Overview of Colorectal Carcinoma
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Questions and Answers

Which age group has the peak incidence of colorectal carcinoma?

  • 70-80 years
  • 60-70 years (correct)
  • 30-40 years
  • 50-60 years

What is the main molecular pathway through which colorectal carcinoma arises?

  • Microsatellite instability (correct)
  • Telomere shortening
  • Angiogenesis
  • Apoptosis

What is the key feature of microsatellites in the context of colorectal carcinoma?

  • They are coding sequences of DNA
  • They encode proteins
  • They maintain stability during cell division (correct)
  • They are involved in RNA processing

Which syndrome is associated with inherited mutations in DNA mismatch repair enzymes?

<p>Hereditary nonpolyposis colorectal carcinoma (HNPCC) (A)</p> Signup and view all the answers

At what age does colorectal carcinoma usually arise de novo (not from adenomatous polyps) in hereditary nonpolyposis colorectal carcinoma?

<p>Before 30 years (A)</p> Signup and view all the answers

'Napkin-ring' lesion is associated with carcinoma located in which part of the colon?

<p>Descending colon (B)</p> Signup and view all the answers

'Raised lesion' is typically seen with carcinoma located in which part of the colon?

<p>Ascending colon (C)</p> Signup and view all the answers

'Vague pain' is a common presentation of colorectal carcinoma arising in which part of the colon?

<p>Ascending colon (D)</p> Signup and view all the answers

'Decreased stool caliber' is a characteristic presentation of colorectal carcinoma located where?

<p>'Napkin-ring' lesion' (A)</p> Signup and view all the answers

'Occult bleeding' may be a symptom of colorectal carcinoma located where?

<p>'Raised lesion' (B)</p> Signup and view all the answers

Which condition is not progressive and presents with intermittent dysphagia but no pain?

<p>Schatzki's ring (D)</p> Signup and view all the answers

Where is Schatzki's ring typically located within the esophagus?

<p>Distal to the lower esophageal sphincter (B)</p> Signup and view all the answers

What is a distinguishing feature of Plummer-Vinson syndrome?

<p>Associated with iron-deficiency anemia (A)</p> Signup and view all the answers

How is Plummer-Vinson syndrome diagnosed?

<p>Barium swallow or barium esophagogram (A)</p> Signup and view all the answers

Which disorder may respond to treatment for iron deficiency?

<p>Plummer-Vinson syndrome (C)</p> Signup and view all the answers

Which disorder is more distal and located at the squamocolumnar junction proximal to the lower esophageal sphincter?

<p>Schatzki’s ring (D)</p> Signup and view all the answers

Which disorder is more proximal and located in the hypopharynx?

<p>Plummer-Vinson syndrome (D)</p> Signup and view all the answers

Which disorder is associated with iron-deficiency anemia and squamous cell cancer?

<p>Plummer-Vinson syndrome (C)</p> Signup and view all the answers

Which disorder leads to intermittent dysphagia and is not associated with pain?

<p>Schatzki’s ring (B)</p> Signup and view all the answers

Which disorder is diagnosed with a barium swallow or barium esophagogram?

<p>Plummer-Vinson syndrome (A)</p> Signup and view all the answers

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