Other Viral Infections and Hyperthermia
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Questions and Answers

Which type of abnormality is primarily caused by environmental and/or genetic factors during organogenesis?

  • Malformation (correct)
  • Anomaly
  • Disruption
  • Deformation
  • What causes deformations in fetal development?

  • Genetic mutations
  • Monogenic disorders
  • Mechanical forces (correct)
  • Vascular accidents
  • What is a common characteristic feature of fetal infection with Toxoplasmosis?

  • Microcephaly
  • Hearing loss
  • Cognitive impairment
  • Calcifications (correct)
  • Which condition is an example of disruption in fetal development?

    <p>Bowel atresia due to a vascular accident</p> Signup and view all the answers

    Which of the following viruses has been linked to malformations following maternal infection?

    <p>Coxsackie virus</p> Signup and view all the answers

    During which weeks of gestation do most malformations originate?

    <p>Third to eighth weeks</p> Signup and view all the answers

    What is noted about the malformation rate after maternal infection with various viruses including measles and mumps?

    <p>Malformation rates are low, if not nonexistent</p> Signup and view all the answers

    Which of the following statements about deformations is true?

    <p>They often involve the musculoskeletal system.</p> Signup and view all the answers

    Which of the following factors can carry the protozoan parasite Toxoplasmosis gondii?

    <p>Domestic animals, especially cats</p> Signup and view all the answers

    What condition can be caused by both Toxoplasmosis and Syphilis during pregnancy?

    <p>Birth defects</p> Signup and view all the answers

    Which infectious agent is currently significantly reduced in causing birth defects due to widespread immunity?

    <p>Rubella</p> Signup and view all the answers

    What is a potential serious outcome of a cytomegalovirus infection in a fetus?

    <p>Meningoencephalitis leading to mental retardation</p> Signup and view all the answers

    Which of the following infectious agents is known to often cause no symptoms in the mother but can lead to severe fetal complications?

    <p>Cytomegalovirus</p> Signup and view all the answers

    What percentage of birth defects are attributed to unknown causes?

    <p>40% to 60%</p> Signup and view all the answers

    How much do genetic factors contribute to the occurrence of birth defects?

    <p>Approximately 15%</p> Signup and view all the answers

    Which of these viruses is not mentioned as a cause of birth defects?

    <p>Influenza virus</p> Signup and view all the answers

    What are the chances of having a major malformation for an infant with two minor anomalies?

    <p>10%</p> Signup and view all the answers

    What percentage of women are currently estimated to be immune to rubella?

    <p>85%</p> Signup and view all the answers

    Which of the following best describes the contribution of environmental factors to birth defects?

    <p>10%</p> Signup and view all the answers

    Minor anomalies can indicate the presence of major defects. What is the likelihood of major malformations in infants with three or more minor anomalies?

    <p>20%</p> Signup and view all the answers

    What percentage of women pregnant during the atomic bomb explosions over Hiroshima and Nagasaki gave birth to children who died in their first year of life?

    <p>25%</p> Signup and view all the answers

    How can exposure to ionizing radiation during pregnancy affect the conceptus?

    <p>It may result in virtually any type of birth defect.</p> Signup and view all the answers

    In addition to being teratogenic, what other effect does radiation have on genetic material?

    <p>It acts as a mutagenic agent.</p> Signup and view all the answers

    Which of the following is NOT an effect of radiation exposure mentioned?

    <p>Enhanced immune system response.</p> Signup and view all the answers

    What percentage of women pregnant during the bomb explosions aborted their pregnancies?

    <p>28%</p> Signup and view all the answers

    What term is commonly used to describe the study of structural and functional disorders present at birth?

    <p>Teratology</p> Signup and view all the answers

    What percentage of liveborn infants are identified to have major structural anomalies at birth?

    <p>2% to 3%</p> Signup and view all the answers

    What is one of the significant consequences associated with birth defects in infants?

    <p>Decreased life expectancy</p> Signup and view all the answers

    Which of the following is NOT a synonym for birth defect?

    <p>Genetic disorder</p> Signup and view all the answers

    Which age range shows an increased identification of birth defects beyond liveborn infants?

    <p>By age 5</p> Signup and view all the answers

    Which aspect influences susceptibility to teratogenesis?

    <p>Genotype of the conceptus and maternal genome</p> Signup and view all the answers

    During which period is the conceptus most susceptible to teratogens?

    <p>Third to eighth weeks of gestation</p> Signup and view all the answers

    What factors determine the manifestations of abnormal development from teratogen exposure?

    <p>Dose and duration of exposure to the teratogen</p> Signup and view all the answers

    What does the pathogenesis of teratogens involve?

    <p>Inhibition of specific biochemical processes and cellular phenomena</p> Signup and view all the answers

    Which of the following is NOT a manifestation of abnormal development from teratogen exposure?

    <p>Enhanced cognitive abilities</p> Signup and view all the answers

    What defines a syndrome in the context of abnormalities?

    <p>A group of anomalies occurring together with a known cause.</p> Signup and view all the answers

    How does an association differ from a syndrome?

    <p>Associations are more frequent groupings of anomalies, but without established causes.</p> Signup and view all the answers

    What is an example of a recognized association?

    <p>VACTERL association.</p> Signup and view all the answers

    Recognition of components in an association can lead to what?

    <p>The search for other abnormalities in the group.</p> Signup and view all the answers

    Which of the following statements is true regarding a syndrome?

    <p>It confirms the anomalies have an established common cause.</p> Signup and view all the answers

    What is a significant challenge in assessing the impact of chemical agents on human abnormalities?

    <p>Pregnant women frequently take many pharmaceutical drugs.</p> Signup and view all the answers

    Which drug was notably linked to an increase in the frequency of amelia and meromelia?

    <p>Thalidomide</p> Signup and view all the answers

    Why might the relationship between a teratogenic drug and a common defect go unnoticed?

    <p>The drug may only cause rare abnormalities.</p> Signup and view all the answers

    What type of study is most commonly relied upon to assess the effects of pharmaceutical drugs taken during pregnancy?

    <p>Retrospective studies</p> Signup and view all the answers

    What can complicate the identification of teratogenic drugs among the various medications taken by pregnant women?

    <p>Pregnant women take a large number of pharmaceutical drugs.</p> Signup and view all the answers

    Study Notes

    Other Viral Infections and Hyperthermia

    • Malformations following maternal infection with measles, mumps, hepatitis, poliomyelitis, echovirus, coxsackie virus, and influenza virus have been described.
    • Prospective studies indicate that the malformation rate after exposure to these agents is low if not nonexistent.
    • Toxoplasmosis and syphilis cause birth defects.
    • Poorly cooked meat; domestic animals, especially cats; and feces in contaminated soil can carry the protozoan parasite Toxoplasma gondii.
    • A characteristic feature of fetal toxoplasmosis infection is calcifications.

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    Description

    Explore the impacts of various viral infections and conditions like hyperthermia on fetal development. This quiz covers maternal infections such as measles, mumps, and the implications of Toxoplasmosis. Learn about the associated risks and malformations linked to these infections.

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