Overview of Crohn's Disease
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Questions and Answers

What is a key characteristic of Crohn's disease as it relates to the gastrointestinal tract?

  • It is primarily caused by bacterial infection.
  • It only affects the lining of the gastrointestinal tract.
  • It exclusively targets the large intestine.
  • It causes transmural inflammation. (correct)

Which type of Crohn's disease accounts for the largest percentage of cases?

  • Ileocolic Crohn's disease (correct)
  • Extended colitis
  • Crohn's ileitis
  • Crohn's colitis

At what age range is the onset of Crohn's disease most commonly observed?

  • 0-15 years
  • 15-30 years (correct)
  • 30-45 years
  • 45-60 years

What is a common complication of stricturing disease in Crohn's disease?

<p>Bowel obstruction or altered fecal caliber (C)</p> Signup and view all the answers

Which of the following presentations of Crohn's disease creates abnormal passageways between the bowel and other structures?

<p>Penetrating disease (D)</p> Signup and view all the answers

Which gene mutation is most commonly associated with Crohn's disease?

<p>NOD2 gene on chromosome 16 (D)</p> Signup and view all the answers

What environmental factors may contribute to the development of Crohn's disease?

<p>Diet, smoking, and hormonal contraception (D)</p> Signup and view all the answers

Which abnormal immune response is indicated in Crohn's disease pathology?

<p>Overproduction of IL-12 and IFN-γ (A)</p> Signup and view all the answers

Which of the following gastrointestinal symptoms is NOT typically associated with Crohn's disease?

<p>Persistent chronic fatigue (C)</p> Signup and view all the answers

In children, what is a potential systemic complication of Crohn's disease?

<p>Growth failure (C)</p> Signup and view all the answers

Flashcards

Crohn's Disease

An inflammatory bowel disease where the immune system attacks the GI tract, causing transmural inflammation.

Ileocolic Crohn's

Type of Crohn's affecting both the ileum and large intestine (50% of cases).

Crohn's Ileitis

Crohn's Disease affecting only the ileum (30% of cases).

Crohn's Colitis

Crohn's Disease affecting only the large intestine (20% of cases).

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Stricturing Disease (Crohn's)

Narrowing of the bowel, potentially causing obstructions in Crohn's disease.

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Crohn's Disease Factors

Crohn's disease is influenced by genetics, environment, immune system abnormalities, and microbes.

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Crohn's Disease Genetics

A mutation in the NOD2 gene is linked to Crohn's disease.

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Crohn's Disease Immune System

Immune system abnormalities cause inflammation in Crohn's disease, activating TH1 cells due to overproduction of IL-12 and IFN-γ.

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Crohn's Disease Microbes

Certain bacteria, including Mycobacterium, Yersinia, and Listeria, are potential causes of Crohn's disease.

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Crohn's Disease Symptoms

Crohn's disease has gastrointestinal symptoms (abdominal pain, diarrhea, vomiting) and systemic symptoms (growth failure, weight loss in adults, issues in children).

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Study Notes

Crohn's Disease Overview

  • Crohn's disease is an inflammatory bowel disease (IBD).
  • The immune system attacks the GI tract causing transmural inflammation.
  • It can affect any part of the GI tract from mouth to anus.
  • Onset typically between 15-30 years old.
  • Males and females are equally affected.

Types of Crohn's Disease

  • Ileocolic Crohn's disease: Affects the ileum and large intestine (50%).
  • Crohn's ileitis: Affects the ileum only (30%).
  • Crohn's colitis: Affects the large intestine (20%). Can be difficult to differentiate from ulcerative colitis.

Disease Presentation Categories

  • Stricturing disease: Narrowing of the bowel, potentially leading to blockages and altered stool consistency.
  • Penetrating disease: Formation of abnormal passages (fistulas) between the bowel and other structures (e.g., skin).
  • Inflammatory disease: Inflammation without strictures or fistulas.

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Description

Explore the intricate aspects of Crohn's disease, an inflammatory bowel disease impacting the gastrointestinal tract. Learn about its types, disease presentation categories, and the immune response involved. This quiz offers insights into the disease's characteristics, affecting individuals equally across genders.

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