10 Questions
What is a characteristic of aromatic rings that enables them to participate in van der Waals interactions with the active site?
Their planar and hydrophobic structure
Why does the cyclohexyl ring not bind well to the active site?
Due to the steric bulk of the cyclohexyl ring that prevents it from fitting into the narrow binding slot
What is the characteristic of alkenes that makes them easier to reduce than aromatic rings?
Their higher energy state compared to aromatic rings
What type of interaction is possible between an aromatic ring and an ammonium or quaternary ammonium ion?
Induced dipole or hydrogen bonding
What is the role of the C=O group in the electronic interaction of esters?
It allows for the formation of a resonance structure that reduces the effectiveness of the ester as a hydrogen bond acceptor
Why are phenols effective as hydrogen bond acceptors?
Due to the presence of the OH group, which allows for aromatic and OH interactions
What is the difference between axial and equatorial protons in the context of cyclohexane rings?
Axial protons can interact weakly and serve as spacers, while equatorial protons do not
What type of interaction is possible between an amine and the active site?
Induced dipole or hydrogen bonding
Why are esters less effective as hydrogen bond acceptors compared to alcohols?
Due to the presence of the C=O group, which reduces the effectiveness of the ester as a hydrogen bond acceptor
What is the characteristic of heteroaromatic amines that enables them to participate in van der Waals interactions with the active site?
Their planar and hydrophobic structure
Test your understanding of the binding roles of alkanes and amines in organic chemistry, including their involvement in hydrogen bonding and protonation. Learn how the structure of amines affects their binding properties and how they are involved in many drugs.
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