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pKa

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Questions and Answers

Which type of drugs are most anesthetic drugs?

Neutral compounds
Strong acids
Weak bases (correct)
Strong bases

What does pKa represent in the context of pharmacology?

The pH at which 50% of the drug is ionized and 50% is non-ionized (correct)
The pH at which a drug is most stable
The pH at which a drug becomes completely ionized
The pH at which a drug becomes completely non-ionized

What does the Henderson-Hasselbach equation measure?

The pH of a solution (correct)
The desolvation of non-ionic, organic drugs
The equilibrium constant of a reversible reaction
The ionization of drugs

What is the relationship of pKa curves to the degree of ionization and pH?

pKa curves represent the pH at which a drug is 50% ionized (D) Signup and view all the answers

What does the equilibrium constant (K) allow for calculation and prediction of?

Reversible reactions (B) Signup and view all the answers

What can be trapped in more acidic environments due to ion trapping?

Basic drugs (D) Signup and view all the answers

What is the average droplet size of propofol emulsion?

0.15 - 0.3 µm (B) Signup and view all the answers

Which of the following does NOT destabilize propofol emulsion?

Increased pH (A) Signup and view all the answers

What is the primary function of phospholipids in egg lecithin in propofol emulsion?

Allow for dispersion in aqueous solution (D) Signup and view all the answers

What is the most common salting out reaction mentioned in the text?

Ceftriaxone + calcium (A) Signup and view all the answers

pKa