Podcast
Questions and Answers
Match the type of white lesion with its description:
Match the type of white lesion with its description:
Leukoplakia = A type of lesion with malignant potential Lichen planus = A mucosal disorder that may cause white lesions Pseudomembranes = Caused by fungal infections or caustic chemicals Leukoedema = A normal variation of the oral mucosa
Match the factors contributing to white lesions with their descriptions:
Match the factors contributing to white lesions with their descriptions:
Thickened keratin layer = Induced by local friction or immunologic reactions Epithelial hyperplasia = Increased proliferation of epithelial cells Reduced vascularity = Decreased blood supply to the underlying tissue Intracellular epithelial edema = Accumulation of fluid within epithelial cells
Match the patterns of white lesions with their characteristics:
Match the patterns of white lesions with their characteristics:
Papular = Small, raised bumps on the mucosa Annular = Ring-shaped lesions Reticular = Lacy or web-like pattern Erosive-ulcerative = Lesions that cause erosion or ulceration
Match the condition to its population prevalence:
Match the condition to its population prevalence:
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Match the diagnostic approach with its goal:
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Match the following lesions with their potential risks:
Match the following lesions with their potential risks:
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Match the definitions with the terms related to oral lesions:
Match the definitions with the terms related to oral lesions:
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Match the key terms with their meanings concerning oral pathology:
Match the key terms with their meanings concerning oral pathology:
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Match the following conditions with their primary features:
Match the following conditions with their primary features:
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Match the following risk factors with the associated condition:
Match the following risk factors with the associated condition:
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Match the following treatments with the respective conditions:
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Match the following types of lesions with their descriptions:
Match the following types of lesions with their descriptions:
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Match the following substances or agents with their associated conditions:
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Match the following symptoms with the related condition:
Match the following symptoms with the related condition:
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Match the following clinical features with their respective conditions:
Match the following clinical features with their respective conditions:
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Match the following terms with their definitions:
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Match the oral condition with its primary characteristic:
Match the oral condition with its primary characteristic:
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Match the oral lichen planus form with its description:
Match the oral lichen planus form with its description:
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Match the tongue condition with its prevalence:
Match the tongue condition with its prevalence:
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Match the oral lichen planus form with its clinical pattern:
Match the oral lichen planus form with its clinical pattern:
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Match the condition with its etiology:
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Match the oral condition with its symptom:
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Match the tongue condition with its common age of occurrence:
Match the tongue condition with its common age of occurrence:
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Match the clinical feature with the correct oral condition:
Match the clinical feature with the correct oral condition:
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Match the forms of lichen planus with their characteristics:
Match the forms of lichen planus with their characteristics:
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Match the form of candidiasis with its description:
Match the form of candidiasis with its description:
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Match the symptoms of lichen planus with their corresponding forms:
Match the symptoms of lichen planus with their corresponding forms:
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Match the type of candidiasis with its primary affected population:
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Match the key features of lichen planus with their descriptions:
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Match the clinical features of candidiasis with their descriptions:
Match the clinical features of candidiasis with their descriptions:
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Match the following terms with their corresponding illnesses:
Match the following terms with their corresponding illnesses:
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Match the forms of lichen planus with their associated appearance:
Match the forms of lichen planus with their associated appearance:
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Match the oral conditions with their characteristics:
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Match the treatment methods with their respective conditions:
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Match the symptoms with the respective conditions:
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Match the conditions with their age of occurrence:
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Match the features with each condition:
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Match the types of lesions with their descriptions:
Match the types of lesions with their descriptions:
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Match the condition with its common location:
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Match the descriptions with the correct condition:
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Study Notes
Oral White Lesions
- Oral White Lesions are a wide spectrum of lesions.
- They range from benign reactive lesions with minimal or no malignant potential, to serious dysplastic and carcinomatous lesions.
- White lesions constitute only 5% of oral pathoses.
- Some white lesions have malignant potential as high as 0.5-100%.
- White lesions require thorough diagnostic evaluation to exclude malignancy.
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Steps to approach oral white lesions:
- Assess if the lesion is congenital or acquired.
- Determine if the lesion can be wiped off and if it has a special pattern.
Hereditary/Congenital Lesions
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Leukoedema
- Common normal variation of the oral mucosa.
- A generalized mild opacification of the buccal mucosa.
- Prevalence is up to 90% among black individuals and 10-50% in white individuals.
- More distinct in smokers, but may become less obvious after smoking cessation.
- More apparent in individuals with more mucosal pigmentation.
- Reverse smoking (lit end inside the mouth) increases risk of malignant transformation.
- Pathogenesis: Palatal mucosa initially responds with erythema, followed by keratinization. Red dots surrounded by white keratotic rings represent inflammation around minor salivary gland excretory ducts.
- Rapidly responds to abstinence from pipe smoking.
- Rarely evolves into malignancy, except in individuals who reverse smoke.
- Although the risk of carcinoma development is minimal, nicotine stomatitis is a marker of intense tobacco use, which may indicate increased risk of epithelial dysplasia and neoplasia.
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White Hairy Tongue
- Opportunistic infection related to the presence of Epstein-Barr virus (EBV).
- Mainly found in HIV-infected individuals.
- May also occur in patients with other forms of immunosuppression.
- Prevalence in HIV-infected patients has been declining due to improved chemotherapeutic regimens.
- Results from retardation of the normal rate of desquamation of the filliform papilla.
- Presents as a well-demarcated white lesion that varies in architecture from flat and plaque-like to papillary/filiform, or corrugated.
- May be unilateral or bilateral.
- Commonly located along the lateral margins of the tongue, with occasional extension onto the dorsal surface.
- Color may range from white to tan to deep brown or black depending on diet, oral hygiene, and bacterial composition.
Other White Lesions
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Geographic Tongue
- Condition of unknown cause.
- More prevalent among whites and blacks.
- Strongly associated with fissured tongue.
- Emotional stress may exacerbate the process.
- Characterized by atrophic patches surrounded by elevated keratotic margins.
- Multiple, well-demarcated, erythematous, depapillated patches, typically surrounded by a slightly elevated whitish border.
- Lesions disappear and recur for no apparent reason.
- May cause irritation or tenderness, especially with spicy foods and alcoholic beverages.
- Often coexists with fissured tongue.
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Oral Lichen Planus (OLP)
- Common chronic mucocutaneous disease of the skin and mucosa.
- Unknown etiology.
- Common after middle age, with a mean age of 55 years.
- Women are affected more frequently than men.
- Multifactorial etiology, with an imbalanced immune system playing a principal role.
- Stress is also implicated in its development.
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Clinical Manifestations:
- Papular form: Most common, small white papules clustered together.
- Reticular form: Small papules form a reticular pattern with interlacing white keratotic lines (Wickham's striae), often in a lace-like or annular pattern.
- Plaque-like form: Resembles leukoplakia but with multifocal distribution. Slightly elevated to smooth and flat plaque, appearing as a homogeneous well-demarcated white plaque with peripheral striae.
- Ulcerative-Erosive form: Central area of lesion is ulcerated and covered by fibrinous plaque or pseudomembrane. Changing patterns of involvement from week to week, with keratotic striae peripheral to the erosion along with erythema.
- Erythematous or atrophic form: Red patches with very fine white striae. Often in four quadrants. May cause burning, sensitivity, and generalized discomfort.
- Bullous form: Rare. Bullae range in size from a few millimeters to centimeters and are generally short-lived, leaving a painful ulcer upon rupture.
Non-Epithelial White-Yellow Lesions
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Candidiasis
- Common opportunistic oral mycotic infection.
- Caused by C.albicans and less commonly by other Candida species.
- Typically superficial, affecting the outer aspects of the oral mucosa or skin.
- Clinical presentation varies depending on whether it is acute or chronic.
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Acute Pseudomembranous Candidiasis (Thrush):
- Most common type.
- Affects young infants and the elderly.
- Common in patients undergoing radiation or chemotherapy.
- White, soft plaques that grow centrifugally and merge.
- Creamy white plaques, patches, or papules that can be wiped off with an erythematous and sometimes bleeding area.
- Characteristic appearance of “curdled milk.”
- Plaques composed of fungal organisms, keratotic debris, inflammatory cells, desquamated epithelial cells, bacteria, and fibrin.
- Sites include buccal mucosa and mucobuccal folds, oropharynx, and lateral aspects of the tongue.
- Minimal symptoms in most cases. Severe cases may cause tenderness, burning, and dysphagia.
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Chronic Erythematous Candidiasis:
- Commonly seen in geriatric individuals with complete maxillary dentures (denture sore mouth).
- Differential Diagnosis: Differentiate from slough associated with chemical burns, traumatic ulcerations, mucous patches of syphilis, and white keratotic lesions. Differentiate red lesions from drug reactions and erosive lichen planus.
- Treatment and Prognosis: Elimination of predisposing factors and antifungal regimen. Topical Nystatin suspension is often effective for most infections.
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Fordyce Granules
- Ectopic sebaceous glands or sebaceous choristomas (normal tissue in an abnormal location).
- Developmental and considered a variation of normal.
- Multiple, often seen in aggregates or confluent arrangements.
- Sites of predilection include buccal mucosa and the vermilion of the upper lip.
- Generally symmetrically distributed.
- Become obvious after puberty, with maximal expression between 20 and 30 years of age.
- Asymptomatic.
- Microscopically, lobules of sebaceous glands are aggregated around or adjacent to excretory ducts.
- No treatment indicated.
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Gingival Cysts
- Occur in adults and infants (Bohn’s nodules).
- Occur along the alveolar ridges.
- Involute spontaneously or rupture and exfoliate.
- Epstein’s pearls: Nonodontogenic neonatal cysts that occur along the palatal midline (fusion of palatine shelves).
- Thought to arise from dental lamina remnants.
- Fetal tissues between 10 and 12 weeks of age show small amounts of keratin within elements of the dental lamina.
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Description
Explore the wide spectrum of oral white lesions, from benign to potentially malignant. This quiz covers key concepts such as the classification of lesions and their diagnostic evaluation processes. Learn about common hereditary lesions like Leukoedema and their prevalence in various demographics.