Novel Approaches in Pharmaceutical Industry for Gastrointestinal Disorders
12 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What has driven the pharmaceutical industry's growing interest in functional gastrointestinal disorders?

  • Success of newer antidepressants in improving symptoms of irritable bowel syndrome (correct)
  • High prevalence of traditional laxatives for constipation
  • Lack of patient needs in the market
  • Negative impact of gastrointestinal motility on patient health
  • Why are traditional laxatives for constipation considered unsatisfactory according to the text?

  • They are poorly targeted with adverse event profiles (correct)
  • They have a low cost burden on patients
  • They target specific abnormalities causing constipation
  • They have a high success rate in treating constipation
  • What is the primary reason for the large cost burden associated with traditional constipation agents?

  • Patient satisfaction
  • Poorly targeted and adverse event profiles (correct)
  • Low prevalence condition
  • High effectiveness in treating constipation
  • What is the main focus of emerging pharmacotherapeutic strategies for constipation according to the text?

    <p>Targeting functional abnormalities causing constipation</p> Signup and view all the answers

    Why is there a pressing need for pharmacological agents that increase colonic transit in the treatment of constipation?

    <p>To correct the disordered bowel habit common to most constipated patients</p> Signup and view all the answers

    Why is the use of erythromycin limited as a treatment for constipation?

    <p>It acts as a motilin agonist</p> Signup and view all the answers

    What is the main limitation of fluoxetine in its use as a colonic prokinetic?

    <p>Central nervous system effects</p> Signup and view all the answers

    In the context of colonic prokinesis, why is it important for drug development to focus on agents acting locally in the colon?

    <p>To be specific and safe</p> Signup and view all the answers

    Which of the following has been identified as a potential novel therapy for colonic irritability (CIC)?

    <p>Selective 5HT-4 agonists</p> Signup and view all the answers

    What aspect of opioid-induced constipation is likely to guide the development of targeted therapies?

    <p>Peripheral neural pathway</p> Signup and view all the answers

    What could represent a novel therapeutic approach involving non-replicating viral vectors for gastrointestinal function?

    <p>Gene therapy</p> Signup and view all the answers

    What effect has biofeedback had in trials on patients with functional constipation?

    <p>Disappointing</p> Signup and view all the answers

    More Like This

    Validation in Pharmaceutical Industry Quiz
    38 questions
    Pharmaceutical Industry History
    17 questions

    Pharmaceutical Industry History

    InventiveMossAgate3116 avatar
    InventiveMossAgate3116
    Pharmaceutical Industry Overview
    10 questions
    Use Quizgecko on...
    Browser
    Browser