10 Questions
What medication can be administered to decrease the risk of kidney and bladder toxicity associated with I.corall WUC?
Mesna
Name a cancer type for which Cyclophosphamide is commonly used in treatment.
Breast cancer
How does Mesna work to prevent kidney and bladder toxicity?
It reacts with electrophilic species
What are the mechanisms of resistance to Cyclophosphamide similar to?
Other alkylating agents
What enzymes are involved in the increased inactivation of Cyclophosphamide?
Glutathione, aldehyde dehydrogenase, alcohol dehydrogenase
What is the main function of mesna in the context of Cyclophosphamide treatment?
React with electrophilic species
Name a type of lymphoma that Cyclophosphamide can be used to treat.
Non-Hodgkin’s lymphoma
What is the role of oxidase enzymes in the resistance to Cyclophosphamide?
Increased inactivation
Which medication can be given both orally and intravenously for cancer treatment?
Cyclophosphamide
What is a common side effect of Cyclophosphamide that mesna can help prevent?
Hemorrhagic cystitis
This quiz covers the first lecture on antineoplastic agents in the field of Organic Pharmaceutical Chemistry by Dr. Mahmoud. It discusses the introduction to neoplasia, tumors (malignant and benign), and the definition of cancer as a group of diseases characterized by uncontrolled cell growth.
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