Pathophysiological Mechanisms in Age-Related Voiding Dysfunction
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Questions and Answers

What is one of the proposed pathophysiological mechanisms for age-related changes in smooth muscle?

  • Reduced activity of muscarinic receptors in the detrusor smooth muscle
  • Hyper-excitability of muscarinic receptors in the detrusor smooth muscle (correct)
  • Increased activity of nicotinic receptors in the urothelium
  • Decreased activity of adrenergic receptors in the neurovascular structures

    • Which structure shows hyper-excitability of muscarinic receptors according to the proposed pathophysiological mechanisms?

  • Neurovascular structures
  • Sensory group C fibres
  • Adrenergic receptors
  • Detrusor smooth muscle (correct)

    • What contributes to atropine resistance according to the proposed pathophysiological mechanisms?

  • Hyper-excitability of adrenergic receptors in the detrusor smooth muscle
  • Increased afferent (sensory group C fibres) nerve activity (correct)
  • Reduced activity of nicotinic receptors in the urothelium
  • Decreased afferent (sensory group C fibres) nerve activity

    • Which level experiences denervation resulting in hyperactive voiding according to the proposed pathophysiological mechanisms?

    <p>Spinal and cortical levels</p> Signup and view all the answers

    What is the proposed pathophysiological mechanism for age-related changes in smooth muscle that leads to hyperactive voiding?

    <p>Increased afferent nerve activity and hypersensitivity of ion channels</p> Signup and view all the answers

    Which structure exhibits hyper-excitability of muscarinic receptors based on the proposed pathophysiological mechanisms?

    <p>Detrusor smooth muscle</p> Signup and view all the answers

    What contributes to atropine resistance according to the proposed pathophysiological mechanisms?

    <p>Hyper-excitability of muscarinic receptors in the detrusor smooth muscle</p> Signup and view all the answers

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