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Overview of B and T Lymphocytes
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Overview of B and T Lymphocytes

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Questions and Answers

What type of immune response is primarily associated with B lymphocytes?

  • Inflammatory response
  • Humoral response (correct)
  • Cell-mediated response
  • Innate response

    • Which cells are formed from the remaining clone cells after the activation of B lymphocytes?

  • Memory cells (correct)
  • Plasma cells
  • Natural killer cells
  • Effector T cells

    • Where do T lymphocytes mature?

  • Lymph nodes
  • Spleen
  • Thymus (correct)
  • Red bone marrow

    • What is the primary target for B lymphocytes?

    <p>Extracellular pathogens</p> Signup and view all the answers

    What is the function of plasma cells after the activation of B lymphocytes?

    <p>Secrete antibodies</p> Signup and view all the answers

    Which of the following statements about B and T lymphocytes is correct?

    <p>Both types have memory cell formation.</p> Signup and view all the answers

    What is the primary role of Helper T cells?

    <p>Activating B and T cells</p> Signup and view all the answers

    What happens to plasma cells after they secrete antibodies for 4 to 5 days?

    <p>They undergo apoptosis.</p> Signup and view all the answers

    What is the structural form of IgA in plasma?

    <p>Dimer</p> Signup and view all the answers

    Which of the following accurately describes the existence of monomers in plasma?

    <p>They exist in limited amounts.</p> Signup and view all the answers

    In what form does IgA primarily function within the immune response?

    <p>As a dimer</p> Signup and view all the answers

    Which class of immunoglobulin is described as potentially existing as a monomer?

    <p>IgA</p> Signup and view all the answers

    What is one key characteristic of IgA molecules?

    <p>They primarily exist in a dimeric form.</p> Signup and view all the answers

    Which of the following statements regarding IgA is true?

    <p>IgA is found in significant amounts in the mucosal surfaces.</p> Signup and view all the answers

    What are the functional implications of IgA's dimeric form?

    <p>Increased stability and resistance to enzymatic degradation.</p> Signup and view all the answers

    Given its characteristics, what is a notable limitation of monomers in plasma?

    <p>They are less effective in binding pathogens.</p> Signup and view all the answers

    What is the primary role of antigen-presenting cells (APCs) when displaying a foreign antigen?

    <p>To indicate self-identity</p> Signup and view all the answers

    When a cell that is not an APC is invaded or cancerous, what message does it send?

    <p>I belong to self, but have been invaded or become cancerous.</p> Signup and view all the answers

    Which of the following statements is true regarding dendritic cells?

    <p>They are a type of APC.</p> Signup and view all the answers

    What message do cells that are recognized as self typically send?

    <p>I belong to self.</p> Signup and view all the answers

    What is a key function of MHC molecules when presenting antigens?

    <p>To help cells identify foreign invaders.</p> Signup and view all the answers

    What might trigger a cell to send a 'kill me' signal?

    <p>Becoming cancerous or being invaded.</p> Signup and view all the answers

    How do APCs contribute to the immune response?

    <p>By presenting antigens to T cells.</p> Signup and view all the answers

    What do APCs use to convey their messages regarding foreign invaders?

    <p>MHC molecules.</p> Signup and view all the answers

    What is the primary role of antigens in the immune response?

    <p>To trigger adaptive defenses</p> Signup and view all the answers

    Which of the following best describes self-antigens?

    <p>Glycoproteins coded by the major histocompatibility complex</p> Signup and view all the answers

    What is the role of antigen-presenting cells (APCs) in the adaptive immune response?

    <p>To present antigens to T cells</p> Signup and view all the answers

    Which type of immunity is provided by B lymphocytes?

    <p>Humoral immunity</p> Signup and view all the answers

    What distinguishes antigens from self-antigens?

    <p>Antigens provoke a response while self-antigens do not trigger an immune response</p> Signup and view all the answers

    Which component is essential for T lymphocytes to bind antigens?

    <p>MHC proteins</p> Signup and view all the answers

    What is an antigenic determinant also known as?

    <p>Epitopes</p> Signup and view all the answers

    What is a key characteristic of most antigens?

    <p>They often exhibit multiple antigenic determinants</p> Signup and view all the answers

    Which immunoglobulin class is primarily produced by plasma cells during the primary immune response?

    <p>IgM</p> Signup and view all the answers

    What role does the presence of IgM play in diagnostics?

    <p>It is a marker of current infection.</p> Signup and view all the answers

    Which cell type is responsible for producing IgM during the immune response?

    <p>B cells</p> Signup and view all the answers

    What is the significance of IgM in the immune response?

    <p>It's the first antibody produced in the primary response.</p> Signup and view all the answers

    What occurrence is most likely indicated by high levels of IgM in a patient?

    <p>Current infection</p> Signup and view all the answers

    During which phase of the immune response is IgM primarily generated?

    <p>Primary response</p> Signup and view all the answers

    What does a high presence of IgM suggest about the patient's immune status?

    <p>The patient is currently fighting an infection.</p> Signup and view all the answers

    Which of the following is NOT a characteristic of IgM?

    <p>It can cross the placenta.</p> Signup and view all the answers

    Which type of immunoglobulin indicates serological response to acute infection?

    <p>IgM</p> Signup and view all the answers

    Why is the presence of IgM often diagnostic in clinical settings?

    <p>It signifies immediate response to pathogens.</p> Signup and view all the answers

    Study Notes

    Overview of B and T Lymphocytes

    • B lymphocytes are part of the humoral immune response; T lymphocytes are involved in the cellular immune response.
    • B cells secrete antibodies, while T cells do not secrete antibodies.
    • B lymphocytes primarily target extracellular pathogens; T lymphocytes target intracellular pathogens and cancer cells.
    • Both types of lymphocytes originate in the red bone marrow; B cells mature there, while T cells mature in the thymus.
    • Effector B cells become plasma cells; T cells differentiate into cytotoxic T cells, helper T cells, and regulatory T cells.
    • Both B and T lymphocytes form memory cells, aiding in quicker responses to subsequent exposures.

    Activation and Differentiation of B Cells

    • Naive B cells activate upon antigen binding through clonal selection, leading to proliferation and differentiation.
    • Most activated B cells become plasma cells, secreting approximately 2000 antibodies per second for 4 to 5 days.
    • Plasma cell antibodies are identical to the antigen receptors on the parent B cells.
    • Some B cells become memory cells, facilitating a rapid response upon future encounters with the same antigen.

    Antigens and Immune Response

    • Antigens are substances that trigger adaptive immune responses, acting as targets for these defenses.
    • Most antigens are large, complex molecules that are foreign to the body, recognized as nonself by the immune system.
    • Many antigens contain multiple antigenic determinants, known as epitopes, which provoke immune responses.

    Self-Antigens and MHC Proteins

    • Self-antigens are proteins on body cell surfaces that are usually non-antigenic to the individual but may provoke responses in others.
    • Major histocompatibility complex (MHC) proteins are a type of self-antigen unique to each person and play a key role in immune recognition.
    • T lymphocytes require antigens to be presented on MHC proteins for binding and activation.

    Cells of the Adaptive Immune Response

    • The adaptive immune system comprises two main lymphocyte populations (B and T cells) and antigen-presenting cells (APCs).
    • B lymphocytes provide humoral immunity, while T lymphocytes deliver cellular immunity.
    • APCs present antigens to T cells, playing essential auxiliary roles in the immune response.

    Lymphocyte Development, Maturation, and Activation

    • Lymphocyte development occurs in the red bone marrow for both B and T cells, followed by maturation in respective sites (B cells in bone marrow, T cells in thymus).
    • Activation of B and T cells leads to differentiation, forming effector cells that execute immune responses.
    • Immunoglobulin classes formed during primary responses, such as IgM, are critical indicators of current infections due to specific antibody formation patterns.

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    Related Documents

    HAP12e Ch 21.pdf

    Description

    Explore the functions and characteristics of B and T lymphocytes. This quiz covers their roles in the immune response, maturation processes, and how they target different types of pathogens. Assess your understanding of lymphocyte activation and differentiation in the immune system.

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