Imidazoles
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Questions and Answers

What is the key characteristic of the azomethine group in heterocyclic compounds?

  • It has two unpaired electrons
  • It has no unpaired electrons
  • It has three unpaired electrons
  • It has one unpaired electron (correct)

Which of the following is the most basic azole?

  • Imidazole (correct)
  • Pyrrole
  • Thiazole
  • Oxazole

What is the boiling point of oxazole?

  • 250-255°C
  • 100-105°C
  • 69-70°C (correct)
  • 150-155°C

What is the general structure of azoles?

<p>Five-membered ring with two heteroatoms (D)</p> Signup and view all the answers

What is the pKa value of pyrrole?

<p>-3.8 (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of azoles?

<p>Aliphaticity (A)</p> Signup and view all the answers

What is the numbering pattern of the ring in azoles?

<p>Starts from the heteroatom with higher atomic number (D)</p> Signup and view all the answers

What is the boiling point of imidazole?

<p>256°C (A)</p> Signup and view all the answers

Which of the following azoles is soluble in water?

<p>Imidazole (C)</p> Signup and view all the answers

What is the molecular formula of imidazole?

<p>C3N2H4 (A)</p> Signup and view all the answers

What is the characteristic of 1,3-azoles compared to 1,2-azoles?

<p>They are more reactive (C)</p> Signup and view all the answers

What is the result of the condensation of a 1,2-dicarbonyl compound with ammonium acetate and an aldehyde?

<p>Formation of imidazole (A)</p> Signup and view all the answers

What is the characteristic of the tautomeric forms of imidazole?

<p>They are equivalent (B)</p> Signup and view all the answers

What is the reaction involved in the preparation of imidazole from oxazole?

<p>Ring transformation reaction (C)</p> Signup and view all the answers

What is the characteristic of imidazole in terms of its acidic and basic properties?

<p>It is an amphoteric substance (C)</p> Signup and view all the answers

Which of the following positions is more susceptible to electrophilic attack in imidazole?

<p>C-4 or C-5 (D)</p> Signup and view all the answers

What is the product of the reaction between imidazole and a nitrating mixture?

<p>4(5)-nitroimidazole (C)</p> Signup and view all the answers

Under what conditions does the iodination of imidazole take place?

<p>Under alkaline conditions (C)</p> Signup and view all the answers

What is the use of metronidazole?

<p>As an anti-amoebic agent (D)</p> Signup and view all the answers

What is the characteristic of the imidazole ring regarding oxidation?

<p>It is resistant to oxidation (B)</p> Signup and view all the answers

What is the use of cimetidine?

<p>As an H2 antagonist-antiulcer drug (C)</p> Signup and view all the answers

What is the molecular formula of oxazole?

<p>C3H3ON (C)</p> Signup and view all the answers

Which of the following is an aromatic heterocyclic compound?

<p>Oxazole (D)</p> Signup and view all the answers

What is the name of the method commonly used for the synthesis of oxazoles?

<p>Robinson-Gabriel synthesis (D)</p> Signup and view all the answers

What is the name of the partially reduced form of oxazole, depending on the position of the double bond?

<p>Oxazolines (C)</p> Signup and view all the answers

What is the odour of oxazole similar to?

<p>Pyridine-like (C)</p> Signup and view all the answers

What is the catalyst used in the Robinson-Gabriel synthesis of oxazoles?

<p>Phosphorus pentoxide (C)</p> Signup and view all the answers

What is the physical state of oxazole?

<p>Liquid (B)</p> Signup and view all the answers

What is the characteristic of oxazole in terms of its basicity?

<p>Weakly basic (A)</p> Signup and view all the answers

What is the fully saturated system of oxazole?

<p>Oxazolidine (B)</p> Signup and view all the answers

What is the consequence of oxazole following Huckel's rule?

<p>It becomes an aromatic heterocyclic compound (D)</p> Signup and view all the answers

What is the common method used for the synthesis of oxazoles?

<p>Robinson-Gabriel synthesis (A)</p> Signup and view all the answers

What is the position of the oxygen and nitrogen atoms in the oxazole ring?

<p>1st and 3rd positions (A)</p> Signup and view all the answers

What is the result of the partial reduction of oxazole?

<p>Oxazolines (A)</p> Signup and view all the answers

What is the characteristic of oxazole in terms of its basicity?

<p>It is a weak base (D)</p> Signup and view all the answers

What is the molecular formula of oxazole?

<p>C3H3ON (B)</p> Signup and view all the answers

What is the physical state of oxazole at room temperature?

<p>It is a liquid (C)</p> Signup and view all the answers

What is the boiling point of oxazole?

<p>69°C (C)</p> Signup and view all the answers

What is the odour of oxazole similar to?

<p>Pyridine-like (B)</p> Signup and view all the answers

What is the fully saturated system of oxazole?

<p>Oxazolidine (A)</p> Signup and view all the answers

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