Questions and Answers
What is pancrelipase?
Creon, Pancreaze, others.
What is the therapeutic class of pancrelipase?
Pancreatic enzymes.
What is the pharmacologic class of pancrelipase?
None.
What are the main actions and uses of pancrelipase?
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Do not crush or open enteric-coated ______.
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What are some common adverse effects of pancrelipase?
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Pancrelipase is contraindicated in patients who are allergic to the drug or to ______ products.
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What are potential drug interactions with pancrelipase?
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Study Notes
Pancrelipase Overview
- Trade names include Creon and Pancreaze, among others.
- Classification as a pancreatic enzyme replacement therapy for insufficient pancreatic exocrine secretions.
Therapeutic and Pharmacologic Class
- Therapeutic class: Pancreatic enzymes.
- No recognized pharmacologic class.
Mechanism of Action
- Contains lipase, protease, and amylase derived from pork.
- Facilitates lipid conversion into glycerol and fatty acids.
- Converts starches to dextrin and sugars, and proteins to peptides.
- Acts locally in the gastrointestinal tract after oral administration.
Administration Guidelines
- Available in powder, tablet, and delayed-release capsule forms.
- Dose depends on dietary fat content; taken right before or with meals.
- Enteric-coated tablets must not be crushed; powder can be mixed with food.
Adverse Effects
- Generally uncommon due to enzyme non-absorption.
- Most frequent effects include nausea, vomiting, and diarrhea.
- Very high doses may lead to hyperuricemia (excess uric acid).
Contraindications
- Not suitable for patients allergic to pancrelipase or pork products.
- Delayed-release forms contraindicated in cases of acute pancreatitis.
Drug Interactions
- Interaction with iron may reduce its absorption.
- Antacids may diminish pancrelipase effectiveness.
- Possible increases in serum or urinary uric acid levels indicated in lab tests.
- Treatment for overdose focuses on symptomatic care for elevated uric acid levels.
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Description
This quiz consists of flashcards about Pancrelipase, a medication used to assist patients with inadequate pancreatic enzyme production. It covers its therapeutic and pharmacologic classifications as well as its actions and uses. Perfect for students and healthcare professionals looking to solidify their understanding of pancreatic enzymes.
