Podcast
Questions and Answers
Which fatty acid is considered an essential fatty acid and must be obtained through diet?
Which fatty acid is considered an essential fatty acid and must be obtained through diet?
- Linoleic acid (correct)
- Stearic acid
- Myristic acid
- Palmitic acid
What is the maximum recommended percentage of total calories that should come from fat in the diet?
What is the maximum recommended percentage of total calories that should come from fat in the diet?
- 45%
- 30% (correct)
- 15%
- 60%
Which of the following is a main derivative of alpha-linolenic acid (ALA)?
Which of the following is a main derivative of alpha-linolenic acid (ALA)?
- Butyric acid
- Hexanoic acid
- Eicosapentaenoic acid (EPA) (correct)
- Capric acid
Which statement about micronutrients is true?
Which statement about micronutrients is true?
Which of the following is NOT one of the essential fatty acids?
Which of the following is NOT one of the essential fatty acids?
What are the daily energy values for macronutrients?
What are the daily energy values for macronutrients?
What is the primary function of vitamins in the body?
What is the primary function of vitamins in the body?
How can micronutrient deficiencies be prevented?
How can micronutrient deficiencies be prevented?
Which role is NOT associated with cellular health?
Which role is NOT associated with cellular health?
Which type of carbohydrate is primarily a storage form in plants?
Which type of carbohydrate is primarily a storage form in plants?
What is the primary function of dietary fiber in the diet?
What is the primary function of dietary fiber in the diet?
Which of the following statements correctly describes disaccharides?
Which of the following statements correctly describes disaccharides?
What happens to excess glucose in the body when glycogen storage is full?
What happens to excess glucose in the body when glycogen storage is full?
What is the primary risk associated with excessive intake of vitamin A?
What is the primary risk associated with excessive intake of vitamin A?
Which statement about proteins is true?
Which statement about proteins is true?
Which vitamin has a recommended dietary allowance of 90.0 mg for males aged 19-70?
Which vitamin has a recommended dietary allowance of 90.0 mg for males aged 19-70?
What deficiency is associated with vitamin D?
What deficiency is associated with vitamin D?
What is a common characteristic of cellulose?
What is a common characteristic of cellulose?
How much dietary fiber is suggested for daily intake?
How much dietary fiber is suggested for daily intake?
What is the upper intake level (UL) for vitamin C per day?
What is the upper intake level (UL) for vitamin C per day?
Which food source is richest in vitamin A?
Which food source is richest in vitamin A?
Which vitamin can lead to hypercalcemia when taken in excess?
Which vitamin can lead to hypercalcemia when taken in excess?
What is the solubility of vitamin C?
What is the solubility of vitamin C?
What condition arises due to a deficiency in vitamin C?
What condition arises due to a deficiency in vitamin C?
Which of the following is a symptom of vitamin D megadosage?
Which of the following is a symptom of vitamin D megadosage?
What is the chemical name for vitamin D3?
What is the chemical name for vitamin D3?
What is the role of peptide bonds in proteins?
What is the role of peptide bonds in proteins?
Which of the following amino acids is considered essential and must be obtained from food?
Which of the following amino acids is considered essential and must be obtained from food?
What differentiates complete proteins from incomplete proteins?
What differentiates complete proteins from incomplete proteins?
Which structure of a protein is characterized by hydrophilic and hydrophobic interactions?
Which structure of a protein is characterized by hydrophilic and hydrophobic interactions?
What is the minimal daily protein requirement for an adult weighing 70 kg?
What is the minimal daily protein requirement for an adult weighing 70 kg?
What is the primary function of immunoglobulins?
What is the primary function of immunoglobulins?
What is the composition of triglycerides?
What is the composition of triglycerides?
Which function is associated with rhodopsin?
Which function is associated with rhodopsin?
Which of the following is a characteristic of animal origin proteins compared to plant origin proteins?
Which of the following is a characteristic of animal origin proteins compared to plant origin proteins?
Which type of the following interactions is NOT involved in protein tertiary structure formation?
Which type of the following interactions is NOT involved in protein tertiary structure formation?
Which of the following is a function of potassium?
Which of the following is a function of potassium?
What is the tolerable upper intake level of magnesium for adults?
What is the tolerable upper intake level of magnesium for adults?
What type of mineral is calcium categorized as?
What type of mineral is calcium categorized as?
What deficiency symptom is associated with iron?
What deficiency symptom is associated with iron?
Which of the following food sources is highest in phosphorus?
Which of the following food sources is highest in phosphorus?
What is the recommended daily intake of sodium for adults?
What is the recommended daily intake of sodium for adults?
What is a consequence of iron toxicity?
What is a consequence of iron toxicity?
Which mineral is necessary for the synthesis of thyroxine?
Which mineral is necessary for the synthesis of thyroxine?
What is the daily recommended intake for magnesium for women aged 19-30 years?
What is the daily recommended intake for magnesium for women aged 19-30 years?
What can occur as a result of potassium toxicity?
What can occur as a result of potassium toxicity?
Which of the following is a common symptom of vitamin B12 deficiency?
Which of the following is a common symptom of vitamin B12 deficiency?
What is the recommended dietary allowance of vitamin E for males aged 19–70?
What is the recommended dietary allowance of vitamin E for males aged 19–70?
Which vitamin is associated with a deficiency that can lead to hemolytic anemia?
Which vitamin is associated with a deficiency that can lead to hemolytic anemia?
What is the active form of vitamin D after it undergoes conversion in the kidneys?
What is the active form of vitamin D after it undergoes conversion in the kidneys?
What are the symptoms associated with vitamin B6 deficiency?
What are the symptoms associated with vitamin B6 deficiency?
Which of the following vitamins is considered a fat-soluble vitamin?
Which of the following vitamins is considered a fat-soluble vitamin?
What is the upper intake level for vitamin B3 before it may cause adverse effects?
What is the upper intake level for vitamin B3 before it may cause adverse effects?
What is a common food source of vitamin B5?
What is a common food source of vitamin B5?
What serious effect can result from an overdose of vitamin K in patients taking warfarin?
What serious effect can result from an overdose of vitamin K in patients taking warfarin?
Which vitamin deficiency is primarily linked to the condition known as beriberi?
Which vitamin deficiency is primarily linked to the condition known as beriberi?
What is a recommended dietary allowance for vitamin B9 for males aged 19–70?
What is a recommended dietary allowance for vitamin B9 for males aged 19–70?
What is the consequence of a deficiency in vitamin B7?
What is the consequence of a deficiency in vitamin B7?
What role do minerals play in the body?
What role do minerals play in the body?
What type of malnutrition is characterized by a lack of both protein and non-protein nutrients?
What type of malnutrition is characterized by a lack of both protein and non-protein nutrients?
What does severe acute malnutrition (SAM) indicate regarding weight for height ratio?
What does severe acute malnutrition (SAM) indicate regarding weight for height ratio?
Which of the following groups of malnutrition includes overweight and obesity?
Which of the following groups of malnutrition includes overweight and obesity?
Which condition is primarily characterized by growth retardation and loss of muscle mass due to nutrient deficient diets?
Which condition is primarily characterized by growth retardation and loss of muscle mass due to nutrient deficient diets?
According to the World Health Organization, what broad group of conditions includes stunting, wasting, and underweight?
According to the World Health Organization, what broad group of conditions includes stunting, wasting, and underweight?
What is the primary characteristic of kwashiorkor?
What is the primary characteristic of kwashiorkor?
What condition is characterized by involuntary weight loss and metabolic alterations due to chronic illness?
What condition is characterized by involuntary weight loss and metabolic alterations due to chronic illness?
Which of the following symptoms is NOT commonly associated with anorexia nervosa?
Which of the following symptoms is NOT commonly associated with anorexia nervosa?
Which factor contributes to the hypercatabolic state observed in cachexia?
Which factor contributes to the hypercatabolic state observed in cachexia?
What common gastrointestinal behavior is associated with bulimia?
What common gastrointestinal behavior is associated with bulimia?
In which scenario is kwashiorkor most likely to develop?
In which scenario is kwashiorkor most likely to develop?
What is a key endocrine effect of anorexia nervosa?
What is a key endocrine effect of anorexia nervosa?
Which of the following does NOT typically occur in patients with cachexia?
Which of the following does NOT typically occur in patients with cachexia?
What is the primary benefit of including bioactive compounds in functional foods?
What is the primary benefit of including bioactive compounds in functional foods?
Which of the following foods is rich in Omega-3 fatty acids and known for its potential to reduce the risk of heart disease?
Which of the following foods is rich in Omega-3 fatty acids and known for its potential to reduce the risk of heart disease?
Which characteristic differentiates functional foods from conventional foods?
Which characteristic differentiates functional foods from conventional foods?
What role do phytochemicals play in functional foods?
What role do phytochemicals play in functional foods?
Which of the following is NOT considered a characteristic or component of functional foods?
Which of the following is NOT considered a characteristic or component of functional foods?
What is a health claim that can often be associated with whole grains?
What is a health claim that can often be associated with whole grains?
In the context of functional foods, what do probiotics specifically contribute to human health?
In the context of functional foods, what do probiotics specifically contribute to human health?
How do organic sulfur compounds in foods like garlic and onion contribute to health?
How do organic sulfur compounds in foods like garlic and onion contribute to health?
What role does enhancing the intestinal barrier function play in health?
What role does enhancing the intestinal barrier function play in health?
How does modulation of the immune system contribute to gut health?
How does modulation of the immune system contribute to gut health?
What is a function of probiotics in relation to pathogenic bacteria?
What is a function of probiotics in relation to pathogenic bacteria?
What key process does Nicotinamide mononucleotide (NMN) promote in human cells?
What key process does Nicotinamide mononucleotide (NMN) promote in human cells?
What are some effects of declining NAD+ levels in the body?
What are some effects of declining NAD+ levels in the body?
Which of the following is NOT a component of Nicotinamide mononucleotide (NMN)?
Which of the following is NOT a component of Nicotinamide mononucleotide (NMN)?
What is a primary function of NAD+ within the human body?
What is a primary function of NAD+ within the human body?
Which statement accurately contrasts the roles of probiotics and NMN in health?
Which statement accurately contrasts the roles of probiotics and NMN in health?
What is the relationship between DNA damage and NAD+ levels as people age?
What is the relationship between DNA damage and NAD+ levels as people age?
Which precursor is considered one of the last steps in the NAD+ synthesis pathway?
Which precursor is considered one of the last steps in the NAD+ synthesis pathway?
Which enzyme is responsible for converting N-formylkynurenine to L-kynurenine during NAD+ biosynthesis?
Which enzyme is responsible for converting N-formylkynurenine to L-kynurenine during NAD+ biosynthesis?
What role does Poly ADP-ribose polymerase (PARP) play in the context of aging?
What role does Poly ADP-ribose polymerase (PARP) play in the context of aging?
Which process can help boost NAD+ levels in mammals?
Which process can help boost NAD+ levels in mammals?
What can excessive DNA damage in mitochondria lead to?
What can excessive DNA damage in mitochondria lead to?
Which of the following statements is true regarding NAD+ and sirtuins?
Which of the following statements is true regarding NAD+ and sirtuins?
What is the main cause of aging according to the cellular processes described?
What is the main cause of aging according to the cellular processes described?
What is the initial conversion of nicotinic acid in the Preiss-Handler pathway?
What is the initial conversion of nicotinic acid in the Preiss-Handler pathway?
Which enzyme is primarily responsible for recycling nicotinamide to nicotinic acid mononucleotide (NMN) in the salvage pathway?
Which enzyme is primarily responsible for recycling nicotinamide to nicotinic acid mononucleotide (NMN) in the salvage pathway?
What effect does age-related reduction in NAD+ levels have on health?
What effect does age-related reduction in NAD+ levels have on health?
Which of the following transporters is responsible for importing nicotinamide riboside (NR) into the cell?
Which of the following transporters is responsible for importing nicotinamide riboside (NR) into the cell?
What is the final product of the Preiss-Handler pathway?
What is the final product of the Preiss-Handler pathway?
Which enzyme functions characteristically to convert nicotinamide to nicotinic acid mononucleotide (NMN) in the salvage pathway?
Which enzyme functions characteristically to convert nicotinamide to nicotinic acid mononucleotide (NMN) in the salvage pathway?
What role do sirtuins (SIRTs) play in cellular function?
What role do sirtuins (SIRTs) play in cellular function?
What facilitates the excretion of nicotinamide mononucleotide (NMN) through urine?
What facilitates the excretion of nicotinamide mononucleotide (NMN) through urine?
Flashcards
Carbohydrates
Carbohydrates
A quick source of energy for the body.
Starch
Starch
A complex carbohydrate made up of many glucose units linked together. It's the main source of glucose in your diet.
Glycogen
Glycogen
A complex carbohydrate that's the storage form of glucose in humans, found mainly in muscles and liver.
Cellulose (Dietary Fiber)
Cellulose (Dietary Fiber)
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Insoluble Fiber
Insoluble Fiber
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Amino Acids
Amino Acids
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Proteins
Proteins
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Protein Digestion
Protein Digestion
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Peptide Bond
Peptide Bond
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Primary Structure
Primary Structure
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Secondary Structure
Secondary Structure
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Tertiary Structure
Tertiary Structure
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Quaternary Structure
Quaternary Structure
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Essential Amino Acids
Essential Amino Acids
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Complete Protein
Complete Protein
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Incomplete Protein
Incomplete Protein
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Triglyceride
Triglyceride
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What are vitamins?
What are vitamins?
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What are water-soluble vitamins?
What are water-soluble vitamins?
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What are fat-soluble vitamins?
What are fat-soluble vitamins?
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What is Vitamin A?
What is Vitamin A?
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What is a symptom of Vitamin A deficiency?
What is a symptom of Vitamin A deficiency?
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What is Vitamin C?
What is Vitamin C?
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What is a symptom of Vitamin C deficiency?
What is a symptom of Vitamin C deficiency?
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What is Vitamin D?
What is Vitamin D?
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What are symptoms of Vitamin D deficiency?
What are symptoms of Vitamin D deficiency?
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What is hypervitaminosis A?
What is hypervitaminosis A?
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What are essential fatty acids?
What are essential fatty acids?
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What are the two major types of essential fatty acids?
What are the two major types of essential fatty acids?
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What is Linoleic Acid (LA) and what is it used for?
What is Linoleic Acid (LA) and what is it used for?
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What is Arachidonic acid and what does it do?
What is Arachidonic acid and what does it do?
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What is Alpha-linolenic acid (ALA) and what does it convert to?
What is Alpha-linolenic acid (ALA) and what does it convert to?
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What are EPA and DHA?
What are EPA and DHA?
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What are Micronutrients?
What are Micronutrients?
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Major Minerals
Major Minerals
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Trace Minerals
Trace Minerals
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Calcium
Calcium
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Calcium Deficiency
Calcium Deficiency
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Phosphorus
Phosphorus
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Magnesium
Magnesium
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Potassium
Potassium
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Sodium
Sodium
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Iron
Iron
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Iodine
Iodine
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Vitamin D
Vitamin D
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Vitamin E (Tocophenols)
Vitamin E (Tocophenols)
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Vitamin K
Vitamin K
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Vitamin B Complex
Vitamin B Complex
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Vitamin B1 (Thiamine)
Vitamin B1 (Thiamine)
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Vitamin B2 (Riboflavin)
Vitamin B2 (Riboflavin)
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Vitamin B3 (Niacin)
Vitamin B3 (Niacin)
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Vitamin B5 (Pantothenic Acid)
Vitamin B5 (Pantothenic Acid)
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Vitamin B6 (Pyridoxine)
Vitamin B6 (Pyridoxine)
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Vitamin B7 (Biotin)
Vitamin B7 (Biotin)
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Vitamin B9 (Folic Acid)
Vitamin B9 (Folic Acid)
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Vitamin B12 (Cobalamin)
Vitamin B12 (Cobalamin)
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Minerals
Minerals
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Marasmus
Marasmus
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Kwashiorkor
Kwashiorkor
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Cachexia
Cachexia
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Anorexia Nervosa
Anorexia Nervosa
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Bulimia Nervosa
Bulimia Nervosa
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Bulimia
Bulimia
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Muscle wasting
Muscle wasting
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Generalized or dependent edema
Generalized or dependent edema
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Concurrent Infections
Concurrent Infections
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Functional Foods
Functional Foods
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Bioactive Compounds
Bioactive Compounds
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Health Claims
Health Claims
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Phytochemicals
Phytochemicals
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Soy Foods
Soy Foods
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Green/Black Tea
Green/Black Tea
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Fatty Fish
Fatty Fish
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Yogurt and Some Dairy Products
Yogurt and Some Dairy Products
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Intestinal Barrier Enhancement
Intestinal Barrier Enhancement
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Immune System Modulation
Immune System Modulation
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Dietary Component Metabolism
Dietary Component Metabolism
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Reduction of Pathogenic Bacteria
Reduction of Pathogenic Bacteria
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What is Nicotinamide Mononucleotide (NMN)?
What is Nicotinamide Mononucleotide (NMN)?
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How does NMN work?
How does NMN work?
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What is Nicotinamide adenine dinucleotide (NAD+)?
What is Nicotinamide adenine dinucleotide (NAD+)?
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How is NAD+ related to aging?
How is NAD+ related to aging?
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What is the primary cause of aging?
What is the primary cause of aging?
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What is DNA repair?
What is DNA repair?
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What is PARP?
What is PARP?
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What is NAD+?
What is NAD+?
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How does NAD+ depletion occur during aging?
How does NAD+ depletion occur during aging?
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What are NAD+ precursors?
What are NAD+ precursors?
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What is NMN?
What is NMN?
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What is the de novo pathway?
What is the de novo pathway?
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Preiss-Handler Pathway
Preiss-Handler Pathway
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Salvage Pathway
Salvage Pathway
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NAD+
NAD+
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Nicotinic Acid Phosphoribosyltransferase (NAPRT)
Nicotinic Acid Phosphoribosyltransferase (NAPRT)
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Nicotinamide Mononucleotide Adenylyltransferases (NMNAT1-3)
Nicotinamide Mononucleotide Adenylyltransferases (NMNAT1-3)
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NAD+ Synthetase (NADS)
NAD+ Synthetase (NADS)
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Intracellular Nicotinamide Phosphoribosyltransferase (iNAMPT)
Intracellular Nicotinamide Phosphoribosyltransferase (iNAMPT)
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Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)
Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)
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Study Notes
BIOL 2006SEF: CELLS IN HEALTH AND DISEASE - TOPIC 5: CELLULAR HEALTH AND NUTRITION I
- The course is BIOL 2006SEF, Cells in Health and Disease, Topic 5: Cellular Health and Nutrition I, taught by Heidi Wong.
Outline
-
Importance of Cellular Health:
- Organ and Tissue Function
- Energy Production
- Growth, Repair and Regeneration
- Immune System Function
- Detoxification and Waste Removal
- Cellular Communication
- Disease Prevention
- Aging and Longevity
-
Macronutrients:
- Carbohydrates
- Protein
- Fats
-
Micronutrients:
- Vitamins
- Minerals
-
Healthy Eating Food Pyramid (for adults) (diagram): A pyramid displaying recommended daily intake amounts for various food groups, including fats, oils, salts and sugars, meat, fish, eggs, vegetables, grains, fruits, milk, and alternatives. Recommended fluid intake is also shown.
Carbohydrates
- Provides quick energy.
- Monosaccharides: 6-carbon molecules (glucose, fructose, galactose).
- Disaccharides: 2 monosaccharides joined (maltose, sucrose, lactose).
- Polysaccharides: Long chains of glucose (starch, glycogen, cellulose).
- Carbohydrates stored as glycogen in muscle and liver, or fat in adipose tissue when excess.
- Starch: Storage form in plants.
- Glycogen: Storage form in animals.
- Cellulose: Dietary fiber, structural component in plants.
- Insoluble in water.
- Cannot be digested by the body.
- Increases bulk in stool and aids in digestion.
- Suggested intake of insoluble fiber: not less than 25 g per day.
- Soluble fiber is also a component of total dietary fiber.
Proteins
- Composed of amino acids (AA).
- Essential for building and repairing tissues.
- Basic Structure: Central carbon atom bound to:
- Amine group (NH2)
- Carboxylic acid group (COOH)
- Hydrogen atom (H)
- Variable side chain (R)
- Primary Structure: Sequence of AAs linked by peptide bonds.
- Secondary Structure: Weak electrical attractions between AAs leading to α-helix structures or β-pleated sheet structures.
- Tertiary Structure: Hydrophilic and hydrophobic interactions fold the polypeptide chain into a 3D structure.
- Quaternary Structure: Two or more polypeptide chains associate to form a functional protein.
- Essential amino acids: 9 cannot be synthesized by the body.
- Minimal daily protein requirements are 0.8 grams per kilogram of body weight. If intake exceeds the body’s need, the surplus is converted to fat and stored in adipose tissue.
- Complete protein sources (animal origin) are slightly more digestible than incomplete sources (plant origin).
- Complete Protein Sources: High in essential amino acids.
- Incomplete Protein Sources: Do not contain all essential amino acids—must combine sources for a complete profile.
Fats (Lipids)
- Triglycerides: Function as long-term energy stores in animals and plants.
- Phospholipids: Structural components of cell membranes.
- Steroids: hormones and structural components (e.g., cholesterol).
- Waxes: protective layer against water loss in plants and animals.
- Carotenoids: light-absorbing pigments in plants.
- Glycolipids: Cell receptor and recognition molecules.
- Two major types of essential fatty acids:
- Omega-6 (e.g., linoleic acid (LA))
- Omega-3 (e.g., alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA))
- Fat intake should be less than 30% of total daily calories.
- Different types of fatty acids (saturated, trans, monounsaturated, polyunsaturated) are described and linked to their sources (e.g., beef, butter, coconut oil, margarine, olive oil, canola oil, peanut oil, soybean oil, corn oil, fatty fish) and health impacts.
Vitamins
- Organic compounds that function with enzymes to convert food into energy.
- Classified into water-soluble and fat-soluble categories.
- Water-soluble vitamins dissolve in water, can't be stored and are lost via urine.
- Fat-soluble vitamins dissolve in fat, can be stored in the body. Different specific vitamins (Vitamin A, C, D, E, K, and B complex vitamins) and their characteristics are detailed regarding chemical names, solubility, recommended daily allowances, deficiencies, and toxicities.
Minerals
- Inorganic substances necessary for proper functioning of cells.
- Two categories:
- Major minerals (needed in amounts greater than 100 mg per day) (e.g., Calcium, phosphorus, magnesium, potassium, sodium, and others.)
- Trace minerals (needed in amounts less than 100 mg per day) (e.g., iron, iodine, and others) Detailed DRI (Dietary Reference Intakes) and Upper Intake Levels (UL) are provided for each mineral.
Energy
- Energetic expenditure per day is approximately 2400-2500 kcal or 35 kcal/kg.
- 1g carbohydrates = 4 kcal
- 1g protein = 4 kcal
- 1g fat = 9 kcal
- Energy balance (input=expenditure) is needed to maintain weight.
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