Nutrition Essentials Quiz

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Questions and Answers

Which fatty acid is considered an essential fatty acid and must be obtained through diet?

  • Linoleic acid (correct)
  • Stearic acid
  • Myristic acid
  • Palmitic acid

What is the maximum recommended percentage of total calories that should come from fat in the diet?

  • 45%
  • 30% (correct)
  • 15%
  • 60%

Which of the following is a main derivative of alpha-linolenic acid (ALA)?

  • Butyric acid
  • Hexanoic acid
  • Eicosapentaenoic acid (EPA) (correct)
  • Capric acid

Which statement about micronutrients is true?

<p>They include vitamins and minerals that support enzyme production. (C)</p> Signup and view all the answers

Which of the following is NOT one of the essential fatty acids?

<p>Arachidonic acid (C)</p> Signup and view all the answers

What are the daily energy values for macronutrients?

<p>1 g Lipids = 9 kcal (A)</p> Signup and view all the answers

What is the primary function of vitamins in the body?

<p>Help produce enzymes and hormones. (B)</p> Signup and view all the answers

How can micronutrient deficiencies be prevented?

<p>Through nutrition education and a diverse diet. (B)</p> Signup and view all the answers

Which role is NOT associated with cellular health?

<p>Increased toxicity levels (B)</p> Signup and view all the answers

Which type of carbohydrate is primarily a storage form in plants?

<p>Starch (A)</p> Signup and view all the answers

What is the primary function of dietary fiber in the diet?

<p>Increases bulk to stool (A)</p> Signup and view all the answers

Which of the following statements correctly describes disaccharides?

<p>They consist of two monosaccharides joined together. (C)</p> Signup and view all the answers

What happens to excess glucose in the body when glycogen storage is full?

<p>It is converted into fat in adipose tissue. (C)</p> Signup and view all the answers

What is the primary risk associated with excessive intake of vitamin A?

<p>Hypervitaminosis A (B)</p> Signup and view all the answers

Which statement about proteins is true?

<p>They play a critical role in tissue repair. (D)</p> Signup and view all the answers

Which vitamin has a recommended dietary allowance of 90.0 mg for males aged 19-70?

<p>Vitamin C (A)</p> Signup and view all the answers

What deficiency is associated with vitamin D?

<p>Rickets (D)</p> Signup and view all the answers

What is a common characteristic of cellulose?

<p>It provides structural support to plant cells. (B)</p> Signup and view all the answers

How much dietary fiber is suggested for daily intake?

<p>At least 25 grams (C)</p> Signup and view all the answers

What is the upper intake level (UL) for vitamin C per day?

<p>2,000 μg (A)</p> Signup and view all the answers

Which food source is richest in vitamin A?

<p>Liver (C)</p> Signup and view all the answers

Which vitamin can lead to hypercalcemia when taken in excess?

<p>Vitamin D (D)</p> Signup and view all the answers

What is the solubility of vitamin C?

<p>Water-soluble (B)</p> Signup and view all the answers

What condition arises due to a deficiency in vitamin C?

<p>Scurvy (B)</p> Signup and view all the answers

Which of the following is a symptom of vitamin D megadosage?

<p>Nausea and vomiting (A)</p> Signup and view all the answers

What is the chemical name for vitamin D3?

<p>Cholecalciferol (A)</p> Signup and view all the answers

What is the role of peptide bonds in proteins?

<p>They link amino acids together to form polypeptide chains. (D)</p> Signup and view all the answers

Which of the following amino acids is considered essential and must be obtained from food?

<p>Leucine (A)</p> Signup and view all the answers

What differentiates complete proteins from incomplete proteins?

<p>Incomplete proteins lack one or more essential amino acids. (A)</p> Signup and view all the answers

Which structure of a protein is characterized by hydrophilic and hydrophobic interactions?

<p>Tertiary structure (D)</p> Signup and view all the answers

What is the minimal daily protein requirement for an adult weighing 70 kg?

<p>56 grams (B)</p> Signup and view all the answers

What is the primary function of immunoglobulins?

<p>Protect against specific antigens. (C)</p> Signup and view all the answers

What is the composition of triglycerides?

<p>Three long-chain fatty acids joined to a glycerol molecule. (B)</p> Signup and view all the answers

Which function is associated with rhodopsin?

<p>Detection of light in the retina. (D)</p> Signup and view all the answers

Which of the following is a characteristic of animal origin proteins compared to plant origin proteins?

<p>Animal proteins are typically richer in essential amino acids. (A)</p> Signup and view all the answers

Which type of the following interactions is NOT involved in protein tertiary structure formation?

<p>Peptide bonds (D)</p> Signup and view all the answers

Which of the following is a function of potassium?

<p>Maintains normal fluid and electrolyte balance (A)</p> Signup and view all the answers

What is the tolerable upper intake level of magnesium for adults?

<p>350 mg/day (A)</p> Signup and view all the answers

What type of mineral is calcium categorized as?

<p>Major mineral (D)</p> Signup and view all the answers

What deficiency symptom is associated with iron?

<p>Anemia and fatigue (A)</p> Signup and view all the answers

Which of the following food sources is highest in phosphorus?

<p>Cottage cheese (D)</p> Signup and view all the answers

What is the recommended daily intake of sodium for adults?

<p>1,500 mg/day (C)</p> Signup and view all the answers

What is a consequence of iron toxicity?

<p>GI distress and organ damage (D)</p> Signup and view all the answers

Which mineral is necessary for the synthesis of thyroxine?

<p>Iodine (B)</p> Signup and view all the answers

What is the daily recommended intake for magnesium for women aged 19-30 years?

<p>310 mg/day (A)</p> Signup and view all the answers

What can occur as a result of potassium toxicity?

<p>Muscle weakness and vomiting (C)</p> Signup and view all the answers

Which of the following is a common symptom of vitamin B12 deficiency?

<p>Megaloblastic anemia (B)</p> Signup and view all the answers

What is the recommended dietary allowance of vitamin E for males aged 19–70?

<p>15 μg (A)</p> Signup and view all the answers

Which vitamin is associated with a deficiency that can lead to hemolytic anemia?

<p>Vitamin E (A)</p> Signup and view all the answers

What is the active form of vitamin D after it undergoes conversion in the kidneys?

<p>Calcitriol (D)</p> Signup and view all the answers

What are the symptoms associated with vitamin B6 deficiency?

<p>Peripheral neuropathy (C)</p> Signup and view all the answers

Which of the following vitamins is considered a fat-soluble vitamin?

<p>Vitamin K (D)</p> Signup and view all the answers

What is the upper intake level for vitamin B3 before it may cause adverse effects?

<p>2 g (C)</p> Signup and view all the answers

What is a common food source of vitamin B5?

<p>Meat (D)</p> Signup and view all the answers

What serious effect can result from an overdose of vitamin K in patients taking warfarin?

<p>Increased coagulation (D)</p> Signup and view all the answers

Which vitamin deficiency is primarily linked to the condition known as beriberi?

<p>Vitamin B1 (B)</p> Signup and view all the answers

What is a recommended dietary allowance for vitamin B9 for males aged 19–70?

<p>400 μg (B)</p> Signup and view all the answers

What is the consequence of a deficiency in vitamin B7?

<p>Dermatitis (C)</p> Signup and view all the answers

What role do minerals play in the body?

<p>They are necessary for proper functioning of body cells (D)</p> Signup and view all the answers

What type of malnutrition is characterized by a lack of both protein and non-protein nutrients?

<p>Marasmus (C)</p> Signup and view all the answers

What does severe acute malnutrition (SAM) indicate regarding weight for height ratio?

<p>Weight for height ratio below 3 standard deviations (D)</p> Signup and view all the answers

Which of the following groups of malnutrition includes overweight and obesity?

<p>Diet-related noncommunicable diseases (D)</p> Signup and view all the answers

Which condition is primarily characterized by growth retardation and loss of muscle mass due to nutrient deficient diets?

<p>Marasmus (B)</p> Signup and view all the answers

According to the World Health Organization, what broad group of conditions includes stunting, wasting, and underweight?

<p>Undernutrition (D)</p> Signup and view all the answers

What is the primary characteristic of kwashiorkor?

<p>Protein deficiency in diet (A)</p> Signup and view all the answers

What condition is characterized by involuntary weight loss and metabolic alterations due to chronic illness?

<p>Cachexia (C)</p> Signup and view all the answers

Which of the following symptoms is NOT commonly associated with anorexia nervosa?

<p>Increased bone density (D)</p> Signup and view all the answers

Which factor contributes to the hypercatabolic state observed in cachexia?

<p>Tumor-derived cachectic factors (B)</p> Signup and view all the answers

What common gastrointestinal behavior is associated with bulimia?

<p>Binge eating followed by vomiting (A)</p> Signup and view all the answers

In which scenario is kwashiorkor most likely to develop?

<p>Child weaned too early and fed a carbohydrate-heavy diet (D)</p> Signup and view all the answers

What is a key endocrine effect of anorexia nervosa?

<p>Decreased secretion of gonadotropin-releasing hormone (C)</p> Signup and view all the answers

Which of the following does NOT typically occur in patients with cachexia?

<p>Metabolic alkalosis (A)</p> Signup and view all the answers

What is the primary benefit of including bioactive compounds in functional foods?

<p>They can support various bodily functions and improve overall health (A)</p> Signup and view all the answers

Which of the following foods is rich in Omega-3 fatty acids and known for its potential to reduce the risk of heart disease?

<p>Fatty Fish (B)</p> Signup and view all the answers

Which characteristic differentiates functional foods from conventional foods?

<p>Functional foods have specific health benefits recognized by research (B)</p> Signup and view all the answers

What role do phytochemicals play in functional foods?

<p>They may reduce the risk of certain cancers and diseases (D)</p> Signup and view all the answers

Which of the following is NOT considered a characteristic or component of functional foods?

<p>High amounts of added sugars (D)</p> Signup and view all the answers

What is a health claim that can often be associated with whole grains?

<p>Reduce the risk of cancer and heart disease (A)</p> Signup and view all the answers

In the context of functional foods, what do probiotics specifically contribute to human health?

<p>They enhance the body’s immune defense (A)</p> Signup and view all the answers

How do organic sulfur compounds in foods like garlic and onion contribute to health?

<p>They reduce the risk of cancer and heart disease (C)</p> Signup and view all the answers

What role does enhancing the intestinal barrier function play in health?

<p>Prevents harmful substances from entering the bloodstream (C)</p> Signup and view all the answers

How does modulation of the immune system contribute to gut health?

<p>Enhances the activity of immune cells and reduces inflammation (A)</p> Signup and view all the answers

What is a function of probiotics in relation to pathogenic bacteria?

<p>Compete with pathogens for nutrients and inhibit their growth (A)</p> Signup and view all the answers

What key process does Nicotinamide mononucleotide (NMN) promote in human cells?

<p>Elevating NAD+ levels (D)</p> Signup and view all the answers

What are some effects of declining NAD+ levels in the body?

<p>Compromised genomic signaling and lower energy production (C)</p> Signup and view all the answers

Which of the following is NOT a component of Nicotinamide mononucleotide (NMN)?

<p>Amino acid (D)</p> Signup and view all the answers

What is a primary function of NAD+ within the human body?

<p>Catalyzing cellular redox reactions and metabolic processes (A)</p> Signup and view all the answers

Which statement accurately contrasts the roles of probiotics and NMN in health?

<p>Probiotics inhibit pathogenic bacteria, while NMN boosts NAD+ levels (B)</p> Signup and view all the answers

What is the relationship between DNA damage and NAD+ levels as people age?

<p>Accumulation of DNA damage causes a decrease in NAD+ concentration. (B)</p> Signup and view all the answers

Which precursor is considered one of the last steps in the NAD+ synthesis pathway?

<p>Nicotinamide mononucleotide (NMN). (A)</p> Signup and view all the answers

Which enzyme is responsible for converting N-formylkynurenine to L-kynurenine during NAD+ biosynthesis?

<p>Indoleamine 2,3-dioxygenase 1 (IDO1). (C)</p> Signup and view all the answers

What role does Poly ADP-ribose polymerase (PARP) play in the context of aging?

<p>It depletes NAD+ levels after DNA damage accumulation. (C)</p> Signup and view all the answers

Which process can help boost NAD+ levels in mammals?

<p>Caloric restriction (CR) and exercise. (A)</p> Signup and view all the answers

What can excessive DNA damage in mitochondria lead to?

<p>Further depletion of NAD+ concentrations. (B)</p> Signup and view all the answers

Which of the following statements is true regarding NAD+ and sirtuins?

<p>Sirtuins require NAD+ for their activation and are linked to anti-aging processes. (D)</p> Signup and view all the answers

What is the main cause of aging according to the cellular processes described?

<p>Accumulation of damaged DNA. (B)</p> Signup and view all the answers

What is the initial conversion of nicotinic acid in the Preiss-Handler pathway?

<p>Conversion to nicotinic acid mononucleotide (NAMN) (B)</p> Signup and view all the answers

Which enzyme is primarily responsible for recycling nicotinamide to nicotinic acid mononucleotide (NMN) in the salvage pathway?

<p>Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) (A)</p> Signup and view all the answers

What effect does age-related reduction in NAD+ levels have on health?

<p>Increased susceptibility to chronic illnesses (C)</p> Signup and view all the answers

Which of the following transporters is responsible for importing nicotinamide riboside (NR) into the cell?

<p>Unknown transporter (A)</p> Signup and view all the answers

What is the final product of the Preiss-Handler pathway?

<p>Nicotinamide adenine dinucleotide (NAD+) (D)</p> Signup and view all the answers

Which enzyme functions characteristically to convert nicotinamide to nicotinic acid mononucleotide (NMN) in the salvage pathway?

<p>Nicotinamide phosphoribosyltransferase (NAMPT) (B)</p> Signup and view all the answers

What role do sirtuins (SIRTs) play in cellular function?

<p>They regulate NAD+-consuming enzymes and are key regulators of aging. (C)</p> Signup and view all the answers

What facilitates the excretion of nicotinamide mononucleotide (NMN) through urine?

<p>Methylation by nicotinamide N-methyltransferase (NNMT) (B)</p> Signup and view all the answers

Flashcards

Carbohydrates

A quick source of energy for the body.

Starch

A complex carbohydrate made up of many glucose units linked together. It's the main source of glucose in your diet.

Glycogen

A complex carbohydrate that's the storage form of glucose in humans, found mainly in muscles and liver.

Cellulose (Dietary Fiber)

A type of carbohydrate that's not digestible by humans. It's found in plants and important for digestion.

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Insoluble Fiber

A type of fiber that doesn't dissolve in water and helps regulate bowel movement.

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Amino Acids

The building blocks of proteins, made up of a combination of carbon, hydrogen, oxygen, and nitrogen.

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Proteins

Large molecules made up of long chains of amino acids linked together. Essential for building and repairing tissues.

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Protein Digestion

The process by which the body breaks down proteins into amino acids.

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Peptide Bond

The covalent bond that links amino acids together to form a polypeptide chain.

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Primary Structure

The sequence of amino acids in a polypeptide chain.

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Secondary Structure

The local three-dimensional structure of a polypeptide chain, formed by hydrogen bonding.

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Tertiary Structure

The overall three-dimensional shape of a protein, determined by interactions between side chains.

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Quaternary Structure

The structure formed when two or more polypeptide chains interact.

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Essential Amino Acids

Amino acids that cannot be synthesized by the body and must be obtained from the diet.

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Complete Protein

Proteins that contain all the essential amino acids in a balanced proportion.

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Incomplete Protein

Proteins that lack one or more essential amino acids.

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Triglyceride

A large molecule composed of three fatty acids linked to a glycerol molecule.

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What are vitamins?

Essential micronutrients that the body needs in small amounts for proper metabolism.

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What are water-soluble vitamins?

Vitamins that dissolve in water and are not stored in the body, being excreted through urine.

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What are fat-soluble vitamins?

Vitamins that dissolve in fat and are stored in the body.

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What is Vitamin A?

A fat-soluble vitamin essential for vision, skin health, and cell growth.

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What is a symptom of Vitamin A deficiency?

Night blindness, a condition where it's difficult to see in low light.

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What is Vitamin C?

A water-soluble vitamin essential for collagen production, immune function, and wound healing.

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What is a symptom of Vitamin C deficiency?

Scurvy, a disease characterized by bleeding gums, fatigue, and joint pain.

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What is Vitamin D?

A fat-soluble vitamin essential for calcium absorption and bone health.

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What are symptoms of Vitamin D deficiency?

Rickets, a disease that causes weak bones, and osteomalacia, a disease that causes soft bones in adults.

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What is hypervitaminosis A?

A condition caused by an excess of Vitamin A, characterized by nausea, vomiting, headaches, and bone pain.

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What are essential fatty acids?

Essential fatty acids are fats that our body cannot produce on its own and must be obtained from our diet. These acids are vital for various bodily functions, including cell growth and development.

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What are the two major types of essential fatty acids?

Omega-3 and Omega-6 are the two main types of essential fatty acids. They have different structures and are involved in different processes within the body.

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What is Linoleic Acid (LA) and what is it used for?

Linoleic acid (LA) is an Omega-6 fatty acid. It's found in many plant-based oils, like sunflower and corn oil. Our body can convert it into arachidonic acid, which is also essential for various body functions.

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What is Arachidonic acid and what does it do?

Arachidonic acid is a derivative of Linoleic acid (LA). It's an Omega-6 fatty acid that plays a role in inflammation and immune responses.

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What is Alpha-linolenic acid (ALA) and what does it convert to?

Alpha-linolenic acid (ALA) is an Omega-3 fatty acid that's found in foods like flaxseed oil, chia seeds, and walnuts. The body converts it into EPA and DHA, which are also essential.

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What are EPA and DHA?

Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) are two important Omega-3 fatty acids. They're commonly found in fatty fish like salmon and tuna. These play a role in brain health, heart health, and reducing inflammation.

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What are Micronutrients?

Micronutrients are vitamins and minerals that the body needs in small quantities. They are crucial for a wide range of functions, including growth, development, and energy production.

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Major Minerals

Essential minerals required in relatively large amounts (over 100mg per day), crucial for various bodily functions.

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Trace Minerals

Minerals needed in smaller amounts (less than 100mg per day) but equally important for health.

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Calcium

Calcium is vital for strong bones and teeth, muscle function, nerve transmission, and blood clotting.

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Calcium Deficiency

Calcium deficiency can lead to stunted growth in children and bone loss (osteoporosis) in adults.

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Phosphorus

A major mineral that helps build bones and teeth, plays a role in energy metabolism, and is crucial for genetic material.

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Magnesium

A crucial mineral for bone health, nerve function, muscle contraction, and various enzymatic processes.

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Potassium

This mineral is essential for maintaining normal fluid balance, supporting nerve function, and assisting muscle contractions.

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Sodium

A mineral critical for regulating blood volume, blood pressure, and maintaining pH balance.

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Iron

Iron plays a crucial role in oxygen transport throughout the body.

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Iodine

Essential for the production of thyroid hormones, which regulate metabolism.

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Vitamin D

A fat-soluble vitamin synthesized in the skin with the help of sunlight and converted to its active form in the liver and kidney. It is essential for calcium absorption and bone health.

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Vitamin E (Tocophenols)

A group of fat-soluble vitamins with antioxidant properties that protect cell membranes from damage. They are crucial for healthy skin, nerves, and blood.

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Vitamin K

A fat-soluble vitamin essential for blood clotting and bone health. It is produced by bacteria in the gut and obtained from leafy green vegetables.

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Vitamin B Complex

A collection of eight water-soluble vitamins crucial for various metabolic processes, including energy production, cell growth, and red blood cell formation.

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Vitamin B1 (Thiamine)

A water-soluble vitamin essential for carbohydrate metabolism and nerve function. Deficiency can lead to beriberi, a neurological disorder.

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Vitamin B2 (Riboflavin)

A water-soluble vitamin essential for cell growth, energy production, and vision. Deficiency can cause skin problems like dermatitis.

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Vitamin B3 (Niacin)

A water-soluble vitamin essential for energy production, DNA repair, and healthy skin. Deficiency can cause Pellagra, a skin and neurological disorder.

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Vitamin B5 (Pantothenic Acid)

A water-soluble vitamin involved in various metabolic processes, including fatty acid synthesis and hormone production.

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Vitamin B6 (Pyridoxine)

A water-soluble vitamin crucial for protein metabolism, neurotransmitter synthesis, and red blood cell formation. It is important for brain function and overall health.

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Vitamin B7 (Biotin)

A water-soluble vitamin involved in various metabolic processes, including fatty acid synthesis, energy production, and cell growth. It is often found in raw egg yolks.

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Vitamin B9 (Folic Acid)

A water-soluble vitamin essential for DNA synthesis, cell division, and red blood cell formation. Deficiency during pregnancy can cause birth defects.

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Vitamin B12 (Cobalamin)

A water-soluble vitamin essential for cell growth, red blood cell formation, and nerve function. It is found primarily in animal products.

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Minerals

Inorganic substances that are essential for proper functioning of body cells.

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Marasmus

A severe form of malnutrition caused by a deficiency in both protein and calories. It's characterized by extreme weight loss, muscle wasting, and growth stunting.

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Kwashiorkor

A type of malnutrition characterized by severe protein deficiency, leading to swelling, edema, and changes in skin pigmentation. It mainly affects young children.

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Cachexia

A complex syndrome that involves loss of muscle mass, fatigue, and weight loss. It often occurs in chronic illness or cancer.

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Anorexia Nervosa

A serious eating disorder characterized by an intense fear of gaining weight and self-induced starvation.

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Bulimia Nervosa

An eating disorder characterized by recurrent episodes of binge eating followed by purging behaviors like vomiting or using laxatives.

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Bulimia

A eating disorder characterized by binge eating followed by self-induced vomiting or other purging behaviors.

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Muscle wasting

A state of severe protein depletion leading to a reduction in muscle mass and overall body size. It often involves burning off muscle tissue for energy due to insufficient nutrient intake.

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Generalized or dependent edema

A condition characterized by swelling and fluid retention in the body due to low protein levels in the blood. This is frequently observed in kwashiorkor due to the depletion of the visceral compartment (internal organs) and low albumin levels.

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Concurrent Infections

A state where the immune system is weakened, making the body more susceptible to infections.

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Functional Foods

Foods that provide health benefits beyond basic nutrition by containing bioactive compounds.

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Bioactive Compounds

These compounds found in functional foods have specific health-promoting effects like reducing the risk of certain diseases. Examples include phytochemicals, antioxidants, fatty acids, and probiotics.

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Health Claims

These are claims made about the health benefits of functional foods. They must be supported by scientific evidence and regulated by authorities. Examples include claims about improved heart health, digestive health, or immune function.

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Phytochemicals

Plant-derived compounds found in functional foods that may offer various health benefits.

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Soy Foods

Soy foods like tofu and soy milk are good sources of protein and isoflavones, which may reduce the risk of certain cancers and heart disease and help manage menopause symptoms.

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Green/Black Tea

Green and black tea contain catechins, powerful antioxidants that may help prevent certain cancers.

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Fatty Fish

These foods are rich in omega-3 fatty acids, which have been linked to reduced risk of heart disease and also contain probiotics that enhance the body's immune defense.

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Yogurt and Some Dairy Products

Yogurt and some dairy products are good sources of probiotics like Bifidobacteria and Lactobacilli, which can help improve gut health and boost the immune system.

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Intestinal Barrier Enhancement

The tight junctions between cells in the gut lining are strengthened, making the gut less permeable and reducing the risk of harmful substances entering the bloodstream.

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Immune System Modulation

Probiotics interact with the immune system, regulating immune responses by promoting the action of immune cells and anti-inflammatory substances, potentially reducing inflammation in the gut.

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Dietary Component Metabolism

Certain strains of probiotics break down complex carbohydrates and fibres that humans can't digest, making those nutrients available for the body to absorb and use.

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Reduction of Pathogenic Bacteria

Probiotics compete with harmful bacteria for nutrients and can also produce substances that directly inhibit their growth or kill them.

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What is Nicotinamide Mononucleotide (NMN)?

A naturally occurring molecule found in every living cell, belonging to the class of nucleotides, building blocks of RNA and DNA.

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How does NMN work?

Directly converted to NAD+ (nicotinamide adenine dinucleotide), boosting its levels and impacting various cellular processes.

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What is Nicotinamide adenine dinucleotide (NAD+)?

NAD+ is a coenzyme found in the human body, essential for metabolic processes like energy production, DNA repair, and genetic signaling.

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How is NAD+ related to aging?

Reduced NAD+ levels are implicated in aging processes, impacting energy production, genomic signaling, and DNA repair.

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What is the primary cause of aging?

The main cause of aging is the accumulation of damaged DNA.

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What is DNA repair?

The process by which cells repair damaged DNA, utilizing energy and NAD+ molecules.

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What is PARP?

A key DNA repair protein that requires NAD+ for activation, involved in combating DNA damage.

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What is NAD+?

A vital coenzyme that declines with age and plays a crucial role in DNA repair and cell functions, including sirtuin activation.

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How does NAD+ depletion occur during aging?

A naturally occurring process where NAD+ levels decrease with age, contributing to DNA damage accumulation.

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What are NAD+ precursors?

Small molecules that the body uses to synthesize NAD+, essential for maintaining healthy cell function.

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What is NMN?

One of the NAD+ precursors, involved in the final stages of NAD+ synthesis.

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What is the de novo pathway?

A crucial metabolic pathway for NAD+ production, starting with tryptophan and ultimately forming NAMN.

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Preiss-Handler Pathway

A metabolic pathway that converts nicotinic acid into NAD+, a crucial coenzyme for various metabolic processes. It involves three steps: nicotinic acid to nicotinic acid mononucleotide (NAMN), NAMN to nicotinic acid adenine dinucleotide (NAAD), and finally NAAD to NAD+. This pathway relies on specific enzymes like NAPRT, NMNAT, and NADS.

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Salvage Pathway

A metabolic pathway that recycles nicotinamide (NAM) back into NAD+. It starts by converting NAM to NMN (nicotinamide mononucleotide) via intracellular NAMPT (iNAMPT), and then to NAD+ via NMNAT. This pathway is vital in NAD+ production and is dominant in mammalian cells.

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NAD+

A crucial coenzyme in cellular metabolism, particularly involved in energy production (e.g., in glycolysis and cellular respiration) and redox reactions. It acts as a carrier of electrons, facilitating oxidation-reduction reactions within cells.

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Nicotinic Acid Phosphoribosyltransferase (NAPRT)

An enzyme responsible for converting nicotinic acid to nicotinic acid mononucleotide (NAMN), a crucial step within the Preiss-Handler pathway.

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Nicotinamide Mononucleotide Adenylyltransferases (NMNAT1-3)

A family of enzymes that convert NAMN (nicotinamide mononucleotide) to NAAD (nicotinic acid adenine dinucleotide) in the Preiss-Handler pathway. They play a critical role in the conversion of nicotinic acid to NAD+.

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NAD+ Synthetase (NADS)

An enzyme that converts NAAD (nicotinic acid adenine dinucleotide) to NAD+ in the final step of the Preiss-Handler pathway. It plays a key role in producing the essential NAD+ coenzyme.

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Intracellular Nicotinamide Phosphoribosyltransferase (iNAMPT)

An enzyme that converts nicotinamide (NAM), released from NAD+ consumption, back to NMN (nicotinamide mononucleotide) in the salvage pathway. It's crucial for recycling nicotinamide and maintaining NAD+ levels.

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Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)

An enzyme that converts NMN (nicotinamide mononucleotide) to NAD+ in the salvage pathway. It plays a crucial role in the final step of NAD+ biosynthesis from salvaged nicotinamide.

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Study Notes

BIOL 2006SEF: CELLS IN HEALTH AND DISEASE - TOPIC 5: CELLULAR HEALTH AND NUTRITION I

  • The course is BIOL 2006SEF, Cells in Health and Disease, Topic 5: Cellular Health and Nutrition I, taught by Heidi Wong.

Outline

  • Importance of Cellular Health:

    • Organ and Tissue Function
    • Energy Production
    • Growth, Repair and Regeneration
    • Immune System Function
    • Detoxification and Waste Removal
    • Cellular Communication
    • Disease Prevention
    • Aging and Longevity
  • Macronutrients:

    • Carbohydrates
    • Protein
    • Fats
  • Micronutrients:

    • Vitamins
    • Minerals
  • Healthy Eating Food Pyramid (for adults) (diagram): A pyramid displaying recommended daily intake amounts for various food groups, including fats, oils, salts and sugars, meat, fish, eggs, vegetables, grains, fruits, milk, and alternatives. Recommended fluid intake is also shown.

Carbohydrates

  • Provides quick energy.
  • Monosaccharides: 6-carbon molecules (glucose, fructose, galactose).
  • Disaccharides: 2 monosaccharides joined (maltose, sucrose, lactose).
  • Polysaccharides: Long chains of glucose (starch, glycogen, cellulose).
  • Carbohydrates stored as glycogen in muscle and liver, or fat in adipose tissue when excess.
  • Starch: Storage form in plants.
  • Glycogen: Storage form in animals.
  • Cellulose: Dietary fiber, structural component in plants.
    • Insoluble in water.
    • Cannot be digested by the body.
    • Increases bulk in stool and aids in digestion.
  • Suggested intake of insoluble fiber: not less than 25 g per day.
  • Soluble fiber is also a component of total dietary fiber.

Proteins

  • Composed of amino acids (AA).
  • Essential for building and repairing tissues.
  • Basic Structure: Central carbon atom bound to:
    • Amine group (NH2)
    • Carboxylic acid group (COOH)
    • Hydrogen atom (H)
    • Variable side chain (R)
  • Primary Structure: Sequence of AAs linked by peptide bonds.
  • Secondary Structure: Weak electrical attractions between AAs leading to α-helix structures or β-pleated sheet structures.
  • Tertiary Structure: Hydrophilic and hydrophobic interactions fold the polypeptide chain into a 3D structure.
  • Quaternary Structure: Two or more polypeptide chains associate to form a functional protein.
  • Essential amino acids: 9 cannot be synthesized by the body.
  • Minimal daily protein requirements are 0.8 grams per kilogram of body weight. If intake exceeds the body’s need, the surplus is converted to fat and stored in adipose tissue.
  • Complete protein sources (animal origin) are slightly more digestible than incomplete sources (plant origin).
  • Complete Protein Sources: High in essential amino acids.
  • Incomplete Protein Sources: Do not contain all essential amino acids—must combine sources for a complete profile.

Fats (Lipids)

  • Triglycerides: Function as long-term energy stores in animals and plants.
  • Phospholipids: Structural components of cell membranes.
  • Steroids: hormones and structural components (e.g., cholesterol).
  • Waxes: protective layer against water loss in plants and animals.
  • Carotenoids: light-absorbing pigments in plants.
  • Glycolipids: Cell receptor and recognition molecules.
  • Two major types of essential fatty acids:
    • Omega-6 (e.g., linoleic acid (LA))
    • Omega-3 (e.g., alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA))
  • Fat intake should be less than 30% of total daily calories.
  • Different types of fatty acids (saturated, trans, monounsaturated, polyunsaturated) are described and linked to their sources (e.g., beef, butter, coconut oil, margarine, olive oil, canola oil, peanut oil, soybean oil, corn oil, fatty fish) and health impacts.

Vitamins

  • Organic compounds that function with enzymes to convert food into energy.
  • Classified into water-soluble and fat-soluble categories.
  • Water-soluble vitamins dissolve in water, can't be stored and are lost via urine.
  • Fat-soluble vitamins dissolve in fat, can be stored in the body. Different specific vitamins (Vitamin A, C, D, E, K, and B complex vitamins) and their characteristics are detailed regarding chemical names, solubility, recommended daily allowances, deficiencies, and toxicities.

Minerals

  • Inorganic substances necessary for proper functioning of cells.
  • Two categories:
    • Major minerals (needed in amounts greater than 100 mg per day) (e.g., Calcium, phosphorus, magnesium, potassium, sodium, and others.)
    • Trace minerals (needed in amounts less than 100 mg per day) (e.g., iron, iodine, and others) Detailed DRI (Dietary Reference Intakes) and Upper Intake Levels (UL) are provided for each mineral.

Energy

  • Energetic expenditure per day is approximately 2400-2500 kcal or 35 kcal/kg.
  • 1g carbohydrates = 4 kcal
  • 1g protein = 4 kcal
  • 1g fat = 9 kcal
  • Energy balance (input=expenditure) is needed to maintain weight.

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