pKa
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Questions and Answers

Which type of drugs are most anesthetic drugs?

  • Neutral compounds
  • Strong acids
  • Weak bases (correct)
  • Strong bases

    • What does pKa represent in the context of pharmacology?

  • The pH at which 50% of the drug is ionized and 50% is non-ionized (correct)
  • The pH at which a drug is most stable
  • The pH at which a drug becomes completely ionized
  • The pH at which a drug becomes completely non-ionized

    • What does the Henderson-Hasselbach equation measure?

  • The pH of a solution (correct)
  • The desolvation of non-ionic, organic drugs
  • The equilibrium constant of a reversible reaction
  • The ionization of drugs

    • What is the relationship of pKa curves to the degree of ionization and pH?

    <p>pKa curves represent the pH at which a drug is 50% ionized</p> Signup and view all the answers

    What does the equilibrium constant (K) allow for calculation and prediction of?

    <p>Reversible reactions</p> Signup and view all the answers

    What can be trapped in more acidic environments due to ion trapping?

    <p>Basic drugs</p> Signup and view all the answers

    What is the average droplet size of propofol emulsion?

    <p>0.15 - 0.3 µm</p> Signup and view all the answers

    Which of the following does NOT destabilize propofol emulsion?

    <p>Increased pH</p> Signup and view all the answers

    What is the primary function of phospholipids in egg lecithin in propofol emulsion?

    <p>Allow for dispersion in aqueous solution</p> Signup and view all the answers

    What is the most common salting out reaction mentioned in the text?

    <p>Ceftriaxone + calcium</p> Signup and view all the answers

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