Podcast
Questions and Answers
What has driven the pharmaceutical industry's growing interest in functional gastrointestinal disorders?
What has driven the pharmaceutical industry's growing interest in functional gastrointestinal disorders?
- Success of newer antidepressants in improving symptoms of irritable bowel syndrome (correct)
- High prevalence of traditional laxatives for constipation
- Lack of patient needs in the market
- Negative impact of gastrointestinal motility on patient health
Why are traditional laxatives for constipation considered unsatisfactory according to the text?
Why are traditional laxatives for constipation considered unsatisfactory according to the text?
- They are poorly targeted with adverse event profiles (correct)
- They have a low cost burden on patients
- They target specific abnormalities causing constipation
- They have a high success rate in treating constipation
What is the primary reason for the large cost burden associated with traditional constipation agents?
What is the primary reason for the large cost burden associated with traditional constipation agents?
- Patient satisfaction
- Poorly targeted and adverse event profiles (correct)
- Low prevalence condition
- High effectiveness in treating constipation
What is the main focus of emerging pharmacotherapeutic strategies for constipation according to the text?
What is the main focus of emerging pharmacotherapeutic strategies for constipation according to the text?
Why is there a pressing need for pharmacological agents that increase colonic transit in the treatment of constipation?
Why is there a pressing need for pharmacological agents that increase colonic transit in the treatment of constipation?
Why is the use of erythromycin limited as a treatment for constipation?
Why is the use of erythromycin limited as a treatment for constipation?
What is the main limitation of fluoxetine in its use as a colonic prokinetic?
What is the main limitation of fluoxetine in its use as a colonic prokinetic?
In the context of colonic prokinesis, why is it important for drug development to focus on agents acting locally in the colon?
In the context of colonic prokinesis, why is it important for drug development to focus on agents acting locally in the colon?
Which of the following has been identified as a potential novel therapy for colonic irritability (CIC)?
Which of the following has been identified as a potential novel therapy for colonic irritability (CIC)?
What aspect of opioid-induced constipation is likely to guide the development of targeted therapies?
What aspect of opioid-induced constipation is likely to guide the development of targeted therapies?
What could represent a novel therapeutic approach involving non-replicating viral vectors for gastrointestinal function?
What could represent a novel therapeutic approach involving non-replicating viral vectors for gastrointestinal function?
What effect has biofeedback had in trials on patients with functional constipation?
What effect has biofeedback had in trials on patients with functional constipation?
