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Questions and Answers
Why does pyrrole tend to react by electrophilic substitution?
Why does pyrrole tend to react by electrophilic substitution?
- Due to protonation at C-2 (correct)
- Due to reduction and oxidation reactions
- Due to protonation at C-3
- Due to the resulting protonated molecule adding to a protonated pyrrole
What is the reason for electrophilic substitution normally occurring at carbon atoms instead of nitrogen in pyrrole?
What is the reason for electrophilic substitution normally occurring at carbon atoms instead of nitrogen in pyrrole?
- Preferential stability of nitrogen atoms
- Lack of resonance structures with nitrogen atoms
- Presence of a positive charge on nitrogen atoms
- Presence of a negative charge on carbon atoms due to delocalization (correct)
Why does electrophilic substitution preferentially occur at C-2 in pyrrole?
Why does electrophilic substitution preferentially occur at C-2 in pyrrole?
- Preferential stability of C-3 attack products
- More stable intermediate from C-2 attack with three resonance structures (correct)
- More stable intermediate from C-3 attack with three resonance structures
- Lack of resonance structures for C-2 attack products
What is the result of pyrrole undergoing electrophilic substitution reaction at the 2nd position (C2)?
What is the result of pyrrole undergoing electrophilic substitution reaction at the 2nd position (C2)?
Why is C-2 attack in pyrrole considered more stable than C-3 attack?
Why is C-2 attack in pyrrole considered more stable than C-3 attack?
What type of reactions does pyrrole undergo with respect to reduction and oxidation?
What type of reactions does pyrrole undergo with respect to reduction and oxidation?
Why are the C-atoms of a pyrrole ring more electron-rich compared to benzene?
Why are the C-atoms of a pyrrole ring more electron-rich compared to benzene?
What evidence supports the aromatic character of pyrrole?
What evidence supports the aromatic character of pyrrole?
What differentiates the acidic properties of pyrrole from other secondary amines?
What differentiates the acidic properties of pyrrole from other secondary amines?
Why is pyrrole sensitive to strong acids?
Why is pyrrole sensitive to strong acids?
How does pyrrole react with strong bases such as KOH?
How does pyrrole react with strong bases such as KOH?
What explains the exceptional lack of basicity in pyrrole compared to pyrrolidine?
What explains the exceptional lack of basicity in pyrrole compared to pyrrolidine?
What is the commercial method for synthesizing Pyrrole from Furan?
What is the commercial method for synthesizing Pyrrole from Furan?
How does the reactivity of Pyrrole compare to benzene in electrophilic substitution reactions?
How does the reactivity of Pyrrole compare to benzene in electrophilic substitution reactions?
Which type of reactions does Pyrrole undergo that benzene does not?
Which type of reactions does Pyrrole undergo that benzene does not?
What effect does the presence of a strong acid have on Pyrrole?
What effect does the presence of a strong acid have on Pyrrole?
Why is Pyrrole considered aromatic?
Why is Pyrrole considered aromatic?
What is a unique feature of Pyrrole's reactivity compared to benzene?
What is a unique feature of Pyrrole's reactivity compared to benzene?
What is the major amino acid found in cartilage and important for maintaining youthful skin?
What is the major amino acid found in cartilage and important for maintaining youthful skin?
Which compound is used for smoking cessation to relieve withdrawal symptoms?
Which compound is used for smoking cessation to relieve withdrawal symptoms?
What is the role of Glycopyrrolate in medical use?
What is the role of Glycopyrrolate in medical use?
What property of Furan allows it to have a planar ring structure?
What property of Furan allows it to have a planar ring structure?
How many non-bonding electrons are present in the furan molecule?
How many non-bonding electrons are present in the furan molecule?
What is the hybridization of the carbon atoms in Furan that contributes to its planar structure?
What is the hybridization of the carbon atoms in Furan that contributes to its planar structure?
Why does pyrrole have exceptionally strong acidic properties for a secondary amine?
Why does pyrrole have exceptionally strong acidic properties for a secondary amine?
What characteristic of pyrrole makes it resemble the reactivity of benzene derivatives like phenols and amines?
What characteristic of pyrrole makes it resemble the reactivity of benzene derivatives like phenols and amines?
What ring bond characteristic in pyrrole contributes to its aromatic character?
What ring bond characteristic in pyrrole contributes to its aromatic character?
How does resonance affect the electron distribution in pyrrole compared to benzene?
How does resonance affect the electron distribution in pyrrole compared to benzene?
Why is pyrrole more reactive than benzene?
Why is pyrrole more reactive than benzene?
What impact does strong acid have on pyrrole's protonation?
What impact does strong acid have on pyrrole's protonation?
Which reaction is used to synthesize pyrrole from furan commercially?
Which reaction is used to synthesize pyrrole from furan commercially?
Which of the following reactions does pyrrole undergo, while benzene does not?
Which of the following reactions does pyrrole undergo, while benzene does not?
What is the major factor contributing to the increased reactivity of pyrrole compared to benzene in electrophilic substitution reactions?
What is the major factor contributing to the increased reactivity of pyrrole compared to benzene in electrophilic substitution reactions?
Which of the following statements best explains the acidic properties of pyrrole?
Which of the following statements best explains the acidic properties of pyrrole?
What is the effect of strong acids on pyrrole?
What is the effect of strong acids on pyrrole?
Which of the following reactions does pyrrole undergo with respect to reduction and oxidation?
Which of the following reactions does pyrrole undergo with respect to reduction and oxidation?
Which of the following statements best explains why electrophilic substitution in pyrrole preferentially occurs at the C-2 position?
Which of the following statements best explains why electrophilic substitution in pyrrole preferentially occurs at the C-2 position?
Which of the following reactions is most likely to occur when pyrrole is treated with a strong electrophile?
Which of the following reactions is most likely to occur when pyrrole is treated with a strong electrophile?
In the electrophilic substitution reaction of pyrrole, what is the initial step that occurs?
In the electrophilic substitution reaction of pyrrole, what is the initial step that occurs?
Which of the following statements best explains why pyrrole is more reactive towards electrophilic substitution compared to benzene?
Which of the following statements best explains why pyrrole is more reactive towards electrophilic substitution compared to benzene?
What is the major product formed when pyrrole undergoes electrophilic substitution followed by further reaction with another pyrrole molecule?
What is the major product formed when pyrrole undergoes electrophilic substitution followed by further reaction with another pyrrole molecule?
Which of the following statements best explains why electrophilic substitution in pyrrole typically occurs at carbon atoms rather than at the nitrogen atom?
Which of the following statements best explains why electrophilic substitution in pyrrole typically occurs at carbon atoms rather than at the nitrogen atom?
Which of the following statements about the reactivity of monosubstituted pyrroles is correct?
Which of the following statements about the reactivity of monosubstituted pyrroles is correct?
Which of the following statements best explains the exceptional lack of basicity in pyrrole compared to pyrrolidine?
Which of the following statements best explains the exceptional lack of basicity in pyrrole compared to pyrrolidine?
Which of the following statements best explains why electrophilic substitution in pyrrole preferentially occurs at the 2-position (C-2)?
Which of the following statements best explains why electrophilic substitution in pyrrole preferentially occurs at the 2-position (C-2)?
Which of the following statements best explains the aromaticity of furan?
Which of the following statements best explains the aromaticity of furan?
Which of the following statements best explains the reactivity of pyrrole towards strong acids?
Which of the following statements best explains the reactivity of pyrrole towards strong acids?
Which of the following statements best describes the role of the nitrogen atom in the reactivity of pyrrole towards electrophilic substitution?
Which of the following statements best describes the role of the nitrogen atom in the reactivity of pyrrole towards electrophilic substitution?
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