Optimization Problems with Derivatives

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Questions and Answers

What is the generic name for Narcan?

  • Buprenorphine
  • Methadone
  • Naltrexone
  • Naloxone (correct)

What is the primary mechanism of action of naloxone?

  • It competes with opioid receptor sites. (correct)
  • It activates opioid receptors.
  • It enhances the effects of opioids.
  • It blocks dopamine reuptake.

What is a therapeutic effect of naloxone?

  • Analgesia
  • Sedation
  • Reversal of respiratory depression (correct)
  • Increased euphoria

Which of the following is a possible side effect of naloxone?

<p>Agitation (C)</p> Signup and view all the answers

What is a common route of excretion for naloxone?

<p>Urine (D)</p> Signup and view all the answers

What is the approximate IV onset time for naloxone?

<p>2 minutes (B)</p> Signup and view all the answers

In what year did the rise in prescription opioid overdose deaths begin?

<p>1999 (B)</p> Signup and view all the answers

When providing naloxone for an overdose, what should be considered?

<p>Providing CPR. (D)</p> Signup and view all the answers

When did the rise in heroin overdose deaths start?

<p>2010 (C)</p> Signup and view all the answers

Flashcards

Naloxone

A opioid antagonist, brand name Narcan.

Naloxone Mechanism

Drug that competes with opioid receptors in the brain, preventing opioid binding or displacing already bound opioids.

Naloxone: Indications

Complete/partial reversal of opioid effects, like respiratory depression.

Naloxone: Side Effects

Agitation, reversal of analgesia, tachycardia, blood pressure changes.

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Naloxone: Nursing

Assess patient condition, consider CPR, comfort measures.

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Naloxone: Contraindications

Allergy, pregnancy, cardiac disease.

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Naloxone: Adverse Effects

CNS: Agitation, reversal of analgesia. CV: Tachycardia, blood pressure changes, dysrhythmias, pulmonary edema. Acute narcotic abstinence syndrome.

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Naloxone: Symptoms

Tremors, drowsiness, sweating, nausea, vomiting, and hypertension.

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Naloxone: Metabolism

Liver.

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Study Notes

Applications of the Derivative: Optimization

  • Optimization involves finding the minimum or maximum value of a function.
  • For example, minimizing the perimeter of a rectangular area with a fixed size.
  • To solve optimization problems, express the function in terms of a single variable using given constraints.
  • Find critical points by setting the derivative equal to zero.
  • Use the second derivative test to confirm whether the critical point is a minimum or maximum.

Optimization - Rectangular Area Example

  • Objective: Minimize perimeter P = 2x + 2y of a rectangle with area xy = 2000 m².
  • Expressed y in terms of x: y = 2000/x.
  • Substitute into the perimeter equation: P(x) = 2x + 4000/x.
  • Found the derivative: P'(x) = 2 - 4000/x².
  • Set P'(x) = 0 and solved for x: x = √2000 = 10√20.
  • Minimum was verified using the second derivative: P''(x) = 8000/x³ > 0.
  • Solved for y: y = 10√20.
  • Calculated the minimum perimeter: P = 40√20.

Optimization - Point on a Line Example

  • Problem: Find the point on the line y = 4x + 7 closest to the origin (0,0).
  • Minimized the distance squared: f(x, y) = x² + y².
  • Substitute y = 4x + 7: f(x) = 17x² + 56x + 49.
  • The derivative was found: f'(x) = 34x + 56.
  • Set f'(x) = 0 and solved for x: x = -56/34 = -28/17.
  • The minimum was verified using the second derivative: f''(x) = 34 > 0.
  • Solved for y: y = 7/17.
  • Closest point to the origin: (-28/17, 7/17).
  • Related Rates problems involve finding the rate of change of one quantity in terms of the rate of change of another.
  • These problems often rely on implicit differentiation.
  • Problem: A snowball melts, its radius decreases at 1 cm/min. How fast is the volume decreasing when r = 5 cm?
  • Volume of a sphere: V = (4/3)Ï€r³.
  • Differentiated with respect to time t: dV/ dt = 4Ï€r² (dr/ dt).
  • Specified dr/ dt = -1 cm/min, r = 5 cm.
  • Solution: dV/ dt = -100Ï€ cm³/min.

Propositional Logic Definition

  • Propositional logic is a formal system that deals with propositions and their relationships.
  • A proposition is a statement that can be either true or false, but not both.

Types of Propositions

  • Simple propositions express a single thought.
  • Compound propositions are formed by connecting simple propositions.

Logical Connectives

  • Conjunction (and): $P \land Q$ means P and Q.
  • disjunction (or): $P \lor Q$ means P or Q.
  • Negation (not): $\neg P$ means not P.
  • Conditional (if... then): $P \rightarrow Q$ means if P then Q.
  • Biconditional (if and only if): $P \leftrightarrow Q$ means P if and only if Q.

Truth Tables

P Q $P \land Q$ $P \lor Q$ $P \rightarrow Q$ $P \leftrightarrow Q$
True True True True True True
True False False True False False
False True False True True False
False False False False True True

Tautology, Contradiction, and Contingency

  • A tautology is always true.
  • A contradiction is always false.
  • A contingency can be either true or false.

Logical Equivalence

  • Two propositions are logically equivalent if they have the same truth table.
  • Example: $P \rightarrow Q \equiv \neg P \lor Q$

De Morgan's Laws

  • $\neg (P \land Q) \equiv \neg P \lor \neg Q$
  • $\neg (P \lor Q) \equiv \neg P \land \neg Q$

Logical Implication

  • P implies Q if, whenever P is true, Q is also true.

Validity of Arguments

  • An argument is valid if the conclusion is a logical consequence of the premises.

Negation of Compound Propositions

  • $\neg (P \land Q) \equiv \neg P \lor \neg Q$
  • $\neg (P \lor Q) \equiv \neg P \land \neg Q$
  • $\neg (P \rightarrow Q) \equiv P \land \neg Q$

Introduction to Optimization

  • The problem of optimization is defined as minimize f(x)
  • $f: \mathbb{R}^n \rightarrow \mathbb{R}$ is the objective function.

Types of Optimization

  • Without constraints: $x \in \mathbb{R}^n$
  • With constraints: $x \in \Omega \subset \mathbb{R}^n$

Types of Optima

  • Global: $x^* \in \mathbb{R}^n \mid f(x^*) \leq f(x) \quad \forall x \in \mathbb{R}^n$
  • Local: $x^* \in \mathbb{R}^n \mid \exists \epsilon > 0 \quad f(x^) \leq f(x) \quad \forall x \in \mathbb{R}^n, |x - x^| < \epsilon$

Optimality Conditions

  • Without constraints:
    • If $f \in C^1$ and $x^$ is a local minimum, then $\nabla f(x^) = 0$
    • If $f \in C^2$ and $x^$ is a local minimum, then $\nabla f(x^) = 0$ and $\nabla^2 f(x^*)$ is positive semidefinite.
    • If $f \in C^2$, and $\nabla f(x^) = 0$ and $\nabla^2 f(x^)$ is positive definite, then $x^*$ is a strict local minimum.

Optimization with Constraints

  • Minimize f(x) subject to $h_i(x) = 0, \quad i = 1, \dots, m$ and $g_j(x) \leq 0, \quad j = 1, \dots, p$.
  • $f, h_i, g_j \in C^1$
  • Lagrangian function:
    • $\mathcal{L}(x, \lambda, \mu) = f(x) + \sum_{i=1}^m \lambda_i h_i(x) + \sum_{j=1}^p \mu_j g_j(x)$

Karush-Kuhn-Tucker (KKT) Conditions

  • If $x^$ is a local minimum, then exist $\lambda^ \in \mathbb{R}^m$ and $\mu^* \in \mathbb{R}^p$ such that:
    • $\nabla_x \mathcal{L}(x^, \lambda^, \mu^*) = 0$
    • $h_i(x^*) = 0, \quad i = 1, \dots, m$
    • $g_j(x^*) \leq 0, \quad j = 1, \dots, p$
    • $\mu_j^* \geq 0, \quad j = 1, \dots, p$
    • $\mu_j^* g_j(x^*) = 0, \quad j = 1, \dots, p$ (Complementary Slackness Condition)

Numerical Methods for Optimization

  • Gradient Descent: $x_{k+1} = x_k - \alpha_k \nabla f(x_k)$
  • Newton's Method: $x_{k+1} = x_k - [\nabla^2 f(x_k)]^{-1} \nabla f(x_k)$
  • Quasi-Newton Methods: BFGS, DFP

Methods for Constrained Optimization

  • Sequential Quadratic Programming (SQP)
  • Penalty Methods
  • Barrier Methods

Convergence Analysis

  • Global Convergence: The algorithm converges to a global minimum from any starting point.
  • Local Convergence: The algorithm converges to a local minimum if the starting point is close enough.
  • Convergence rate:
    • Linear
    • Superlinear
    • Quadratic

Additional Optimization Notes

  • If f is convex, then every local minimum is a global minimum.
  • Duality includes: primal problem, dual problem, complementary slackness
  • Robustness is the ability to maintain performance despite errors.

What is Machine Learning?

  • Enables computers to adapt behavior through experience, improving performance P at a task T based on experience E.
  • Definition based on Tom Mitchell's work.

Machine Learning Chess Example

  • Task T: Playing chess
  • Performance measure P: % of games won against opponents
  • Training experience E: Playing practice games against itself

Other Machine Learning Examples

  • Detecting if emails a spam -> # of emails correctly classified
  • Diagnosing patients -> # of patients correctly diagnosed
  • Recommending movies -> Difference between your rating and the system's prediction |

Machine Learning Types

  • Supervised learning
  • Unsupervised learning
  • Semi-supervised learning
  • Reinforcement learning

Supervised Learning

  • Uses labeled data for training.
  • Includes classification (e.g., spam detection) and regression (e.g., stock price prediction).
  • Involves training a model f on input-output pairs (x, y) to approximate y = f(x).

Unsupervised Learning

  • Training data has no labels, with algorithms finding patterns in the data.
  • Ex: Clustering (grouping customers).
  • Ex: Dimensionality reduction (reducing the number of features in a dataset).

Semi-Supervised Learning

  • Data contains a few labels.
  • Images are classified.
  • Algorithm trains on inputs x, where some inputs have labels y.
  • Use both laballed and unlabelled data.

Reinforcement Learning

  • Training based on rewards for good actions.
  • Game trains the agent by maximizing the reward system.

Model Selection

  • Overfitting occurs when a model learns noise and is too complex.
  • Underfitting occurs when a model is too simple.
  • The bias-variance tradeoff manages overfitting and underfitting.

Machine Learning Jargon

  • Key terms include features, labels, training data, test data, model parameters, and hyperparameters.

Algorithmic Trading

  • Automated order execution based on pre-programmed instructions, factoring in:
    • Price
    • Timing
    • Volume

Trend Following Strategies

  • Utilizes moving averages and channel breakouts for trend detection.

Arbitrage Opportunities

  • Exploits price discrepancies across different markets.

Market Making

  • Generates profits from the bid-ask spread.

Mean Reversion

  • Capitalizes on prices reverting to their average.

Statistical Arbitrage

  • Employs statistical models that identify and exploit pricing inefficiencies.

TWAP (Time Weighted Average Price)

  • Minimizes market impact by executing large orders over periods of time/ chunks.

VWAP (Volume Weighted Average Price)

  • Average executrion price is close to the volume-weighted average price.

Implementation Shortfall

  • Minimizes the difference between the actual and ideal execution price.

Advantages of Algorithmic Trading

  • Speed and Efficiency: Algorithms react quickly to market changes.
  • Reduced Emotional Bias: Rational trading decisions are achieved by this.
  • Backtesting Capabilities: Strategies can be evaluated with historical data.
  • Allows for portfolio Diversification.

Disadvantages of Algorithmic Trading

  • Technical Issues such as software glitches may occur, leading to loss.
  • Over-Optimization: Historical data may lead to worse performance in a live environment.
  • Algo's struggle to adapt: Market Complexity or rapid dynamics change and cause issues.

Simple Moving Average Crossover Strategy

  • Strategy: Buy when the short-term moving average crosses above the long-term moving average, sell when it crosses below.
  • Libraries: Utilizes yfinance, pandas, and numpy.
  • Implemented by code:
    • Downloads financial data, and calculates moving averages.
    • Generates trading signals.
    • Backtests the strategy, assessing portfolio performance, calculates the Sharpe ratio.
    • Visualizes with plots of the historical price data

Simple Moving Average Crossover Strategy Code Explanation

  • Import Libraries: Import yfinance for data, pandas for manipulation, numpy for numerical operations.
  • Download Data: Download data for Apple Inc. ('AAPL') from Yahoo Finance using yfinance.
  • Calculate Moving Averages: Calculate short-term 20-day and long-term 50-day simple moving averages (SMAs) of the prices.
  • Generate Signals: Buy if the short-term SMA crosses above, sell if crosses below.
  • Backtesting: Trading strategy: simulate performance.
    • Calculated daily positions in AAPL.
    • Calculated portfolio value, cash balance, and total returns.
  • Plotting*: Shows the strategy.
    • Plots moving averages.
    • Highlights signals.
  • Evaluation: Evaluates performance with the Sharpe ratio.

What is Static Electricity

  • Static Electricity: A imbalance of electric charge across a surface
  • Static Electricity: The excess of either positive or negative charges

How do objects become charged?

  • Charging via Friction: Electrons are transferred
  • Charging via Conduction: Electrons move from a charged object to uncharged object
  • Charging via Induction: Rearrangement of uncharged objects occurs

Static Electricity: Conductors

  • Materials that allow electron travel such as metals
  • Atoms loosely hold electrons

Static Electricity: Insulators

  • Materials prevent electron travel such as plastic
  • Atoms tightly hold electrons

Static Electricity: Grounding

  • Connect a charged object to the Earth to neutralize charges

Static Electricity: Coulomb's Law

  • $F=k \frac{q_{1} q_{2}}{d^{2}}$
    • F = Force (N)
    • $q_1, q_2$ = charge (C)
    • d = distance between objects (m)
    • $k=9.0 \times 10^{9} \mathrm{Nm}^{2} / \mathrm{C}^{2}$

Static Electricity: Electrical Fields

  • Regions where charges objects exert force
  • Field lines point away from positive, close to negative.

Static Electricity: Electrical Potential

  • Electrical potential energy per unit charge measured in volts
  • Known as voltage

Static Electricity: Potential Difference

  • Difference between two points, also measured in volts
  • Known as voltage

Static Electricity: Capacitance

  • Capacity of energy storage, measured in Farads or F
  • $C=\frac{Q}{V}$
    • C = Capacitance (F)
    • Q = Charge (C)
    • V = Voltage (V)

Static Electricity: Diagram

  • Showing negative charges repelling and neutralizing.

Pythagorean Theorem: Parts

  • Hypotenuse: Longest side, opposite the right angle.
  • Legs: The shorter sides forming the right angle.

Pythagorean Theorem: Definition

  • $a^2 + b^2 = c^2$ where a and b and the legs, and c is the hypotenuse

Pythagorean Theorem: Hypotenuse Length

  • Can be found when given the legs: $c = \sqrt{a^2 + b^2}$

Pythagorean Theorem: Leg Length

  • Can be found when given the hypotenuse and another leg: $b = \sqrt{c^2 - a^2}$

Pythagorean Theorem: Triples

  • 3, 4 and 5
  • 5, 12 and 13
  • 8, 15 and 17
  • 7, 24 and 25

Pythagorean Theorem: Applications

  • Can be used for: height of buildins, distance, or the length of other variables

Pythagorean Theorem: Problems

  • Solutions in order: 10, 8, 13, 7

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