Questions and Answers
What is the drug classification of Parnate?
What is the dose range for Parnate?
30 to 50 mg/day in 2 divided doses
What is the primary pharmacological action of Parnate?
Inhibits monoamine oxidase
Which of the following are side effects of Parnate? (Select all that apply)
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What kind of interactions does Parnate have with food or other medications? (Select all that apply)
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What nursing intervention is important when administering Parnate?
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Parnate should not be taken with alcohol.
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What is an expected evaluation of medication effectiveness for patients on Parnate?
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What are the therapeutic uses of Parnate?
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Match the following side effects with their descriptions:
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Study Notes
Drug Classification
- Tranylcypromine is classified as a monoamine oxidase inhibitor (MAOI) antidepressant.
Dose Range
- Recommended dosage is typically between 30 to 50 mg per day, divided into two doses.
Pharmacological Action
- Tranylcypromine works by inhibiting monoamine oxidase, leading to an increase in neurotransmitters such as dopamine, epinephrine, norepinephrine, and serotonin.
Side Effects/Adverse Effects
- Common side effects include seizures, dizziness, blurred vision, and drowsiness.
- Potentially serious effects include hypertensive crisis, edema, tachycardia, and sexual dysfunction.
- Blood disorders such as agranulocytosis, leukopenia, and thrombocytopenia can occur.
Medication/Food Interactions
- Interactions may occur with other MAOIs, SSRIs, various antidepressants, narcotics, and stimulants like amphetamines.
- Risk of adverse effects with dextromethorphan, antihypertensives, opioids, insulin, and tramadol.
- Foods high in tyramine can lead to severe reactions and should be avoided.
Nursing Interventions/Client Education
- Monitor patient’s mental status, mood fluctuations, and suicidal ideation.
- Regularly check blood pressure and heart rate.
- Track intake and output, daily weight, and assess for signs of fluid retention.
- Evaluate liver function and monitor serum glucose levels in diabetic patients.
- Educate to avoid tyramine-rich foods, alcohol, CNS depressants, and OTC products containing tyramine.
- Discontinue medication at least 10 days prior to any surgery requiring anesthesia.
Nursing Administration Concerns
- Monitor for hypersensitivity and contraindications such as liver disease, cardiovascular and cerebrovascular diseases, and hypertension.
- Consider history of headaches, excessive caffeine use, renal dysfunction, and diabetes.
- Caution with concurrent use of meperidine, SSRIs, other antidepressants, and substances like alcohol and narcotics.
- Special care for populations like pregnant women, the elderly, and those with hyperthyroidism or seizure disorders.
Evaluation of Medication Effectiveness
- Effectiveness is assessed through improved mood, increased appetite, reduced anxiety, enhanced energy levels, and better sleep.
- Therapeutic effects may take 3 to 6 weeks to manifest.
Therapeutic Uses
- Primarily used for treating major depressive episodes without melancholic features.
- Often prescribed for patients who have not responded to or tolerated other treatments effectively.
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Description
Test your knowledge of Parnate (tranylcypromine) with these flashcards. Covering drug classification, pharmacological actions, dosing, and side effects, this quiz provides essential insights into this MAOI antidepressant. Perfect for students in pharmacology or healthcare fields.
