10 Questions
Which type of drugs are most anesthetic drugs?
Weak bases
What does pKa represent in the context of pharmacology?
The pH at which 50% of the drug is ionized and 50% is non-ionized
What does the Henderson-Hasselbach equation measure?
The pH of a solution
What is the relationship of pKa curves to the degree of ionization and pH?
pKa curves represent the pH at which a drug is 50% ionized
What does the equilibrium constant (K) allow for calculation and prediction of?
Reversible reactions
What can be trapped in more acidic environments due to ion trapping?
Basic drugs
What is the average droplet size of propofol emulsion?
0.15 - 0.3 µm
Which of the following does NOT destabilize propofol emulsion?
Increased pH
What is the primary function of phospholipids in egg lecithin in propofol emulsion?
Allow for dispersion in aqueous solution
What is the most common salting out reaction mentioned in the text?
Ceftriaxone + calcium
Test your knowledge of pKa and drug stability in nurse anesthesia with this quiz. Explore concepts such as drug incompatibility, ionization, acid-base equilibrium constant, pKa curves, ion trapping, and desolvation, with a focus on the anesthetic drug propofol.
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