Nutrition and Longevity Quiz

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Questions and Answers

What is a significant risk associated with high plasma levels of Vitamin A in older adults?

  • Increased absorption of dietary Vitamin A
  • Enhanced clearance from the blood
  • Toxicity and potential liver damage (correct)
  • Lower risk of deficiency

Which vitamin is mentioned as being poorly synthesized by the skin in elderly individuals?

  • Vitamin A
  • Vitamin K
  • Vitamin B12
  • Vitamin D (correct)

What dietary factor is emphasized to help offset the negative effects of sodium intake?

  • Adequate intakes of potassium (correct)
  • Increased sugar consumption
  • Supplements of Vitamin C
  • High protein diets

Why might older adults have lower serum Vitamin B12 levels despite adequate dietary intake?

<p>Reduced hydrochloric acid and pepsin production in the stomach (A)</p> Signup and view all the answers

What is the recommended minimum fluid intake for older adults?

<p>1500 mL (C)</p> Signup and view all the answers

What percentage of longevity is influenced by lifestyle according to the CDC?

<p>51% (A)</p> Signup and view all the answers

Which of the following organisms has NOT been cited as receiving benefits from calorie restriction?

<p>Humans (C)</p> Signup and view all the answers

What is the approximate lifespan of a rhesus monkey as mentioned in the context?

<p>27 years (D)</p> Signup and view all the answers

Starting calorie restriction at what age results in a lower life extension in mice?

<p>1 year (C)</p> Signup and view all the answers

What impact does starting calorie restriction at age 55 have on life expectancy, according to the provided scenario?

<p>6 weeks life extension (D)</p> Signup and view all the answers

Which of these is a key finding related to centenarians from Okinawa?

<p>Low caloric intake from youth (A)</p> Signup and view all the answers

What percentage of caloric restriction is observed in adults residing in Redman?

<p>20% (B)</p> Signup and view all the answers

What was the percentage change in body weight observed during the Biosphere study for participants practicing calorie restriction?

<p>15% (C)</p> Signup and view all the answers

Which of the following health measures showed improvement due to calorie restriction in humans?

<p>Total cholesterol (A)</p> Signup and view all the answers

In the CALERIE study, what was the duration of the calorie restriction intervention?

<p>2 years (A)</p> Signup and view all the answers

Which age group comprised participants in the CALERIE study?

<p>25-45 years (B)</p> Signup and view all the answers

What adverse effect is associated with significant calorie restriction?

<p>Amenorrhea (D)</p> Signup and view all the answers

What is a limitation of calorie restriction studies mentioned?

<p>They overlook individual genetic variability (B)</p> Signup and view all the answers

What metabolic change was NOT associated with calorie restriction according to the provided studies?

<p>Increased metabolic rate (A)</p> Signup and view all the answers

Why is a calorie restriction level of 30-40% considered impractical?

<p>It may cause lack of concentration. (D)</p> Signup and view all the answers

What main focus is suggested in the limitations regarding the effects of calorie restriction on human lifespan?

<p>Prioritize quality of life and health span (C)</p> Signup and view all the answers

What level of calorie restriction is considered more feasible than 30-40%?

<p>10-15% (C)</p> Signup and view all the answers

Flashcards

Calorie Restriction

A dietary approach that involves reducing calorie intake by 30-40% while maintaining essential nutrients.

Lifespan Extension through Calorie Restriction

Studies have shown that calorie restriction consistently extends lifespan in various species, including mice, rats, flies, dogs, and worms.

Calorie Restriction Timing

The earlier calorie restriction is implemented in life, the greater the lifespan extension observed in mice.

Calorie Restriction in Non-Human Primates

A large-scale study involving rhesus monkeys showed that those on a 30% calorie restriction diet experienced lower blood pressure, body temperature, insulin resistance, and reduced incidences of cancer.

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Calorie Restriction in Humans

Calorie restriction for humans is estimated to result in a modest life extension of a few years. However, the potential benefits diminish with age.

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Calorie Restriction in Okinawa

Okinawan centenarians provide an example of a population with a lifestyle characterized by low caloric intake and nutrient-dense diets, contributing to longer lifespans.

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Long-Term Dietary Impact

Lifelong dietary habits contribute significantly to the health and longevity of individuals in old age.

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Vitamin B12 Malabsorption in Elderly

The reduced ability of the body to absorb vitamin B12 from food, despite adequate intake. This is often due to age-related changes in the stomach, like atrophic gastritis, which affects the production of hydrochloric acid and pepsin, making it harder to separate B12 from protein carriers.

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Reduced Vitamin D Synthesis in Elderly

The reduced ability of the skin to synthesize vitamin D, which is crucial for bone health. This is often due to factors like decreased sunlight exposure from aging, institutionalization, winter, clothing, or sunscreen.

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Increased Vitamin A Storage in Elderly

The body's ability to store vitamin A increases with age, making it more vulnerable to toxicity from excessive intake. Therefore, it is important to be mindful of the recommended upper limit.

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Decreased Body Water in Elderly

The body's water content decreases with age, leading to a smaller safety margin for staying hydrated. It is crucial to ensure adequate fluid intake, especially with age.

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Importance of Potassium in Elderly

A diet rich in potassium can help counteract the negative effects of high sodium intake, which is often a concern for older adults. Potassium-rich sources include fruits and vegetables, such as those found in the DASH diet plan.

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CALERIE study

A study investigating the effects of calorie restriction on healthy adults. Participants were randomly assigned to either a calorie-restricted diet (25% reduction) or an ad libitum diet, over a period of two years. The study aimed to examine the long-term effects of calorie restriction, including changes in health markers and biomarkers.

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Okinawa vs mainland study

A research study exploring the impact of calorie restriction on individuals residing in Okinawa, Japan. The study aimed to investigate the potential benefits of calorie restriction in relation to age-related changes and metabolic health, comparing the Okinawan population to mainland Japanese groups.

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Reduced metabolic rate

A state of reduced metabolic rate, achieved through calorie restriction, characterized by lower energy expenditure and slowed metabolic processes. It's a physiological response to reduced calorie availability.

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Weight loss

A reduction in body weight, often associated with calorie restriction, marked by a significant decrease in overall body mass.

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Increased lifespan

An increase in lifespan, typically associated with interventions like calorie restriction, signifying an extension of life expectancy.

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Health span

The duration of a healthy and active life, often influenced by interventions like calorie restriction. It encompasses the period of optimal physical and cognitive function.

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Lack of concentration

A potential drawback of calorie restriction, characterized by a lack of focus and difficulty concentrating, which could impede daily activities.

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Amenorrhea

A potential consequence of calorie restriction, particularly in women, characterized by an absence of menstruation, which can be associated with hormonal imbalances.

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Practicality of calorie restriction

A potential limitation of calorie restriction, highlighting the difficulty in achieving high levels of reduction (30-40%) in daily calorie intake.

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Study Notes

Learning Objectives

  • Describe nutritional interventions for lifespan extension
  • Discuss nutrients of concern for this age group

Food Matters: Nutrition and Longevity

  • Lifelong dietary habits cumulatively affect nutritional status in old age
  • Longevity depends on several factors, 51% attributed to lifestyle

How to Extend Lifespan

  • Calorie restriction is the only non-genetic manipulation proven to extend lifespan
  • Proper nutrient intake is essential while restricting calories

Calorie Restriction for Longevity

  • Reducing calories by 30-40% extends lifespan in rodents compared to a full-fed diet
  • The earlier the restriction, the greater the lifespan extension in mice

Calorie Restriction in Non-Human Primates

  • A study in 2017, involving 30% calorie restriction, showed benefits in rhesus monkeys, including lowered blood pressure, body temperature, insulin sensitivity and plasma lipids; a lowered incidence of cancer.
  • Diet, nutrient composition, and genetic background can influence the effects of calorie restriction.

Can Calorie Restriction Extend Human Life?

  • A 48-year-old male, reducing calories by 30% for 30 years, would extend their lifespan by approximately 2.8 years, if they initiate the change from age 48
  • Starting calorie restriction at 55 for 23 years would offer 6 weeks of life extension

Calorie Restriction in Humans - Okinawa Centenarians

  • Okinawa's centenarians have a low caloric intake during childhood and adolescence, along with a 10-15% energy deficit from young to middle-age.
  • Diet is nutrient-dense and daily activities require significant physical exertion.

Calorie Restriction in Humans - Biosphere Study

  • A 6-month study involving a -750 kcal/d unexpected CR led to a 10-15% weight loss, along with measurable improvements in measures relating to heart disease and decreased levels of some blood glucose markers.

Calorie Restriction in Humans - CALERIE Study

  • A prospective, randomized, controlled study observed the long-term effects of reducing caloric intake by 25%, 20% and 30% over 2 years in non-obese healthy adults aged 25-45.

Calorie Restriction in Humans - Limitations

  • 30-40% caloric restriction may be impractical; 10-15% is more manageable reduction
  • Potential adverse effects include concentration issues and amenorrhea
  • Genetic variability affects the response to calorie restriction and overall lifespan
  • Difficult to identify significant, direct measurable endpoints of calorie restriction in humans

Nutrients of Concern: Age-Associated

  • Vitamin A levels and liver stores increase with age; however, the risk for toxicity increases
  • Vitamin D Synthesis decreases with age

Nutrients of Concern: Low Dietary Intake

  • Potassium is critical for electrolyte balance, and adequate intake can mitigate the negative effects of high sodium intake.
  • Vitamin K is essential for blood coagulation and bone health.
  • Vitamin B12 is essential for maintaining appropriate cell function and development, however, absorption may be affected by age related changes, for instance, in stomach function.
  • Sufficient fluid intake is crucial for hydration, as the ability to maintain hydration decreases with age.

Summary

  • Aging is linked to cellular structure and metabolic abnormalities
  • Defining aging based on function is more accurate than chronological age
  • Physiological changes accompany aging
  • Calorie restriction can be an effective longevity strategy for both humans and animals.

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