Overview of Colorectal Carcinoma

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20 Questions

Which age group has the peak incidence of colorectal carcinoma?

60-70 years

What is the main molecular pathway through which colorectal carcinoma arises?

Microsatellite instability

What is the key feature of microsatellites in the context of colorectal carcinoma?

They maintain stability during cell division

Which syndrome is associated with inherited mutations in DNA mismatch repair enzymes?

Hereditary nonpolyposis colorectal carcinoma (HNPCC)

At what age does colorectal carcinoma usually arise de novo (not from adenomatous polyps) in hereditary nonpolyposis colorectal carcinoma?

Before 30 years

'Napkin-ring' lesion is associated with carcinoma located in which part of the colon?

Descending colon

'Raised lesion' is typically seen with carcinoma located in which part of the colon?

Ascending colon

'Vague pain' is a common presentation of colorectal carcinoma arising in which part of the colon?

Ascending colon

'Decreased stool caliber' is a characteristic presentation of colorectal carcinoma located where?

'Napkin-ring' lesion'

'Occult bleeding' may be a symptom of colorectal carcinoma located where?

'Raised lesion'

Which condition is not progressive and presents with intermittent dysphagia but no pain?

Schatzki's ring

Where is Schatzki's ring typically located within the esophagus?

Distal to the lower esophageal sphincter

What is a distinguishing feature of Plummer-Vinson syndrome?

Associated with iron-deficiency anemia

How is Plummer-Vinson syndrome diagnosed?

Barium swallow or barium esophagogram

Which disorder may respond to treatment for iron deficiency?

Plummer-Vinson syndrome

Which disorder is more distal and located at the squamocolumnar junction proximal to the lower esophageal sphincter?

Schatzki’s ring

Which disorder is more proximal and located in the hypopharynx?

Plummer-Vinson syndrome

Which disorder is associated with iron-deficiency anemia and squamous cell cancer?

Plummer-Vinson syndrome

Which disorder leads to intermittent dysphagia and is not associated with pain?

Schatzki’s ring

Which disorder is diagnosed with a barium swallow or barium esophagogram?

Plummer-Vinson syndrome

This quiz provides an overview of colorectal carcinoma, covering its incidence, molecular pathways, and key characteristics. It discusses important concepts such as adenoma-carcinoma sequence and microsatellite instability (MSI).

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