Novel Approaches in Pharmaceutical Industry for Gastrointestinal Disorders
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Questions and Answers

What has driven the pharmaceutical industry's growing interest in functional gastrointestinal disorders?

  • Success of newer antidepressants in improving symptoms of irritable bowel syndrome (correct)
  • High prevalence of traditional laxatives for constipation
  • Lack of patient needs in the market
  • Negative impact of gastrointestinal motility on patient health
  • Why are traditional laxatives for constipation considered unsatisfactory according to the text?

  • They are poorly targeted with adverse event profiles (correct)
  • They have a low cost burden on patients
  • They target specific abnormalities causing constipation
  • They have a high success rate in treating constipation
  • What is the primary reason for the large cost burden associated with traditional constipation agents?

  • Patient satisfaction
  • Poorly targeted and adverse event profiles (correct)
  • Low prevalence condition
  • High effectiveness in treating constipation
  • What is the main focus of emerging pharmacotherapeutic strategies for constipation according to the text?

    <p>Targeting functional abnormalities causing constipation</p> Signup and view all the answers

    Why is there a pressing need for pharmacological agents that increase colonic transit in the treatment of constipation?

    <p>To correct the disordered bowel habit common to most constipated patients</p> Signup and view all the answers

    Why is the use of erythromycin limited as a treatment for constipation?

    <p>It acts as a motilin agonist</p> Signup and view all the answers

    What is the main limitation of fluoxetine in its use as a colonic prokinetic?

    <p>Central nervous system effects</p> Signup and view all the answers

    In the context of colonic prokinesis, why is it important for drug development to focus on agents acting locally in the colon?

    <p>To be specific and safe</p> Signup and view all the answers

    Which of the following has been identified as a potential novel therapy for colonic irritability (CIC)?

    <p>Selective 5HT-4 agonists</p> Signup and view all the answers

    What aspect of opioid-induced constipation is likely to guide the development of targeted therapies?

    <p>Peripheral neural pathway</p> Signup and view all the answers

    What could represent a novel therapeutic approach involving non-replicating viral vectors for gastrointestinal function?

    <p>Gene therapy</p> Signup and view all the answers

    What effect has biofeedback had in trials on patients with functional constipation?

    <p>Disappointing</p> Signup and view all the answers

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