Imidazoles
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Questions and Answers

What is the key characteristic of the azomethine group in heterocyclic compounds?

  • It has two unpaired electrons
  • It has no unpaired electrons
  • It has three unpaired electrons
  • It has one unpaired electron (correct)

    • Which of the following is the most basic azole?

  • Imidazole (correct)
  • Pyrrole
  • Thiazole
  • Oxazole

    • What is the boiling point of oxazole?

  • 250-255°C
  • 100-105°C
  • 69-70°C (correct)
  • 150-155°C

    • What is the general structure of azoles?

    <p>Five-membered ring with two heteroatoms</p> Signup and view all the answers

    What is the pKa value of pyrrole?

    <p>-3.8</p> Signup and view all the answers

    Which of the following is NOT a characteristic of azoles?

    <p>Aliphaticity</p> Signup and view all the answers

    What is the numbering pattern of the ring in azoles?

    <p>Starts from the heteroatom with higher atomic number</p> Signup and view all the answers

    What is the boiling point of imidazole?

    <p>256°C</p> Signup and view all the answers

    Which of the following azoles is soluble in water?

    <p>Imidazole</p> Signup and view all the answers

    What is the molecular formula of imidazole?

    <p>C3N2H4</p> Signup and view all the answers

    What is the characteristic of 1,3-azoles compared to 1,2-azoles?

    <p>They are more reactive</p> Signup and view all the answers

    What is the result of the condensation of a 1,2-dicarbonyl compound with ammonium acetate and an aldehyde?

    <p>Formation of imidazole</p> Signup and view all the answers

    What is the characteristic of the tautomeric forms of imidazole?

    <p>They are equivalent</p> Signup and view all the answers

    What is the reaction involved in the preparation of imidazole from oxazole?

    <p>Ring transformation reaction</p> Signup and view all the answers

    What is the characteristic of imidazole in terms of its acidic and basic properties?

    <p>It is an amphoteric substance</p> Signup and view all the answers

    Which of the following positions is more susceptible to electrophilic attack in imidazole?

    <p>C-4 or C-5</p> Signup and view all the answers

    What is the product of the reaction between imidazole and a nitrating mixture?

    <p>4(5)-nitroimidazole</p> Signup and view all the answers

    Under what conditions does the iodination of imidazole take place?

    <p>Under alkaline conditions</p> Signup and view all the answers

    What is the use of metronidazole?

    <p>As an anti-amoebic agent</p> Signup and view all the answers

    What is the characteristic of the imidazole ring regarding oxidation?

    <p>It is resistant to oxidation</p> Signup and view all the answers

    What is the use of cimetidine?

    <p>As an H2 antagonist-antiulcer drug</p> Signup and view all the answers

    What is the molecular formula of oxazole?

    <p>C3H3ON</p> Signup and view all the answers

    Which of the following is an aromatic heterocyclic compound?

    <p>Oxazole</p> Signup and view all the answers

    What is the name of the method commonly used for the synthesis of oxazoles?

    <p>Robinson-Gabriel synthesis</p> Signup and view all the answers

    What is the name of the partially reduced form of oxazole, depending on the position of the double bond?

    <p>Oxazolines</p> Signup and view all the answers

    What is the odour of oxazole similar to?

    <p>Pyridine-like</p> Signup and view all the answers

    What is the catalyst used in the Robinson-Gabriel synthesis of oxazoles?

    <p>Phosphorus pentoxide</p> Signup and view all the answers

    What is the physical state of oxazole?

    <p>Liquid</p> Signup and view all the answers

    What is the characteristic of oxazole in terms of its basicity?

    <p>Weakly basic</p> Signup and view all the answers

    What is the fully saturated system of oxazole?

    <p>Oxazolidine</p> Signup and view all the answers

    What is the consequence of oxazole following Huckel's rule?

    <p>It becomes an aromatic heterocyclic compound</p> Signup and view all the answers

    What is the common method used for the synthesis of oxazoles?

    <p>Robinson-Gabriel synthesis</p> Signup and view all the answers

    What is the position of the oxygen and nitrogen atoms in the oxazole ring?

    <p>1st and 3rd positions</p> Signup and view all the answers

    What is the result of the partial reduction of oxazole?

    <p>Oxazolines</p> Signup and view all the answers

    What is the characteristic of oxazole in terms of its basicity?

    <p>It is a weak base</p> Signup and view all the answers

    What is the molecular formula of oxazole?

    <p>C3H3ON</p> Signup and view all the answers

    What is the physical state of oxazole at room temperature?

    <p>It is a liquid</p> Signup and view all the answers

    What is the boiling point of oxazole?

    <p>69°C</p> Signup and view all the answers

    What is the odour of oxazole similar to?

    <p>Pyridine-like</p> Signup and view all the answers

    What is the fully saturated system of oxazole?

    <p>Oxazolidine</p> Signup and view all the answers

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