Organophosphates: History and Toxicity

True or false: All organophosphates are currently registered for use in the United States.

True or false: Chlorpyrifos is no longer registered for home use.

True or false: Exposure to multiple organophosphates by multiple routes may lead to serious additive toxicity.

True or false: There is a wide range of toxicity in organophosphates.

True or false: Dermal absorption of organophosphates does not vary significantly between different agents.

What is the primary mechanism by which organophosphates poison insects and other animals?

What is the role of acetylcholinesterase (AChE) in the nervous system?

What happens when a critical proportion of the tissue enzyme mass is inactivated by phosphorylation?

What is the consequence of excess acetylcholine (ACh) in the nerve ending due to organophosphate poisoning?

True or false: The primary mechanism by which organophosphates poison insects and other animals is by phosphorylation of the acetylcholinesterase enzyme at nerve endings.

True or false: Excess acetylcholine (ACh) in the nerve ending due to organophosphate poisoning leads to overstimulation of the effector organ.

True or false: Once a critical proportion of the tissue enzyme mass is inactivated by phosphorylation, symptoms and signs of cholinergic poisoning become manifest.

True or false: The enzyme acetylcholinesterase (AChE) is critical to normal control of nerve impulse transmission from nerve fibers to smooth and skeletal muscle cells, secretory cells and autonomic ganglia, and within the central nervous system.