Organic Pharmaceutical Chemistry - Dr. Mahmoud - Lecture 1: Antineoplastic Agents
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Questions and Answers

What medication can be administered to decrease the risk of kidney and bladder toxicity associated with I.corall WUC?

Mesna

Name a cancer type for which Cyclophosphamide is commonly used in treatment.

Breast cancer

How does Mesna work to prevent kidney and bladder toxicity?

It reacts with electrophilic species

What are the mechanisms of resistance to Cyclophosphamide similar to?

<p>Other alkylating agents</p> Signup and view all the answers

What enzymes are involved in the increased inactivation of Cyclophosphamide?

<p>Glutathione, aldehyde dehydrogenase, alcohol dehydrogenase</p> Signup and view all the answers

What is the main function of mesna in the context of Cyclophosphamide treatment?

<p>React with electrophilic species</p> Signup and view all the answers

Name a type of lymphoma that Cyclophosphamide can be used to treat.

<p>Non-Hodgkin’s lymphoma</p> Signup and view all the answers

What is the role of oxidase enzymes in the resistance to Cyclophosphamide?

<p>Increased inactivation</p> Signup and view all the answers

Which medication can be given both orally and intravenously for cancer treatment?

<p>Cyclophosphamide</p> Signup and view all the answers

What is a common side effect of Cyclophosphamide that mesna can help prevent?

<p>Hemorrhagic cystitis</p> Signup and view all the answers

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