Opioids: Central and Peripheral Effects

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What is the main mechanism of the central effects of opioids?

Suppression of spinal nociceptive impulses

Which effect is NOT associated with opioids?

Stimulation of the cough reflex

What causes intense itch as a result of opioid use?

Histamine release

What is a common side effect experienced at the beginning of opioid therapy?

<p>Nausea and vomiting</p> Signup and view all the answers

What effect do opioids have on the respiratory center?

<p>Suppression and respiratory depression</p> Signup and view all the answers

What is one peripheral effect of opioids?

<p>Delayed gastric emptying due to pyloric contraction</p> Signup and view all the answers

What is the main cause of miosis (pinpoint pupils) associated with opioids use?

<p>Stimulation of the Edinger-Westphal nucleus in the midbrain</p> Signup and view all the answers

What effect do opioids have on the respiratory center?

<p>Suppresses the respiratory center</p> Signup and view all the answers

What is a common side effect experienced at the beginning of opioid therapy?

<p>Nausea and vomiting</p> Signup and view all the answers

Which effect is NOT associated with opioids?

<p>Stimulation of appetite</p> Signup and view all the answers

What causes delayed gastric emptying and reduced gastric motility in opioid use?

<p>Increased tone of the smooth musculature of the gastrointestinal tract</p> Signup and view all the answers

What is a peripheral effect of opioids?

<p>Stimulates bladder muscle tone</p> Signup and view all the answers

What is a relative contraindication to opioid use?

<p>Asthma</p> Signup and view all the answers

In which condition should opioids be used with caution due to the risk of urinary retention?

<p>Gallbladder disease</p> Signup and view all the answers

Which gastrointestinal condition requires caution when using opioids due to the risk of increased smooth musculature tone?

<p>Irritable bowel syndrome (IBS)</p> Signup and view all the answers

In which condition should opioids be used with caution due to the risk of ileus and perforation?

<p>Pancreatitis</p> Signup and view all the answers

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