Nucleic Acids Chapter 1 Quiz
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What are nucleic acids?

Nucleic acids are intracellular components that are required for the storage and expression of genetic information.

Which of the following are examples of nucleic acids?

  • Carbohydrates
  • Proteins
  • DNA (correct)
  • RNA (correct)
  • What are nucleotides, and what are they called in relation to DNA and RNA?

    Nucleotides are the building blocks of DNA and RNA. They are also known as the subunits of DNA and RNA.

    Which of the following are purines?

    <p>Guanine</p> Signup and view all the answers

    Which of the following are pyrimidines?

    <p>Cytosine</p> Signup and view all the answers

    Ribose is found in RNA.

    <p>True</p> Signup and view all the answers

    Deoxyribose is found in DNA.

    <p>True</p> Signup and view all the answers

    What is the difference between a nucleoside and a nucleotide?

    <p>A nucleoside consists of a nitrogenous base and a pentose sugar, while a nucleotide includes a phosphate group in addition to the nitrogenous base and pentose sugar.</p> Signup and view all the answers

    What are the functions of nucleotides?

    <p>Activation of chemical compounds</p> Signup and view all the answers

    What role does ATP play in cells?

    <p>ATP acts as the primary energy currency in cells, providing energy for various cellular processes.</p> Signup and view all the answers

    What are second messengers in cell signaling?

    <p>Second messengers are molecules that relay signals from the cell surface to intracellular targets, amplifying the signal and initiating specific cellular responses.</p> Signup and view all the answers

    What are co-enzymes, and what are some examples?

    <p>Co-enzymes are non-protein organic molecules that assist enzymes in catalyzing biochemical reactions. Examples include NAD, FAD, and coenzyme A.</p> Signup and view all the answers

    Explain the role of UDP-glucose in glycogen synthesis.

    <p>UDP-glucose is involved in the synthesis of glycogen, a storage form of glucose, by acting as a carrier of glucose molecules.</p> Signup and view all the answers

    How do CDP-choline and CDP-ethanolamine contribute to phospholipid synthesis?

    <p>CDP-choline and CDP-ethanolamine are involved in the synthesis of phospholipids, key components of cell membranes, by carrying the choline and ethanolamine head groups, respectively.</p> Signup and view all the answers

    What is the function of PAPS in sulfolipid synthesis?

    <p>Sulfate donor</p> Signup and view all the answers

    SAM is a sulfate donor involved in reactions.

    <p>False</p> Signup and view all the answers

    What are synthetic analogues of nucleotides, and what are they used for?

    <p>Synthetic analogues of nucleotides are modified versions of natural nucleotides, created by altering the base ring or sugar part. These analogues are used for therapeutic purposes, such as cancer treatment and gout management.</p> Signup and view all the answers

    How does 5-fluorouracil work as an anti-cancer agent?

    <p>5-fluorouracil is a pyrimidine analogue that inhibits thymine synthesis, leading to a reduction in DNA synthesis and ultimately the growth of cancer cells.</p> Signup and view all the answers

    What is the role of allopurinol in the treatment of gout?

    <p>Allopurinol, a hypoxanthine analogue, is used to treat gout by inhibiting the production of uric acid, which accumulates in joints and causes inflammation.</p> Signup and view all the answers

    Define what DNA is.

    <p>DNA, deoxyribonucleic acid, is a very large molecule composed of a long chain of nucleotides.</p> Signup and view all the answers

    Describe the structure of DNA in terms of its shape and components.

    <p>DNA has a double helix structure, resembling a twisted ladder. Its two strands are composed of nucleotides linked by phosphodiester bonds, forming the sugar-phosphate backbone. The nitrogenous bases, adenine, guanine, cytosine, and thymine, project inward and pair with their complementary bases on the opposing strand.</p> Signup and view all the answers

    What is meant by the antiparallel nature of DNA strands?

    <p>The two strands of DNA run in opposite directions: one strand runs from 5' to 3', while the other strand runs from 3' to 5', with the phosphates at the 5' end and the hydroxyl groups at the 3' end of each strand.</p> Signup and view all the answers

    Describe the base pairing rule (Chargaff's rule) in DNA.

    <p>The base pairing rule, also known as Chargaff's rule, states that adenine (A) always pairs with thymine (T), and guanine (G) always pairs with cytosine (C) in DNA.</p> Signup and view all the answers

    What is the importance of the sequence of bases in DNA?

    <p>The specific sequence of bases in DNA is crucial for determining the genetic information that is encoded and passed on to future generations.</p> Signup and view all the answers

    How is DNA replicated?

    <p>DNA replication involves the separation of the double helix into two separate strands, followed by the synthesis of two new complementary strands using each original strand as a template.</p> Signup and view all the answers

    What are the two main functions of DNA?

    <p>DNA has two main functions: it serves as a carrier of genetic information, directing the synthesis of proteins and other essential molecules, and it directs its own replication during cell division, ensuring the accurate transmission of genetic information to daughter cells.</p> Signup and view all the answers

    What is RNA, and what are its key features?

    <p>RNA, ribonucleic acid, is a single-stranded nucleic acid that plays a crucial role in protein synthesis. It is similar to DNA but contains a different sugar (ribose) and the base uracil instead of thymine.</p> Signup and view all the answers

    Which of the following bases is found in RNA but not in DNA?

    <p>Uracil</p> Signup and view all the answers

    How are nucleotides linked together in RNA?

    <p>Nucleotides in RNA are linked together by 3',5' phosphodiester bonds, similar to the linkage in DNA.</p> Signup and view all the answers

    Where is RNA formed, and how?

    <p>RNA is formed in the nucleus of a cell through a process called transcription.</p> Signup and view all the answers

    What are the four main types of RNA?

    <p>Small nuclear RNA (snRNA)</p> Signup and view all the answers

    What is mRNA, and what is its function?

    <p>Messenger RNA (mRNA) carries the genetic information from DNA to ribosomes, where it directs the synthesis of specific proteins.</p> Signup and view all the answers

    What is rRNA, and what is its function?

    <p>Ribosomal RNA (rRNA) forms the structural and functional core of ribosomes, the protein synthesis machinery in cells.</p> Signup and view all the answers

    What is tRNA, and what is its function?

    <p>Transfer RNA (tRNA) acts as a molecular adapter, carrying amino acids to ribosomes and matching them to the codons on mRNA, ensuring the correct amino acid sequence in the protein being assembled.</p> Signup and view all the answers

    What is snRNA, and what is its function?

    <p>Small nuclear RNA (snRNA) participates in various nuclear processes, including the splicing of pre-mRNA and the assembly of ribosomes.</p> Signup and view all the answers

    Match each type of RNA with its primary function:

    <p>mRNA = Carries genetic information from DNA to ribosomes, directing protein synthesis tRNA = Acts as a molecular adapter, bringing amino acids to ribosomes for protein assembly rRNA = Forms the structural and functional core of ribosomes, the protein synthesis machinery snRNA = Involved in nuclear processes like pre-mRNA splicing and ribosome assembly</p> Signup and view all the answers

    Study Notes

    Mansoura National University

    • Mansoura National University is a university in Egypt.
    • The semester is 1.

    Nucleic Acids

    • Nucleic acids are intracellular components for storing and expressing genetic information
    • Include DNA (deoxyribonucleic acid) and RNA (ribonucleic acid)
    • Nucleic acids (DNA & RNA) are long chains of repeated nucleotides.

    Learning Outcomes

    • Identify nucleotides and nucleosides nomenclature and structure
    • List functions of nucleotides and their biological importance.
    • Recognize DNA structure
    • Recognize RNA structure
    • Recognize types of RNA
    • Identify differences between DNA and RNA

    Agenda

    • Nucleotides and nucleosides (nomenclature and structure)
    • Nucleotides of biological importance and their roles
    • DNA (types and structure)
    • RNA (types and structure)
    • Structure/function relation of RNA
    • Differences between DNA and RNA

    Learning Outcome 1

    • Identify nucleotides and nucleosides nomenclature and structure

    Nucleotide Structure

    • Nucleotides are the building blocks of DNA and RNA
    • Each nucleotide has three parts: a nitrogenous base, a pentose sugar, and a phosphate group.
    • Purines include adenine (A) and guanine (G).
    • Pyrimidines include cytosine (C), thymine (T), and uracil (U).
    • Ribose sugar is found in RNA.
    • 2-deoxyribose sugar is found in DNA

    Nucleoside

    • Nucleosides are made of a nitrogenous base and a five-carbon carbohydrate (ribose).
    • Nucleotides are nucleosides with an additional phosphate group.

    Learning Outcome 2

    • Functions of nucleotides and their biological roles

    Functions of Nucleotides

    • Building blocks of RNA and DNA.
    • Source of energy (ATP, GTP).
    • Mediating hormone action (cAMP, cGMP).
    • Co-enzymes (NAD, FAD, Coenzyme A).
    • Activation of chemical compounds (UDP-glucose, CDP choline, CDP-ethanolamine, PAPS, SAM).

    Learning Outcome 3

    • Recognize DNA structure

    DNA Structure

    • DNA is 2 strands of polynucleotides (d.AMP, d.GMP, d.TMP, d.CMP)
    • The nucleotides are linked by 3', 5' phosphodiester bonds
    • One strand of DNA has many millions of nucleotides
    • DNA is a double helix, with paired strands and antiparallel orientation (one strand runs 5' to 3', the other runs 3' to 5').
    • Base pairing rule (Chargaff's Rule): A pairs with T, and G pairs with C.
    • DNA has a sugar phosphate backbone, within that the nitrogenous bases form hydrogen bonds.

    Functions of DNA

    • DNA stores and transfers genetic information and it is responsible for genetic information.
    • DNA carries genetic information and is stored in the nucleotide sequence.
    • DNA replicates in cell division.
    • DNA directs synthesis of RNA (transcription).

    The strands separate during replication

    • The DNA strands separate during replication.

    Structural forms of the double strand helix

    • A-DNA
    • B-DNA
    • Z-DNA

    Learning Outcome 4

    • Recognize RNA structure

    RNA Structure

    • RNA (Ribonucleic acid) is single-stranded polynucleotides
    • RNA contains four types of nucleotides: AMP, GMP, CMP, and UMP.
    • The nucleotides are linked together by 3',5' phosphodiester bonds.
    • RNA molecules are formed in the nucleus by transcription from DNA.

    Learning Outcome 5

    • Recognize types of RNA

    Types of RNA

    • Messenger RNA (mRNA): 5% of cellular RNA; carries messages from DNA to ribosomes for protein synthesis.
    • Transfer RNA (tRNA): 15% of cellular RNA; brings amino acids to the ribosome during protein synthesis.
    • Ribosomal RNA (rRNA): 80% of cellular RNA; a component of ribosomes, where protein synthesis takes place.
    • Small nuclear RNA (snRNA): less than 1% of cellular RNA; involved in RNA processing.

    Learning Outcome 6

    • Recognize differences between DNA and RNA

    Differences between DNA and RNA

    Feature DNA RNA
    Site Nucleus & mitochondria Cytoplasm mainly
    Function Storage and transfer of genetic characters Protein biosynthesis
    Bases A, G, C, and T A, G, C, and U
    Sugar Deoxy-ribose Ribose
    Strands 2 strands = double helix One strand
    Types One type (3 forms: A, B, and Z) 4 types (mRNA, tRNA, rRNA, snRNA)

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    Description

    Test your knowledge on nucleic acids, including DNA and RNA, and their role in genetic information storage and expression. Identify the structures and functions of nucleotides and their biological importance. This quiz will cover essential concepts from your first semester at Mansoura National University.

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