Outcomes of Acute and Chronic Inflammation ILOs Quiz

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Questions and Answers

What are the three outcomes of acute inflammation?

Complete resolution, healing by connective tissue replacement (fibrosis), progression to chronic inflammation

What are the factors that can affect the outcome of acute inflammation?

The nature of injury, the intensity of injury, the tissue involved, host responsiveness

Under what conditions is complete resolution the usual outcome of acute inflammation?

When the injury is limited or short-lived, when there has been little tissue destruction, when the damaged parenchymal cells can regenerate

What is meant by healing by connective tissue replacement (fibrosis) in the context of acute inflammation?

It occurs when there has been significant tissue destruction Signup and view all the answers

What occurs when acute inflammation progresses to chronic inflammation?

Specific and non-specific chronic inflammation, granulomatous reaction Signup and view all the answers

What is granulomatous inflammation characterized by?

Focal accumulations of activated macrophages (granulomas); enlargement and flattening of the cells (epithelioid macrophages); surrounded by a collar of lymphocytes; formation of multinucleated giant cells; central necrosis may be present; surrounded by a rim of fibrosis in older granulomas. Signup and view all the answers

List three causes of granulomatous inflammation.

<ol> <li>Infectious etiologies: Tuberculosis, leprosy, syphilis, cat-scratch disease, schistosomiasis, certain fungal infections 2. Inflammatory causes: Temporal arteritis, Crohn disease, sarcoidosis 3. Inorganic particulates: Silicosis, berylliosis</li> </ol> Signup and view all the answers

What are the two types of granulomas and how are they formed?

<ol> <li>Foreign body granulomas: incited by particles that cannot be readily phagocytosed by a single macrophage but do not elicit a specific immune response (e.g., suture or talc) 2. Immune granulomas: formed by immune T cell-mediated responses to persistent, poorly degradable antigens. IFN-γ from activated T cells causes the macrophage transformation to epithelioid cells and the formation of multinucleated giant cells.</li> </ol> Signup and view all the answers