Nutrition and Metabolism Quiz
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Questions and Answers

What does the Respiratory Exchange Ratio (RER) indicate regarding energy expenditure?

  • The duration of the active and inactive periods.
  • The relative contribution of carbohydrates and lipids. (correct)
  • The total caloric intake for a day.
  • The amount of carbohydrates used exclusively.
  • Which of the following statements about caloric intake is true when eating time is restricted?

  • Subjects reported a 20% reduction in calories consumed. (correct)
  • Caloric intake was not affected by feeding time restriction.
  • Subjects showed a 20% increase in caloric intake.
  • Subjects consume more calories overall.
  • What triggers the release of insulin in the body?

  • Exercising vigorously
  • Rising blood glucose level (correct)
  • Low fat consumption
  • High protein intake
  • During which period is carbohydrate metabolism predominantly utilized according to the RER findings?

    <p>During the active period (night). (D)</p> Signup and view all the answers

    What happens to insulin release when blood glucose levels return to the set point?

    <p>It diminishes (D)</p> Signup and view all the answers

    What is the effect of the high-fat diet when compared to regular chow in terms of metabolic response?

    <p>It alters the types of metabolites used for energy. (D)</p> Signup and view all the answers

    What is the primary purpose of using mobile apps as discussed in the study by Gill and Panda?

    <p>To answer questions related to circadian rhythms and feeding. (A)</p> Signup and view all the answers

    Which hormone is released by the alpha cells of the pancreas when blood glucose levels are low?

    <p>Glucagon (A)</p> Signup and view all the answers

    What is the primary function of glucagon in the body?

    <p>Convert glycogen back to glucose (D)</p> Signup and view all the answers

    What physiological state occurs when blood glucose levels fall too low?

    <p>Hypoglycemia (B)</p> Signup and view all the answers

    How does glucose transport change in response to rising blood glucose levels?

    <p>Glucose is transported into cells and converted to glycogen (A)</p> Signup and view all the answers

    When do the alpha cells stop releasing glucagon?

    <p>When blood glucose levels rise (C)</p> Signup and view all the answers

    What occurs if insulin sensitivity decreases in the body?

    <p>Higher blood glucose levels (C)</p> Signup and view all the answers

    What primarily sets the phase of the liver peripheral oscillator?

    <p>The time of feeding (C)</p> Signup and view all the answers

    What effect does restricting high fat feeding to the active phase have on mice?

    <p>It prevents weight gain (D)</p> Signup and view all the answers

    Which factor does NOT influence energy balance according to the content?

    <p>Your genetic makeup (D)</p> Signup and view all the answers

    In the context of energy balance, which two components are crucial?

    <p>Calories IN and Calories OUT (B)</p> Signup and view all the answers

    What does the respiratory exchange ratio help to measure?

    <p>Proportion of carbohydrates vs fats metabolized (B)</p> Signup and view all the answers

    What was a finding regarding mice under feeding restriction?

    <p>They do not show changes in calorie intake or activity (C)</p> Signup and view all the answers

    What two factors are included in the energy expenditure category?

    <p>Basal metabolic rate and physical activity (C)</p> Signup and view all the answers

    How does the time of feeding relate to the liver clock?

    <p>It helps synchronize the liver clock to meal timing (D)</p> Signup and view all the answers

    What is the role of the Food Entrainable Oscillator (FEO) in relation to feeding behavior?

    <p>It regulates anticipatory activity before feeding. (A)</p> Signup and view all the answers

    Which statement correctly describes the relationship between clock genes and the FEO?

    <p>Disrupting clock genes diminishes the FEO effect. (B)</p> Signup and view all the answers

    What implication does the functionality of FEO without the SCN suggest?

    <p>FEO can function independently of the master clock. (D)</p> Signup and view all the answers

    Why is the role of the SCN considered unique within the mammalian circadian system?

    <p>It is the master clock and influences all biological rhythms. (A)</p> Signup and view all the answers

    What does anticipatory locomotor activity refer to?

    <p>Activity patterns that occur prior to food availability. (A)</p> Signup and view all the answers

    What can disrupt the synchronization of circadian rhythms in mammals?

    <p>Light exposure during the night. (B)</p> Signup and view all the answers

    What condition would best illustrate the need for both FEO and SCN function?

    <p>Normal eating patterns synchronized with sleep. (D)</p> Signup and view all the answers

    What is the current understanding of the neuronal locus associated with FEO behavior?

    <p>FEO behavior occurs without a known neuronal locus. (B)</p> Signup and view all the answers

    What effect does nightshift work have on total daily energy expenditure?

    <p>Reduces total daily energy expenditure (B)</p> Signup and view all the answers

    How can meal timing affect weight management according to the research?

    <p>It can impact lipid oxidation (A)</p> Signup and view all the answers

    In the context of lipid oxidation, what meal timing has been studied?

    <p>Both early and late night feeding (C)</p> Signup and view all the answers

    What was one of the study populations mentioned for IV feeding in the hospital?

    <p>Children recovering from HSCT (C)</p> Signup and view all the answers

    Which of the following is a potential consequence of suboptimal meal timing?

    <p>Unwanted weight gain (A)</p> Signup and view all the answers

    What is a finding regarding lipid oxidation levels during specific feeding regimes?

    <p>Lipid oxidation varies significantly with daily feeding patterns (B)</p> Signup and view all the answers

    What is a benefit of restricting IV feeding to daytime only?

    <p>Patients recover more quickly. (A)</p> Signup and view all the answers

    What does the research imply about the relationship between lipid oxidation and weight management?

    <p>Changes in lipid oxidation can influence weight gain or loss (B)</p> Signup and view all the answers

    What dietary strategy could potentially be used to enhance lipid oxidation?

    <p>Optimizing meal timing for activity levels (D)</p> Signup and view all the answers

    What metabolic effect can occur from feeding at irregular times?

    <p>Metabolic dys-synchrony. (D)</p> Signup and view all the answers

    How does eating before bedtime affect metabolism?

    <p>It delays the switch to lipid burning mode. (B)</p> Signup and view all the answers

    What is a potential consequence for individuals with Night Eating syndrome?

    <p>Dysregulation of glucose and insulin levels. (B)</p> Signup and view all the answers

    Why might continuous IV feeding lead to hyperglycemia in patients?

    <p>Continuous feeding can lead to insulin resistance. (C)</p> Signup and view all the answers

    What happens to the amount of calories burned when there is metabolic dys-synchrony?

    <p>Calories burned decrease. (B)</p> Signup and view all the answers

    Which group of patients is more likely to recover quickly?

    <p>Patients with IV feeding restricted to daytime. (B)</p> Signup and view all the answers

    What can lead to increased fat accumulation before bedtime?

    <p>Eating irregular meals throughout the day. (B)</p> Signup and view all the answers

    What is the primary function of photoperiodism in plants?

    <p>To regulate flowering based on daylength (C)</p> Signup and view all the answers

    Which plant cultivar is mentioned as a spontaneous mutant that exhibits specific flowering responses?

    <p>Maryland Mammoth (D)</p> Signup and view all the answers

    What type of plant typically requires shorter day lengths to flower?

    <p>Short-day plant (A)</p> Signup and view all the answers

    What is suggested by the term 'circannual rhythms' in the context of biology?

    <p>Cycles that last throughout the year (B)</p> Signup and view all the answers

    Who were the researchers credited with the early findings on photoperiodism in plants?

    <p>W.Garner and H.Allard (C)</p> Signup and view all the answers

    Which factor primarily entrains the circannual clock in many species?

    <p>Day length (C)</p> Signup and view all the answers

    What characteristic defines a circannual clock?

    <p>It generates cycles without environmental input. (C)</p> Signup and view all the answers

    In laboratory conditions, what was noted about golden-mantled ground squirrels regarding hibernation?

    <p>They had never experienced seasonal changes. (A)</p> Signup and view all the answers

    What role does TSH play in the context of seasonal reproduction?

    <p>It serves as a master factor in regulating reproductive cycles across species. (D)</p> Signup and view all the answers

    What is a main characteristic of the circannual cycles observed in various species?

    <p>They maintain a consistent 12-month period once entrained. (B)</p> Signup and view all the answers

    What effect does the introduction of artificial lighting in human culture have on traditional annual cycles?

    <p>It dramatically alters human life and behavior. (A)</p> Signup and view all the answers

    In the Nanda-Hamner experiment, what would indicate a short-day response in the LH hormone response?

    <p>Increased duration of darkness in the cycle. (B)</p> Signup and view all the answers

    What role does melatonin potentially have in lower mammals' reproduction?

    <p>It might stimulate reproductive functions. (D)</p> Signup and view all the answers

    Which factor challenges the conclusion that humans do not experience photoperiodism?

    <p>Artificial indoor lighting. (D)</p> Signup and view all the answers

    What is the critical photoperiod (PP) for long days according to the Nanda-Hamner experiment?

    <p>Approximately 12 hours (C)</p> Signup and view all the answers

    What is a common misconception regarding the effects of photoperiodism in humans?

    <p>Humans are completely unaffected by light cycles. (D)</p> Signup and view all the answers

    How does melatonin production vary between long and short days?

    <p>Melatonin profiles differ between long days and short days (B)</p> Signup and view all the answers

    Which statement best describes the effect of light on melatonin levels?

    <p>Melatonin production is suppressed by light (C)</p> Signup and view all the answers

    What characteristic of the 'circadian model' is tested with the T-cycle experiment?

    <p>The consistency of resonating cycles across different day lengths (D)</p> Signup and view all the answers

    What does the 'hourglass model' refer to in terms of photoperiodic time measurement?

    <p>An interpretation of photoperiodic response based solely on natural days (C)</p> Signup and view all the answers

    Why are melatonin levels in the blood considered to represent the 'hormone of darkness'?

    <p>They are related to nighttime production (C)</p> Signup and view all the answers

    What is the significance of analyzing the melatonin profile across different species?

    <p>It highlights variations in environmental adaptations (A)</p> Signup and view all the answers

    What role does the Nanda-Hamner Resonance Experiment play in photoperiodic time measurement?

    <p>It provides insights into the interaction of light and circadian responses (A)</p> Signup and view all the answers

    What regulates GnRH secretion and subsequently gonadotropin secretion from the anterior pituitary gland?

    <p>Circadian rhythms (C)</p> Signup and view all the answers

    In mammals, what is the pathway for light information to regulate TSH secretion?

    <p>From the eye to the pineal gland via the SCN (B)</p> Signup and view all the answers

    Which cells in the 3rd ventricle are involved in the photoperiodic time measurement in mammals?

    <p>Tanycytes (A)</p> Signup and view all the answers

    How does the melatonin signal from the pineal gland affect TSH secretion?

    <p>It encodes the length of night affecting TSH secretion (C)</p> Signup and view all the answers

    What is a significant difference between the photoperiodic signal transduction in mammals compared to birds?

    <p>Mammals transmit light information via the SCN while birds use different receptors (C)</p> Signup and view all the answers

    What role do thyroxine and TSH play in photoperiodic time measurement in birds and mammals?

    <p>They are involved in the encoding of day length (C)</p> Signup and view all the answers

    Which structure is essential for transmitting light information in mammals?

    <p>SCN (A)</p> Signup and view all the answers

    What is the primary function of the pineal gland in relation to light signals?

    <p>To secrete melatonin based on light duration (B)</p> Signup and view all the answers

    What role do black bars play in the study of hibernation in stonechats?

    <p>Signify periods of hibernation (A)</p> Signup and view all the answers

    During the annual migration of monarch butterflies, what occurs in March?

    <p>They lay eggs for the next generation (D)</p> Signup and view all the answers

    What is meant by 'zugunruhe' in the context of migratory birds?

    <p>A migratory restlessness observed in birds (C)</p> Signup and view all the answers

    Which species exemplifies the role of circannual clocks in migration and provides cues for physiological changes?

    <p>Blackcap (C)</p> Signup and view all the answers

    How does the annual cycle of monarch butterflies typically progress?

    <p>Multiple generations are involved in the round trip (C)</p> Signup and view all the answers

    What characteristic of circannual rhythms allows them to adapt to environmental changes?

    <p>They can be entrained by changes in photoperiod (A)</p> Signup and view all the answers

    What is the significance of the 12:12 photoperiod in the study of stonechats?

    <p>Represents a constant light condition (A)</p> Signup and view all the answers

    What is a primary method by which monarch butterflies orient themselves during migration?

    <p>Detecting the sun's position using UV polarization (B)</p> Signup and view all the answers

    Flashcards

    Insulin's function

    Insulin helps cells absorb glucose and store it as glycogen or fat.

    Blood glucose regulation

    The process by which the body maintains a stable level of glucose in the blood.

    Glucagon's role

    Glucagon raises blood glucose levels by stimulating glycogen breakdown.

    Blood glucose set point

    The desired level of glucose in the blood.

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    Insulin release

    Released from the pancreas when blood sugar rises.

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    Glucagon release

    Released when blood glucose levels fall.

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    Glycogen breakdown

    Liver converts glycogen to glucose when blood sugar is low.

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    Homeostasis

    Maintaining a stable internal environment, including blood sugar.

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    Food Entrainable Oscillator (FEO)

    A biological rhythm that is responsive to the availability of food.

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    Anticipatory Activity

    Activity that occurs before a predictable event, like feeding.

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    SCN

    The suprachiasmatic nucleus, a part of the brain involved in regulating the circadian rhythm.

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    Circadian Rhythm

    A natural, internal process that repeats roughly every 24 hours, influencing various bodily functions.

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    FEO and SCN

    FEO, unlike the SCN (suprachiasmatic nucleus), doesn't critically rely on this brain region for its function.

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    Clock Genes

    Genes that control the body's internal clock.

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    Jet lag and shift work implications

    Potential disruption of the circadian rhythm resulting from travel across time zones or irregular work schedules.

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    TTFL System

    A system within the body impacting the circadian rhythm but seemingly not required for food-entrained rhythms

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    RER and Energy Expenditure

    RER is a key indicator of energy expenditure. Knowing the values of RER and oxygen consumption (VO2) allows us to estimate the calories burned and which type of fuel (carbohydrates or lipids) is being used.

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    Time-Restricted Feeding

    Time-Restricted Feeding (TRF) is a dietary strategy that restricts food intake to specific periods of the day, regardless of calorie intake. This can affect energy expenditure and calorie consumption.

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    TRF Impact on Calories

    Studies have found that limiting feeding duration to 12 hours (regardless of calorie restriction) can result in a significant decrease in calorie intake, averaging around 20% reduction.

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    TRF and Circadian Rhythms

    Time-Restricted Feeding can influence circadian rhythms, which are the natural, internal processes that repeat roughly every 24 hours.

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    Liver Clock

    A biological oscillator in the liver that regulates metabolic processes, influenced by feeding times.

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    SCN (Suprachiasmatic Nucleus)

    The master clock in the brain that regulates circadian rhythms, including feeding behavior.

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    Uncoupling of Liver Clock

    The liver clock can operate independently from the SCN, being synchronized by meal timing.

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    Energy Balance

    The state when calorie intake equals calorie expenditure, maintaining a stable weight.

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    How does WHEN you eat impact your metabolism?

    The timing of meals influences calorie burning efficiency, affecting weight gain or loss even with equal calories.

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    Restricted Feeding (RF)

    Limiting food intake to specific times, like a 4-hour window, to influence the liver clock and metabolism.

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    Indirect Calorimetry

    A method to measure calorie expenditure by analyzing the respiratory exchange ratio (RER), revealing metabolism details.

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    Respiratory Exchange Ratio (RER)

    A ratio of carbon dioxide produced to oxygen consumed during breathing, indicating what energy source is being used.

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    Circadian Clock

    The body's natural 24-hour internal clock that regulates various bodily functions, including metabolism.

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    Metabolic Dys-synchrony

    A disruption in the timing of metabolic processes, often due to irregular eating patterns.

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    Late-Night Snacking

    Eating food close to bedtime, which can disrupt the circadian rhythm and lead to metabolic dys-synchrony.

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    Time-Restricted Feeding (TRF)

    A dietary approach that restricts food intake to specific periods of the day, regardless of calorie intake.

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    TRF Benefits

    Time-Restricted Feeding can lead to quicker recovery, earlier hospital discharge, and reduced hyperglycemia compared to continuous feeding.

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    Impact of Meal Timing

    The timing of meals significantly influences calorie burning efficiency, affecting weight gain or loss even with equal calorie intake.

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    Metabolic Dys-synchrony and Insulin Resistance

    When your metabolic processes are out of sync, you become more resistant to the effects of insulin, potentially leading to blood sugar fluctuations, particularly during periods of sleep.

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    Night Shift Work and Energy Expenditure

    Working at night reduces the total amount of energy a person burns in a day, which can contribute to weight gain and obesity.

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    Suboptimal Meal Timing

    Eating at inconsistent times or outside of the body's natural rhythm can negatively impact how efficiently fat is burned, potentially leading to weight gain.

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    Lipid Oxidation and Weight Gain

    The process of breaking down fats for energy is affected by meal timing, impacting how weight is gained or lost.

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    TRF and Calorie Intake

    Limiting feeding time to around 12 hours per day has been shown to significantly reduce calorie intake, even without calorie restriction.

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    Hospital IV Feeding

    Patients recovering from certain procedures may receive nutrition through intravenous (IV) fluids, bypassing normal eating routines.

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    TRF Implications for Hospital Patients

    The concept of TRF, while not directly related to IV feeding, could potentially have implications for patients recovering from procedures and their nutritional strategies.

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    Photoperiodism

    The biological response of organisms to changes in day length, influencing processes like flowering in plants and seasonal behaviors in animals.

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    Maryland Mammoth

    A tobacco cultivar that was a spontaneous mutant, demonstrating that day length controls flowering in plants.

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    Short-day Plant

    A plant that flowers when the day length is shorter than a critical threshold, often flowering in the fall or winter.

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    Long-day Plant

    A plant that flowers when the day length is longer than a critical threshold, often flowering in the spring or summer.

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    W. Garner and H. Allard

    Scientists who first discovered photoperiodism in 1920, revolutionizing our understanding of plant growth and development.

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    Nanda-Hamner Resonance Experiment

    A classic experiment testing the "circadian model" of photoperiodic time measurement (PPTM) in plants. It involves exposing plants to different day lengths (LD cycles) and observing their growth response.

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    Resonance Cycles in PPTM

    In the Nanda-Hamner experiment, plants exposed to specific LD cycles close to their critical photoperiod (the day length required for a response) show a rhythmic growth pattern, reflecting a "resonance" with their internal circadian clock.

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    T-Cycle Experiment

    An experiment testing the "circadian model" by exposing plants to different cycles of darkness (T) and observing their growth response, revealing how their internal clocks react to changes in the duration of darkness.

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    Photoperiodic Time Measurement (PPTM)

    The process by which plants measure the relative lengths of day and night to regulate their seasonal development, such as flowering or dormancy.

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    Melatonin and PTM

    The hormone melatonin, produced by the pineal gland, plays a significant role in photoperiodic time measurement (PTM), particularly in regulating seasonal changes in animals.

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    Melatonin Profile in Long vs. Short Days

    The pattern of melatonin production differs in animals depending on the length of daylight hours, with higher levels at night during shorter days compared to longer days.

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    Relevance of Melatonin Profile Variations

    The differences in melatonin profiles between long and short days suggest that melatonin plays a crucial role in regulating seasonal changes in various physiological processes, including reproduction and hibernation.

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    Pineal Gland and PPTM in Mammals

    In mammals, light information is perceived by the eyes and transmitted to the pineal gland via the SCN. The pineal gland produces melatonin, a hormone that encodes the length of night and regulates TSH secretion.

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    Pars Tuberalis and PPTM

    The pars tuberalis, a part of the pituitary gland, plays a role in PPTM by regulating TSH secretion in response to melatonin signals from the pineal gland.

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    Deep Brain Photoreceptors in Birds

    Unlike mammals, birds have deep brain photoreceptors that receive light information directly, inducing TSH secretion from the pars tuberalis.

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    Tanycytes

    Specialized ependymal cells in the third ventricle of the brain that are involved in the communication between the hypothalamus and the pars tuberalis, playing a role in PPTM.

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    Thyroxine and TSH in PPTM

    Thyroxine (T4) and TSH (thyroid-stimulating hormone) are hormones that are involved in PPTM in both birds and mammals.

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    How Does Light Information Affect PPTM?

    In mammals, light information perceived by the eyes is transmitted to the SCN, which then influences the pineal gland's melatonin production, impacting TSH secretion and seasonal changes.

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    Key Differences in PPTM Between Mammals and Birds

    Mammals perceive light only through their eyes and rely on the pineal gland for melatonin production. Birds, however, have deep brain photoreceptors that directly induce TSH secretion, bypassing the pineal gland.

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    Circannual Clock

    A biological rhythm that generates seasonal or annual cycles, independent of environmental cues. It continues in consistent conditions (constant darkness or light) with a cyclical period close to a year.

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    Environmental Entrainment

    The process of adjusting the circannual clock to a 12-month period by external environmental cues, mainly day length.

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    Free-Running Cycle

    The natural, internal cycle of the circannual clock without external cues, often lasting around 10 months.

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    Pars tuberalis TSH

    A key hormone acting as a 'master controller' for seasonal reproduction in both birds and mammals.

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    Cross-talk between TSH and Metabolism

    The possible interaction between TSH, regulating seasonal reproduction, and the control of overall metabolism.

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    What is photoperiodism?

    Photoperiodism is the biological response of organisms to changes in day length or night length. It influences a wide variety of processes, including flowering in plants and seasonal behaviors in animals.

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    What are long-day plants?

    Long-day plants flower when the day length is longer than a critical threshold. They typically flower in the spring or summer when days are longer.

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    What are short-day plants?

    Short-day plants flower when the day length is shorter than a critical threshold. They typically flower in the fall or winter when days are shorter.

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    Zugunruhe

    A restless behavior observed in migratory birds, particularly during periods of impending migration.

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    What is zugunruhe?

    Zugunruhe is a German term that describes migratory restlessness or anxiety in birds, indicating their innate urge to migrate.

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    Entrainment

    Entrainment is the process of synchronizing a biological rhythm, like circannual clocks, to external cues, such as changes in day length.

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    Monarch Butterfly Migration

    Monarch butterflies migrate thousands of miles annually, taking advantage of the sun's UV polarization to navigate.

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    Stonechat Migration

    Both European and Siberian Stonechats are birds that exhibit varying migratory patterns, influenced by environmental factors.

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    Sun Compass Orientation

    Animals, especially birds, use the sun's position to navigate, even on cloudy days by detecting its plane of UV polarization.

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    Annual Cycles in Migrating Birds

    Migrating birds experience annual cycles that involve changes in behavior, physiology, and morphology, including reproduction, molting, and migration.

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    Study Notes

    BSci 3230 Study Notes

    • These files are for BSci 3230 student use only for studying for exams and not to be copied or distributed, they may contain copyrighted material
    • The course focuses on Biological Clocks and Metabolism
    • Topics covered include obesity, biological clocks and metabolism in model systems (mice), Food-Entrainable Oscillator (FEO), Time-restricted Feeding (daily), and biological clocks and metabolism in humans
    • Prevalence maps of obesity in the USA (2020) categorized by race are included;
      • Asians, Whites, Hispanics, and African Americans.
    • Night-time light exposure may disrupt daily clocks, potentially causing metabolic disorders.
    • Shift work in humans is linked to obesity, diabetes, and cardiovascular disease due to physiological maladaptation
    • Circadian misalignment, induced by a T28 Forced Desynchrony protocol, can cause metabolic dysfunction, affecting leptin, glucose, insulin, arterial blood pressure and sleep efficiency.
    • Biological clocks and metabolism are studied in model systems of mice
    • Circadian-controlled gene expression (mRNA) is examined in mouse adipose tissues, including brown adipose tissue (BAT), inguinal white adipose tissue (iWAT), and epididymal (male gonadal) white adipose tissue (eWAT).
    • Circadian patterns exist in 650 genes across liver, BAT, and iWAT.
    • Results of studies on mice with mutant or knocked-out clock genes show impacting factors of hormones (e.g., insulin, glucocorticoids), time of food intake, light and metabolic stimuli.
    • Genetic disruption of the clock leads to fat accumulation in mice (Bmal1-ko mice).
    • Studies on mouse models (mutant "Clock" gene) demonstrated impacts on energy intake, body weight, activity, and metabolic rate
    • The control of glucose levels in the blood involves the pancreas, where beta cells produce insulin and alpha cells produce glucagon. Insulin is released after a meal when blood glucose rises, stimulating cells to transport glucose and convert to glycogen/fats; glucagon is released when blood sugar drops for liver conversion of glycogen to glucose).
    • Insulin sensitivity/resistance measurements use insulin clamps to measure glucose levels using continuous insulin infusion and adjusted glucose infusion rate
    • Insulin sensitivity shows daily rhythmicity, with lower sensitivity during the inactive phase (for mice), with specific results at certain times of day.
    • Time-Restricted Feeding (TRF) is discussed, with findings on the potential separation between the liver's circadian clock and the SCN. The phase of the liver peripheral oscillator can change with feeding patterns and be uncoupled from SCN to entrained to meal timing.
    • Energy balance is also important; the factors affecting energy intake (calories IN), weight gain, calorie output and weight loss. Included in that are baseline metabolism and exercise.
    • Calorie intake and activity in mice under restricted feeding are examined, indicating the potential lack of change in calorie intake and activity, despite the restriction.
    • Restricting high-fat feeding specifically during active phase / daytime prevented obesity in mice.
    • Measuring calories involves indirect calorimetry. Glucose and fat oxidation are factors in determining how to determine the metabolic processes underway in indirect calorimetry, along with RER factors.
    • Energy expenditure, as measured by RER, can show higher rates in restricted feeding groups.
    • Implications of jet lag and shift work in humans are discussed in some contexts related to conflicting meal times
    • Mobile apps, such as myCircadianClock, are being used to study circadian rhythms in humans.
    • Feeding time and eating duration in humans are highly variable.
    • Restricting eating duration to 12 hours affects caloric intake.
    • Early Time-Restricted Feeding (TRF) reduces appetite, increases fat oxidation but doesn't affect energy expenditure in humans
    • Meal Timing Regulates the Human Circadian System.
    • Simulated shiftwork schedule impacts metabolic rate.
    • Meal timing work in a Johnson lab setting is examined.
    • Suboptimal meal timing can affect lipid oxidation, and consequently, weight gain/loss.
    • An important example of TRF is using IV feeding given in the hospital to patients.

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