Where do B cells and T cells develop from?
Where do B cells and T cells develop from?
- Stromal cells
- Multipotent progenitor cells
- Hematopoietic stem cells (correct)
- Mature lymphocytes
What is the role of stromal cells in lymphocyte development?
What is the role of stromal cells in lymphocyte development?
- They regulate hematopoietic stem cell differentiation
- They differentiate into B cells and T cells
- They produce cytokines and chemokines
- They form adhesive contacts with developing lymphocytes (correct)
Which receptor tyrosine kinase is expressed by multipotent progenitor cells?
Which receptor tyrosine kinase is expressed by multipotent progenitor cells?
Where does the production of new lymphocytes take place?
Where does the production of new lymphocytes take place?
Where do B cells complete most of their development?
Where do B cells complete most of their development?
Where do the precursors of most T cells migrate to?
Where do the precursors of most T cells migrate to?
Which lymphoid tissues are considered secondary lymphoid tissues?
Which lymphoid tissues are considered secondary lymphoid tissues?
Which cells undergo positive selection during development?
Which cells undergo positive selection during development?
What is the default fate of developing lymphocytes in the absence of any signal from the receptor?
What is the default fate of developing lymphocytes in the absence of any signal from the receptor?
Where do B cells develop?
Where do B cells develop?
Which cells develop from bone marrow stem cells and comprise the cells of the adaptive immune response?
Which cells develop from bone marrow stem cells and comprise the cells of the adaptive immune response?
Which cytokine is essential for the growth and survival of developing B cells in mice?
Which cytokine is essential for the growth and survival of developing B cells in mice?
Which receptor is composed of the IL-7 receptor α chain and the common cytokine receptor γ chain?
Which receptor is composed of the IL-7 receptor α chain and the common cytokine receptor γ chain?
Which cytokine receptor shares the tyrosine kinase Jak3?
Which cytokine receptor shares the tyrosine kinase Jak3?
Which membrane-bound cytokine stimulates the growth of hematopoietic stem cells and the earliest B-lineage progenitors?
Which membrane-bound cytokine stimulates the growth of hematopoietic stem cells and the earliest B-lineage progenitors?
Which receptor is expressed on multipotent progenitor cells and is required for differentiation into common lymphoid progenitors?
Which receptor is expressed on multipotent progenitor cells and is required for differentiation into common lymphoid progenitors?
Which subset of common lymphoid progenitor cells is able to generate B cells, T cells, and NK cells?
Which subset of common lymphoid progenitor cells is able to generate B cells, T cells, and NK cells?
Which progenitor cell produces the ILC subsets ILC1, ILC2, and ILC3 cells?
Which progenitor cell produces the ILC subsets ILC1, ILC2, and ILC3 cells?
Which adhesion molecule on stromal cells is bound by progenitor cells through the integrin VLA-4?
Which adhesion molecule on stromal cells is bound by progenitor cells through the integrin VLA-4?
Which protein is required for commitment of the pro-B cell to the B-cell lineage?
Which protein is required for commitment of the pro-B cell to the B-cell lineage?
What is the function of the pre-B-cell receptor?
What is the function of the pre-B-cell receptor?
Which cell surface markers are expressed throughout B-cell development?
Which cell surface markers are expressed throughout B-cell development?
Where does the final maturation to IgM+IgD+ mature B cells occur?
Where does the final maturation to IgM+IgD+ mature B cells occur?
Which reading frame(s) can most human D gene segments be translated in without encountering a stop codon?
Which reading frame(s) can most human D gene segments be translated in without encountering a stop codon?
At what stage is there no need to ensure that only one allele undergoes rearrangement?
At what stage is there no need to ensure that only one allele undergoes rearrangement?
What is the advantage of starting off with two successfully rearranged D–JH sequences?
What is the advantage of starting off with two successfully rearranged D–JH sequences?
In which type of B cell do VH to DJH rearrangements occur?
In which type of B cell do VH to DJH rearrangements occur?
At which stage does the progression to light-chain gene rearrangement occur in small pre-B cells?
At which stage does the progression to light-chain gene rearrangement occur in small pre-B cells?
In which type of B cell is IgM expressed?
In which type of B cell is IgM expressed?
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