Oxidative Stress and Cell Damage
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Questions and Answers

What is the outcome of hyperplasia when the underlying stimulus is removed?

  • Spontaneous cell death
  • Immediate transition to dysplasia
  • Complete reversal of cellular changes (correct)
  • Prolonged persistence of adapted cells

What is the primary driver of cellular changes from one adult/mature cell type to another?

  • Chronic inflammation
  • Acute injury
  • Genetic mutation
  • Chronic irritation or stress (correct)

What is the term for abnormal changes in the size, shape, or organization of cells?

  • Metaplasia
  • Dysplasia (correct)
  • Hypertrophy
  • Hyperplasia

What is the primary purpose of Pap Smears?

<p>To detect abnormal cellular changes in the cervix (B)</p> Signup and view all the answers

What is the result of smoking on the respiratory lining in the airway?

<p>Replacement of normal cells with cells better suited for handling smoking (C)</p> Signup and view all the answers

What is the primary consequence of DNA damage on cell function?

<p>Impaired cell function and increased risk of mutations (C)</p> Signup and view all the answers

What is the role of protein p53 in response to DNA damage?

<p>Stopping the cell cycle to allow time for DNA repair (D)</p> Signup and view all the answers

What is the characteristic of a free radical?

<p>Having an unpaired electron in its outer shell (C)</p> Signup and view all the answers

Phagolysosomes can be described as cellular structures that

<p>engulf and digest foreign particles (D)</p> Signup and view all the answers

What is the effect of free radicals on cells?

<p>Causing damage to cells and tissues (C)</p> Signup and view all the answers

Why can cancer cells continue to divide with damaged DNA?

<p>They lack functional p53 proteins (D)</p> Signup and view all the answers

What is a characteristic of necrotic cell death?

<p>Cell swelling, membrane rupture, and inflammation (B)</p> Signup and view all the answers

Phagolysosomes play a role in which part of the immune system's defense mechanism?

<p>Breakdown and destruction of foreign particles (C)</p> Signup and view all the answers

What is the relationship between reactive oxygen species (ROS) and free radicals?

<p>ROS are a type of free radical (C)</p> Signup and view all the answers

What is the main difference between necrosis and apoptosis?

<p>Necrosis is uncontrolled, while apoptosis is controlled (A)</p> Signup and view all the answers

What happens to cells that undergo necrosis?

<p>They swell due to the influx of water and ions (D)</p> Signup and view all the answers

What is the primary consequence of excessive free radicals in the body?

<p>Cell damage and DNA disruption (C)</p> Signup and view all the answers

Which of the following is a key contributor to membrane damage?

<p>Reactive oxygen species (ROS) (D)</p> Signup and view all the answers

What can disrupt cellular functions and signaling pathways within cells?

<p>Imbalances in calcium levels (D)</p> Signup and view all the answers

What is the primary outcome of membrane damage?

<p>Disrupted cellular function and communication (B)</p> Signup and view all the answers

Which of the following is NOT a factor contributing to membrane damage?

<p>Increased phospholipid production (A)</p> Signup and view all the answers

What is the primary function of the endoplasmic reticulum (ER) in a cell?

<p>To synthesize and fold proteins (B)</p> Signup and view all the answers

What is the result of high calcium levels in a cell?

<p>Activation of enzymes that can harm the cell (A)</p> Signup and view all the answers

What happens to a misfolded protein in a cell?

<p>It is targeted for destruction through ubiquination (A)</p> Signup and view all the answers

What is the unfolded protein response triggered by?

<p>An overload of misfolded proteins (A)</p> Signup and view all the answers

What is the result of stress on the endoplasmic reticulum?

<p>Cell injury response and dysfunction (D)</p> Signup and view all the answers

What do chaperones do in the endoplasmic reticulum?

<p>They help proteins fold correctly (C)</p> Signup and view all the answers

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