NPB110A: Discussion Week 4 Problem 1 - Diabetes Genetic Mutation
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NPB110A: Discussion Week 4 Problem 1 - Diabetes Genetic Mutation

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Questions and Answers

Why was type 1 diabetes ruled out in the child?

  • Presence of both elevated glucose and thirst
  • Due to extremely elevated glucose levels and thirst
  • Absence of extremely elevated glucose and thirst, and lack of auto-antibodies (correct)
  • Because of the presence of auto-antibodies

    • How does the mutation in the gene glucokinase contribute to elevated glucose levels?

  • Disrupts the glucose storage process (correct)
  • Enhances the efficiency of insulin production
  • Increases the production of insulin
  • Decreases the rate of insulin production

    • Why did the mutation in glucokinase have a significant impact on insulin production?

  • It affected the rate-limiting step of insulin production (correct)
  • It enhanced the efficiency of other insulin production steps
  • It had no effect on insulin production
  • It increased the amount of insulin produced

    • How is the child's small size related to the function of insulin as a growth factor?

    <p>Child's inability to produce sufficient insulin affects energy storage and growth</p> Signup and view all the answers

    Why is glucokinase's role as the rate-limiting step important in glucose sensing?

    <p>It controls the overall efficiency of glucose regulation</p> Signup and view all the answers

    Which of the following explains why the woman's children are larger than normal?

    <p>They secrete more insulin than their mom, storing more of what they eat as fat and muscle.</p> Signup and view all the answers

    What equation is used to calculate/predict the equilibrium potential of ions in a cell?

    <p>Nernst equation</p> Signup and view all the answers

    In a cell with a resting membrane potential of -70mV, which ion would have the largest net driving force?

    <p>Na+ (sodium) with an equilibrium potential of +60mV</p> Signup and view all the answers

    Why would slightly elevated blood glucose levels in the child not result in the well-known complications associated with diabetes?

    <p>The child's body compensates by secreting more insulin to manage glucose levels efficiently.</p> Signup and view all the answers

    If a cell with a membrane potential of -50mV has an ion X- with an EX- of -30mV, what would happen if the membrane is permeable to ion X-?

    <p>The ion X- would flow into the cell due to a concentration gradient.</p> Signup and view all the answers

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