48 Questions
What is the main control over salivary secretion?
Parasympathetic branch of the autonomic nervous system
How does saliva help in the process of swallowing?
It lubricates the mouth and throat
What is the composition of gastric secretion when released into the duodenum?
Acid and pepsin
What influences the cephalic phase of gastric secretion?
Food preferences
What stimulates the release of secretin in the digestive system?
Acid bathing the mucosa of the upper small intestine
What is the role of secretin in the digestive system?
Causes the secretion of bicarbonate by the duct cells of the pancreas and biliary tract
How does secretin affect the release of gastric acid in the digestive system?
Decreases gastric acid secretion and may cause contraction of the pyloric sphincter
Where are S cells, which secrete secretin, located?
Glands of the mucosa of the upper portion of the small intestine
What controls the secretion of pancreatic juice?
Reflex mechanism
How are the digestive enzymes discharged from the pancreatic cells?
By exocytosis
What activates most of the digestive enzymes in the pancreatic juice?
Intestinal lumen
What important function do bile acids serve in gastrointestinal function?
Digesting and absorbing fats
What is the primary role of parietal cells in the stomach?
Secreting hydrochloric acid and intrinsic factor
What is the function of gastrin in the stomach?
Triggering parietal cell secretion
What is the importance of intrinsic factor in the stomach?
Facilitating the later absorption of vitamin B12
Which trigger is responsible for parietal cell secretion via binding to H2-receptors?
Histamine
What is the primary function of the gastrointestinal tract?
To absorb nutrients and water into the body
Which parts of the gastrointestinal tract are encountered by the meal or its residues in order?
Mouth, esophagus, duodenum, ileum
Which organ secretes saliva when food is ingested?
Salivary glands
What is the role of saliva in digestion?
To break down starch with amylase
What is the primary function of secretin in the digestive system?
Increases the secretion of bicarbonate by the duct cells
What influences the release of secretin in the digestive system?
Products of protein digestion and acidic environment in the upper small intestine
What effect does secretin have on gastric acid secretion in the digestive system?
Decreases gastric acid secretion
How does CCK influence the secretion of secretin in the digestive system?
Stimulates further secretion of secretin through positive feedback
Which hormone increases acid secretion but is then inhibited by the feedback of the acid?
Gastrin
What is the most important action of Cholecystokinin (CCK) in the digestive system?
Relaxes the sphincter of Oddi
Where is Cholecystokinin (CCK) found in addition to its secretion by I cells?
Nerves in the distal ileum and colon
What role does Cholecystokinin (CCK) play in the brain?
Affects the production of anxiety and analgesia
What is the role of ghrelin in the gastrointestinal system?
Stimulating growth hormone secretion
Which nervous system is sometimes referred to as the 'little brain' due to its role in regulating gastrointestinal function?
Enteric Nervous System (ENS)
What is the primary function of the myenteric plexus within the gastrointestinal tract?
Innervating the longitudinal and circular smooth muscle layers
Which of the following hormones inhibits pancreatic exocrine secretion?
Secretin
What is the primary role of bile acids in the digestive system?
Emulsifying fats for better digestion
What triggers endocrine regulation of the gastrointestinal tract?
Hormones released by meal-associated triggers
What is responsible for the golden yellow color of bile?
Bilirubin and biliverdin
What is the function of enterohepatic circulation in the digestive system?
Reabsorbing some components of bile in the intestine
What is the primary function of secretin in the regulation of digestive system?
It increases the secretion of bicarbonate by the pancreas and biliary tract
How does the release of secretin illustrate feedback control in the digestive system?
It causes alkaline pancreatic juice to neutralize stomach acid, inhibiting further hormone secretion
What effect does the products of protein digestion and acid bathing have on the secretion of secretin?
They increase the release of secretin, leading to an influx of alkaline pancreatic juice
What is the role of Gastric Inhibitory Peptide (GIP) in the digestive system?
It is involved in regulating insulin secretion and lipid metabolism
What triggers substantial release of gastrin and activates stretch receptors, leading to vago-vagal and local reflexes during the gastric phase?
Meal constituents
What is the primary method of activation for most of the digestive enzymes in the pancreatic juice?
Proteolytic cleavage by trypsin
What is the primary function of the mitochondria in the gastric parietal cells?
To supply energy for the apical H+/K+/ATPase
What is the main function of pancreatic juice in digestion?
To contain enzymes for digestion
What is the primary role of a trypsin inhibitor secreted by the pancreas?
Prevention of potential self-digestion of the pancreas
What is the role of bile acids in the digestion and absorption of fats?
Emulsification and absorption of fats
What serves to neutralize gastric acidity once its function is complete?
Bicarbonate ions
What is the primary method through which pancreatic juice is secreted?
Hormonal control
Study Notes
Salivary Secretion
- The main control over salivary secretion is the parasympathetic nervous system.
- Saliva helps in the process of swallowing by lubricating food and making it easier to swallow.
Gastric Secretion
- The composition of gastric secretion when released into the duodenum is a mixture of mucus, pepsinogen, and hydrochloric acid.
- The cephalic phase of gastric secretion is influenced by the vagus nerve, sight, smell, and taste of food.
Secretin
- Secretin is released in response to the presence of acid in the duodenum.
- The role of secretin in the digestive system is to stimulate the release of bicarbonate-rich pancreatic juice and bile to neutralize the acid.
- Secretin affects the release of gastric acid by inhibiting it.
- S cells, which secrete secretin, are located in the mucosa of the duodenum.
Pancreatic Juice
- The secretion of pancreatic juice is controlled by the hormones secretin and cholecystokinin (CCK).
- Digestive enzymes are discharged from pancreatic cells through exocytosis.
- Most of the digestive enzymes in pancreatic juice are activated by trypsin.
Bile Acids
- Bile acids serve an important function in gastrointestinal function by emulsifying fats and facilitating their absorption.
Parietal Cells
- The primary role of parietal cells in the stomach is to secrete hydrochloric acid.
- Histamine is the trigger that is responsible for parietal cell secretion via binding to H2-receptors.
Gastrin
- The function of gastrin in the stomach is to stimulate the release of gastric acid.
- The importance of intrinsic factor in the stomach is that it helps in the absorption of vitamin B12.
Gastrointestinal Tract
- The primary function of the gastrointestinal tract is to digest and absorb nutrients.
- The parts of the gastrointestinal tract that are encountered by the meal or its residues in order are mouth, esophagus, stomach, small intestine, and large intestine.
- The salivary gland is the organ that secretes saliva when food is ingested.
Cholecystokinin (CCK)
- The primary function of CCK in the digestive system is to stimulate the release of pancreatic enzymes and bile.
- CCK is found in the brain, in addition to its secretion by I cells.
- CCK plays a role in the brain by regulating appetite and satiety.
Ghrelin
- The role of ghrelin in the gastrointestinal system is to stimulate appetite.
Enteric Nervous System
- The enteric nervous system is sometimes referred to as the 'little brain' due to its role in regulating gastrointestinal function.
- The primary function of the myenteric plexus within the gastrointestinal tract is to regulate gut motility.
Other Hormones
- Somatostatin is a hormone that inhibits pancreatic exocrine secretion.
- Gastric Inhibitory Peptide (GIP) plays a role in the digestive system by stimulating the release of insulin.
- The primary function of enterohepatic circulation in the digestive system is to recycle bile acids.
Digestive Enzymes
- The primary method of activation for most of the digestive enzymes in pancreatic juice is trypsin.
- The primary function of the mitochondria in the gastric parietal cells is to generate energy for the secretion of hydrochloric acid.
- The primary function of pancreatic juice in digestion is to break down proteins, carbohydrates, and fats.
- The primary role of a trypsin inhibitor secreted by the pancreas is to prevent the premature activation of digestive enzymes.
- Bile acids play a crucial role in the digestion and absorption of fats.
- Bicarbonate-rich pancreatic juice serves to neutralize gastric acidity once its function is complete.
- The primary method through which pancreatic juice is secreted is through exocytosis.
Test your knowledge about the secretion of pancreatic juice, including the control mechanisms, formation of digestive enzymes, and daily secretion volume. Explore the role of gastrointestinal hormones and the neutralization of gastric acid by pancreatic, bile, and intestinal secretions.
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