10 Questions
Why was type 1 diabetes ruled out in the child?
Absence of extremely elevated glucose and thirst, and lack of auto-antibodies
How does the mutation in the gene glucokinase contribute to elevated glucose levels?
Disrupts the glucose storage process
Why did the mutation in glucokinase have a significant impact on insulin production?
It affected the rate-limiting step of insulin production
How is the child's small size related to the function of insulin as a growth factor?
Child's inability to produce sufficient insulin affects energy storage and growth
Why is glucokinase's role as the rate-limiting step important in glucose sensing?
It controls the overall efficiency of glucose regulation
Which of the following explains why the woman's children are larger than normal?
They secrete more insulin than their mom, storing more of what they eat as fat and muscle.
What equation is used to calculate/predict the equilibrium potential of ions in a cell?
Nernst equation
In a cell with a resting membrane potential of -70mV, which ion would have the largest net driving force?
Na+ (sodium) with an equilibrium potential of +60mV
Why would slightly elevated blood glucose levels in the child not result in the well-known complications associated with diabetes?
The child's body compensates by secreting more insulin to manage glucose levels efficiently.
If a cell with a membrane potential of -50mV has an ion X- with an EX- of -30mV, what would happen if the membrane is permeable to ion X-?
The ion X- would flow into the cell due to a concentration gradient.
This quiz discusses a case where a child is born to a healthy mother but later diagnosed with genetic diabetes due to a mutation in one allele of the gene glucokinase. The quiz explores the implications of the mutation and its impact on glucose sensing in beta cells.
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