NSAIDs and Coxibs: Selectivity and Characteristics

Test your knowledge of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Coxibs, including their selectivity for COX-1 and COX-2 enzymes, chemical structures, and licenses for administration. Learn about the differences between COX-2 preferential drugs and non-selective NSAIDs.

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@CongratulatoryDidgeridoo

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Questions and Answers

What is the primary concern when switching between NSAIDs for chronic pain management?

Allowing an adequate 'wash-out' period

What is a key factor to consider when choosing an NSAID for peri-operative pain?

Availability of an injectable preparation

Which NSAID is licensed for long-term use in cats for chronic pain?

Meloxicam

What is a potential risk of NSAID administration to patients that become hypotensive?

Renal ischaemia Signup and view all the answers

What is the primary benefit of giving an NSAID pre-operatively as opposed to post-operatively?

Prevention of secondary hyperalgesia Signup and view all the answers

What is a common side effect of NSAIDs in cats and dogs that tends to occur in the first couple of weeks of administration?

Gastrointestinal ulceration Signup and view all the answers

What is the main characteristic of COX-2 preferential drugs?

They have greater selectivity for COX-2 than COX-1 Signup and view all the answers

What should you check before administering an NSAID to a dog?

The SPC/data sheet Signup and view all the answers

How can you differentiate between NSAIDs?

By their formulation, licensed indications, duration of action, relative selectivity, and cost Signup and view all the answers

What is a characteristic of non-selective NSAIDs?

They have equal selectivity for COX-1 and COX-2 Signup and view all the answers

Which of the following is NOT a characteristic of coxibs?

Their chemical name refers to their chemical structure Signup and view all the answers

What is a characteristic of mavacoxib?

It has a monthly duration of action Signup and view all the answers