12 Questions
What has driven the pharmaceutical industry's growing interest in functional gastrointestinal disorders?
Success of newer antidepressants in improving symptoms of irritable bowel syndrome
Why are traditional laxatives for constipation considered unsatisfactory according to the text?
They are poorly targeted with adverse event profiles
What is the primary reason for the large cost burden associated with traditional constipation agents?
Poorly targeted and adverse event profiles
What is the main focus of emerging pharmacotherapeutic strategies for constipation according to the text?
Targeting functional abnormalities causing constipation
Why is there a pressing need for pharmacological agents that increase colonic transit in the treatment of constipation?
To correct the disordered bowel habit common to most constipated patients
Why is the use of erythromycin limited as a treatment for constipation?
It acts as a motilin agonist
What is the main limitation of fluoxetine in its use as a colonic prokinetic?
Central nervous system effects
In the context of colonic prokinesis, why is it important for drug development to focus on agents acting locally in the colon?
To be specific and safe
Which of the following has been identified as a potential novel therapy for colonic irritability (CIC)?
Selective 5HT-4 agonists
What aspect of opioid-induced constipation is likely to guide the development of targeted therapies?
Peripheral neural pathway
What could represent a novel therapeutic approach involving non-replicating viral vectors for gastrointestinal function?
Gene therapy
What effect has biofeedback had in trials on patients with functional constipation?
Disappointing
Explore the innovative strategies and interest of the pharmaceutical industry in addressing functional gastrointestinal disorders, with a focus on improving symptoms of irritable bowel syndrome. Learn about the shortcomings of traditional laxatives and the growing need for more targeted and effective treatments.
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