Podcast
Questions and Answers
In a patient presenting with symptoms indicative of Restless Leg Syndrome (RLS), what neurophysiological mechanism, amidst competing theories, is most implicated in the manifestation of nocturnal exacerbation, and how does this inform the selection of targeted pharmacological interventions?
In a patient presenting with symptoms indicative of Restless Leg Syndrome (RLS), what neurophysiological mechanism, amidst competing theories, is most implicated in the manifestation of nocturnal exacerbation, and how does this inform the selection of targeted pharmacological interventions?
- Circadian dysregulation of iron transport across the blood-brain barrier, impacting neuronal excitability in the sensorimotor cortex. (correct)
- Reduced glutamatergic inhibition in the spinal cord circuits modulating proprioceptive feedback during the transition from wakefulness to sleep.
- Increased dopaminergic activity in the basal ganglia during sleep leading to enhanced sensory amplification.
- Peripheral neuropathy-induced sensitization of nociceptors, resulting in heightened pain perception at rest, irrespective of sleep cycle.
Considering the interplay between sleep architecture and cognitive function, which of the following polysomnographic findings would be most indicative of a patient experiencing clinically significant sleep fragmentation, with consequential impairments in declarative memory consolidation and executive function?
Considering the interplay between sleep architecture and cognitive function, which of the following polysomnographic findings would be most indicative of a patient experiencing clinically significant sleep fragmentation, with consequential impairments in declarative memory consolidation and executive function?
- Elevated alpha intrusion during stages N1 and N2 sleep, evidenced by cyclic alternating pattern rate exceeding 20/hour. (correct)
- Reduced sleep efficiency index with a predominance of stage N2 sleep and K-complex absence.
- Normal apnea-hypopnea index but with frequent arousals associated with periodic limb movements during REM sleep.
- Increased REM latency with a normal percentage of stage N3 sleep.
Evaluating the efficacy of cognitive behavioral therapy for insomnia (CBT-I), which neuroimaging study would provide the most compelling evidence of sustained neuroplastic changes associated with successful long-term outcomes, distinguishing it from pharmacological interventions?
Evaluating the efficacy of cognitive behavioral therapy for insomnia (CBT-I), which neuroimaging study would provide the most compelling evidence of sustained neuroplastic changes associated with successful long-term outcomes, distinguishing it from pharmacological interventions?
- Reduced activity in the anterior cingulate cortex during error monitoring tasks outside of sleep periods.
- Increased gray matter volume in the hippocampus correlating with improved sleep efficiency and subjective sleep quality. (correct)
- Increased regional cerebral blood flow in the default mode network during wakeful rest.
- Enhanced GABAergic neurotransmission evidenced by increased receptor binding potential in the thalamus.
When evaluating sleep patterns in older adults presenting with multiple comorbidities, which factor is most critical in differentiating between normal age-related sleep changes and pathological insomnia requiring targeted intervention?
When evaluating sleep patterns in older adults presenting with multiple comorbidities, which factor is most critical in differentiating between normal age-related sleep changes and pathological insomnia requiring targeted intervention?
In managing sleep disturbances for patients undergoing chemotherapy, which intervention demonstrates the highest level of multimodal efficacy in mitigating both insomnia and chemotherapy-induced cognitive impairment?
In managing sleep disturbances for patients undergoing chemotherapy, which intervention demonstrates the highest level of multimodal efficacy in mitigating both insomnia and chemotherapy-induced cognitive impairment?
Considering the evolving understanding of the glymphatic system, what modifiable lifestyle factor could most significantly impact cerebral waste clearance during sleep, and how might this inform preventative strategies against neurodegenerative diseases?
Considering the evolving understanding of the glymphatic system, what modifiable lifestyle factor could most significantly impact cerebral waste clearance during sleep, and how might this inform preventative strategies against neurodegenerative diseases?
When assessing the impact of shift work on cognitive performance among healthcare professionals, what neurocognitive assessment paradigm would be most sensitive in detecting subtle deficits in sustained attention and vigilant performance that correlate with increased medical error rates?
When assessing the impact of shift work on cognitive performance among healthcare professionals, what neurocognitive assessment paradigm would be most sensitive in detecting subtle deficits in sustained attention and vigilant performance that correlate with increased medical error rates?
Analyzing the neuroendocrine axis in patients with chronic sleep deprivation, which hormonal alteration, mediated by orexin and glucocorticoid dysregulation, would most significantly contribute to metabolic syndrome and increased cardiovascular risk?
Analyzing the neuroendocrine axis in patients with chronic sleep deprivation, which hormonal alteration, mediated by orexin and glucocorticoid dysregulation, would most significantly contribute to metabolic syndrome and increased cardiovascular risk?
In developing targeted interventions for sleep disturbances associated with Post-Traumatic Stress Disorder (PTSD), which psychotherapeutic modality demonstrates superior efficacy in modulating amygdala hyperactivity and consolidating traumatic memories, thereby improving sleep quality and reducing nightmares?
In developing targeted interventions for sleep disturbances associated with Post-Traumatic Stress Disorder (PTSD), which psychotherapeutic modality demonstrates superior efficacy in modulating amygdala hyperactivity and consolidating traumatic memories, thereby improving sleep quality and reducing nightmares?
Considering the economic implications of chronic insomnia, what population-level intervention would yield the most substantial long-term reduction in healthcare costs associated with sleep-related accidents, productivity losses, and comorbid conditions?
Considering the economic implications of chronic insomnia, what population-level intervention would yield the most substantial long-term reduction in healthcare costs associated with sleep-related accidents, productivity losses, and comorbid conditions?
Which pharmacological intervention for insomnia augments sleep by modulating the orexin neuropeptide system, thereby promoting wakefulness inhibition, as opposed to directly influencing GABAergic or melatonergic pathways?
Which pharmacological intervention for insomnia augments sleep by modulating the orexin neuropeptide system, thereby promoting wakefulness inhibition, as opposed to directly influencing GABAergic or melatonergic pathways?
How does chronic sleep restriction (CSR) affect glucose metabolism and insulin sensitivity at the molecular level, and how does this relate to the increased risk of type 2 diabetes?
How does chronic sleep restriction (CSR) affect glucose metabolism and insulin sensitivity at the molecular level, and how does this relate to the increased risk of type 2 diabetes?
What role does slow-wave sleep (SWS) play in the consolidation of declarative memories, and what neurophysiological mechanisms mediate this process?
What role does slow-wave sleep (SWS) play in the consolidation of declarative memories, and what neurophysiological mechanisms mediate this process?
In the context of sleep disorders, how do the diagnostic criteria for narcolepsy differ between the presence and absence of cataplexy, and what role does hypocretin-1 (orexin-A) play in this differentiation?
In the context of sleep disorders, how do the diagnostic criteria for narcolepsy differ between the presence and absence of cataplexy, and what role does hypocretin-1 (orexin-A) play in this differentiation?
Among the interventions for sleep apnea, including continuous positive airway pressure (CPAP), mandibular advancement devices (MADs), and surgical approaches, which factor most critically influences their relative efficacy in reducing cardiovascular risk and improving long-term mortality outcomes?
Among the interventions for sleep apnea, including continuous positive airway pressure (CPAP), mandibular advancement devices (MADs), and surgical approaches, which factor most critically influences their relative efficacy in reducing cardiovascular risk and improving long-term mortality outcomes?
For patients diagnosed with sleep-related eating disorder (SRED), what is the most crucial differential diagnostic consideration to distinguish it from other parasomnias or nocturnal eating behaviors, and how does this distinction inform treatment strategies?
For patients diagnosed with sleep-related eating disorder (SRED), what is the most crucial differential diagnostic consideration to distinguish it from other parasomnias or nocturnal eating behaviors, and how does this distinction inform treatment strategies?
Which cognitive domain is most vulnerable to impairment as a result of chronic healthcare worker fatigue? Additionally, what standardized neuropsychological test would be most reliable for assessing the severity of this particular impairment?
Which cognitive domain is most vulnerable to impairment as a result of chronic healthcare worker fatigue? Additionally, what standardized neuropsychological test would be most reliable for assessing the severity of this particular impairment?
Analyzing the risk factors for healthcare worker fatigue, what organizational-level intervention would most effectively mitigate the adverse consequences related to medication errors and adverse medical events?
Analyzing the risk factors for healthcare worker fatigue, what organizational-level intervention would most effectively mitigate the adverse consequences related to medication errors and adverse medical events?
Among the age groups, which experiences the most fragmentation of sleep?
Among the age groups, which experiences the most fragmentation of sleep?
Several factors will affect a person's sleep. Occupation is one of them. Which of the following occupations have the most affect on the sleep patterns?
Several factors will affect a person's sleep. Occupation is one of them. Which of the following occupations have the most affect on the sleep patterns?
What is the primary difference between stage NREM II and NREM III?
What is the primary difference between stage NREM II and NREM III?
How are hypnotics different from opioids?
How are hypnotics different from opioids?
How does "family bed" affect the sleep pattern?
How does "family bed" affect the sleep pattern?
How does pain affect sleep?
How does pain affect sleep?
Which of the following is not true regarding sleep in stage REM?
Which of the following is not true regarding sleep in stage REM?
Flashcards
NREM Stage I
NREM Stage I
Stage I of NREM sleep is a transition between wake and sleep. The person is relaxed and easily aroused and lasts only minutes. It is only 5% of sleep.
NREM Stage II
NREM Stage II
Stage II of NREM sleep is when you fall into a stage of sleep and can be aroused with relative ease, 50% of sleep.
NREM Stage III
NREM Stage III
Stage III of NREM sleep is when the depth of sleep increases, it's difficult to arouse and you may be confused, VSS decreases, skeletal muscle very relaxed, snoring may occur. It is 20-25% of sleep.
Rapid Eye Movement (REM)
Rapid Eye Movement (REM)
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Loss of REM
Loss of REM
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REM rebound
REM rebound
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Newborns (0-3 months)
Newborns (0-3 months)
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Infants (4-12 months)
Infants (4-12 months)
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Toddlers (1-2 years)
Toddlers (1-2 years)
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Preschoolers (3-5 years)
Preschoolers (3-5 years)
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School-age (6-12 years)
School-age (6-12 years)
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Teens (13-18 years)
Teens (13-18 years)
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Adults (18-60 years)
Adults (18-60 years)
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Adults (61-64 years)
Adults (61-64 years)
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Adults (65 years & older)
Adults (65 years & older)
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Short Sleeper
Short Sleeper
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Insomnia
Insomnia
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Disturbed Sleep Pattern
Disturbed Sleep Pattern
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Healthcare Worker Fatigue
Healthcare Worker Fatigue
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Restless Leg Syndrome
Restless Leg Syndrome
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Sleep Deprivation
Sleep Deprivation
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Hypersomnia
Hypersomnia
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Obstructive Sleep Apnea
Obstructive Sleep Apnea
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Narcolepsy
Narcolepsy
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Parasomnias
Parasomnias
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Study Notes
- Rest and Sleep are being discussed in NURS 230.
CDC Guidelines for Sleep Duration
- Newborns (0-3 months) need 14-17 hours of sleep, according to the National Sleep Foundation; the American Academy of Sleep Medicine has no recommendation.
- Infants (4-12 months) need 12-16 hours of sleep, including naps, per 24 hours.
- Toddlers (1-2 years) need 11-14 hours of sleep, including naps, per 24 hours.
- Preschoolers (3-5 years) need 10-13 hours of sleep, including naps, per 24 hours.
- School-age children (6-12 years) need 9-12 hours of sleep per 24 hours.
- Teens (13-18 years) need 8-10 hours of sleep per 24 hours.
- Adults (18-60 years) need 7 or more hours of sleep per night.
- Adults (61-64 years) need 7-9 hours of sleep.
- Adults (65 years and older) need 7-8 hours of sleep.
Non-Rapid Eye Movement (NREM) Sleep Stages
- NREM Stage I involves the transition between wakefulness and sleep.
- Individuals in NREM Stage I are relaxed, easily aroused, and this stage lasts only minutes, accounting for 5% of total sleep.
- NREM Stage II is when one falls into a deeper stage of sleep but can still be aroused with relative ease, making up 50% of sleep.
- NREM Stage III is characterized by an increased depth of sleep.
- Arousing someone in NREM Stage III is difficult, and they may be confused, with vital signs decreasing.
- Skeletal muscles are very relaxed during NREM Stage III, snoring may occur, and this stage accounts for 20-25% of sleep.
Rapid Eye Movement (REM) Sleep
- Eyes dart quickly back and forth during REM sleep.
- Small muscle twitching and large muscle immobilization are typical in REM.
- Vital signs increase, as do gastric secretions and metabolism.
- Dreaming occurs during REM sleep, which constitutes 25% of total sleep.
- More spontaneous awakenings may occur during REM.
- Loss of REM sleep impairs memory and learning.
- REM rebound occurs after sleep deprivation, leading to increased time in REM on successive nights to keep total REM constant over time.
- individuals Reenter NREM at Stage II, repeats the cycle 4-6 times per night.
Sleep Patterns in Young Adults
- Young adults typically require 8 hours of sleep.
- Factors affecting sleep in young adults include physical health, occupation (shift work, work demands, travel), exercise, and lifestyle demands.
- Nursing interventions include reinforcing good sleep habits, exploring lifestyle demands and stressors, and teaching relaxation and stress reduction techniques.
- Medications can decrease REM sleep, may be habit-forming, and lose effectiveness over time, can result to medication.
Sleep Patterns in Middle-Aged Adults
- Middle-aged adults experience a decrease in total sleep time, including stage IV sleep
- They also experience an increase in awake time.
- Middle-aged adults are more aware of sleep disturbances.
- Menopausal women experience fluctuations in sleeping patterns.
- Nursing interventions include exploring pathological causes and anxiety or depression, and encouraging avoidance of sleep-inducing medications on regular basis.
Sleep Patterns in Older Adults
- Older adults average 7-9 hours of sleep
- have a tendency to sleep less soundly, including absent or shortened Stage IV sleep, and shorter periods of REM.
- Older adults may experience more difficulty falling asleep.
- They may have a decline in physical health, psychosocial/environmental factors, and drug therapy issues that affect sleep.
- Nursing interventions include comprehensive assessment and provision of a safe environment.
- Common medications affecting sleep are diuretics, sedatives, and pain medications.
Factors Affecting Sleep
- Motivation: Being interested and engaged promotes wakefulness, while being disinterested and bored promotes sleep.
- Culture: Beliefs and practices, such as co-sleeping arrangements ("family bed"), herbal remedies, and considerations for privacy, impact sleep.
- Lifestyle and Habits: Shift work, melatonin production at night, and screen time affect sleep patterns.
- Physical Activity and Exercise: Exercise increases REM and NREM sleep, but there is a 2-hour rule to avoid exercise too close to bedtime, and exhaustion decreases sleep quality.
- Environmental: Factors like city vs. country living, home vs. away atmosphere, noise levels, and light vs. dark exposure influence sleep.
- Dietary Habits: Consuming carbohydrates and protein may improve sleep.
- Alcohol: Large amounts can limit REM and delta sleep; cessation 6 hours before sleep can improve sleep quality.
- Caffeine: It binds to adenosine receptors and prevents drowsiness.
- Smoking: Nicotine is a stimulant, and refraining from smoking after dinner can improve the ability to fall asleep.
- Psychological: Anxiety or depression and general psychological health affect amount of sleep.
- Illness: Conditions like GERD, CAD, and ESRD, as well as pain and respiratory issues, can disrupt sleep.
- Medications: Hypnotics promote sleep but can decrease sleep quality.
- Opioids: suppress REM sleep and cause frequent awakenings.
Insomnia
- Insomnia is the most common sleep disorder.
- It is characterized by symptoms that occur at least 3 nights per week and persist for at least 3 months or longer.
- Characteristics include difficulty falling asleep, intermittent sleep, and early awakening.
- It is more common in individuals over 60 years of age.
- Women experiencing menopause and individuals on shift work or experiencing jet lag, may experience this disorder more often.
- Non-pharmacologic interventions include cognitive behavioral therapy (CBT) + biofeedback and relation and avoiding napping during the day.
- It can also include getting up at the same time, or going to bed when feeling sleepy.
- Pharmacologic interventions include sedatives and hypnotics for short-term use.
- OTC medications are generally not effective.
Restless Leg Syndrome (RLS)
- RLS is characterized by the inability to lie still, with creeping, crawling, tingling sensations in the legs (ankle to thigh).
- There is an "irresistible urge" to move legs as a result of RLS.
- RLS is associated with medical conditions such as ESRD, diabetes, iron deficiency, peripheral neuropathy, and pregnancy.
- There is no specific diagnostic test for restless leg syndrome.
- Treatment involves walking, massage, and knee bends.
- Eliminating caffeine, alcohol, and tobacco can improve symptoms.
- Mild analgesics at HS (hour of sleep).
- TENS and biofeedback for relaxation techniques can improve the impact of RLS.
- Medications such as Requip, Mirapex, Horizant ER, and Neupro transdermal can be used for treatment.
Sleep Deprivation
- Sleep deprivation is defined in NANDA nursing diagnosis as a decrease in the amount, consistency, or quality of sleep affecting REM or NREM.
- Experiencing more than 30 hours of wakefulness may be an indicator.
- Safety risks increase with sleep deprivation with impaired level of concentration, information processing, and performance.
- Hospital environment issues, such as unfamiliar surroundings, noise, and “ICU psychosis” contribute.
- Causal relationships exist between sleep deprivation and other conditions such as cancer, obesity, diabetes, and cardiovascular disease (CAD).
Hypersomnia
- Hypersomnia is a condition characterized by excessive sleep, especially during the day.
- Individuals experiencing it may fall asleep at work or in the middle of conversations or while eating.
- Naps do not relieve the symptoms.
- When awake, individuals are typically disoriented, irritated, restless, and have slowed speech and thinking processes.
- The cause is often unknown but it can be a caused by other sleep disorder, such as sleep apnea or narcolepsy.
- It can attributed to substance abuse, a head injury, or trauma, or a variety of conditions, such as kidney, liver, metabolic conditions, DKA, or hypothyroidism.
- Hypersomnia can be a symptom of depression.
- Treatment is symptomatic which can include the use of stimulants, antidepressants, dietary changes, and avoidance of shift work or late nights.
Obstructive Sleep Apnea
- Obstructive sleep apnea is characterized by sleep-disordered breathing and apnea (cessation of breathing) during snoring intervals.
- This causes Hypopharynx collapses.
- These collapses last 10 to 20 seconds, up to 2 minutes.
- Causes Fight or Flight → startle awake.
- This causes excessive daytime sleepiness.
- Indicators are being overweight with short, thick neck and enlarged tonsils, adenoids, deviated septum, or enlarged thyroid.
- Diagnosis: sleep study.
- Treatment: CPAP (Compliance issues).
- It can also be treated with MAD (mandibular advancement device) or surgical removal of soft tissue at the back of the mouth.
- Treatment includes Weight loss and smoking or alcohol cessation.
Narcolepsy
- Narcolepsy is characterized by an uncontrollable desire to sleep.
- Sufferers quickly fall asleep, have difficulty to wake up, have less & restless sleep.
- It typically onsets around adolescence, or early adulthood.
- There is no cure.
- It can diagnosis with a sleep study.
- Treatment: includes No driving.
- The use of medications, and lifestyle changes.
Parasomnias
- Parasomnias are waking behavior patterns that appear during REM or NREM sleep.
- Common in children.
- They include: Sleepwalking, REM Sleep Behavior Disorder, Night terrors, Nightmares, Bruxism, Enuresis, and Sleep-related eating disorder.
- It may be important to focus SAFETY & INJURY PREVENTION.
Nursing Assessment
- Look at Usual sleep/wake pattern, any recent changes?, the number of hours undisturbed sleep, the quality of sleep, naps, the ability to perform ADLs, and sleep diary.
- Consider sleep aids either pharmacologic & non-pharmacologic, and observe sleep disturbances & contributing factors.
Physical Assessment
- Evaluate level of consciousness LOC, how is the Focus, is the Ability to answer questions is hindered, Speech.
- Examine Posture, and Body mass index BMI and note the presence of Deviated septum, and Enlarged tonsils/adenoids.
- Information from a partner may identify Restlessness and Snoring with sudden stop/snort.
- Nurses should observe Nursing observation during sleep behaviors of Restlessness, Snoring with sleep apnea, posture while sleeping, and observable sleep activity.
Nursing Diagnoses
- Potential diagnosis for a disturbed sleeping pattern include Difficulty Falling Asleep, Difficulty Remaining Asleep, and Altered Sleep-Wake Patterns.
- Recognize the Risk for injury such as Narcolepsy , Sleep walking.
- Be aware to look for Alteration in Nutrition r/t sleep depravation.
- The are potential concerns of role conflict should look to Fatigue r/t prolonged.
Nursing Interventions
- Identify sleep stressors in the patient.
- Adjust sleep environment to promote rest.
- Assess current medications for impact on sleeping patterns.
- Provide comfort measures utilizing massage or repositioning.
- Educate patient family on creating a Positive sleep environment with no caffeine, alcohol, or smoking.
- Decrease screen time, increase physical activity and evaluate medication use with patients.
Effects of Insufficient Sleep
- Short Sleepers who get less than 6 hours of sleep might have Increasing! and potential link to sleep to Sleep-weight.
- Shift Work which can can lead to Increased risk of Type 2 diabetes, Breast/colorectal cancer, Cardiovascular disease, and Substance abuse.
- Performance of person awake 17 hours that of alcohol intoxication !
Healthcare Worker Fatigue
- Cause: Rotating shifts, Mandatory overtime, and 12-hour shifts.
- Consequences: Medication errors, Adverse Medical Events, Patient Safety compromised, Ability to competently perform tasks compromised and Decision-making compromised.
Healthcare Worker Fatigue - Impact
- Poor concentration
- Increased errors & injuries
- Impaired judgement & decision making
- Decreased reaction time
- Altered communication
- Reduced motivation, apathy
Insufficient Sleep & Medical Errors
- TJC Sentinel Alert 48 (2011)
- Assess schedules & staffing to get Staff input encouraged
- Review handoff procedures
- Have a Fatigue Management Plan
- Encourage Education: sleep/fatigue effect on patient safety
- Respond to Fatigue issue in Adverse events
- Teamwork to support shift workers
Factors caused by Sleep Deprivation
- Med Errors cause Significant issues after 8 hours or with being Higher > 12.5 hours
- Employee Accidents tend to Increases after 9 hours and Doubles after 12 hours
- General function can cause Lapses in attention, Diminished reaction time, as well as Decision Regret.
Healthcare Worker Fatigue - Strategies
- Know your tolerance when working rotating shifts, or 12-hour shifts or Overtime hours
- Try to Get up and move around.
- Engage in conversation
- Take frequent breaks if possible
- Use caffeine wisely
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