Podcast
Questions and Answers
Why is the oral route of administration preferred for therapeutic proteins?
Why is the oral route of administration preferred for therapeutic proteins?
- It has higher bioavailability compared to other routes
- It allows for better permeation of the protein across the intestinal epithelium
- It is more patient-friendly and does not require healthcare professional intervention (correct)
- It avoids protein degradation in the gastrointestinal tract
What is the primary factor that affects the uptake of a protein into the blood circulation after injection?
What is the primary factor that affects the uptake of a protein into the blood circulation after injection?
- Molecular weight of the protein (correct)
- The state of the tissue at the injection site
- The heat applied to the injection site
- Exercise level of the muscle at the injection site
What is the primary reason for the low oral bioavailability of therapeutic proteins?
What is the primary reason for the low oral bioavailability of therapeutic proteins?
- Degradation of the protein in the gastrointestinal tract (correct)
- Inability of the protein to reach the target cells in the body
- Poor permeation of the protein across the intestinal epithelium
- Rapid clearance of the protein from the systemic circulation
How do Peyer's patches in the intestine contribute to the immune response for oral vaccines?
How do Peyer's patches in the intestine contribute to the immune response for oral vaccines?
What is the primary reason why active transport of intact therapeutic recombinant proteins across the gastrointestinal epithelium has not been described yet?
What is the primary reason why active transport of intact therapeutic recombinant proteins across the gastrointestinal epithelium has not been described yet?
Which of the following routes of administration involves using a needle?
Which of the following routes of administration involves using a needle?
Which of the following factors contributes to the differences in therapeutic performance of a drug administered via different parenteral routes?
Which of the following factors contributes to the differences in therapeutic performance of a drug administered via different parenteral routes?
What is a potential reason for developing modified proteins through site-directed mutagenesis?
What is a potential reason for developing modified proteins through site-directed mutagenesis?
What is the reason mentioned in the text for diabetics potentially becoming insulin resistant?
What is the reason mentioned in the text for diabetics potentially becoming insulin resistant?
Which of the following statements about the circulation half-life of biotechnology products is true, according to the text?
Which of the following statements about the circulation half-life of biotechnology products is true, according to the text?
