40 Questions
What is the key characteristic of the azomethine group in heterocyclic compounds?
It has one unpaired electron
Which of the following is the most basic azole?
Imidazole
What is the boiling point of oxazole?
69-70°C
What is the general structure of azoles?
Five-membered ring with two heteroatoms
What is the pKa value of pyrrole?
-3.8
Which of the following is NOT a characteristic of azoles?
Aliphaticity
What is the numbering pattern of the ring in azoles?
Starts from the heteroatom with higher atomic number
What is the boiling point of imidazole?
256°C
Which of the following azoles is soluble in water?
Imidazole
What is the molecular formula of imidazole?
C3N2H4
What is the characteristic of 1,3-azoles compared to 1,2-azoles?
They are more reactive
What is the result of the condensation of a 1,2-dicarbonyl compound with ammonium acetate and an aldehyde?
Formation of imidazole
What is the characteristic of the tautomeric forms of imidazole?
They are equivalent
What is the reaction involved in the preparation of imidazole from oxazole?
Ring transformation reaction
What is the characteristic of imidazole in terms of its acidic and basic properties?
It is an amphoteric substance
Which of the following positions is more susceptible to electrophilic attack in imidazole?
C-4 or C-5
What is the product of the reaction between imidazole and a nitrating mixture?
4(5)-nitroimidazole
Under what conditions does the iodination of imidazole take place?
Under alkaline conditions
What is the use of metronidazole?
As an anti-amoebic agent
What is the characteristic of the imidazole ring regarding oxidation?
It is resistant to oxidation
What is the use of cimetidine?
As an H2 antagonist-antiulcer drug
What is the molecular formula of oxazole?
C3H3ON
Which of the following is an aromatic heterocyclic compound?
Oxazole
What is the name of the method commonly used for the synthesis of oxazoles?
Robinson-Gabriel synthesis
What is the name of the partially reduced form of oxazole, depending on the position of the double bond?
Oxazolines
What is the odour of oxazole similar to?
Pyridine-like
What is the catalyst used in the Robinson-Gabriel synthesis of oxazoles?
Phosphorus pentoxide
What is the physical state of oxazole?
Liquid
What is the characteristic of oxazole in terms of its basicity?
Weakly basic
What is the fully saturated system of oxazole?
Oxazolidine
What is the consequence of oxazole following Huckel's rule?
It becomes an aromatic heterocyclic compound
What is the common method used for the synthesis of oxazoles?
Robinson-Gabriel synthesis
What is the position of the oxygen and nitrogen atoms in the oxazole ring?
1st and 3rd positions
What is the result of the partial reduction of oxazole?
Oxazolines
What is the characteristic of oxazole in terms of its basicity?
It is a weak base
What is the molecular formula of oxazole?
C3H3ON
What is the physical state of oxazole at room temperature?
It is a liquid
What is the boiling point of oxazole?
69°C
What is the odour of oxazole similar to?
Pyridine-like
What is the fully saturated system of oxazole?
Oxazolidine
Test your knowledge of azoles and oxazoles, including their general structure, physical properties, aromaticity, basicity, and reactions. Also, learn about the medicinal uses of these heterocyclic compounds.
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