Podcast
Questions and Answers
Which functional class of genes is involved in regulating proliferation, differentiation, DNA repair, and cell survival?
Which functional class of genes is involved in regulating proliferation, differentiation, DNA repair, and cell survival?
- DNA Repair Genes
- Proto-oncogenes and Oncogenes (correct)
- Apoptosis Genes
- Tumor Suppressor Genes
What type of gene alteration occurs after conception and is not present in the germline?
What type of gene alteration occurs after conception and is not present in the germline?
- Acquired or Somatic (correct)
- Germline
- Proto-oncogenes and Oncogenes
- Tumor Suppressor Genes
Which type of variant directly contributes to the development of disease?
Which type of variant directly contributes to the development of disease?
- Likely Benign
- Uncertain Significance
- Likely Pathogenic
- Pathogenic (correct)
What type of variant is expected to have a major effect on disease?
What type of variant is expected to have a major effect on disease?
Which type of variant does not cause disease?
Which type of variant does not cause disease?
Which of the following is NOT a characteristic of neoplastic cells?
Which of the following is NOT a characteristic of neoplastic cells?
Which of the following is a classification for somatic variants?
Which of the following is a classification for somatic variants?
What is the main difference between driver mutations and passenger mutations?
What is the main difference between driver mutations and passenger mutations?
What is the purpose of in silico prediction algorithms in determining functional changes in proteins?
What is the purpose of in silico prediction algorithms in determining functional changes in proteins?
What are the two classifications for functional mutations?
What are the two classifications for functional mutations?
Which type of mutation is considered dominant because just one copy of a proto-oncogene turned oncogene can produce a transformed phenotype?
Which type of mutation is considered dominant because just one copy of a proto-oncogene turned oncogene can produce a transformed phenotype?
What is the function of tumor suppressor genes in normal cells?
What is the function of tumor suppressor genes in normal cells?
Which gene is normally involved in the activation of the RAS/MAPK signaling pathway?
Which gene is normally involved in the activation of the RAS/MAPK signaling pathway?
What happens when an activating variant is present in the BRAF gene?
What happens when an activating variant is present in the BRAF gene?
What is the function of the p16INK4a protein in normal cells?
What is the function of the p16INK4a protein in normal cells?
Which gene product inhibits the formation of cyclin-CDK complexes and prevents RB phosphorylation and release of E2F proteins?
Which gene product inhibits the formation of cyclin-CDK complexes and prevents RB phosphorylation and release of E2F proteins?
Which gene is downregulated by p53 if DNA repair is successful?
Which gene is downregulated by p53 if DNA repair is successful?
Which gene is activated by p53 if DNA repair is not successful?
Which gene is activated by p53 if DNA repair is not successful?
Which type of mutation in the MET gene leads to impaired receptor degradation and oncogenic transformation in lung cancer?
Which type of mutation in the MET gene leads to impaired receptor degradation and oncogenic transformation in lung cancer?
Which oncogene is encoded by the Human ERBB2 gene and is amplified in 15-30% of breast cancers?
Which oncogene is encoded by the Human ERBB2 gene and is amplified in 15-30% of breast cancers?
Which of the following is NOT a type of alteration in genotype associated with malignant transformation?
Which of the following is NOT a type of alteration in genotype associated with malignant transformation?
Which of the following is NOT a trademark of cancer?
Which of the following is NOT a trademark of cancer?
What is the main focus of the Human Genome Project?
What is the main focus of the Human Genome Project?
Which book would be the most relevant for understanding the genetic basis of cancer?
Which book would be the most relevant for understanding the genetic basis of cancer?
According to Bishop and Weinberg (1996), what are the two classes of cancer genes?
According to Bishop and Weinberg (1996), what are the two classes of cancer genes?
Which of the following is true about oncogene addiction?
Which of the following is true about oncogene addiction?
Which statement accurately describes the Human Genome Project?
Which statement accurately describes the Human Genome Project?
What percentage of the human genome accounts for the coding portion?
What percentage of the human genome accounts for the coding portion?
What is the impact of the completion of the human genome on research into disease mechanisms?
What is the impact of the completion of the human genome on research into disease mechanisms?
What were the additional hallmarks of cancer added after 10 years of research?
What were the additional hallmarks of cancer added after 10 years of research?
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