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Questions and Answers
What is the role of GnRH in the normal menstrual cycle?
GnRH is released from the hypothalamus to stimulate the release of LH and FSH from the anterior pituitary, which then act on the ovary.
What is the main function of LH and FSH in the ovary?
LH and FSH stimulate the thecal and granulosa cells of the follicle to produce estrogen and progesterone.
What is the negative feedback effect of progesterone on GnRH?
Progesterone reduces the release of GnRH from the hypothalamus, maintaining the correct ratios of LH and FSH.
What happens in polycystic ovarian syndrome (PCOS)?
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What causes the increase in GnRH pulse frequency in PCOS?
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