Overview of Colorectal Carcinoma
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Questions and Answers

Which age group has the peak incidence of colorectal carcinoma?

  • 70-80 years
  • 60-70 years (correct)
  • 30-40 years
  • 50-60 years
  • What is the main molecular pathway through which colorectal carcinoma arises?

  • Microsatellite instability (correct)
  • Telomere shortening
  • Angiogenesis
  • Apoptosis
  • What is the key feature of microsatellites in the context of colorectal carcinoma?

  • They are coding sequences of DNA
  • They encode proteins
  • They maintain stability during cell division (correct)
  • They are involved in RNA processing
  • Which syndrome is associated with inherited mutations in DNA mismatch repair enzymes?

    <p>Hereditary nonpolyposis colorectal carcinoma (HNPCC)</p> Signup and view all the answers

    At what age does colorectal carcinoma usually arise de novo (not from adenomatous polyps) in hereditary nonpolyposis colorectal carcinoma?

    <p>Before 30 years</p> Signup and view all the answers

    'Napkin-ring' lesion is associated with carcinoma located in which part of the colon?

    <p>Descending colon</p> Signup and view all the answers

    'Raised lesion' is typically seen with carcinoma located in which part of the colon?

    <p>Ascending colon</p> Signup and view all the answers

    'Vague pain' is a common presentation of colorectal carcinoma arising in which part of the colon?

    <p>Ascending colon</p> Signup and view all the answers

    'Decreased stool caliber' is a characteristic presentation of colorectal carcinoma located where?

    <p>'Napkin-ring' lesion'</p> Signup and view all the answers

    'Occult bleeding' may be a symptom of colorectal carcinoma located where?

    <p>'Raised lesion'</p> Signup and view all the answers

    Which condition is not progressive and presents with intermittent dysphagia but no pain?

    <p>Schatzki's ring</p> Signup and view all the answers

    Where is Schatzki's ring typically located within the esophagus?

    <p>Distal to the lower esophageal sphincter</p> Signup and view all the answers

    What is a distinguishing feature of Plummer-Vinson syndrome?

    <p>Associated with iron-deficiency anemia</p> Signup and view all the answers

    How is Plummer-Vinson syndrome diagnosed?

    <p>Barium swallow or barium esophagogram</p> Signup and view all the answers

    Which disorder may respond to treatment for iron deficiency?

    <p>Plummer-Vinson syndrome</p> Signup and view all the answers

    Which disorder is more distal and located at the squamocolumnar junction proximal to the lower esophageal sphincter?

    <p>Schatzki’s ring</p> Signup and view all the answers

    Which disorder is more proximal and located in the hypopharynx?

    <p>Plummer-Vinson syndrome</p> Signup and view all the answers

    Which disorder is associated with iron-deficiency anemia and squamous cell cancer?

    <p>Plummer-Vinson syndrome</p> Signup and view all the answers

    Which disorder leads to intermittent dysphagia and is not associated with pain?

    <p>Schatzki’s ring</p> Signup and view all the answers

    Which disorder is diagnosed with a barium swallow or barium esophagogram?

    <p>Plummer-Vinson syndrome</p> Signup and view all the answers

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