Pancrelipase Flashcards

Study Notes

Pancrelipase Overview

Trade names include Creon and Pancreaze, among others.
Classification as a pancreatic enzyme replacement therapy for insufficient pancreatic exocrine secretions.

Therapeutic and Pharmacologic Class

Therapeutic class: Pancreatic enzymes.
No recognized pharmacologic class.

Mechanism of Action

Contains lipase, protease, and amylase derived from pork.
Facilitates lipid conversion into glycerol and fatty acids.
Converts starches to dextrin and sugars, and proteins to peptides.
Acts locally in the gastrointestinal tract after oral administration.

Administration Guidelines

Available in powder, tablet, and delayed-release capsule forms.
Dose depends on dietary fat content; taken right before or with meals.
Enteric-coated tablets must not be crushed; powder can be mixed with food.

Adverse Effects

Generally uncommon due to enzyme non-absorption.
Most frequent effects include nausea, vomiting, and diarrhea.
Very high doses may lead to hyperuricemia (excess uric acid).

Contraindications

Not suitable for patients allergic to pancrelipase or pork products.
Delayed-release forms contraindicated in cases of acute pancreatitis.

Drug Interactions

Interaction with iron may reduce its absorption.
Antacids may diminish pancrelipase effectiveness.
Possible increases in serum or urinary uric acid levels indicated in lab tests.
Treatment for overdose focuses on symptomatic care for elevated uric acid levels.

Description

This quiz consists of flashcards about Pancrelipase, a medication used to assist patients with inadequate pancreatic enzyme production. It covers its therapeutic and pharmacologic classifications as well as its actions and uses. Perfect for students and healthcare professionals looking to solidify their understanding of pancreatic enzymes.