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Parenteral Route of Administration Quiz

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Questions and Answers

Why is the oral route of administration preferred for therapeutic proteins?

It has higher bioavailability compared to other routes

It allows for better permeation of the protein across the intestinal epithelium

It is more patient-friendly and does not require healthcare professional intervention (correct)

It avoids protein degradation in the gastrointestinal tract

What is the primary factor that affects the uptake of a protein into the blood circulation after injection?

Molecular weight of the protein (correct)

The state of the tissue at the injection site

The heat applied to the injection site

Exercise level of the muscle at the injection site

What is the primary reason for the low oral bioavailability of therapeutic proteins?

Degradation of the protein in the gastrointestinal tract (correct)

Inability of the protein to reach the target cells in the body

Poor permeation of the protein across the intestinal epithelium

Rapid clearance of the protein from the systemic circulation

How do Peyer's patches in the intestine contribute to the immune response for oral vaccines?

They attract lymphocytes and antigen-presenting cells to the site of vaccine administration Signup and view all the answers

What is the primary reason why active transport of intact therapeutic recombinant proteins across the gastrointestinal epithelium has not been described yet?

The proteins are too large to be actively transported Signup and view all the answers

Which of the following routes of administration involves using a needle?

All of the above Signup and view all the answers

Which of the following factors contributes to the differences in therapeutic performance of a drug administered via different parenteral routes?

All of the above Signup and view all the answers

What is a potential reason for developing modified proteins through site-directed mutagenesis?

To enhance circulation half-life Signup and view all the answers

What is the reason mentioned in the text for diabetics potentially becoming insulin resistant?

High tissue peptidase activity Signup and view all the answers

Which of the following statements about the circulation half-life of biotechnology products is true, according to the text?

The circulation half-life of biotechnology products can vary over a wide range Signup and view all the answers