Pathogenesis of Fever Core Messages
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Questions and Answers

What is the primary mediator of the febrile response?

  • Exogenous pyrogens
  • Toxins
  • Cytokines (correct)
  • Endogenous pyrogens

    • In fever, what causes the body to increase heat production and decrease heat loss?

  • Activation of B cells and T-lymphocytes
  • Overproduction of cytokines
  • Elevated set point due to endogenous pyrogens (correct)
  • Imbalance between cytokines and their inhibitors

    • What constitutes the clearest and strongest evidence in favor of the protective role of fever?

  • Lymphocyte activation
  • Production of fever simultaneously with lymphocyte activation (correct)
  • High temperature (around 39.5 °C)
  • Activation of B cells

    • What can lead to harmful and even lethal effects during fever generation?

    <p>Overproduction of cytokines</p> Signup and view all the answers

    What is the optimal temperature for the protective processes of the immune response?

    <p>Around 39.5 °C</p> Signup and view all the answers

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