Outcomes of Acute and Chronic Inflammation ILOs Quiz

Complete resolution, healing by connective tissue replacement (fibrosis), progression to chronic inflammation

The nature of injury, the intensity of injury, the tissue involved, host responsiveness

When the injury is limited or short-lived, when there has been little tissue destruction, when the damaged parenchymal cells can regenerate

<p>It occurs when there has been significant tissue destruction</p> Signup and view all the answers

<p>Specific and non-specific chronic inflammation, granulomatous reaction</p> Signup and view all the answers

<p>Focal accumulations of activated macrophages (granulomas); enlargement and flattening of the cells (epithelioid macrophages); surrounded by a collar of lymphocytes; formation of multinucleated giant cells; central necrosis may be present; surrounded by a rim of fibrosis in older granulomas.</p> Signup and view all the answers

<ol> <li>Infectious etiologies: Tuberculosis, leprosy, syphilis, cat-scratch disease, schistosomiasis, certain fungal infections 2. Inflammatory causes: Temporal arteritis, Crohn disease, sarcoidosis 3. Inorganic particulates: Silicosis, berylliosis</li> </ol> Signup and view all the answers

<ol> <li>Foreign body granulomas: incited by particles that cannot be readily phagocytosed by a single macrophage but do not elicit a specific immune response (e.g., suture or talc) 2. Immune granulomas: formed by immune T cell-mediated responses to persistent, poorly degradable antigens. IFN-γ from activated T cells causes the macrophage transformation to epithelioid cells and the formation of multinucleated giant cells.</li> </ol> Signup and view all the answers

<p>Lymphocytes elaborate factors necessary to induce macrophage activation.</p> Signup and view all the answers

<p>Central necrosis may be present in some granulomas, particularly from infectious causes.</p> Signup and view all the answers