Pathology and Infectious Disease Overview
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Questions and Answers

Which of the following statements accurately describes the concept of disease?

  • The invasion of pathogens in the body
  • A mild illness that resolves spontaneously
  • A temporary state of health
  • An abnormal state where normal body functions are disrupted (correct)
  • What is the first criterion of Koch's postulates?

  • The pathogen must be isolated from the environment
  • The pathogen must be invisible under a microscope
  • The pathogen should be present in every instance of the disease (correct)
  • The pathogen must be extracted from a healthy host
  • How are communicable diseases best defined?

  • Diseases that are caused by genetic factors
  • Diseases that can be transmitted only via direct contact
  • Diseases unable to be transferred between hosts
  • Diseases that can be spread from one host to another (correct)
  • What structure of the skin is primarily responsible for waterproofing?

    <p>Keratin (A)</p> Signup and view all the answers

    What type of diseases are characterized by specific groups of signs and symptoms?

    <p>Syndrome (C)</p> Signup and view all the answers

    What is the main characteristic of nonbullous impetigo?

    <p>It involves crusting sores that can spread by autoinoculation. (B)</p> Signup and view all the answers

    Which of the following correctly characterizes a contagious disease?

    <p>A communicable disease that spreads easily and rapidly (D)</p> Signup and view all the answers

    Which condition is associated with a blistering form of impetigo?

    <p>Scalded skin syndrome (C)</p> Signup and view all the answers

    Which of the following components is NOT part of the normal microbiota of the skin?

    <p>Pathogenic bacteria (B)</p> Signup and view all the answers

    What are the common symptoms of Toxic Shock Syndrome (TSS)?

    <p>Fever, vomiting, shock, and organ failure (A)</p> Signup and view all the answers

    What is a primary virulence factor produced by Group A streptococci?

    <p>M proteins (A)</p> Signup and view all the answers

    Which of the following best describes the structure of the epidermis?

    <p>Thin outer portion composed of epithelial cells (C)</p> Signup and view all the answers

    Which disease is characterized by deep skin infection due to skin breaks?

    <p>Cellulitis (A)</p> Signup and view all the answers

    What is the characteristic feature of erysipelas caused by Streptococcus pyogenes?

    <p>Infection of the dermal layer of the skin (C)</p> Signup and view all the answers

    What is the most common cause of necrotizing fasciitis?

    <p>Streptococcus pyogenes (C)</p> Signup and view all the answers

    Which statement about Streptococcus pyogenes is false?

    <p>It produces only endotoxins. (A)</p> Signup and view all the answers

    What is the defining characteristic of bullae?

    <p>Vesicles larger than 1 cm in diameter (D)</p> Signup and view all the answers

    Which bacterium is known for being antibiotic-resistant and often associated with severe skin infections?

    <p>Staphylococcus aureus (A)</p> Signup and view all the answers

    Which of the following describes a furuncle?

    <p>Localized region of pus surrounded by inflamed tissue (A)</p> Signup and view all the answers

    What percentage of normal skin microbiota is Staphylococcus epidermidis estimated to represent?

    <p>90% (B)</p> Signup and view all the answers

    What is the primary transmission method for MRSA infections?

    <p>Direct contact with an infected wound or contaminated surfaces (C)</p> Signup and view all the answers

    Which skin condition is characterized as folliculitis of an eyelash?

    <p>Sty (C)</p> Signup and view all the answers

    Which of the following is NOT a skin abnormality mentioned?

    <p>Cysts (C)</p> Signup and view all the answers

    What type of bacteria are Staphylococci classified as?

    <p>Gram-positive cocci in clusters (C)</p> Signup and view all the answers

    What is the primary transmission method for Pseudomonas dermatitis?

    <p>Acquired in swimming pools (C)</p> Signup and view all the answers

    What is a key characteristic of Mycobacterium ulcerans?

    <p>It produces the toxin mycolactone (B)</p> Signup and view all the answers

    What type of acne is primarily caused by the digestion of sebum by Propionibacterium acnes?

    <p>Inflammatory acne (C)</p> Signup and view all the answers

    Which condition is characterized by deep and damaging ulcers that may require amputation?

    <p>Buruli Ulcer (A)</p> Signup and view all the answers

    Which of the following skin diseases is NOT primarily caused by a bacterium?

    <p>Smallpox (B)</p> Signup and view all the answers

    What treatment is common for combating Propionibacterium acnes?

    <p>Antibiotics and benzoyl peroxide (C)</p> Signup and view all the answers

    What is a prominent symptom of Otitis externa, caused by Pseudomonas aeruginosa?

    <p>Ear pain and inflammation (C)</p> Signup and view all the answers

    Which of the following skin diseases primarily affects children and developing fetuses?

    <p>Chickenpox (C)</p> Signup and view all the answers

    Flashcards

    Pathology

    The study of disease

    Koch's postulates

    Steps to prove a pathogen causes a disease

    Infectious disease classification

    Categorizing diseases based on spread (communicable/noncommunicable) and ease of spread (contagious)

    Skin microbiota

    Types of bacteria, fungi and other microbes living on the human skin's surface

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    Skin diseases

    Diseases caused by microbes impacting the skin (bacteria, viruses, fungi or insects)

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    Bacterial skin diseases

    Skin conditions caused by bacteria

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    Viral skin diseases

    Skin conditions caused by viruses

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    Fungal skin diseases

    Skin conditions caused by fungi

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    Vesicles

    Small, fluid-filled lesions on the skin.

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    Bullae

    Larger fluid-filled lesions on the skin, greater than 1 cm in diameter.

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    Macules

    Flat, reddened lesions on the skin, without elevation.

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    Papules

    Raised lesions on the skin, solid and firm.

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    Pustules

    Raised lesions on the skin filled with pus.

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    Exanthem

    A skin rash arising from a systemic disease.

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    Staphylococcus epidermidis

    A common bacterium found on the skin of most people, usually harmless, but can cause infections in vulnerable individuals.

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    Staphylococcus aureus

    A bacterium commonly found in the nasal passage, which can cause various skin infections and even sepsis.

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    Impetigo

    A bacterial skin infection caused by Streptococcus pyogenes, characterized by crusting sores that spread easily through autoinoculation.

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    Scalded Skin Syndrome

    A severe form of impetigo caused by Staphylococcus aureus, resulting in blistering and peeling of the skin, resembling a severe sunburn.

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    Toxic Shock Syndrome (TSS)

    A potentially life-threatening condition caused by toxins released from Staphylococcus aureus, leading to fever, vomiting, shock, and organ failure.

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    Group A Streptococci (GAS)

    A type of bacteria responsible for various infections, including strep throat, cellulitis, and impetigo. The most common member is Streptococcus pyogenes.

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    M Proteins

    Virulence factors produced by Streptococcus pyogenes that allow the bacteria to stick to surfaces and evade the immune system.

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    Erysipelas

    A skin infection caused by Streptococcus pyogenes affecting the superficial layers of the skin, characterized by redness, swelling, and pain.

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    Cellulitis

    A deeper skin infection caused by bacteria entering through a break in the skin, leading to inflammation and swelling.

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    Necrotizing Fasciitis

    A rare but serious flesh-eating disease caused by bacteria, often Streptococcus pyogenes, that destroys the tissue under the skin.

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    Pseudomonas aeruginosa

    A gram-negative, aerobic rod bacterium that produces toxins and can form biofilms. Often opportunistic in burn patients and resistant to many antibiotics.

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    Pseudomonas dermatitis

    A skin infection caused by Pseudomonas aeruginosa, often acquired in swimming pools. Characterized by a self-limiting rash that usually resolves on its own.

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    Otitis externa (Swimmer's ear)

    An infection of the outer ear canal often caused by Pseudomonas aeruginosa. Commonly acquired in swimming pools.

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    Mycobacterium ulcerans

    A gram-positive bacteria that causes Buruli ulcer, a deep and damaging skin infection. It produces a toxin called mycolactone and is often transmitted via skin breaks or insect bites.

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    Buruli ulcer

    A chronic skin infection caused by Mycobacterium ulcerans, characterized by deep, destructive ulcers that may require amputation.

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    Propionibacterium acnes

    An anaerobic bacterium that causes inflammatory acne. It thrives on sebum and fatty acids, leading to inflammation in the hair follicles.

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    Inflammatory acne

    A type of acne characterized by inflamed lesions caused by Propionibacterium acnes. Often treated with antibiotics and benzoyl peroxide.

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    Study Notes

    Pathology, Infection, and Disease

    • Pathology: The study of disease
    • Infection: The invasion of the body by pathogens
    • Disease: When the body is not functioning normally due to an abnormal state.

    Koch's Postulates

    • Koch's postulates are used to prove that a specific pathogen causes a specific disease.
    • The same pathogen must be present in every case of the disease.
    • The pathogen must be isolated from the diseased host and grown in a pure culture.
    • The pathogen from the culture must cause the disease when inoculated into a healthy lab animal.
    • The pathogen must be isolated from the inoculated animal and must be the original species.

    Infectious Disease Classification

    • Symptoms: Changes in bodily functions that patients experience, e.g., fatigue, nausea. Measurable changes in the body.
    • Signs: Changes in the body that can be measured or observed, e.g., fever, changes in white blood cell count.
    • Syndrome: A specific collection of signs and symptoms that are frequently associated with a disease.
    • Communicable disease: A disease spread from one host to another.
    • Contagious disease: A communicable disease that spreads easily and rapidly.
    • Noncommunicable disease: A disease that is not spread from one host to another.

    Skin Structure and Microbiota

    • Epidermis: The thin, outermost layer of skin, composed of epithelial cells.
    • Keratin: A protein that provides a waterproof barrier to the outer layer of the epidermis (also found in hair and nails) .
    • Dermis: The thick layer of skin beneath the epidermis, primarily composed of connective tissue.
    • Normal skin microbiota: Includes gram-positive cocci (like staphylococci) and some yeasts. They are resistant to drying and high salt concentrations, often colonizing hair follicles or skin surfaces.

    Microbial Skin Diseases - Characteristics

    • Vesicles: Small fluid-filled lesions.
    • Bullae: Vesicles larger than 1 cm in diameter.
    • Macules: Flat, reddened lesions.
    • Papules: Raised lesions.
    • Pustules: Raised lesions with pus.
    • Exanthem: A skin rash arising from a disease.

    Bacterial Skin Diseases

    • Staphylococci: Gram-positive cocci in clusters; common skin bacteria. Includes Staphylococcus epidermidis and Staphylococcus aureus.
    • Streptococci: Gram-positive cocci in chains; a common cause of skin diseases and Streptococcus pyogenes.
    • Pseudomonas aeruginosa: Gram-negative, aerobic rod; opportunistic pathogen; can cause skin infections.
    • Mycobacterium ulcerans: Gram-positive; causes Buruli ulcer.
    • Propionibacterium acnes: Anaerobic microbe; common cause of acne.

    Viral Skin Diseases

    • Warts: Caused by papillomaviruses; transmitted by contact.
    • Smallpox: Caused by Orthopoxvirus; eradicated thanks to vaccination.
    • Chickenpox: Caused by varicella-zoster virus; prevented by vaccine.
    • Shingles: Caused by varicella-zoster virus; reactivation of the latent virus; commonly in elderly, immunocompromised cases.
    • Herpes simplex: Caused by HSV-1 and HSV-2; transmitted via contact; causes cold sores and genital herpes.
    • Measles: Caused by rubella virus; transmitted via respiratory route; prevented by vaccine.
    • Rubella: Caused by rubella virus; transmitted via respiratory route; prevented by vaccine. (German measles)

    Fungal Skin and Nail Diseases

    • Cutaneous mycoses: Superficial fungal infections of the skin and nails (caused by dermatophytes).
    • Athlete's foot: Fungal infection causing itchy rash.
    • Ringworm: Fungal infection causing circular rash.
    • Subcutaneous mycoses: More serious fungal infections that penetrate the stratum corneum (e.g., sporotrichosis).

    Insect-Caused Diseases

    • Scabies: Caused by Sarcoptes scabiei mites; transmitted through close contact. Causes inflammatory skin lesions.
    • Pediculosis: Caused by lice (Pediculus humanus capitis - head lice and P.h. corporis - body lice)

    Eye Diseases

    • Conjunctivitis: Inflammation of the conjunctiva, commonly caused by Haemophilus influenzae bacterium or in some cases viral or bacterial infections.
    • Ophthalmia Neonatorum: Transmission through birth canal (often due to untreated gonorrhea); inflammation of newborn eyes, potentially resulting in blindness.
    • Inclusion Conjunctivitis: Caused by Chlamydia trachomatis; transmitted through birth canal and can spread in swimming pools, in which case it's rare.
    • Trachoma: Caused by Chlamydia trachomatis; leading cause of blindness worldwide, transmitted through hand contact and flies.

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    Description

    This quiz explores the fundamentals of pathology, infection, and disease. It delves into Koch's postulates and the classification of infectious diseases based on symptoms and signs. Test your understanding of how pathogens affect the body and the criteria used to establish disease causation.

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