Odontogenic Cysts and Tumors

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Questions and Answers

A 25-year-old patient presents with a unilocular radiolucency associated with an unerupted mandibular third molar. Radiographic examination reveals no root resorption of adjacent teeth and a well-defined border. Which of the following is the MOST likely diagnosis?

  • Unicystic ameloblastoma
  • Ameloblastic fibroma
  • Dentigerous cyst (correct)
  • Odontogenic keratocyst (OKC)

Which odontogenic lesion, known for its aggressive growth and potential association with Nevoid Basal Cell Carcinoma Syndrome, is often characterized by a multilocular radiolucency and a high recurrence rate if not adequately treated?

  • Odontogenic keratocyst (OKC) (correct)
  • Dentigerous cyst
  • Central giant cell granuloma (CGCG)
  • Odontogenic myxoma

A 15-year-old patient presents with a painless, expansile lesion in the posterior mandible. Radiographic examination reveals a multilocular 'soap bubble' appearance. Which of the following is the MOST likely diagnosis?

  • Ameloblastoma (correct)
  • Central odontogenic fibroma
  • Ameloblastic fibroma
  • Adenomatoid odontogenic tumor (AOT)

Which of the following odontogenic lesions is MOST likely to be associated with 'spiking root resorption' of adjacent teeth and may radiographically resemble a 'blood-soaked sponge' upon aspiration?

<p>Aneurysmal bone cyst (ABC) (D)</p> Signup and view all the answers

A 12-year-old patient presents with a radiopaque lesion in the anterior maxilla, composed of numerous small tooth-like structures. Which of the following is the MOST probable diagnosis?

<p>Compound odontoma (D)</p> Signup and view all the answers

Which of the following odontogenic lesions is typically treated with resection due to its locally aggressive nature and potential for recurrence?

<p>Ameloblastoma (A)</p> Signup and view all the answers

A 45-year-old patient presents with a radiolucent lesion at the apex of a non-vital maxillary central incisor. Which of the following is the MOST likely diagnosis?

<p>Periapical cyst (Radicular cyst) (A)</p> Signup and view all the answers

Which cyst is characterized by its location along the lateral root surface of a vital tooth, commonly in the mandibular canine-premolar region, and often presents as a small, teardrop-shaped radiolucency?

<p>Lateral periodontal cyst (D)</p> Signup and view all the answers

Decompression followed by enucleation is a common treatment approach for which of the following odontogenic cysts, particularly when large?

<p>Dentigerous cyst (C)</p> Signup and view all the answers

A 'scalloped' radiolucency around the roots of vital teeth, often associated with orthodontic treatment, is characteristic of which lesion?

<p>Simple bone cyst (A)</p> Signup and view all the answers

A 7-year-old patient presents with a unilocular radiolucency in the posterior mandible associated with an unerupted permanent molar. Which of the following is the MOST likely diagnosis, considering the patient's age?

<p>Ameloblastic fibroma (C)</p> Signup and view all the answers

Which of the following non-odontogenic lesions is characterized by a focal concavity of the cortical bone on the lingual aspect of the mandible below the inferior alveolar nerve canal?

<p>Stafne bone cyst (Static bone cyst) (D)</p> Signup and view all the answers

A patient presents with a multilocular radiolucency in the anterior mandible that crosses the midline. Which of the following should be HIGHLY considered in the differential diagnosis due to its tendency to cross the midline?

<p>Central giant cell granuloma (CGCG) (D)</p> Signup and view all the answers

Which of the following lesions requires aspiration prior to biopsy or surgical intervention due to its potential vascular nature and risk of significant bleeding?

<p>Central hemangioma (C)</p> Signup and view all the answers

A 'sunburst' periosteal reaction is MOST commonly associated with which of the following bone lesions?

<p>Osteosarcoma (A)</p> Signup and view all the answers

Which radiopaque lesion is characterized by being fused to the root of a vital tooth, often a mandibular molar, and radiographically presents with a thin radiolucent halo?

<p>Cementoblastoma (A)</p> Signup and view all the answers

Florid cemento-osseous dysplasia (FCOD) is typically characterized by which radiographic presentation?

<p>Multiquadrant, mixed radiopaque and radiolucent lesions (A)</p> Signup and view all the answers

Downward bowing of the mandible is a clinical feature that can be associated with which fibro-osseous lesion?

<p>Ossifying fibroma (B)</p> Signup and view all the answers

Which of the following is a benign, non-odontogenic tumor composed of mature bone and is often associated with Gardner's Syndrome?

<p>Osteoma (C)</p> Signup and view all the answers

Which malignant tumor, common in young adults, is characterized by 'punched-out' radiolucencies on radiographs and may present with 'teeth floating in air' appearance?

<p>Ewing sarcoma (D)</p> Signup and view all the answers

Elevated Bence-Jones proteins in urine and 'punched-out' radiolucencies in the jaws are suggestive of which malignancy?

<p>Multiple myeloma (A)</p> Signup and view all the answers

A 'moth-eaten' radiolucency in the mandible, especially in a patient with a known history of primary malignancy elsewhere in the body, should raise suspicion for:

<p>Metastasis to the jaw (D)</p> Signup and view all the answers

Which of the following benign lesions is MOST likely to present with pain that is relieved by aspirin?

<p>Osteoid osteoma (D)</p> Signup and view all the answers

Which of the following developmental cysts, commonly found in newborns, are small, white or yellowish nodules located along the median palatal raphe?

<p>Epstein pearls (C)</p> Signup and view all the answers

A dome-shaped swelling on the gingiva overlying an erupting tooth in a child is MOST likely a(n):

<p>Eruption cyst (A)</p> Signup and view all the answers

Which soft tissue cyst, located in the midline of the floor of the mouth, is described as doughy or rubbery upon palpation?

<p>Dermoid cyst (B)</p> Signup and view all the answers

A soft fluctuant swelling in the lateral neck is MOST suggestive of which soft tissue cyst?

<p>Branchial cleft cyst (C)</p> Signup and view all the answers

Which soft tissue lesion, often seen on the gingiva of children and young adults, is characterized by proliferation of connective tissue and is NOT a true granuloma?

<p>Peripheral ossifying fibroma (A)</p> Signup and view all the answers

A 35-year-old patient presents with a painful, expansile lesion in the posterior mandible. Radiographic examination reveals a multilocular 'soap bubble' appearance and root resorption. Biopsy shows palisading columnar ameloblast-like cells. What is the MOST likely diagnosis?

<p>Ameloblastoma (A)</p> Signup and view all the answers

A radiopaque lesion in the posterior mandible is noted to be asymptomatic and composed of poorly defined calcified deposits. What is the MOST probable diagnosis?

<p>Complex odontoma (D)</p> Signup and view all the answers

Which odontogenic tumor is known to exhibit 'internal calcifications around the crown' of an unerupted tooth and may present with a 'driven snow' appearance histologically?

<p>Calcifying epithelial odontogenic tumor (CEOT) (D)</p> Signup and view all the answers

Which of the following lesions is LEAST likely to be associated with an unerupted tooth?

<p>Lateral periodontal cyst (B)</p> Signup and view all the answers

Orthodontic treatment is sometimes considered as part of the management of which of the following lesions?

<p>Simple bone cyst (D)</p> Signup and view all the answers

Which of the following lesions is characterized by 'soap bubble' appearance, straight septa, and scalloping borders (not always present) and is known for its myxomatous stroma?

<p>Odontogenic myxoma (A)</p> Signup and view all the answers

A patient presents with 'cafe au lait' spots, polyostotic fibrous dysplasia, and endocrine abnormalities. This clinical presentation is MOST consistent with:

<p>McCune-Albright syndrome (B)</p> Signup and view all the answers

Which of the following is a benign odontogenic tumor that is almost exclusively found in the anterior maxilla, frequently associated with impacted canines, and often demonstrates a 'duct-like' histologic pattern?

<p>Adenomatoid odontogenic tumor (AOT) (D)</p> Signup and view all the answers

Which lesion is described as a 'ghost cell tumor' due to the presence of ghost cells histologically and may be associated with Calcifying Odontogenic Cyst?

<p>Calcifying odontogenic cyst (COC) (B)</p> Signup and view all the answers

Which of the following lesions is treated with 'extraction or root amputation with RCT' due to its intimate association with the root of a vital tooth?

<p>Cementoblastoma (C)</p> Signup and view all the answers

Flashcards

Ameloblastic Fibroma (AF)

Benign, bone expansion; associated with unerupted teeth.

Unicystic Ameloblastoma

Arises in dentigerous cysts, RL around the crown of unerupted tooth.

Dentigerous Cyst

Attached to CEJ of unerupted 3rd molars.

Odontogenic Keratocyst (OKC)

Aggressive, possible root resorption, may be multilocular.

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Lateral Periodontal Cyst

Vital teeth, teardrop shape, asymptomatic.

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Squamous Odontogenic Tumor (SOT)

Mobility, semilunar RL, can mimic perio disease.

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ABC

Swelling, pain, paresthesia; fast growing, rapid swelling. Spiking root resportion.

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Odontogenic Myxoma

Soap bubble appearance, scalloping borders, expansion.

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Ameloblastic Fibro-Odontoma (AFO)

Mixed radiolucent/radiopaque, odontoma associated.

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Adenomatoid Odontogenic Tumor (AOT)

Associated with impacted canines.

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Calcifying Odontogenic Cyst (COC)

Ghost cell tumor, unerupted teeth.

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Calcifying Epithelial Odontogenic Tumor (CEOT)

Internal calcifications, unerupted teeth.

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Central Odontogenic Fibroma

Peri-radicular.

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Compound Odontoma

Rudimentary teeth like structures.

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Complex Odontoma

Poorly defined calcified deposits.

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Stafne Bone Cyst

Focal concavity of cortical bone.

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Central Giant Cell Granuloma (CGCG)

Multiplanar root resorption.

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Central Hemangioma

Bleeding sulcus, AV malformation.

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Osteoma

Periosteal rxn, mushroom like growth.

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Osteoid Osteoma

Pain relief with aspirin, < 2 cm.

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Fibrous Dysplasia

Ground glass appearance, bone expansion.

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Ameloblastic Fibrosarcoma

Excision.

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Langerhans Cell Histiocytosis

Punched out lesions.

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Chondrosarcoma

Painless swelling, soft tissue expansion, loose teeth.

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Study Notes

  • These notes cover various odontogenic and non-odontogenic cysts and tumors, focusing on their classification, location, radiographic features (unilocular, multilocular, mixed, radiopaque), and key characteristics.

Unilocular Radiolucent Lesions

  • Ameloblastic Fibroma (AF):
    • Typically found in individuals aged 0-20
    • Located in the posterior mandible
    • Treatment involves surgical excision or curettage
    • Characterized by bone expansion.
    • Often associated with unerupted teeth
    • Can be multilocular
  • Unicystic Ameloblastoma:
    • Occurs in individuals aged 10-20
    • Located in the mandible
    • Treated by enucleation or excision
    • Can arise within a dentigerous cyst
    • Presents as a radiolucency around the crown of an unerupted tooth
  • Simple Bone Cyst:
    • Affects individuals aged 10-20
    • Found in the mandible
    • Treatment involves curettage
    • Associated with scalloping around roots of teeth
    • Teeth are vital
    • Orthodontic treatment may be considered
  • Dentigerous Cyst:
    • Occurs in individuals aged 10-30
    • Located in the mandible around an unerupted third molar
    • Initial treatment involves decompression, followed by excision
    • Attached to the cementoenamel junction (CEJ) of the tooth
    • Associated with impacted teeth
  • Odontogenic Keratocyst (OKC):
    • Occurs in individuals aged 20-30
    • Located in the posterior mandible and ramus area, often associated with unerupted teeth
    • Treatment involves decompression followed by extraction of the affected tooth
    • Does not cause root resorption
    • Exhibits anterior-posterior (AP) growth before lateral expansion
    • Multiple OKCs may indicate Nevoid Basal Cell Carcinoma Syndrome (NBCCS)
    • Can be multilocular
  • Periapical Cyst/Radicular Cyst:
    • Affects individuals in their 20s to 50s
    • Located in the anterior maxilla, more common than in the mandible
    • Treatment involves root canal therapy (RCT)
    • Teeth are non-vital and painless
    • Causes blunt root resorption
  • Lateral Periodontal Cyst:
    • Occurs in individuals aged 30+
    • Located in the mandibular lateral incisor/canine/premolar region
    • Treatment involves enucleation
    • Teeth are vital
    • Presents as a teardrop-shaped radiolucency
    • Asymptomatic
    • Does not cause root resorption

Multilocular Radiolucent Lesions

  • Squamous Odontogenic Tumor (SOT):
    • Affects individuals in their 10s to 60s
    • Located in the anterior alveolar ridge
    • Treated via excision
    • Causes tooth mobility
    • Appears as a semilunar radiolucency
    • Can resemble periodontal disease
    • May present in multiple quadrants
  • Aneurysmal Bone Cyst (ABC):
    • Occurs in individuals aged 0-20
    • Located more commonly in the mandible
    • Treatment involves enucleation with curettage
    • Causes swelling, pain, and paresthesia
    • Characterized by rapid growth/swelling
    • Can cause spiking root resorption
    • Described as a "blood-soaked sponge"
  • Odontogenic Myxoma:
    • Affects individuals in their 20s
    • Found more often in the mandible
    • Located anywhere within the jaws
    • Undergoes excision
    • Exhibits a soap bubble appearance with straight septa
    • Has scalloping borders
    • Leads to expansion of the mandible
  • Ameloblastoma:
    • Occurs in individuals aged 30-40
    • Located in the mandibular ramus area, associated with unerupted teeth
    • Treatment involves resection
    • Typically painless
    • Causes expansion of the mandible
    • Blunt root resorption

Mixed (Radiolucent and Radiopaque) Lesions

  • Ameloblastic Fibro-Odontoma (AFO):
    • Affects individuals aged 0-20
    • Located in the posterior mandible
    • Treated via excision
    • Odontoma is often associated
  • Adenomatoid Odontogenic Tumor (AOT):
    • Occurs in individuals aged 10-20
    • More common in the anterior jaw (2/3) and maxilla (2/3)
    • Frequently associated with canines
    • Treatment involves enucleation
    • Associated with impacted teeth, usually canines
    • Causes expansion of bone and displacement of teeth
    • Appears as 75% unilocular radiolucency

Radiopaque Lesions

  • Calcifying Odontogenic Cyst (COC):
    • Occurs in individuals aged 10-20
    • Located in the maxilla, anterior to molars, or near canines
    • Treated via enucleation with peripheral ostectomy
    • Often associated with unerupted teeth, especially canines
    • May display ghost cell tumor characteristics
    • Can cause root resorption and displacement
  • Calcifying Epithelial Odontogenic Tumor (CEOT):
    • Occurs in individuals aged 30-40
    • Post mandible
    • Maxilla
    • Resection
  • Central Odontogenic Fibroma:
    • Affects individuals aged 20-30
    • Located in the maxilla or mandible
    • Treated via enucleation with curettage
    • Usually rare
    • Located peri-radicularly
    • RO (radiopaque) flecks within RL (radiolucent)
    • Associated with unerupted teeth
    • Causes root resorption or divergence
  • Compound Odontoma:
    • Affects individuals aged 0-20
    • Located in the anterior jaw
    • Treated via excision
    • Asymptomatic
    • Structures resemble rudimentary teeth
  • Complex Odontoma:
    • Occurs in the posterior jaw
    • Mostly asymptomatic
    • Consists of poorly defined calcified deposits
  • Cementoblastoma:
    • Affects individuals in their 10s to 30s
    • Located in the mandible near molars/premolars
    • Treatment involves extraction or root amputation with root canal therapy (RCT)
    • Patient experiences pain and swelling
    • Attached to a vital tooth
    • Radiopaque with a thin radiolucent halo, fused to the root of the tooth

Non-Odontogenic Cysts and Tumors

  • Stafne Bone Cyst:
    • Affects adults
    • Located below the mandibular canal at the angle of the mandible
    • Monitor the lesion
    • Causes a focal concavity of cortical bone on the lingual aspect of the mandible

Multilocular Non-Odontogenic Lesions

  • Central Giant Cell Granuloma (CGCG):
    • Affects individuals aged 0-30
    • Located in the anterior mandible, crossing the midline
    • Treatment involves curettage with intralesional corticosteroid injection or bisphosphonates
    • Rule out brown tumor of hyperparathyroidism
    • Soap bubble appearance
    • Causes multiplanar root resorption and displaces teeth
  • Central Hemangioma:
    • Affects individuals aged 10-20
    • Located in the mandible
    • Requires aspiration before biopsy
    • Cauterize and sclerose to stop blood supply, followed by resection
    • Causes soap bubble appearance, bleeding in the sulcus, pain, swelling, and bruits
    • AV malformation causes a "wiggly" radiolucency and tooth mobility

Mixed Non-Odontogenic Lesions

  • Hyperparathyroidism / Brown Tumor:
    • Affects individuals aged 30-60
    • Located in the anterior mandible
    • Treatment involves treating HPT
  • Osteoma:
    • Affects individuals aged 10-20
    • Located at the mandibular angle and condyle
    • Multiple osteomas may indicate Gardner's Syndrome
  • Osteoid Osteoma/Osteoblastoma:
    • Affects individuals before age 30
    • Located in the posterior mandible
    • Treatment includes Excision, curettage, and monitoring

Radiopaque Non-Odontogenic Lesions

  • Cemento-Osseous Dysplasia (COD):
    • Occurs in individuals aged 30+
    • Periapical COD occurs in anterior mandible, Focal COD in posterior mandible, Florid COD in multiple quadrants
    • Vital Teeth
    • FCOD: Contraindicated for implants
    • FCOD: Ground glass
  • Ossifying Fibroma:
    • Occurs in young female adults aged 20-30
    • Located in the posterior mandible
    • Treated with surgical removal
    • Downward Bowing,Unilocular at first- Mixed RL
    • Vital teeth, Round
    • FCOD: Ground glass
  • Juvenile Ossifying Fibroma:
    • Occurs in individuals aged <15
    • Found in the Mx>MD
    • Aggressive rapid growth
    • Needs bone
    • FCOD: Ground glass

Radiopaque Non-Odontogenic Lesions

  • Dense Bone Island:
    • Located in the MD
    • No tx
    • No RL rim
  • Fibrous Dysplasia:
    • Occurs in young patients
    • Located in the Mx>MD
    • No tx
    • Unilateral Swelling
    • FCOD: Ground glass

Malignancy

  • More common in younger patients

Malignant Tumors

  • Ameloblastic Fibrosarcoma:
    • Located in the mandible
    • Treated via excision
    • Rapid Growth
  • Langerhans Cell Histiocytosis:
    • Occurs 0-10 yo
    • Located in the MD (Skull, rib)
    • Teeth floating in the air
  • Ewing Sarcoma:
    • Occurs 5-30yo
    • Located on the MD
    • Chemo, RT, Surgery
  • Chondrosarcoma:
    • Occurs in individuals in their 20s
    • Excision is not responsive to RT or chemo
    • Painless swelling, loose teeth
  • Osteosarcoma:
    • Occurs in individuals 30 yo
    • Chemo, then surgery
  • Ewing Sarcoma: Similar to above

Older population-Malignant Tumors

  • Multiple Myeloma: -Occurs in individuals 40+
    • Ramus location
    • Macroglossia, Punched Out RL
  • Metastasis to the jaw:
    • Occurs in individuals 40+
    • Check history
  • SCC:
  • Occurs in individuals 40+
  • Tongue location most common
  • Vasculature

Infant Cysts

  • Bohn Nodules:
    • Benign and usually resolve on their own
    • Newborns tend to have this cysts
    • Over the HP junction
  • Epstein Pearls:
    • Most likely located along median palatal raphae
    • Typically occurs in newborns
  • Congenital epulis:
  • Most likely located on anterior gingiva at birth
  • Tx: Excision
  • Melanotic Neuroectodermal tumor of infancy:
    • Most likely located on Anterior MX
    • Tx: Excision

Soft tissue cysts

  • Dermoid cyst:
    • Ant FOM Location most common
    • Doughy, rubbery

Eruption Cyst

  • dome shaped swelling

This is a more detailed version, including key words from the original summary as well as common treatments.

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