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Questions and Answers
What is one of the mechanisms by which red ginseng oil exhibits antioxidant properties?
What is one of the mechanisms by which red ginseng oil exhibits antioxidant properties?
- Inhibition of gluconeogenesis
- Stimulation of insulin production
- Scavenging of free radicals (correct)
- Promotion of vasodilation
Which property of red ginseng oil is linked to its anticancer effects?
Which property of red ginseng oil is linked to its anticancer effects?
- Promotion of LDL clearance
- Reduction of glucose absorption
- Boosting of insulin sensitivity
- Inhibition of caspase activation (correct)
Which is a hypoglycemic effect of berberine?
Which is a hypoglycemic effect of berberine?
- Stimulation of LDL receptor genes
- Activation of Nrf2
- Promotion of insulin sensitivity (correct)
- Inhibition of ACE enzyme
How does Gymnema Sylvestre contribute to blood glucose regulation?
How does Gymnema Sylvestre contribute to blood glucose regulation?
What effect does Momordica Charantia have on insulin?
What effect does Momordica Charantia have on insulin?
Which mechanism underlies the antihypertensive effect of berberine?
Which mechanism underlies the antihypertensive effect of berberine?
What advantage does Irvingia Gabonensis offer regarding lipid profiles?
What advantage does Irvingia Gabonensis offer regarding lipid profiles?
Which pathway is activated by red ginseng oil to support hair growth?
Which pathway is activated by red ginseng oil to support hair growth?
What is the primary way that red yeast rice contributes to hypolipidemic effects?
What is the primary way that red yeast rice contributes to hypolipidemic effects?
Which property of resveratrol allows it to act as a defense mechanism in plants?
Which property of resveratrol allows it to act as a defense mechanism in plants?
Which of the following is a mechanism by which ursolic acid aids in managing obesity?
Which of the following is a mechanism by which ursolic acid aids in managing obesity?
What potential adverse side effect is associated with Monacolin K due to its similarity to lovastatin?
What potential adverse side effect is associated with Monacolin K due to its similarity to lovastatin?
How do plant sterols manage cholesterol levels?
How do plant sterols manage cholesterol levels?
Which two compounds are primarily associated with the anti-inflammatory effects of saffron?
Which two compounds are primarily associated with the anti-inflammatory effects of saffron?
What role does vitamin D play in cancer prevention, specifically colorectal cancer?
What role does vitamin D play in cancer prevention, specifically colorectal cancer?
How do omega-3 fatty acids improve neuronal function?
How do omega-3 fatty acids improve neuronal function?
What significant effect does curcumin have on serotonin?
What significant effect does curcumin have on serotonin?
What is a major risk associated with high levels of beta-carotene?
What is a major risk associated with high levels of beta-carotene?
What effect does red ginseng oil have on free radicals?
What effect does red ginseng oil have on free radicals?
Which compound is associated with antihypertensive effects as a result of vasodilation?
Which compound is associated with antihypertensive effects as a result of vasodilation?
What is a mechanism by which Momordica Charantia reduces blood glucose levels?
What is a mechanism by which Momordica Charantia reduces blood glucose levels?
Which metabolic action does Gymnema Sylvestre primarily support?
Which metabolic action does Gymnema Sylvestre primarily support?
What effect do the alkaloids from Berberine have on lipid profiles?
What effect do the alkaloids from Berberine have on lipid profiles?
What activity is NOT attributed to red ginseng oil?
What activity is NOT attributed to red ginseng oil?
How does Irvingia Gabonensis primarily impact metabolic health?
How does Irvingia Gabonensis primarily impact metabolic health?
Which pathway is activated by red ginseng oil to stimulate hair growth?
Which pathway is activated by red ginseng oil to stimulate hair growth?
Which of the following properties is associated with resveratrol?
Which of the following properties is associated with resveratrol?
What is a potential risk associated with the consumption of Monacolin K?
What is a potential risk associated with the consumption of Monacolin K?
Which nutrient is specifically linked to the overexpression of LDL receptors in the liver?
Which nutrient is specifically linked to the overexpression of LDL receptors in the liver?
Which of the following compounds is known for its anti-inflammatory properties by inhibiting COX-2?
Which of the following compounds is known for its anti-inflammatory properties by inhibiting COX-2?
What is the primary mechanism by which plant sterols manage cholesterol levels?
What is the primary mechanism by which plant sterols manage cholesterol levels?
Which of the following effects has been attributed to omega-3 fatty acids?
Which of the following effects has been attributed to omega-3 fatty acids?
Which active compound in saffron is associated with its antioxidant and anti-inflammatory effects?
Which active compound in saffron is associated with its antioxidant and anti-inflammatory effects?
What preventive effect has been linked to the intake of vitamin D?
What preventive effect has been linked to the intake of vitamin D?
Which of the following nutrients is known to improve mitochondrial function?
Which of the following nutrients is known to improve mitochondrial function?
Which property of curcumin is particularly significant in relation to mental health?
Which property of curcumin is particularly significant in relation to mental health?
Flashcards
What is red ginseng oil (RGO)?
What is red ginseng oil (RGO)?
Red ginseng oil (RGO) is extracted from ginseng roots that have been steamed and dried. It contains unsaturated fatty acids and lipophilic components.
What are the antioxidant properties of red ginseng oil?
What are the antioxidant properties of red ginseng oil?
RGO has antioxidant properties, helping to protect cells from damage caused by free radicals. It does this by scavenging free radicals and increasing the activity of antioxidant enzymes.
How does red ginseng oil have anti-inflammatory effects?
How does red ginseng oil have anti-inflammatory effects?
RGO can help reduce inflammation by inhibiting the activity of AP-1 and NF-κB, which are key players in the inflammatory process.
What is berberine?
What is berberine?
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What are the potential benefits of berberine for metabolic health?
What are the potential benefits of berberine for metabolic health?
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How does berberine have hypoglycemic effects?
How does berberine have hypoglycemic effects?
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What is Momordica charantia?
What is Momordica charantia?
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What are the hypoglycemic effects of Momordica charantia?
What are the hypoglycemic effects of Momordica charantia?
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Resveratrol
Resveratrol
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Ursolic Acid
Ursolic Acid
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Red Yeast Rice
Red Yeast Rice
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Omega-3 Fatty Acids
Omega-3 Fatty Acids
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Annurca Apples
Annurca Apples
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Plant Sterols and Stanols
Plant Sterols and Stanols
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Petasites Hybridus
Petasites Hybridus
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Riboflavin
Riboflavin
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Hypericin
Hypericin
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Saffron (Crocus Sativus)
Saffron (Crocus Sativus)
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How does Berberine lower blood sugar levels?
How does Berberine lower blood sugar levels?
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How does Momordica charantia help regulate blood sugar?
How does Momordica charantia help regulate blood sugar?
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What is Gymnema Sylvestre?
What is Gymnema Sylvestre?
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How does Gymnema Sylvestre affect blood sugar levels?
How does Gymnema Sylvestre affect blood sugar levels?
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What is Resveratrol?
What is Resveratrol?
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What is Ursolic Acid?
What is Ursolic Acid?
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What is Red Yeast Rice known for?
What is Red Yeast Rice known for?
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What are Omega-3 Fatty Acids?
What are Omega-3 Fatty Acids?
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What are Annurca apples known for?
What are Annurca apples known for?
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What are Plant Sterols and Stanols?
What are Plant Sterols and Stanols?
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What is Petasites Hybridus known for?
What is Petasites Hybridus known for?
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What is Riboflavin and its role?
What is Riboflavin and its role?
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What is Hypericin and its effects?
What is Hypericin and its effects?
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What are the benefits of Saffron (Crocus Sativus)?
What are the benefits of Saffron (Crocus Sativus)?
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Study Notes
Nutraceutical Compounds for Metabolic Syndrome
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Red Ginseng Oil (RGO): Derived from red ginseng root through steaming (1-3 hours) and drying, then water extraction.
- Properties: Antioxidant (free radical scavenging, upregulates antioxidant enzymes), anti-inflammatory (inhibits AP-1 and NFkB), chemopreventive (activates Nrf2, increases phase II detoxifying and antioxidant enzymes), antiapoptotic (inhibits caspase activation, reduces Bax/Bcl-2 ratio, and P-cJun), anticancer, promotes hair growth (activates IGF-1, VEGF, Wnt/beta-catenin, and Sonic hedgehog pathways), improves skin quality/appearance, immunomodulatory, and antiatherogenic. Contains unsaturated fatty acids and lipophilic components.
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Berberine: An alkaloid found in various plants, traditionally used for gastrointestinal issues.
- Properties: Hypoglycemic (inhibits gluconeogenesis, stimulates glycolysis, increases insulin sensitivity; similar to metformin), lipid-lowering (increases LDL clearance, stabilizes LDL receptors, inhibits lipid synthesis), antihypertensive (promotes vasodilation, inhibits ACE enzyme, alpha-1 adrenergic antagonism).
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Momordica Charantia (Bitter Melon): Tropical plant used in traditional medicine, particularly in Asia. Contains momordicin, charantin, polypeptide p, and vicine.
- Properties: Hypoglycemic (promotes insulin production and sensitivity, reduces glucose absorption; polypeptide p similar to insulin), hypolipidemic, antihypertensive.
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Gymnema Sylvestre ("Sugar Destroyer"): Plant native to India and Africa. Contains a mixture of saponins, acidic glycosides, and anthroquinones.
- Properties: Hypoglycemic (gymnemic acids inhibit sweetness, reduce cravings, enhance insulin activity, reducing glucose absorption), hypolipidemic.
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Irvingia Gabonensis (African Mango): Central and West African plant.
- Properties: Hypoglycemic, hypolipidemic (inhibits adipogenesis), likely due to its high dietary fiber content.
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Resveratrol: Polyphenolic compound found in plants (phytoalexin).
- Properties: Antioxidant, metabolic regulation (interacts with SIRT1 and AMPK), antihypertension (boosts NO synthesis), hypolipidemic, hypoglycemic, anti-atherogenic plaque formation. Has poor bioavailability.
-
Ursolic Acid: Pentacyclic triterpenoid found in fruits and herbs.
- Properties: Hypoglycemic, impacts lipid metabolism (reduces adipocyte differentiation and lipolysis), manages obesity.
Hypercholesterolemia Nutraceuticals
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Red Yeast Rice: Traditional Chinese fermented rice product containing Monacolin K and related compounds.
- Properties: Hypolipidemic (inhibits HMG-CoA reductase; chemically identical to lovastatin; higher bioavailability, more severe side effects); variability in response.
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Omega-3 Fatty Acids (e.g., Krill Oil): Polyunsaturated fatty acids, rich in EPA, DHA, and astaxanthin.
- Properties: Lipid-lowering (lowers triglycerides and LDL, increases HDL), anti-inflammatory, improves glucose tolerance.
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Annurca Apples: High polyphenolic content, particularly catechins.
- Properties: Hypolipidemic (overexpresses LDL receptors, increases HDL).
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Plant Sterols/Stanols:
- Properties: Hypolipidemic (compete with dietary cholesterol for intestine absorption); potential atherogenic properties.
Other Nutraceuticals
- ... (Existing information)
Depression Nutraceuticals
- ... (Existing information)
Cancer Nutraceuticals
- Carotenoids: Diverse group of compounds with antioxidant properties.
- Beta-carotene & other carotenoids: Conversion to retinol may increase some cancer risks (lung, prostate, stomach). However, it decreases risk for others. Beta-carotene is linked to lung cancer; however, others may have protective effects.
- Lycopene: Reduced risk of prostate cancer; decreases ROS, induces apoptosis, and attenuates metastasis.
- Vitamin D: Reduced risk of colorectal cancer
- Vitamin E & Selenium: Not currently recommended
- Curcumin: Anti-colorectal tumor
- Resveratrol
- Tea polyphenols
- Other polyphenols
- Folic acid: Cofactor in one carbon metabolism.
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