Overview of Lymphomas
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Questions and Answers

Which type of lymphoma is known to grow rapidly and behave aggressively, posing a life-threatening risk if left untreated?

  • Follicular lymphoma
  • High grade lymphoma (correct)
  • Chronic lymphocytic leukemia
  • Marginal zone lymphoma
  • What characteristic is typical of low-grade lymphomas?

  • Rapid disease progression
  • Involvement of crucial sites like the brain or spinal cord
  • Immediate treatment required
  • Long periods without noticeable symptoms (correct)
  • Which of the following is NOT a WHO classified type of lymphoma?

  • Anaplastic large cell lymphoma
  • Atypical lymphocytosis (correct)
  • Follicular lymphoma
  • Burkitt's lymphoma
  • In the management of a low-grade lymphoma that poses no immediate risk, what is a recommended approach?

    <p>Close monitoring with no treatment</p> Signup and view all the answers

    Which symptom may indicate lymphoma affecting organ function?

    <p>Kidney failure due to urinary tube compression</p> Signup and view all the answers

    Which of the following is NOT a common constitutional symptom of lymphoma?

    <p>Increased appetite</p> Signup and view all the answers

    What is the purpose of a bone marrow aspirate and trephine in the context of lymphoma?

    <p>To examine bone marrow function and detect lymphoma spread</p> Signup and view all the answers

    Which prognostic factor is NOT typically considered in the management of diffuse large B cell lymphoma?

    <p>Type of chemotherapy used</p> Signup and view all the answers

    What distinguishes curative from non-curative management strategies in lymphoma treatment?

    <p>Intensity of chemotherapy</p> Signup and view all the answers

    In the staging of lymphoma, what does the Ann Arbor Staging primarily assess?

    <p>Extent of disease spread in the body</p> Signup and view all the answers

    Study Notes

    Overview of Lymphomas

    • Lymphomas are cancers of the lymphatic system.
    • Can present with a lump in the neck, armpit, or groin.
    • Can affect the chest and abdomen, which may only be detected on scans.
    • Can affect the function of an organ leading to related symptoms.
    • Can cause bone marrow failure, leading to fatigue, loss of appetite, weight loss, fever, and night sweats.
    • Can occur almost anywhere in the body, including the brain, eye, and skin.

    Classification of Lymphomas

    • WHO Lymphoma Types:
      • Precursor B-lymphoblastic leukemia/lymphoma
      • Precursor T-lymphoblastic leukemia/lymphoma
      • Aggressive NK-Cell leukemia
      • Burkitt's lymphoma/leukemia
      • Extranodal NK/T-cell nasal type
      • Diffuse large B-cell lymphoma
      • Anaplastic large cell lymphoma
      • Prolymphocytic leukemia
      • Adult T cell lymphoma/leukemia
      • Mantle cell lymphoma
      • T cell prolymphocytic leukemia
      • Chronic lymphocytic leukemia
      • Enteropathy-associated T-cell lymphoma
      • Lymphoplasmacytic lymphoma
      • Hepatosplenic gamma/delta T-cell lymphoma
      • Marginal zone lymphoma
      • Subcutaneous panniculitis-like T-cell lymphoma
      • Hairy cell leukemia
      • Peripheral T cell lymphoma, NOS
      • Follicular lymphoma
      • Angioimmunoblastic T cell lymphoma
      • Mycosis fungoides/Sézary syndrome
      • T-cell large granular lymphocytic leukemia
      • Hodgkin’s lymphoma

    Lymphoma Management

    • Intention of Management:

      • Curative: Usually for aggressive malignancies, with intensive chemotherapy and other treatments.
      • Non-Curative (Control): Usually for indolent malignancies, with less intensive treatments.
    • Management Options:

      • Chemotherapy
      • Radiation Therapy
      • Immunotherapy:
        • Monoclonal antibodies
        • Cellular therapy (allogeneic stem cell transplant)
        • Immunostimulants
        • CAR (chimeric antigen receptor) T-cell therapy
      • Targeted therapy
    • Treatment Considerations:

      • Disease factors: low-grade vs high-grade lymphoma
      • Patient factors: fitness
      • Drug efficacy and toxicity

    Prognostic Factors for Diffuse Large B Cell Lymphoma (DLBCL)

    • Clinical:
      • Age
      • Performance status
      • LDH levels
      • Extranodal sites
      • Stage
    • Biologic:
      • Cell of origin (germinal center or non-GC)
      • Double-hit (c-myc, Bcl-2)
      • Molecular subtype

    Treatment of Diffuse Large B Cell Lymphoma (DLBCL)

    • R-CHOP Regimen: One of the standard treatment regimens for DLBCL.
    • R-CHOP with Polatuzumab Vedotin (Pola): Shows superior outcomes compared to R-CHOP.
    • Other Novel Therapies: CAR T-cell therapy, targeted therapies are emerging options in treating DLBCL.

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    Related Documents

    Lymphoma Slides PDF

    Description

    This quiz provides an overview of lymphomas, types, and their effects on the lymphatic system. Learn about the symptoms, classifications, and impacts of various lymphoma types. Enhance your understanding of how these cancers present and affect patients.

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