Oral White Lesions Overview
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Questions and Answers

Match the type of white lesion with its description:

Leukoplakia = A type of lesion with malignant potential Lichen planus = A mucosal disorder that may cause white lesions Pseudomembranes = Caused by fungal infections or caustic chemicals Leukoedema = A normal variation of the oral mucosa

Match the factors contributing to white lesions with their descriptions:

Thickened keratin layer = Induced by local friction or immunologic reactions Epithelial hyperplasia = Increased proliferation of epithelial cells Reduced vascularity = Decreased blood supply to the underlying tissue Intracellular epithelial edema = Accumulation of fluid within epithelial cells

Match the patterns of white lesions with their characteristics:

Papular = Small, raised bumps on the mucosa Annular = Ring-shaped lesions Reticular = Lacy or web-like pattern Erosive-ulcerative = Lesions that cause erosion or ulceration

Match the condition to its population prevalence:

<p>Leukoedema = Up to 90% among blacks Lichen planus = Variable prevalence in the general population Pseudomembranes = Common in fungal infections Epithelial hyperplasia = Less clearly defined prevalence</p> Signup and view all the answers

Match the diagnostic approach with its goal:

<p>Determine congenital or acquired = Clarifying the nature of the lesion Inspect for wipe-off = Identifying superficial lesions Identify special patterns = Distinguishing lesion types Conduct appropriate diagnostics = Excluding malignancy risks</p> Signup and view all the answers

Match the following lesions with their potential risks:

<p>Leukoplakia = High malignant potential Lichen planus = May have malignant transformations Proliferative verrucous leukoplakia = Variable malignant potential Leukoedema = Generally non-risky and normal variation</p> Signup and view all the answers

Match the definitions with the terms related to oral lesions:

<p>Hyperkeratosis = Thickened layer of keratin Edema = Swelling due to fluid accumulation Vascularity = Blood supply within tissues Epithelial = Relating to the outer layer of cells</p> Signup and view all the answers

Match the key terms with their meanings concerning oral pathology:

<p>Malignancy = Potential for a lesion to become cancerous Etiology = Study of the cause of diseases Diagnostic approach = Methodical examination of lesions Clinical pattern = Observable traits of oral lesions</p> Signup and view all the answers

Match the following conditions with their primary features:

<p>Nicotine Stomatitis = Erythematous change and keratinization of the palate White Hairy Tongue = Overgrowth of filliform papilla Hairy Leukoplakia = Well-demarcated white lesion on the tongue Malignant Transformation = Risk increased by reverse smoking</p> Signup and view all the answers

Match the following risk factors with the associated condition:

<p>Reverse Smoking = Intensified risk for malignant transformation HIV Infection = Opportunistic infection leading to hairy leukoplakia Nicotine Use = Indicator of epithelial dysplasia risk Immunosuppression = Potential cause of hairy leukoplakia</p> Signup and view all the answers

Match the following treatments with the respective conditions:

<p>Abstinence from pipe smoking = Rapid response in nicotine stomatitis Chemotherapeutic regimens = Declining prevalence of hairy leukoplakia in HIV Oral hygiene improvement = Management of hairy tongue's appearance Antiviral therapy = Treatment option for EBV-associated conditions</p> Signup and view all the answers

Match the following types of lesions with their descriptions:

<p>Keratinized lesions = Red dots surrounded by white keratotic rings White patches = Lesions caused by overgrowth of papilla Erythematous lesions = Initial response of the palatal mucosa Plaquelike lesions = Architecture of hairy leukoplakia</p> Signup and view all the answers

Match the following substances or agents with their associated conditions:

<p>Tobacco = Causes nicotine stomatitis Epstein-Barr Virus (EBV) = Linked to hairy leukoplakia Corticosteroids = May lead to hairy leukoplakia in immunosuppressed Minor salivary glands = Inflammation in nicotine stomatitis</p> Signup and view all the answers

Match the following symptoms with the related condition:

<p>Gagging sensation = Occurring with extensive elongation of papilla Tingling sensation = Resulting from overgrowth in white hairy tongue Increased keratinization = Response in nicotine stomatitis Color variation = Observed in hairy tongue depending on diet</p> Signup and view all the answers

Match the following clinical features with their respective conditions:

<p>Bilateral lesions = Common in hairy leukoplakia White keratotic rings = Seen in nicotine stomatitis Flat or corrugated lesions = Characteristic of hairy leukoplakia Localized along lateral margins = Typical of white hairy tongue</p> Signup and view all the answers

Match the following terms with their definitions:

<p>Immunosuppression = Decreased immune response associated with disease Desquamation = Normal shedding of skin cells, retarded in hairy tongue Malignancy = Potential outcome of prolonged tobacco use Keratinization = Process leading to thickened skin in nicotine stomatitis</p> Signup and view all the answers

Match the oral condition with its primary characteristic:

<p>Geographic Tongue = Desquamated red patches with elevated borders Oral Lichen Planus = Chronic mucocutaneous disease Fissured Tongue = Grooved appearance on the tongue Benign Migratory Glossitis = Patches that move across tongue</p> Signup and view all the answers

Match the oral lichen planus form with its description:

<p>Papular form = Found in the primary phase of the disease Reticular form = Features Wickham's striae Plaque-like form = Resembles leukoplakia, multifocal distribution Ulcerative-Erosive form = Central area ulcerated with fibrinous plaque</p> Signup and view all the answers

Match the tongue condition with its prevalence:

<p>Geographic Tongue = More prevalent in whites and blacks Oral Lichen Planus = Affects women more frequently than men Fissured Tongue = Strong association with geographic tongue Benign Migratory Glossitis = Occurs in patients with emotional stress</p> Signup and view all the answers

Match the oral lichen planus form with its clinical pattern:

<p>Papular form = Small white papules combined together Reticular form = Interlacing fine white keratotic lines Plaque-like form = Homogeneous white plaque with striae Ulcerative-Erosive form = Central ulcerated area with pseudomembrane</p> Signup and view all the answers

Match the condition with its etiology:

<p>Geographic Tongue = Unknown cause with stress influence Oral Lichen Planus = Imbalanced immune system Fissured Tongue = Often coexists with geographic tongue Benign Migratory Glossitis = Patches disappear and reappear</p> Signup and view all the answers

Match the oral condition with its symptom:

<p>Geographic Tongue = Irritation with spicy foods Oral Lichen Planus = Chronic inflammation and ulcers Fissured Tongue = May be asymptomatic Benign Migratory Glossitis = Tenderness reported occasionally</p> Signup and view all the answers

Match the tongue condition with its common age of occurrence:

<p>Geographic Tongue = No specific age, seen in all adults Oral Lichen Planus = Mean age of 55 years Fissured Tongue = Common in older adults Benign Migratory Glossitis = Occurs across various ages</p> Signup and view all the answers

Match the clinical feature with the correct oral condition:

<p>Geographic Tongue = Well-demarcated erythematous patches Oral Lichen Planus = Reticular pattern with striae Fissured Tongue = Deep grooves on the tongue Benign Migratory Glossitis = Movement of patches over time</p> Signup and view all the answers

Match the forms of lichen planus with their characteristics:

<p>Erythematous/Atrophic = Red patches with fine white striae Bullous = Short-lived bullae that rupture and cause ulcers Reticular = Exhibits a patchy distribution in four quadrants Ulcerative-Erosive = Involves painful ulcers at the erosion site</p> Signup and view all the answers

Match the form of candidiasis with its description:

<p>Pseudomembranous = Characterized by white, soft plaques that can be wiped off Chronic = Often associated with predisposing conditions affecting the immune system Angular Cheilitis = Involves inflammation at the corners of the mouth Oropharyngeal = Commonly affects the oropharynx in elderly and infants</p> Signup and view all the answers

Match the symptoms of lichen planus with their corresponding forms:

<p>Papular form = Commonly presents as papules in patches Plaque-like form = Leads to raised lesions that resemble plaques Reticular form = Often presents with lace-like white striae Ulcerative-Erosive = Causes burning and sensitivity along with sores</p> Signup and view all the answers

Match the type of candidiasis with its primary affected population:

<p>Acute pseudomembranous = Common in young infants and the elderly Chronic candidiasis = Often seen in immunocompromised patients Oral candidiasis = Frequently occurs in patients undergoing chemotherapy Angular Cheilitis = Common in elderly patients with dry mouth</p> Signup and view all the answers

Match the key features of lichen planus with their descriptions:

<p>Keratotic striae = Often seen peripheral to erosion sites Attached gingiva involvement = Commonly affected in erythematous form Burning sensation = Common complaint among lichen planus patients Patchy distribution = Typically seen in reticular form</p> Signup and view all the answers

Match the clinical features of candidiasis with their descriptions:

<p>Curdled milk appearance = Classic representation of pseudomembranous candidiasis Erythematous base = Seen after removal of the soft plaques in thrush Centrifugal growth = Characteristic of acute pseudomembranous candidiasis Mucosal sites = Frequently affected areas include buccal mucosa and tongue</p> Signup and view all the answers

Match the following terms with their corresponding illnesses:

<p>C.albicans = Primary causative agent of candidiasis Keratotic debris = Found in pseudomembranous candidiasis lesions Inflammatory cells = Component of the plaques in candidiasis Desquamated epithelial cells = Part of the composition in candidiasis lesions</p> Signup and view all the answers

Match the forms of lichen planus with their associated appearance:

<p>Bullous form = Presents as bullae that lead to painful ulcers Plaque-like form = Identified by raised lesions resembling plaques Reticular form = Characterized by lace-like white striae Erythematous/Atrophic = Presents as red patches with white striae</p> Signup and view all the answers

Match the oral conditions with their characteristics:

<p>Chronic erythematous candidiasis = Common in geriatric individuals with dentures Fordyce Granules = Ectopic sebaceous glands seen in aggregates Gingival cysts = Can occur in adults and infants Epstein's pearls = Nonodontogenic neonatal cysts along the palatal midline</p> Signup and view all the answers

Match the treatment methods with their respective conditions:

<p>Candidiasis = Topical applications of nystatin Fordyce Granules = No treatment indicated Gingival cysts = Spontaneous involution or rupture Epstein's pearls = Exfoliation during oral examination</p> Signup and view all the answers

Match the symptoms with the respective conditions:

<p>Candidiasis = Tenderness, burning, dysphagia Fordyce Granules = Asymptomatic and discovered incidentally Gingival cysts = Found along the alveolar ridges Epstein's pearls = Commonly seen in neonatal phase</p> Signup and view all the answers

Match the conditions with their age of occurrence:

<p>Chronic erythematous candidiasis = Mostly in geriatric individuals Fordyce Granules = Prominent between 20 and 30 years of age Gingival cysts = Can occur in infants and adults Epstein's pearls = Observed frequently in infants</p> Signup and view all the answers

Match the features with each condition:

<p>Candidiasis = White lesions requiring differential diagnosis Fordyce Granules = Regarded as a developmental variation Gingival cysts = Associated with dental lamina remnants Epstein's pearls = Present along the palatal midline</p> Signup and view all the answers

Match the types of lesions with their descriptions:

<p>Candidal white lesions = Differential diagnosis includes traumatic ulcerations Tender red lesions = Differentiated from drug reactions Bohn's nodules = Found in infants during neonatal phase Sebaceous glands = Aggregated around excretory ducts</p> Signup and view all the answers

Match the condition with its common location:

<p>Candidiasis = Minimal disturbances unless severe Fordyce Granules = Buccal mucosa and upper lip vermilion Gingival cysts = Alveolar ridges of the mouth Epstein's pearls = Palatal midline</p> Signup and view all the answers

Match the descriptions with the correct condition:

<p>Candidiasis = Requires antifungal regimen as treatment Fordyce Granules = Normal tissue in an abnormal location Gingival cysts = May involute spontaneously without treatment Epstein's pearls = Commonly found in newborns</p> Signup and view all the answers

Study Notes

Oral White Lesions

  • Oral White Lesions are a wide spectrum of lesions.
  • They range from benign reactive lesions with minimal or no malignant potential, to serious dysplastic and carcinomatous lesions.
  • White lesions constitute only 5% of oral pathoses.
  • Some white lesions have malignant potential as high as 0.5-100%.
  • White lesions require thorough diagnostic evaluation to exclude malignancy.
  • Steps to approach oral white lesions:
    • Assess if the lesion is congenital or acquired.
    • Determine if the lesion can be wiped off and if it has a special pattern.

Hereditary/Congenital Lesions

  • Leukoedema
    • Common normal variation of the oral mucosa.
    • A generalized mild opacification of the buccal mucosa.
    • Prevalence is up to 90% among black individuals and 10-50% in white individuals.
    • More distinct in smokers, but may become less obvious after smoking cessation.
    • More apparent in individuals with more mucosal pigmentation.
    • Reverse smoking (lit end inside the mouth) increases risk of malignant transformation.
    • Pathogenesis: Palatal mucosa initially responds with erythema, followed by keratinization. Red dots surrounded by white keratotic rings represent inflammation around minor salivary gland excretory ducts.
    • Rapidly responds to abstinence from pipe smoking.
    • Rarely evolves into malignancy, except in individuals who reverse smoke.
    • Although the risk of carcinoma development is minimal, nicotine stomatitis is a marker of intense tobacco use, which may indicate increased risk of epithelial dysplasia and neoplasia.
  • White Hairy Tongue
    • Opportunistic infection related to the presence of Epstein-Barr virus (EBV).
    • Mainly found in HIV-infected individuals.
    • May also occur in patients with other forms of immunosuppression.
    • Prevalence in HIV-infected patients has been declining due to improved chemotherapeutic regimens.
    • Results from retardation of the normal rate of desquamation of the filliform papilla.
    • Presents as a well-demarcated white lesion that varies in architecture from flat and plaque-like to papillary/filiform, or corrugated.
    • May be unilateral or bilateral.
    • Commonly located along the lateral margins of the tongue, with occasional extension onto the dorsal surface.
    • Color may range from white to tan to deep brown or black depending on diet, oral hygiene, and bacterial composition.

Other White Lesions

  • Geographic Tongue
    • Condition of unknown cause.
    • More prevalent among whites and blacks.
    • Strongly associated with fissured tongue.
    • Emotional stress may exacerbate the process.
    • Characterized by atrophic patches surrounded by elevated keratotic margins.
    • Multiple, well-demarcated, erythematous, depapillated patches, typically surrounded by a slightly elevated whitish border.
    • Lesions disappear and recur for no apparent reason.
    • May cause irritation or tenderness, especially with spicy foods and alcoholic beverages.
    • Often coexists with fissured tongue.
  • Oral Lichen Planus (OLP)
    • Common chronic mucocutaneous disease of the skin and mucosa.
    • Unknown etiology.
    • Common after middle age, with a mean age of 55 years.
    • Women are affected more frequently than men.
    • Multifactorial etiology, with an imbalanced immune system playing a principal role.
    • Stress is also implicated in its development.
    • Clinical Manifestations:
      • Papular form: Most common, small white papules clustered together.
      • Reticular form: Small papules form a reticular pattern with interlacing white keratotic lines (Wickham's striae), often in a lace-like or annular pattern.
      • Plaque-like form: Resembles leukoplakia but with multifocal distribution. Slightly elevated to smooth and flat plaque, appearing as a homogeneous well-demarcated white plaque with peripheral striae.
      • Ulcerative-Erosive form: Central area of lesion is ulcerated and covered by fibrinous plaque or pseudomembrane. Changing patterns of involvement from week to week, with keratotic striae peripheral to the erosion along with erythema.
      • Erythematous or atrophic form: Red patches with very fine white striae. Often in four quadrants. May cause burning, sensitivity, and generalized discomfort.
      • Bullous form: Rare. Bullae range in size from a few millimeters to centimeters and are generally short-lived, leaving a painful ulcer upon rupture.

Non-Epithelial White-Yellow Lesions

  • Candidiasis
    • Common opportunistic oral mycotic infection.
    • Caused by C.albicans and less commonly by other Candida species.
    • Typically superficial, affecting the outer aspects of the oral mucosa or skin.
    • Clinical presentation varies depending on whether it is acute or chronic.
    • Acute Pseudomembranous Candidiasis (Thrush):
      • Most common type.
      • Affects young infants and the elderly.
      • Common in patients undergoing radiation or chemotherapy.
      • White, soft plaques that grow centrifugally and merge.
      • Creamy white plaques, patches, or papules that can be wiped off with an erythematous and sometimes bleeding area.
      • Characteristic appearance of “curdled milk.”
      • Plaques composed of fungal organisms, keratotic debris, inflammatory cells, desquamated epithelial cells, bacteria, and fibrin.
      • Sites include buccal mucosa and mucobuccal folds, oropharynx, and lateral aspects of the tongue.
      • Minimal symptoms in most cases. Severe cases may cause tenderness, burning, and dysphagia.
    • Chronic Erythematous Candidiasis:
      • Commonly seen in geriatric individuals with complete maxillary dentures (denture sore mouth).
    • Differential Diagnosis: Differentiate from slough associated with chemical burns, traumatic ulcerations, mucous patches of syphilis, and white keratotic lesions. Differentiate red lesions from drug reactions and erosive lichen planus.
    • Treatment and Prognosis: Elimination of predisposing factors and antifungal regimen. Topical Nystatin suspension is often effective for most infections.
  • Fordyce Granules
    • Ectopic sebaceous glands or sebaceous choristomas (normal tissue in an abnormal location).
    • Developmental and considered a variation of normal.
    • Multiple, often seen in aggregates or confluent arrangements.
    • Sites of predilection include buccal mucosa and the vermilion of the upper lip.
    • Generally symmetrically distributed.
    • Become obvious after puberty, with maximal expression between 20 and 30 years of age.
    • Asymptomatic.
    • Microscopically, lobules of sebaceous glands are aggregated around or adjacent to excretory ducts.
    • No treatment indicated.
  • Gingival Cysts
    • Occur in adults and infants (Bohn’s nodules).
    • Occur along the alveolar ridges.
    • Involute spontaneously or rupture and exfoliate.
    • Epstein’s pearls: Nonodontogenic neonatal cysts that occur along the palatal midline (fusion of palatine shelves).
    • Thought to arise from dental lamina remnants.
    • Fetal tissues between 10 and 12 weeks of age show small amounts of keratin within elements of the dental lamina.

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Oral White Lesions PDF

Description

Explore the wide spectrum of oral white lesions, from benign to potentially malignant. This quiz covers key concepts such as the classification of lesions and their diagnostic evaluation processes. Learn about common hereditary lesions like Leukoedema and their prevalence in various demographics.

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